18,450 results match your criteria: "Reactive Arthritis"

Reactive Oxygen and Nitrogen Species - "Nanosweeper" for Rheumatoid Arthritis Theranostics by Macrophage Reprogramming.

ACS Appl Mater Interfaces

December 2024

National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.

Excessive reactive oxygen and nitrogen species (RONS) accumulation in joints are significant variables that affect the course of rheumatoid arthritis (RA). Scavenging of RONS to remodel macrophage homeostasis is a potentially powerful treatment for RA. Here, a visualized "nanosweeper" by functionalizing ultrasmall Gd/FeO nanoparticles with thiol-polyethylene glycol-phosphoric acid and 2-(3-(2-aminophenyl)ureido) ethyl methacrylate hydrochloride (APUEMA), namely GIA NPs, can simultaneously scavenge both nitric oxide (NO) and reactive oxygen species (ROS), as well as enhance magnetic resonance imaging (MRI) for the diagnosis and therapy of RA.

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Background The rising prevalence of osteoarthritis (OA) will create significant challenges for low-resource public health systems in countries like India, leading to increased disability and reduced quality of life. Limited access to imaging and specialized orthopedic care in rural areas often delays diagnosis and treatment until the disease has progressed to advanced stages, further burdening the economy. Objectives To estimate the community prevalence and assess the risk factors associated with OA among adults aged 40 and older in rural areas of South India and to determine their functional assessment among OA-diagnosed patients.

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Background: In April 2024, our hospital confirmed a rare case of intra-abdominal infection by Kodamaea ohmeri. The patient sought medical attention at our hospital after taking painkillers orally for one month, experiencing recurrent abdominal pain for 17 days and worsening for 7 days. In March 2024, the patient received symptomatic treatment with oral analgesics (diclofenac sodium) for arthritis.

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() is a Gram-negative pathogen associated with gastrointestinal infections, such as enterocolitis. While complications like reactive arthritis can occur, progression to myositis is extremely rare. This report describes a five-year-old boy who developed myositis following a infection.

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Objective: The aim of this study was to investigate the impact of estrogen and progesterone analog supplementation on the development of autoimmune conditions.

Methods: This retrospective observational study used data from the TriNetX network, which comprised over 100 million patients from 89 health care organizations. We compared patients exposed to estrogen and progesterone analogs to those exposed to progesterone-only therapy, using 1:1 propensity score matching based on age, ethnicity, and additional criteria.

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Objectives: We characterised early changes in laboratory parameters in Japanese patients with rheumatoid arthritis (RA) and assessed whether these changes at Month (M)1 were predictive of tofacitinib efficacy at M3.

Methods: This post hoc analysis included data from Japanese patients with RA receiving tofacitinib or placebo pooled from two Phase (P)2 studies in Japan (NCT00603512; NCT00687193) and one global P3 study (NCT00847613). Outcomes: changes from baseline in laboratory parameters (Week 2 and M1/3); efficacy endpoints (Disease Activity Score in 28 joints, based on C-reactive protein [DAS28-4(CRP)], DAS28-4, based on erythrocyte sedimentation rate [DAS28-4(ESR)], and American College of Rheumatology-N index) at M3.

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Macrophage extracellular traps are induced by Mycoplasma bovis in bovine macrophages through NADPH oxidase/ROS-dependent manner and their antibacterial efficacy.

FASEB J

December 2024

State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Mycoplasma bovis has emerged as a significant pathogen in cattle, leading to considerable economic losses in the cattle industry. It is associated with various clinical syndromes, including pneumoniae, mastitis, and arthritis. The innate immune response, particularly macrophages, plays a crucial role in combating infections caused by such pathogens.

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Objective: Rheumatoid arthritis (RA) is associated with depression in approximately 15% of patients, most of whom have been studied using questionnaires. As the depression questionnaire includes questions about physical symptoms, caution should be exercised when interpreting the results due to an underlying disease. In addition, few studies have been conducted on other psychiatric disorders.

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Rheumatoid Arthritis: A Rare Cause of Pachymeningitis and Optic Neuritis.

Eur J Case Rep Intern Med

November 2024

Department of Internal Medicine, Tower Health, Reading Hospital, West Reading, USA.

Introduction: Rheumatoid pachymeningitis and optic neuritis are rare complications of rheumatoid arthritis (RA) and are a diagnosis of exclusion.

Case Description: A 75-year-old male with a history of seronegative RA presented to the emergency department with left eye pain and blurry vision lasting two days. He had been diagnosed with seronegative RA around nine months previously.

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Antibody-based therapeutic proteins (TPs) emerged as a promising therapeutic modality for chronic inflammatory diseases. During clinical development, the impact of disease on pharmacokinetics (PK) should be carefully considered to reliably extrapolate PK from healthy volunteers (HVs) in early-phase studies to patients in later-phase studies. This paper aimed to provide an overview of the impact of chronic inflammatory diseases on the PK of antibody-based TPs.

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Background: To investigate the association between the development of incident interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) and the disease activity of RA with its various components, especially C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

Methods: We analysed data from RA patients, observed in the German biologics register RABBIT between 2001 and 2021. In a nested case-control study, patients with a reported incident ILD diagnosis during follow-up were matched 1:5 to patients without ILD.

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Article Synopsis
  • Rheumatoid Arthritis (RA) is a chronic autoimmune disease, and previous research highlighted α-Taxilin as a key protein elevated in RA, necessitating further exploration of its role in the disease.
  • In a study involving 106 RA patients, α-Taxilin levels were significantly higher compared to those with osteoarthritis, systemic lupus erythematosus, and healthy individuals, and it correlated with RA severity markers.
  • The study identified 17 proteins interacting with α-Taxilin, suggesting its involvement in key metabolic pathways, and experiments showed that reducing α-Taxilin levels lowered inflammation and improved symptoms in both cell cultures and a rat model of arthritis.
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Axial Spondyloarthritis: A Review.

JAMA

December 2024

Division of Arthritis and Rheumatic Diseases (OP09), Oregon Health & Science University, Portland.

Article Synopsis
  • * The main symptom is inflammatory back pain starting before age 45, often accompanied by morning stiffness and improved by exercise; it can also involve issues in peripheral joints and other inflammatory conditions.
  • * Diagnosis is often delayed by 6 to 8 years and relies on a combination of patient history, lab tests, and imaging; treatment usually starts with physical therapy and NSAIDs, but many patients may need advanced biologic therapies to manage their symptoms effectively.
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Natural killer cell activity and its relationship with disease activity in rheumatoid arthritis patients.

Hum Immunol

December 2024

Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. Electronic address:

Article Synopsis
  • The study investigated how natural killer cell activity (NKA) relates to the severity of rheumatoid arthritis (RA) by analyzing data from 259 patients.
  • Patients were split into low NKA (< 100 pg/mL) and high NKA (100-250 pg/mL) groups, with the low NKA group showing more severe RA symptoms and higher usage of TNF-α antagonists.
  • Results indicated a negative correlation between NKA levels and various measures of RA severity, suggesting that lower NKA is associated with worse disease characteristics and increased inflammation.
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Article Synopsis
  • - The study investigates the role of Pentraxin 3 (PTX3) as a marker for inflammation and cardiovascular risk in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).
  • - Results show that RA patients have significantly higher PTX3 levels and carotid intima media thickness (cIMT) compared to SpA patients, indicating greater cardiovascular risk associated with higher disease activity in RA.
  • - PTX3 is confirmed to be a dual biomarker in RA, correlating with disease activity parameters and serving as an indicator of cardiovascular complications, while no significant relationships were found in SpA patients.
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Article Synopsis
  • - Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation, and the role of ferroptosis (a type of cell death) in this condition is not fully understood.
  • - The study examined the therapeutic effects of ferroptosis through experiments on RA patients' plasma, human synovial fibroblasts, and a collagen-induced arthritis model in rats, focusing on key proteins and health indicators.
  • - Results showed that while ferroptosis activation helped reduce inflammation and arthritis symptoms in rats, the relationship between findings in animal models and human RA symptoms is complex and nonlinear.
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[Reactive arthritis].

Z Rheumatol

December 2024

Klinik für internistische Rheumatologie, Rotes Kreuz Krankenhaus, St.-Pauli-Deich 24, 28199, Bremen, Deutschland.

Article Synopsis
  • Reactive arthritis (ReA) is a condition caused by an external infection that leads to joint inflammation without detectable pathogens, indicating a possible ongoing interaction between the host and pathogen remnants.
  • The main trigger for classical ReA is bacterial infections, often from urogenital or gastrointestinal sources, with common pathogens including Chlamydia species and enterobacteria.
  • Diagnosis relies on clinical symptoms, evidence of prior infection, and ruling out other arthritis types, while treatment focuses on managing inflammation with NSAIDs and other immunomodulators; antibiotics do not typically help reduce the disease duration.
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Prevalence of Hyperuricemia and Rheumatoid Factor Positivity Among Patients Aged 35 and Above in Huye District, Southern Province of Rwanda.

Open Access Rheumatol

November 2024

Department of Biomedical Laboratory Sciences, School of Health Sciences, College of Medicine and Health Sciences, University of Rwanda, Kigali, 3286, Rwanda.

Article Synopsis
  • * A cross-sectional study conducted from October 2023 to January 2024 involved 367 patients from Huye district, measuring RF, C-reactive protein, and serum uric acid levels while collecting data on risk factors through questionnaires.
  • * The results indicated a high prevalence of hyperuricemia (38.1%) and a lower prevalence of RF and CRP positivity, particularly in older adults and women, with important implications for health interventions
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Article Synopsis
  • A 71-year-old man experienced fever and joint pain after a recent throat infection, showing signs of group A streptococcal (GAS) infection with high antistreptolysin O (ASO) levels.
  • The case raised questions about whether he had acute rheumatic fever (ARF) or post-streptococcal reactive arthritis (PSReA), as he displayed symptoms of both conditions.
  • The authors highlight the need for careful consideration of ARF in patients with recent streptococcal infections and joint pain to ensure timely treatment and avoid complications.
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Article Synopsis
  • The study aimed to evaluate the effectiveness and safety of various Traditional Chinese Medicine (TCM) therapies for treating rheumatoid arthritis (RA).
  • A Bayesian network Meta-analysis was conducted, analyzing 42 studies with a total of 3,779 cases using software tools like RevMan and Stata.
  • Findings indicated that Wanbi decoction was the most effective, Bushen Quhan Zhiwang decoction had the least adverse effects, and Qiwei Tongbi oral liquid effectively lowered inflammation markers, suggesting TCM could enhance RA treatment when combined with Western Medicine, though more rigorous clinical trials are needed.
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Article Synopsis
  • PELI1 is a crucial factor influencing inflammatory and autoimmune diseases, but its specific role in juvenile idiopathic arthritis (JIA) is not well understood.
  • Research showed that JIA patients have elevated PELI1 levels, which correlate positively with clinical indicators like erythrocyte sedimentation rate and C-reactive protein levels.
  • Interfering with PELI1 promotes naïve CD4 T cells to differentiate into Th2 and Treg cells while inhibiting Th1 and Th17 cell differentiation, with TCF-1 playing a key role in these processes.
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Does non-surgical periodontal treatment contribute to rheumatoid arthritis amelioration? Evidence based on an overview and meta-analysis.

Odontology

November 2024

Department of Oral Surgery, Pathology, and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Room 3204, Belo Horizonte, Minas Gerais, Brazil.

Article Synopsis
  • - The study aimed to review the impact of non-surgical periodontal treatment on rheumatoid arthritis symptoms, specifically looking at the 28-joint Disease Activity Score (DAS28) and inflammatory markers like C-reactive protein and erythrocyte sedimentation rate, from existing systematic reviews.
  • - Researchers conducted thorough electronic searches for relevant studies up to August 2024, including 10 systematic reviews (six with meta-analyses), which collectively examined data before and after the treatment.
  • - Findings indicated that non-surgical periodontal treatment significantly reduced levels of C-reactive protein, erythrocyte sedimentation rate, and DAS28 in individuals with rheumatoid arthritis, with a notable reduction in DAS28 observed after three months. *
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Article Synopsis
  • Rheumatoid arthritis (RA) is an autoimmune disorder that leads to inflammation, pain, and damage in joints, and this study investigates the effects of Jingfang Granule (JFG), a traditional Chinese medicine, as a treatment.
  • The research involved creating a rat model of RA and administering either JFG or a standard drug, measuring outcomes like foot swelling and various inflammatory markers to evaluate the treatment's efficacy.
  • Results showed that JFG significantly reduced RA symptoms and levels of pro-inflammatory cytokines by targeting specific pathways in the body, suggesting it may be an effective therapeutic option for RA.
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