10,831 results match your criteria: "Raynaud Phenomenon"

Objective: The Very Early Diagnosis of Systemic Sclerosis (VEDOSS) EUSTAR study showed that, despite not showing any clinical sign of disease, patients with Raynaud's and antinuclear antibodies and/or capillaroscopy abnormalities often progress to systemic sclerosis (SSc) within 5 years. We aimed to determine whether VEDOSS biosamples show biological SSc activity pre-clinically.

Methods: Skin biopsies were histologically analysed.

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Objective: To comprehensively understand the COVID-19 vaccination and infection status among patients with systemic sclerosis (SSc).

Methods: We conducted a retrospective analysis of patients diagnosed with SSc who were hospitalized in the Rheumatology and Immunology Department of Peking University People' s Hospital from January 2016 to March 2023. We collected detailed clinical cha-racteristics, vaccination status, and infection details through a systematic review of medical records and telephone follow-ups with the SSc patients.

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The role of nailfold video-capillaroscopy in the assessment of dermatomyositis.

Rheumatology (Oxford)

December 2024

Department of Rheumatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Jiangsu Province, Nantong, 226001, China.

Objectives: The clinical manifestations of dermatomyositis (DM) are diverse, nailfold video-capillaroscopy (NVC) can reflect microangiopathy, a process believed to contribute significantly to the clinical manifestations of DM. We aimed to explore the distinctive alterations and implications of nailfold capillary for evaluating disease progression in individuals with DM.

Methods: We gathered clinical data from 76 DM patients who underwent NVC in the Affiliated Hospital of Nantong University between September 2017 and September 2022.

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Purpose: Interstitial lung disease (ILD) damages the lungs and can be caused by environmental exposures and collagen-vascular diseases. The systemic immune-inflammation index (SII) is investigated to diagnose and manage ILDs in different etiological diseases. The study aims to examine the usefulness of SII in diagnosing specific ILDs like Sjogren's syndrome (SjS)-ILD, interstitial pneumonia with autoimmune features (IPAF), and idiopathic pulmonary fibrosis (IPF).

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Objective: Systemic sclerosis (SSc) is disabling. However, the different factors contributing to this disability and how these change over time have been little studied. Our aim was to examine the trajectories over time of the six visual analogue scales (VAS) of the scleroderma HAQ (SHAQ), associations of disease-related factors with these trajectories, and relationships with overall functional ability.

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Introduction: Dimethyl fumarate (DMF) has demonstrated a favorable benefit-risk profile in patients with relapsing-remitting multiple sclerosis (RRMS) in clinical and real-world studies. The ESTEEM study (NCT02047097) was conducted to assess the long-term safety and effectiveness of delayed-release DMF in patients with relapsing forms of MS in routine clinical practice. We report final outcomes from ESTEEM with up to 6.

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This case report describes a rare occurrence of a 25-year-old female diagnosed with both systemic sclerosis (SSc) and ankylosing spondylitis (AS), two distinct autoimmune diseases. The patient presented with a combination of symptoms, including progressive skin tightening, lumbosacral pain, and Raynaud's phenomenon, which complicated the diagnosis. Despite the challenges posed by the coexistence of SSc and AS, a multidisciplinary treatment approach involving corticosteroids, immunosuppressants, and supportive therapies led to significant clinical improvement.

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A 16-year-old male with hypermobility spectrum disorder (HSD) and Raynaud's phenomenon (RP) was referred to a clinical exercise physiologist (CEP) by their pediatric rheumatologist. The patient presented with arthralgia in the left knee and shoulder. Specifically, the left knee presented discomfort during activities of daily living (ADL), and the left shoulder had a reduced range of motion resulting from pain.

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Cutaneous vasculitis in systemic lupus erythematosus: epidemiology and risk factors over a 20-year follow-up.

Rheumatology (Oxford)

December 2024

Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Objectives: Cutaneous vasculitis (CV) is common in SLE, but the epidemiology and risk factors remain unclear. We aimed to identify the trends and risk factors for CV in patients with SLE over a period of 20 years.

Methods: The Birmingham Lupus Cohort is an observational longitudinal cohort of SLE patients.

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A 58-year-old female smoker diagnosed with myelodysplastic syndrome (MDS) presented with Raynaud's phenomenon and a "scleroderma-like" pattern on nailfold capillaroscopy. The capillaroscopic abnormalities were observed across all fingers, including those without clinical manifestations of onychomycosis. Over a two-year follow-up, there was no evidence of clinical or serological progression toward a connective tissue disease, particularly systemic sclerosis.

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Objectives: To assess short-term barnidipine efficacy and tolerability on Systemic Sclerosis (SSc)-Raynaud's phenomenon (RP).

Methods: We retrospectively evaluated patients with SSc starting barnidipine 10 mg/day. Raynaud's Condition Score (RCS) and mean blood pressure (MBP) were assessed at baseline and 6-month follow-up.

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Comment on« Botulinum toxin for Raynaud's phenomenon: a decade of world-evidence".

J Am Acad Dermatol

December 2024

Univ. Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France; Univ. Grenoble Alpes, Service de Médecine Vasculaire, Grenoble University Hospital, 38000 Grenoble, France.

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We present the case of a 13-year-old female diagnosed with juvenile systemic sclerosis, diffuse cutaneous subtype, along with active disseminated tuberculosis. This co-occurrence poses unique diagnostic and therapeutic challenges, particularly given the risk of tuberculosis exacerbation due to immunosuppressive therapy required for systemic sclerosis. The patient had signs/symptoms like progressive skin tightening and Raynaud's phenomenon; the diagnosis was confirmed by the presence of anti-Scl-70 antibodies.

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Radial cortex transverse distraction help to treat the Raynaud's phenomenon.

Sci Rep

December 2024

Department of Hand Surgery, Department of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhua Xilu, Jinan, China.

Article Synopsis
  • - Raynaud's phenomenon is a condition that causes spasms in blood vessels of the fingers, leading to reduced quality of life and often fails to respond to conventional treatments for over six months.
  • - A study involving six patients who underwent a new procedure called radial cortex transverse distraction showed promising results, with significant improvements in pain, skin color, and healing of finger ulcers.
  • - The follow-up indicated that this surgical method not only healed bone without complications but also effectively addressed symptoms of Raynaud's phenomenon, suggesting it could be a beneficial treatment option.
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Idiopathic inflammatory myopathies related lung disease in adults.

Lancet Respir Med

November 2024

Department of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA.

Article Synopsis
  • Interstitial lung disease (ILD) frequently occurs in adults with idiopathic inflammatory myopathies, particularly those with antisynthetase syndrome and anti-MDA5 antibodies, manifesting in various severities from mild to rapidly worsening symptoms.
  • Common symptoms include lung issues along with myositis, skin lesions, arthritis, and Raynaud’s phenomenon, but 16-65% may have lung problems as the only indication.
  • Treatment typically involves immunosuppression, combining therapies for aggressive cases, and possibly lung transplantation for severe cases, although short-term mortality is notably high in rapidly progressive disease associated with anti-MDA5 antibodies.
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Article Synopsis
  • * By October 2022, the woman experienced liver dysfunction and had multiple liver masses detected through medical testing.
  • * Despite a biopsy revealing peliosis hepatitis, her age made her ineligible for a liver transplant, and she unfortunately passed away in September 2023; this case is significant as it's the first reported instance of peliosis hepatis complicated by scleroderma.
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Peripheral vascular disorders associated with anti-centromere antibody (ACA) present generally with sclerodactyly in connective tissue disorders (CTD). It is unusual for ACA-associated digital necrosis to develop without preexisting raynaud's phenomena or vascular risk factors. We report a novel case of a 60-year-old non-smoker, non-diabetic woman with ACA and isolated finger necrosis without any other features of CTD.

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Introduction: Systemic sclerosis (SSc) is an autoimmune disorder with fibrosis in multiple organs, autoantibodies, and microvascular abnormalities. Its origin is unclear, but it may result from circulatory damage, collagen metabolism disruption, and modifications in immunoregulation. The disease affects various organs and has high morbidity and mortality rates.

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A systematic review of botulinum toxin as a treatment for Raynaud's disease secondary to scleroderma.

Clin Rheumatol

November 2024

Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust, London, UK.

Raynaud's phenomenon (RP) is a vasospastic disorder that affects the small blood vessels in the extremities such as the hands, feet, fingers or toes. It is a debilitating condition that can severely impact the patient's quality of life. Botulinum toxin (BTX) has been examined as a treatment option for RP, but its effect has been inconclusive.

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Article Synopsis
  • - PDE5 inhibitors are mainly known for treating erectile dysfunction but also have a range of other applications, including conditions like benign prostatic hypertrophy and pulmonary hypertension.
  • - These drugs have sparked significant research interest due to their potential benefits beyond ED, including anti-inflammatory effects and applications in diseases like Alzheimer's and diabetes.
  • - Ongoing studies are focused on improving the structure and pharmacokinetics of PDE5 inhibitors, with some variants already in clinical trials or FDA-approved, even being explored for use in addressing issues related to COVID-19.
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Raynaud's conditions of the hand, referred to commonly as Raynaud's phenomenon, both primary and secondary, represents a spectrum of disorders affecting the digits, characterised by recurrent episodes of vasospasm that result in a triad of symptoms: pain, pallor, and cyanosis. Various therapies, ranging from conservative hand therapy techniques to surgical sympathectomy, have been explored with inconsistent results. Recently, the local administration of botulinum toxin type-A (BTX-A) has re-emerged as a treatment option for this condition.

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High prevalence of esophageal motility disorders in patients with rheumatologic diseases.

Dis Esophagus

November 2024

Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA.

Article Synopsis
  • * A study of 289 adults showed that 58% had esophageal motility disorders, with various types identified, despite normal barium swallow results in half of these cases.
  • * Specific rheumatic conditions affected the likelihood of esophageal dysmotility, with lower rates in those with psoriatic arthritis and varying odds for rheumatoid arthritis and scleroderma.
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The pathogenesis, diagnostic utility and clinical relevance of cutaneous telangiectasia in systemic sclerosis.

Semin Arthritis Rheum

November 2024

Department of Rheumatology, North Bristol NHS Trust, Bristol, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:

Cutaneous telangiectasia (Tel) are visible permanently dilated postcapillary dermal venules and are one of the most common disease-specific manifestations of systemic sclerosis (SSc). Telangiectasia have long been recognised for their utility in the diagnosis and classification of SSc, but the clinical and prognostic relevance of these aberrant cutaneous vascular manifestations has been somewhat neglected by clinicians. Similarly, the impact of SSc-Tel on body image dissatisfaction and social discomfort has been under-appreciated.

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Pulmonary involvement in systemic sclerosis: can sex play a role?

Rheumatology (Oxford)

November 2024

Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disease with significant complications. During the last few years, research interest focuses on the differences between female and male patients. However, there is a lack of data regarding the role of sex in the presence of small airway disease (SAD).

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