3 results match your criteria: "Rangos Research Centre[Affiliation]"
The C. elegans healthspan and stress-resistance assay toolkit.
Methods
August 2014
Department of Pediatrics, University of Pittsburgh School of Medicine, 7129 Rangos Research Centre, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, United States. Electronic address:
A wealth of knowledge on the genetic mechanisms that govern aging has emerged from the study of mutants that exhibit enhanced longevity and exceptional resilience to adverse environmental conditions. In these studies, lifespan has been an excellent proxy for establishing the rate of aging, but it is not always correlated with qualitative measures of healthy aging or 'healthspan'. Although the attributes of healthspan have been challenging to define, they share some universal features that are increasingly being incorporated into aging studies.
View Article and Find Full Text PDFThe C. elegans lifespan assay toolkit.
Methods
August 2014
Department of Pediatrics, University of Pittsburgh School of Medicine, 7129 Rangos Research Centre, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, United States. Electronic address:
Since the discovery of single gene mutations that double its lifespan, the nematode Caenorhabditis elegans has provided remarkable insights into the biology of aging. The precisely measurable lifespan of worms has proven to be an efficient tool to assess the impact of various genetic, physiological and environmental factors on organismal aging. In this article, we describe methods to set up and monitor experiments to determine worm lifespan.
View Article and Find Full Text PDFMetabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice.
Diabetologia
January 2008
Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Rangos Research Centre, Rm 6103, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA.
Article Synopsis
- The study investigates the metabolic compatibility between pigs, monkeys, and the pig-to-monkey islet transplantation model to understand potential outcomes for pig-to-human islet transplants.
- Results show that non-diabetic monkeys have better glucose regulation than pigs, suggesting closer metabolic similarities between humans and pigs than between humans and monkeys.
- The research highlights that the success of islet transplants may depend more on the recipient's metabolic state rather than the donor's, emphasizing the need to consider species differences in assessing xenotransplantation outcomes.