Ensemble learning driven Kolmogorov-Arnold Networks-based Lung Cancer classification.

Early Lung Cancer (LC) detection is essential for reducing the global mortality rate. The limitations of traditional diagnostic techniques cause challenges in identifying LC using medical imaging data. In this study, we aim to develop a robust LC detection model.

Ameliorating Effects of β-Myrcene, a Monoterpene in Many Plants, on Thioacetamide-Induced Acute Hepatic Encephalopathy in Rats.

Hepatic encephalopathy (HE) is a clinical syndrome that can result from acute and chronic liver disorders, such as hepatitis, liver failure caused by alcohol or drugs, autoimmune diseases, metabolic diseases, cirrhosis, different types of tumors, and infections. This study aimed to investigate the effects of different doses of Beta-myrcene (β-myrcene) on the improvement of HE caused by thioacetamide (TAC) in male rats. To induce liver failure and acute damage in the studied animals, TAC was administered to rats at a dose of 100 mg/kg of body weight through an intraperitoneal (IP) injection with 24-hour intervals for seven consecutive days.

Imaging in atypical van der knaap disease with subependymal nodular heterotopia: A case report.

Here, we discuss a rare and to our knowledge, the first case of an atypical Van der Knaap's disease in a 6-year-old boy who presented with motor difficulties, developmental delay, cognitive impairment, seizures. The objective of this report is to highlight its unusual findings on MRI including internal capsule, brainstem, cerebellum involvement; subependymal nodular heterotopia, subependymal cysts, cortical laminar necrosis along with typical findings of megalencephalic leukoencephalopathy and subcortical cysts. The study also underscores the clinical implications of this complex pathology, with emphasis on comprehensive neuroradiological evaluation for atypical presentations to guide better diagnostic and management outcomes.

A rare complication of intracardiac double knotting of temporary pacemaker lead during bedside insertion: a case report.

Background: Temporary pacemaker lead implantation is a common low-risk procedure, but can occasionally get complicated by infections, arrhythmias, thromboembolic events, and perforation of the vessel or the heart. However, intracardiac knotting of the temporary pacemaker lead has been rarely reported. This could lead to vascular or valvular injury, pneumothorax, symptomatic loss of pacing or haemodynamic compromise, and difficult lead removal.

Implications of the Gut Microbiome in Alzheimer's Disease: A Narrative Review.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with its prevalence doubling approximately every decade. It is a significant contributor to disability-adjusted life-years in individuals aged 50 and older, impacting a substantial portion of this population globally. The pathophysiology of AD is primarily explained by two hypotheses: the amyloid cascade hypothesis and the tau hypothesis.

Imaging in Zinner Syndrome, A Case Series: The Wolf in Sheep's Clothing.

Zinner syndrome is a rare congenital malformation of the Wolffian duct with seminal vesicle cyst, ipsilateral renal agenesis and ejaculatory duct obstruction, seen in less than 0.002 % of the male population. An increased awareness among clinicians, urologists, and radiologists is essential, as early diagnosis and management can impact fertility outcomes.

Crosstalk between miRNAs and signaling pathways in the development of drug resistance in breast cancer.

One of the biggest challenges of today's society is cancer, which imposes a significant financial, emotional and spiritual burden on human life. Breast cancer (BC) is one of the most common cancers that affects people in society, especially women, and due to advanced treatment strategies and primary prevention, it is still the second cause of cancer-related deaths in society. Various genetic and environmental factors are involved in the development of BC.

Impact of normal vs. caesarean deliveries on child nutritional status and mortality in India: insights from NFHS-5 data.

Objective: Skilled birth attendance and place of delivery have a significant effect on child growth. The present paper examined the mode of delivery and its impact on child health among children 0-59 months in India.

Methods: A total of 200,794 samples were used in the study.

Optimizing Outcomes in Heart Transplantation: The Role of High-Intensity Statin Therapy.

Heart transplantation is a vital procedure for patients with end-stage heart failure, but it faces significant challenges, including graft dysfunction, rejection, and cardiac allograft vasculopathy (CAV), which can compromise long-term graft success. Research suggests that statin therapy may offer significant benefits to heart transplant recipients, such as improved long-term survival and reduced rates of graft rejection and mortality. The aim of this review is to thoroughly examine the recent literature on this topic since 2005.

Bridging knowledge gaps: impact of remedial classes on first-year medical students in biochemistry - a cross-sectional study.

Background: Remedial teaching is a tailored educational approach dedicated to enhancing the academic performance of students facing challenges within the curriculum. By identifying and addressing specific learning difficulties, it provides essential support and guidance to bring students closer to expected standards while preventing future setbacks. We hypothesize that underperforming medical students who receive daily, tailored remediation will demonstrate significant improvement in their formative and summative assessment scores in biochemistry.

Appraisal of malachite green biodegradation and detoxification potential of laccase from Trametes cubensis.

The laccase from the newly isolated Trametes cubensis was investigated for its potential to degrade malachite green (MG) dye. Optimized solid-substrate fermentation enhanced laccase production by 8.8-fold, reaching an activity of 6577.

Enhancing Tonsillectomy Recovery with AI: A Comparative Study on Postoperative Care Outcomes.

Unlabelled: Introduction: Tonsillectomy is commonly associated with significant postoperative challenges such as pain management, complication monitoring, and patient recovery. Traditional care methods, while effective, often do not adequately address these issues, particularly in personalized care and remote monitoring. This study assesses the impact of Artificial Intelligence (AI)-assisted postoperative care on recovery outcomes in tonsillectomy patients compared to conventional care methods.

Right ventricular strain as a predictor of trastuzumab-induced chemotherapy-related cardiac dysfunction: A meta-analysis.

Introduction: The survival rates of breast cancer patients have improved drastically in the past few decades due to advancements in anti-neoplastic drugs. Trastuzumab (TZ) chemotherapy is associated with left ventricular dysfunction leading to cardiotoxicity. Two-dimensional speckle-tracking echocardiography has demonstrated efficacy in predicting TZ-induced cardiotoxicity; however, its role in using right ventricular (RV) strain parameters remains unclear.

A Feature-Fusion Technique-Based Alzheimer's Disease Classification Using Magnetic Resonance Imaging.

Background: Early identification of Alzheimer's disease (AD) is essential for optimal treatment and management. Deep learning (DL) technologies, including convolutional neural networks (CNNs) and vision transformers (ViTs) can provide promising outcomes in AD diagnosis. However, these technologies lack model interpretability and demand substantial computational resources, causing challenges in the resource-constrained environment.

Pollution status of microplastics in the sediments of warm monomictic Dal lake, India: Abundance, composition, and risk assessment.

This report presents the first investigation of microplastic (MP) contamination in the shoreline sediments of Dal Lake, Jammu and Kashmir, India. The MP concentrations ranged from 503 to 3154 MP/kg, with a notable seasonal variation. The highest concentrations of microplastics occurred in the Spring, ranging from 467 to 3445 MP/kg.

Molecular docking and network pharmacology study on active compounds of for the treatment of diabetes mellitus.

Background: Diabetes Mellitus (DM) is a complex metabolic disorder with increasing global prevalence, necessitating the exploration of novel therapeutic strategies. , a medicinal plant with a long history of traditional use, has shown promising potential in managing DM.

Aim Of The Study: This study aims to elucidate the mechanism of action of active components of in managing DM using a combination of network pharmacology and molecular docking approaches.

ZnO Nanowall Network-Based Tactile/Gesture Sensors and Prediction with Machine Learning.

In low-dimensional material systems, augmented physical and chemical properties may be witnessed through a unique morphological evolution. Here, we report the development of an optimized nanowall network of ZnO for the fabrication of a flexible single-electrode triboelectric nanogenerator (STENG)-based tactile and gesture sensors. The chemically grown nanowall network with an adequate pore area endows superior triboelectric output (current ∼0.

Carboxymethyl cellulose assisted morphology controlled synthesis of MnO nanostructures for adsorptive removal of malachite green from water.

The physicochemical properties of manganese oxides and their different applications mainly depend upon their crystallite size, morphology, phase structure, and surface properties, which are again dependent on the preparation methods. So, a simple, cost-effective, and versatile synthesis method for such materials is highly desirable. Intending to accomplish this, herein we report the synthesis of MnO nanostructures by alkaline hydrolysis of the corresponding metal ions in an aqueous medium.

Nanodiagnostics in global eradication of hepatitis C virus.

Hepatitis C, caused by the hepatitis C virus (HCV), is a prevalent liver disease with severe outcomes, including cirrhosis and hepatocellular carcinoma. Traditional diagnostic methods primarily detect antiviral antibodies (anti-HCV) or viral RNA, but these approaches have limitations. Anti-HCV antibodies may take 2-4 weeks to develop in acute cases and can be absent in some individuals, leading to undiagnosed early-stage infections.

Navigating the death attitudes and anxiety during COVID-19: Role of dispositional mindfulness and tranquil ego.

Background: Anecdotally, the concept of death consistently evokes profound unease. This study explores the intricate relationship between individuals' attitudes toward death and the associated anxiety, introducing a two-step model that posits dispositional mindfulness and tranquil ego as mediators.

Materials And Methods: We used a correlational design in this study and assessed 209 Indian adults (111 males and 98 females) who recovered from corona symptoms on self-report measures of attitudes toward death, death anxiety, dispositional mindfulness, and tranquil ego.

Current Advances in Diagnosis, Therapeutics, and Surgical Interventions for the Management of Refractory Gastroesophageal Reflux Disease (GERD): An Update.

Gastroesophageal reflux disease (GERD) is a chronic illness characterized by complications arising from the reflux of stomach contents, which significantly lower the quality of life, increase morbidity, and increase medical expenses associated with treating the condition. The main goal of treatment in GERD is symptomatic relief, relapse prevention, and healing of erosive esophagitis. The treatment mainly involves lifestyle changes to control acid production and proton pump inhibitors (PPIs) as the first line of treatment.

Perceived causes and stigmatization of tuberculosis among Apatani tribe of Arunachal Pradesh.

Background: Tuberculosis (TB) is a pressing public health issue in many developing countries, with India having the highest number of cases. Lack of awareness and stigmatization of TB remains a significant barrier to addressing this challenge. This paper examines the perceived causes and stigma associated with TB among Apatani tribe of Arunachal Pradesh.

Synthesis, Structural Characterization and Catalytic Application of Ferrocenyl Based Bis(pyrazolyl) Palladium Complexes.

Here we report, synthesis of ferrocenyl based bis(pyrazolyl) palladium complexes. The catalytic utility of the complexes in the cross-coupling of triarylbismuthanes and aryl bromides was evaluated. Our ferrocenyl based palladium complex showed wide substrate scope for both triarylbismuthanes and aryl bromides.