Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionurbgrssp1gj5uscri4e4i5t5rbupr7d4): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
414 results match your criteria: "Rajendra Memorial Research Institute of Medical Sciences[Affiliation]"
Indian J Dermatol
October 2024
From the Department of Pharmacology, Lovely Professional University, Phagwara, Punjab, India.
Post-kala-azar dermal leishmaniasis (PKDL) is a neglected skin disease that has tremendous epidemiological significance as a reservoir of Leishmania parasites. Relapse, drug resistance, non-compliance to prolonged treatment, poor health-seeking behaviour, along with limited therapeutic options pose a significant impact on the management of PKDL. In this study, we aimed to review the efficacy, safety and tolerability data of combination therapies for PKDL in the published literature.
View Article and Find Full Text PDFVector Borne Zoonotic Dis
November 2024
Vector Biology and Control Division, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India.
The global burden of mosquito-borne diseases transmitted by and mosquitoes has become a pressing public health concern. This study sought to quantify and evaluate about eight decades of publication data on the global epidemiological trend of the diseases transmitted by and . A comprehensive bibliographic review of literature was performed on and transmitted diseases, focusing on disease transmission, epidemiological trends, vector control strategies, surveillance and monitoring, and international collaborations and initiatives.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
February 2025
Viral Research and Diagnostic Laboratory, Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India. Electronic address:
Sci Rep
November 2024
ICMR- Vector Control Research Centre, Field Station, Kottayam, Kerala, 686003, India.
India is accelerating efforts to eliminate kala-azar by aligning its National Kala-Azar Elimination Program with the World Health Organization's (WHO) roadmap for Neglected Tropical Diseases (NTDs) 2021-2030. Elimination relies on comprehensive vector surveillance and integrated vector management. This study aimed to conduct nationwide entomological surveillance to detect Leishmania donovani in phlebotomine sand flies.
View Article and Find Full Text PDFCureus
October 2024
Public Health, Indian Council of Medical Research, Rajendra Memorial Research Institute of Medical Sciences, Patna, IND.
Amidst the multifaceted challenges posed by COVID-19, interest in complementary and alternative medicine (CAM) has risen. Chyawanprash (CP), an Ayurvedic formulation, is recognized for its multifunctional properties. This systematic review aims to evaluate its safety and effectiveness as a COVID-19 prophylactic.
View Article and Find Full Text PDFJ Infect Dis
October 2024
ICMR- National Institute of Pathology, Safdarjung Hospital Campus, New Delhi-110029, India.
Am J Trop Med Hyg
December 2024
Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India.
Indian J Tuberc
October 2024
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur, Bihar, India. Electronic address:
Background: This study aimed to determine the prevalence of TB among patients living with HIV in Patna district, India. It also assessed the factors contributing to co-infection and evaluated patients' quality of life.
Methods: This cross-sectional study was conducted at the Antiretroviral Therapy (ART) Centre in Patna, India, for a period of eight months.
Lancet Infect Dis
September 2024
Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India. Electronic address:
Cureus
August 2024
Drug Regulatory Affairs, Delhi Pharmaceutical Sciences and Research University, New Delhi, IND.
Background: Adverse events following immunization (AEFI) must be reported and assessed to promote patient safety. This longitudinal study examined the nature and severity of adverse events reported after Covishield (Serum Institute of India, Pune, India) vaccine administration to North Indians in a tertiary care hospital.
Method: A retrospective evaluation of adverse drug reactions (ADRs) reported after Covishield vaccine administration in our hospital over 18 months was conducted.
Indian J Tuberc
October 2024
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; Viral Research and Diagnostic Laboratory, Department of Virology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, Bihar, India. Electronic address:
Silico-Tuberculosis (silico-TB) is a severe combination of tuberculosis and silicosis, caused by occupational exposure to fine crystalline silica dust, which has become a global health concern. This comprehensive review compiles the updated knowledge regarding pathophysiology, clinical manifestations, important diagnostic techniques, treatment aspects, and challenges in understanding silico-TB. The review compiles the disease's history and epidemiology, highlighting a lack of data owing to poor monitoring and healthcare particularly in low- and middle-income countries like India.
View Article and Find Full Text PDFActa Trop
December 2024
Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, 800007, Bihar, India. Electronic address:
The control and eradication of any infectious disease is only possible with a potential vaccine, which has not been accomplished for human visceral leishmaniasis (VL). The lack of vaccines may increase the risk of VL outbreaks periodically in endemic zones. Identifying a reliable vaccine candidate for Leishmania is a major challenge.
View Article and Find Full Text PDFJ Trace Elem Med Biol
December 2024
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Industrial area Hajipur, Vaishali, Bihar 844102, India. Electronic address:
Unlabelled: This study highlights the potential neurotoxic and impaired behavioral effects associated with high fluoride concentrations in drinking water.
Purpose: Fluoride is known to cause neurotoxicity, evinced by lower I.Q.
Parasit Vectors
August 2024
Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Background: Vector control based on indoor residual spraying (IRS) is one of the main components of the visceral leishmaniasis (VL) elimination programme in India. Dichlorodiphenyltrichloroethane (DDT) was used for IRS until 2015 and was later replaced by the synthetic pyrethroid alpha-cypermethrin. Both classes of insecticides share the same target site, the voltage-gated sodium channel (Vgsc).
View Article and Find Full Text PDFExp Parasitol
August 2024
Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India; Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases, Beleghata, Kolkata, West Bengal, 700 010, India. Electronic address:
The infectivity of Leishmania is determined by its ability to invade and evade host and its thriving capacity within the macrophage. Our study revealed the role of Leishmania donovani mevalonate kinase (MVK), an enzyme of mevalonate pathway in visceral leishmaniasis pathogenesis. Peritoneal exudate cells (PEC)-derived macrophages from BALB/c mice were infected with wild type (WT), MVK over expressing (MVK OE) and knockdown (KD) parasites and MVK OE parasites were found to be more infective than WT and MVK KD parasites.
View Article and Find Full Text PDFElectrophoresis
October 2024
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Affinity-based protein depletion and TiO enrichment methods play a crucial role in detection of low-abundant proteins and phosphopeptides enrichment, respectively. Here, we assessed the effectiveness of HSA/IgG (HU2) and Human 7 (HU7) depletion methods and their impact on phosphopeptides coverage through comparative proteome analysis, utilizing in-solution digestion and nano-LC-Orbitrap mass spectrometry (MS). Our results demonstrated that both HU2 and HU7 affinity depletion significantly decreased high-abundant proteins by 1.
View Article and Find Full Text PDFCutan Ocul Toxicol
September 2024
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Objective: Miltefosine stands as the sole oral medication approved for the treatment of leishmaniasis. The appearance of severe ophthalmic toxicities induced by miltefosine in the context of leishmaniasis treatment is a matter of significant concern. The main objective of this study is to present a comprehensive summary of the ophthalmic adverse effects associated with miltefosine when used in the treatment of leishmaniasis.
View Article and Find Full Text PDFIndian J Psychiatry
May 2024
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Background: The coronavirus disease 2019 (COVID-19) pandemic outbreak created a challenge to manage the health, especially the mental health of various care providers involved in treating the patients infected with the virus. Previously published literature has shown a significant effect of the pandemic on the psychological health of healthcare workers (HCWs) globally; so, this study aimed to describe the psychological health outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Indian HCWs.
Methods: An extensive literature search was conducted in databases including PubMed and Google Scholar.
PLoS Negl Trop Dis
June 2024
Drugs for Neglected Diseases initiative, Geneva, Switzerland.
Background: In Southeast Asia, treatment is recommended for all patients with post-kala-azar dermal leishmaniasis (PKDL). Adherence to the first-line regimen, twelve weeks of miltefosine (MF), is low and ocular toxicity has been observed with this exposure period. We assessed the safety and efficacy of two shorter-course treatments: liposomal amphotericin B (LAmB) alone and combined with MF.
View Article and Find Full Text PDFJ Antimicrob Chemother
July 2024
Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Introduction: Post-kala-azar dermal leishmaniasis (PKDL) arises as a dermal complication following a visceral leishmaniasis (VL) infection. Current treatment options for PKDL are unsatisfactory, and there is a knowledge gap regarding the distribution of antileishmanial compounds within human skin. The present study investigated the skin distribution of miltefosine in PKDL patients, with the aim to improve the understanding of the pharmacokinetics at the skin target site in PKDL.
View Article and Find Full Text PDFPLoS Negl Trop Dis
April 2024
ICMR-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, Bihar, India.
Background: Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis which can occur after successful treatment of visceral leishmaniasis (VL) and is a public health problem in VL endemic areas. We conducted a systematic scoping review to assess the characteristics of published PKDL clinical studies, understand the scope of research and explore the feasibility and value of developing a PKDL individual patient data (IPD) platform.
Methods: A systematic review of published literature was conducted to identify PKDL clinical studies by searching the following databases: PubMed, Scopus, Ovid Embase, Web of Science Core Collection, WHO Global Index Medicus, PASCAL, Clinicaltrials.
Sci Rep
March 2024
Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, 800007, India.
Heavy metal ions can be introduced into the water through several point and non-point sources including leather industry, coal mining, agriculture activity and domestic waste. Regrettably, these toxic heavy metals may pose a threat to both humans and animals, particularly when they infiltrate water and soil. Heavy metal poisoning can lead to many health complications, such as liver and renal dysfunction, dermatological difficulties, and potentially even malignancies.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2024
Serum Institute of India Pvt Ltd, Pune, India.
AZD1222 (ChAdOx1 nCoV-19) is a replication-deficient adenoviral vectored coronavirus disease-19 (COVID-19) vaccine that is manufactured as SII-ChAdOx1 nCoV-19 by the Serum Institute of India Pvt Ltd following technology transfer from Oxford University/AstraZeneca. The non-inferiority of SII-ChAdOx1 nCoV-19 with AZD1222 was previously demonstrated in an observer-blind, phase 2/3 immuno-bridging study (trial registration: CTRI/2020/08/027170). In this analysis of immunogenicity and safety data 6 months post first vaccination (Day 180), 1,601 participants were randomized 3:1 to SII-ChAdOx1 nCoV-19 or AZD1222 (immunogenicity/reactogenicity cohort = 401) and 3:1 to SII-ChAdOx1 nCoV-19 or placebo (safety cohort = 1,200).
View Article and Find Full Text PDFInt J Biol Macromol
April 2024
Department of Bioinformatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna 800007, India. Electronic address:
The COVID-19 pandemic has emerged as a critical global health crisis, demanding urgent and effective strategies for containment. While some knowledge exists about epitope sequences recognized by human immune cells and their activation of CD8+ T cells within the HLA context, comprehensive information remains limited. This study employs reverse vaccinology to explore antigenic HLA-restricted T-cell epitopes capable of eliciting durable immunity.
View Article and Find Full Text PDFExp Parasitol
April 2024
ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, 800007. Electronic address:
The recurrence of visceral leishmaniasis (VL), also called kala-azar (KA), in endemic regions of tropical countries like India, is primarily attributed to asymptomatic VL, post-kala azar dermal leishmaniasis (PKDL), and human immunodeficiency virus (HIV) co-infection. To effectively manage VL cases and elimination targets, an early and rapid diagnosis as well as accurate field surveillance is highly essential. The traditional sampling methods like bone marrow (BM), spleen, and lymph node (LN) tissue aspirations are invasive, painful, tedious, and prone to nosocomial infections, require skilled persons and hospital facilities, and are not feasible in rural areas.
View Article and Find Full Text PDF