2,154 results match your criteria: "Rajasthan University of Health & Sciences[Affiliation]"

Article Synopsis
  • * Activation of AURKs triggers important cellular signaling pathways, and their dysregulation is linked to cancer, making them key targets for anticancer drug research.
  • * Recent studies have identified several potent AURK inhibitors, with specific compounds showing very low IC values, suggesting their potential effectiveness in suppressing tumor growth and inducing cancer cell death, guiding medicinal chemists in developing stronger and safer treatments.
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This paper presents an ultra-wideband (UWB) microstrip antenna with a simple structure operating at 2.2-6 GHz bandwidth. The proposed antenna has been demonstrated for its suitability in UWB and multi-band applications, such as wireless local area network (WLAN), Wi-Fi, 5G, Internet of Things (IoT), etc.

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Article Synopsis
  • People living with HIV (PLWH) face increased mortality risks from air pollution due to chronic inflammation and immune dysfunction, a link that has not been widely studied.
  • A systematic review analyzed nine studies, primarily from China, revealing that long-term exposure to pollutants like particulate matter significantly correlates with higher AIDS-related and overall mortality rates in PLWH, with certain populations being more susceptible.
  • The findings indicate that targeted interventions to lessen air pollution exposure could benefit vulnerable groups, emphasizing the need for further research in this area.
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This paper addresses the pressing issue of diabetes, which is a widespread condition affecting a huge population worldwide. As cells become less responsive to insulin or fail to produce it adequately, blood sugar levels rise. This has the potential to cause severe health complications including kidney disease, vision impairment and heart conditions.

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Changing the horizon of food frying from the use of liquid oil to semi-solid gel.

Food Res Int

December 2024

Amity Institute of Biotechnology, Amity University Jaipur, Rajasthan, India. Electronic address:

Deep fat frying is the most adopted process of producing fried food products; it involves mass and heat transfer to form fried products with good colour, crispiness, flavour, taste, and texture. However, frequent consumption of these products is a concern due to higher oil content that poses threats to human health. Hence, there is a need to find an alternative frying medium for deep fat frying of food products to obtain fried products having lower fat content.

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Biomaterials for bone tissue engineering: achievements to date and future directions.

Biomed Mater

December 2024

Engineered Biomedical Materials Research and Innovation Centre (EnBioMatRIC), Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan, India.

Advancement in medicine and technology has resulted into prevention of countless deaths and increased life span. However, it is important to note that, the modern lifestyle has altered the food habits, witnessed increased life-style stresses and road accidents leading to several health complications and one of the primary victims is the bone health. More often than ever, healthcare professionals encounter cases of massive bone fracture, bone loss and generation of critical sized bone defects.

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Online Formative Assessments in Medical Education During COVID-19.

J Nepal Health Res Counc

October 2024

Department of Biochemistry, RUHS College of Medical Sciences, Jaipur, Rajasthan, India.

Background: This study aimed to evaluate perception of medical students regarding online mode of assessments and to compare the academic outcomes of various methodologies adopted for online formative assessments.

Methods: This was a descriptive cross-sectional study. This study was conducted in the department of biochemistry at the constituent medical college of Health University in India and included 150 first year medical undergraduates of either gender.

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Quitting tobacco through quitline services: impact in India.

Monaldi Arch Chest Dis

November 2024

Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi.

Tobacco quitline services offer telephone-based counseling to assist tobacco users in quitting through behavioral modification. It is a sponsored scheme by the Ministry of Health and Family Welfare, Government of India. The present study has two objectives: primarily, to study the correlation between socio-demographic variables and tobacco abuse, and secondly, to study the impact of National Tobacco Quit-Line Services (NTQLS) in India.

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Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells in liver tissue. The secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease.

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Article Synopsis
  • The COVID-19 pandemic has had serious effects on maternal and neonatal health, prompting a systematic review to assess how it influences respiratory distress syndrome (RDS) in newborns from infected mothers.
  • The review analyzed 22 studies and found that 11.5% of newborns from COVID-19-positive mothers experienced RDS, with a risk ratio of 2.69 indicating a significantly higher risk compared to newborns from non-infected mothers.
  • The findings stress the importance of closely monitoring and managing pregnant women with COVID-19 to reduce potential health issues in their newborns.
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Unveiling the Neurotransmitter Symphony: Dynamic Shifts in Neurotransmitter Levels during Menstruation.

Reprod Sci

November 2024

Societe Francophone de Nutritherapie et de Nutrigenetique Appliquee, Villeurbanne, France.

The menstrual cycle is an intricate biological process governed by hormonal changes that affect different facets of a woman's reproductive system. This review provides an overview of neurotransmitter alterations during different menstrual cycle phases and their effects on physiology and psychology. During the follicular phase, rising estrogen levels increase serotonin synthesis, enhancing mood, cognition, and pain tolerance.

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Exploring the impact of material selection on the efficacy of hot-melt extrusion.

Int J Pharm

January 2025

Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand; Academy of Science, The Royal Society of Thailand, Bangkok 10300, Thailand; Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India. Electronic address:

Hot-melt extrusion (HME) has emerged as a versatile and efficient technique in pharmaceutical formulation development, particularly for enhancing the solubility and bioavailability of poorly water-soluble drugs. This review delves into the fundamental principles of HME, exploring its application in drug delivery systems. A comprehensive analysis of polymers utilized in HME, such as hydroxypropyl methylcellulose, ethyl cellulose, hydroxypropyl cellulose, and polyvinylpyrrolidone, is presented, highlighting their roles in achieving controlled drug release and improved stability.

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Article Synopsis
  • E-cigarettes are becoming popular as a way for people to quit smoking, but there are concerns about their use alongside traditional cigarettes, particularly among pregnant women, who may face increased health risks.
  • A systematic review analyzed data from 18 studies involving nearly 6 million pregnant women, finding that 4.6% of them reported using both e-cigarettes and traditional tobacco.
  • The findings suggest that dual use is a significant health issue, highlighting the need for further research and public health measures to inform and protect pregnant women from the risks of tobacco.
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Association of celiac disease and myocardial infarction: a systematic review and meta-analysis.

BMC Cardiovasc Disord

November 2024

Global Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.

Article Synopsis
  • Celiac disease (CD) is an autoimmune disorder linked to gluten intolerance that may affect cardiovascular health, with some studies suggesting a connection to myocardial infarction (MI), although results have been inconsistent.* -
  • A systematic review and meta-analysis of 8 studies were conducted to evaluate the risk of MI in adults with CD, using data from databases like PubMed and Web of Science, analyzed with R software.* -
  • The analysis found no significant association between CD and MI, but indicated high variability in study results, suggesting a need for more research on larger, more uniform samples to clarify potential cardiovascular risks for CD patients.*
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India is accelerating efforts to eliminate kala-azar by aligning its National Kala-Azar Elimination Program with the World Health Organization's (WHO) roadmap for Neglected Tropical Diseases (NTDs) 2021-2030. Elimination relies on comprehensive vector surveillance and integrated vector management. This study aimed to conduct nationwide entomological surveillance to detect Leishmania donovani in phlebotomine sand flies.

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Safety and efficacy of ensifentrine in COPD: A systemic review and meta-analysis.

Respir Med

January 2025

Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Electronic address:

Background: Chronic obstructive pulmonary disease (COPD) significantly impacts global health due to persistent airflow limitation and inflammation. Despite standard therapies, symptoms persist. Ensifentrine, targeting both bronchoconstriction and inflammation as a dual phosphodiesterase 3 and 4 inhibitor, offers a promising therapeutic advancement for COPD management.

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Risk of Hepatocellular Carcinoma with Glucagon-like Peptide-1 receptor agonist treatment in patients: a systematic review and meta-analysis.

BMC Endocr Disord

November 2024

Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India.

Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide, with increased prevalence in individuals with chronic liver conditions and type 2 diabetes mellitus (T2DM). Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) have shown promise in diabetes management and may influence liver disease progression. This systematic review and meta-analysis aimed to assess the efficacy of GLP-1 RAs in reducing the risk of HCC in patients with T2DM.

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Article Synopsis
  • * RIF may result from imbalances in endometrial inflammatory responses, indicating that the female immune system is vital for successful implantation.
  • * Recent research explores how long non-coding RNAs (lncRNAs) influence immune responses, suggesting that dysfunctional lncRNAs might contribute to RIF by affecting protein interactions and inflammatory processes.
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Background: The elderly population is rapidly growing worldwide. By the year 2050, the elderly population will increase up to 2.1 billion.

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Advanced 2D Nanomaterials for Phototheranostics of Breast Cancer: A Paradigm Shift.

Adv Biol (Weinh)

November 2024

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, P.O. Box 17011, Johannesburg, 2028, South Africa.

Breast cancer is the leading cause of women's deaths and associated comorbidities. The advanced and targeted strategies against breast cancer have gained considerable attention due to their potential enhanced therapeutic efficacy over conventional therapies. In this context, phototherapies like photodynamic therapy (PDT) and photothermal therapy (PTT) have shown promise as an effective and alternative strategy due to reduced side effects, noninvasiveness, and spatiotemporal specificity.

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Background And Objectives: Sovateltide (Tycamzzi™), an endothelin-B (ET-B) receptor agonist, increases cerebral blood flow, has anti-apoptotic activity, and promotes neural repair following cerebral ischaemic stroke. The objectives of this study were to evaluate the efficacy and safety of sovateltide in adult participants with acute cerebral ischaemic stroke.

Methods: This was a randomised, double-blind, placebo-controlled, multicentre, Phase III clinical trial of sovateltide in participants with cerebral ischaemic stroke receiving standard of care (SOC) in India.

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The COVID-19 vaccine has been available in India since January 2021, although many individuals have refused to take the vaccine for various reasons. Vaccination plays a crucial role in disease control by preventing a substantial number of cases and associated disabilities. However, vaccine hesitancy poses a barrier that hinders these efforts.

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Article Synopsis
  • The COVID-19 vaccination campaign has successfully reduced severe illness and mortality, but concerns about potential side effects like Postural Orthostatic Tachycardia Syndrome (POTS) have emerged.
  • A systematic review examined studies of POTS post-vaccination, with 10 out of 1,531 articles meeting inclusion criteria, involving nearly 285,000 participants.
  • Results indicated that while the odds of developing POTS after vaccination are lower compared to post-infection, research is still limited and further studies are necessary.
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