Comparative evaluation of efficacy of different irrigation devices in removal of calcium hydroxide in teeth with simulated internal resorption cavities - An study.

Aim: The aim of this study was to compare the efficacy of newly developed irrigation systems, i.e., XP-endo Finisher file (XP-endo), EndoActivator (EA), and Endo-Irrigator Plus (EI) with gold standard passive ultrasonic irrigation (PUI) tip and in removal of calcium hydroxide (CH) from single-rooted teeth with artificial simulated internal resorption cavities.

Biomarkers and outcomes in hospitalised patients with COVID-19: a prospective registry.

Objectives: To determine association of biomarkers-high-sensitivity C reactive protein (hsCRP), D-dimer, interleukin-6 (IL-6), lactic dehydrogenase (LDH), ferritin and neutrophil-lymphocyte ratio (NLR)-at hospitalisation with outcomes in COVID-19.

Design And Setting: Tertiary-care hospital based prospective registry.

Participants: Successive virologically confirmed patients with COVID-19 hospitalised from April 2020 to July 2021 were prospectively recruited.

A Comparative Evaluation of Digital Radiography and Ultrasound Imaging to Detect Periapical Lesions in the Oral Cavity.

Purpose This study evaluates the efficacy of digital radiography and ultrasound (USG) for the distinction between periapical cysts and granulomas, determines the nature and extent of the periapical lesion, visualizes the lumen of the lesion, assesses its size, content, and vascularity. Material and Methods Thirty patients, ages 18 to 40, with well-defined periapical radiolucencies on maxillary or mandibular teeth, indicated for the extraction or periapical surgery, underwent digital radiography examination using the paralleling technique, followed by USG examination. A sonologist evaluated the lesions' size, echogenicity, and vascular content.

Guidance Prostheses for Partial Mandibulectomy Patients: A Case Series.

This case series discusses the fabrication of guidance prostheses (GPs) for patients who presented to the Department of Prosthodontics with marked mandibular deviation, resulting in facial disfigurement and deranged occlusion. These GPs guide the mandible to the unresected side to achieve stable occlusion. This case series included three approaches to reducing mandibular deviation: a maxillary guidance ramp, a mandibular guidance prosthesis, and a twin occlusal appliance.

Is Epithelial-Mesenchymal Transition a New Roadway in the Pathogenesis of Oral Submucous Fibrosis: A Comprehensive Review.

Epithelial-mesenchymal transition (EMT) collectively refers to a series of episodes that reshape polarized, intact epithelial cells into discrete motile cells that can conquer the extracellular matrix (ECM). It performs a pivotal role in embryonic development, wound healing, and tissue repair. Surprisingly, the exact mechanism can also lead to the onset of malignancy and organ fibrosis contributing to scar formation and loss of function.

An In Vitro Study Comparing the Diametral Tensile Strength of Composite Core Build-Up Material With Three Different Prefabricated Post Systems.

Statement of problem Dental restorations are subjected to tensile stresses from oblique or transverse loading of their complex geometric forms, making tensile strength a fundamental mechanical property. Since composite core build-up materials are brittle, the integrity of the post and core depends on their tensile strength and resistance to fracture when utilized with various prefabricated post systems. Therefore, it is essential to determine the tensile strength of the prefabricated metallic and nonmetallic posts used to reinforce the composite resin core.

ROCK1/MLC2 inhibition induces decay of viral mRNA in BPXV infected cells.

Rho-associated coiled-coil containing protein kinase 1 (ROCK1) intracellular cell signaling pathway regulates cell morphology, polarity, and cytoskeletal remodeling. We observed the activation of ROCK1/myosin light chain (MLC2) signaling pathway in buffalopox virus (BPXV) infected Vero cells. ROCK1 depletion by siRNA and specific small molecule chemical inhibitors (Thiazovivin and Y27632) resulted in a reduced BPXV replication, as evidenced by reductions in viral mRNA/protein synthesis, genome copy numbers and progeny virus particles.

Premature coronary artery disease, risk factors, clinical presentation, angiography and interventions: Hospital based registry.

Background & Aims: Premature coronary artery disease (CAD) is endemic in India. We performed a study to identify risk factors, clinical presentation, angiographic findings and interventions in premature CAD.

Methods: Successive patients who underwent percutaneous intervention (PCI) were enrolled from January 2018 to June 2021.

Acquaintance and Awareness of Budding Physicians toward Antimicrobials' Use: Need of the Hour.

 Development of new antibiotics has been slow in the past decades, despite the urgent need. Final-year undergraduate students, interns, and postgraduate students are future prescribers of antimicrobials. It is important they have proper knowledge and attitude toward antibiotic prescription, so that antibiotic resistance could be dealt wisely.

Proportionate clinical burden of respiratory diseases in Indian outdoor services and its relationship with seasonal transitions and risk factors: The results of SWORD survey.

Background: The Global Burden of Disease data suggest that respiratory diseases contribute to high morbidity in India. However, the factors responsible for high morbidity are not quite clear. Therefore, the Seasonal Waves Of Respiratory Disorders (SWORD) study was planned to estimate the point prevalence due to respiratory diseases in Indian OPD services and its association with risk factors and change in seasons.

Pretreatment Immune Status, Predicts Response to Definite Chemo Radiotherapy in Advanced Stages of Cervical Cancer Patients.

Objective: To evaluate the prognostic role of pretreatment CD4 + , CD8 + T lymphocytes in predicting response to definite chemo radiotherapy in advanced cervical cancer. Design: A hospital-based prospective one-year follow-up study.

Method: This observational study was conducted on 74 patients with advanced cervical cancer.

Nursing competency inventory and professional competence of graduating students in six Asian countries: A cross-sectional study.

Aims: To investigate graduating nursing students' nursing and professional competencies and the predictors of their competencies.

Background: Across Asian countries, there is a paucity of literature that explores graduating nursing students' competency and professional competence during the ongoing COVID-19 pandemic.

Design: Descriptive, cross-sectional, and predictive approaches.

Full Mouth Rehabilitation Using the Twin Stage Procedure in a Patient with Amelogenesis Imperfecta: A Case Report.

Amelogenesis imperfecta (AI) refers to a group of inherited odontological disorders that alter enamel formation. The AI variant is based on the primary enamel defect, classified as hypoplastic type I, hypo maturation type II, hypo calcification type III, and hypo maturation type IV. AI is commonly linked with the loss of the normal occlusal plane, the loss of the vertical dimension of occlusion (VDO), and impaired functions and esthetics.

Characterization of thermo-physiological, hematological, and molecular changes in response to seasonal variations in two tropically adapted native cattle breeds of Bos indicus lineage in hot arid ambience of Thar Desert.

The selection of climate resilient animal is necessary to secure the future of sustainable animal production. The present investigation therefore was an effort to unravel answers to the adaptation at physiological, hematological, and molecular levels in cows of hot arid region that helps them to survive harsh environment, to continue production and reproduction. This investigation was carried out in indicine cows over a period of one year, encompassing four seasons, wherein physiological data of 50 animals, hematological data of 15 animals, and gene expression profile of 5 animals from each of Sahiwal and Kankrej breeds per season was generated.

Healthcare worker-based opportunistic screening for familial hypercholesterolemia in a low-resource setting.

Background & Objective: Heterozygous familial hypercholesterolemia (FHeH) is important risk factor for premature coronary artery disease (CAD). Strategies for its diagnosis and prevalence have not been well studied in India. We performed healthcare worker-based opportunistic screening to assess feasibility for determining its prevalence.

A Novel Technique for Retention of the Immediate Obturator Following Maxillectomy in Mucormycosis: A Case Report.

Mucormycosis is an aggressive opportunistic fungal infection that affects blood supply-rich areas such as the maxilla. Because of the compromised immune system caused by coronavirus disease 2019 (COVID-19) infection and diabetes, this infection has spread at a rapid rate. Early detection and treatment can reduce disease mortality and morbidity.

Shielding effect of melatonin improves seminal quality and oxidative stress indices during chilled storage of ram semen.

Supplementation of antioxidant to semen extender maintains seminal quality by reducing oxidative stress during preservation time period. The main aim of this study was to investigate the effect of different concentrations of melatonin supplementation on liquid storage of Magra ram semen. This study was performed on adult Magra ram (n = 8), and seminal ejaculates (48) were collected and evaluated for various macroscopic and microscopic seminal quality parameters for further processing.

Comparative Evaluation of the Clinical Efficacy of Four Different Gingival Retraction Systems: An In Vivo Study.

Introduction: There are numerous gingival retraction systems available on the market. This study aimed to evaluate the clinical efficacy of four gingival retraction systems, namely, impregnated retraction cord, gingival retraction capsule, retraction paste, and polyvinyl acetate strips.

Methods: A total of 20 people were chosen for the study, and 100 specimens were collected.

Microstrain Analysis of Selective Pressure Techniques for Mandibular Complete Denture Impression: An In Vivo Study.

Aim The present in vivo study was undertaken for microstrain analysis of the selective pressure impression technique using strain gauges in mandibular complete denture impression. Methodology Ten completely edentulous patients undergoing complete denture treatment were selected for the study. For each patient, mandibular casts were made, and two custom trays were fabricated on the mandibular cast.

Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium.

To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations of India given the paucity of data, we aimed to determine the prevalence of T2D and estimate its heritability using family-based cohorts from three distinct Endogamous Ethnic Groups (EEGs) representing Northern (Rajasthan [Agarwals: AG]) and Southern (Tamil Nadu [Chettiars: CH] and Andhra Pradesh [Reddys: RE]) states of India. For comparison, family-based data collected previously from another North Indian Punjabi Sikh (SI) EEG was used. In addition, we examined various T2D-related cardiometabolic traits and determined their heritabilities.

Progress Report: Antimicrobial Drug Discovery in the Resistance Era.

Antibiotic resistance continues to be a most serious threat to public health. This situation demands that the scientific community increase their efforts for the discovery of alternative strategies to circumvent the problems associated with conventional small molecule therapeutics. The Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report (published in June 2021) discloses the rapidly increasing number of bacterial infections that are mainly caused by antimicrobial-resistant bacteria.

Endodontic management of an atypical permanent mandibular second molar with one buccal and two lingual roots.

This article describes an unusual location of the orifices and roots in a permanent mandibular second molar with symptomatic irreversible pulpitis and symptomatic apical periodontitis. During its micro-endodontic management, the cone-beam computed tomography evaluation revealed a rare variant of a three-rooted permanent mandibular second molar with four canals. The single buccal root had two canals with Vertucci's Type II pattern and a lingual root dividing into two with a single canal in each root, respectively.

Hyperlipidemia management in diabetes: First line or supportive therapy?

Background & Aims: Coronary heart disease (CHD) is the most important cause of morbidity and mortality in type 2 diabetes. Current therapeutic approach has changed from glucocentric to vasculoprotective. This brief review highlights importance of management of hyperlipidemia (raised LDL cholesterol and triglycerides) on CHD outcomes in diabetes.

Educational status and COVID-19 related outcomes in India: hospital-based cross-sectional study.

Objective: Association of educational status, as marker of socioeconomic status, with COVID-19 outcomes has not been well studied. We performed a hospital-based cross-sectional study to determine its association with outcomes.

Methods: Successive patients of COVID-19 presenting at government hospital were recruited.