Role of Salivary Protease Enzymatic Activity in Saliva of Children with and without Early Childhood Caries: A Randomized Clinical Trial.

Background/introduction: Early childhood caries (ECC) is one of the most prevalent diseases in children worldwide. Early childhood caries is driven by a dysbiotic state of oral microorganisms, mainly caused by a sugar-rich diet. Additionally, poor oral hygiene or insufficient dental plaque removal leads to the rapid progression of ECC.

Estimation and Correlation of Alkaline Phosphatase Enzymatic Activity in Saliva with and without Early Childhood Caries in South Indian Children: A Randomized Clinical Trial.

Introduction: Early childhood caries (ECC) is a major common problem seen in children and is the most prevalent chronic disease that leads to discomfort, pain, and poor quality of life, affecting the health of children. Alkaline phosphatase (ALP) is a nonspecific phosphomonoesterase that functions through a phosphoery 1 intermediate to produce free inorganic phosphate. It has different isoenzymes produced by different cell types such as polymorphonuclear leukocytes, osteoblasts, macrophages, and fibroblasts within alveolar bone and/or salivary glands.

The Effect of Average Value Mounting and Facebow Transfer on Condylar Guidance Settings in a Semi-Adjustable Articulator - A Comparative Study using Digital Lateral Cephalographs in Edentulous Patients.

Background: While we attempt to restore occlusion in completely edentulous patients there is a consensus among clinicians to articulate the cast using average value and avoid performing facebow transfer. Various studies question the application of facebow transfer in the fabrication of removable complete denture fabrication.

Aim: This study was therefore aimed to study the effect on condylar guidance with casts mounted by the facebow method, Bonwill's method, and radiographic method.

Diabetes and Oral Health: Advancements in Prevention, Screening and Treatment of Periodontal Diseases.

Diabetes is a pervasive metabolic disorder that notably impacts various body systems, including oral health. One of the critical manifestations of diabetes in oral health is its exacerbating effect on periodontal diseases. Recent advancements in the prevention, screening, and treatment of periodontal diseases have become increasingly significant due to the bidirectional link between periodontal health and diabetes management.

Comparative Evaluation of Clinical and Microbiological Assessment of Caries Excavation Using Conventional, Smart Bur, Chemomechanical Method and ErCr: YSGG Laser.

Objectives: Caries removal efficacy in terms of microbiological burden using Tungsten Carbide Bur No. 330, Polymer bur, BRIX 3000, and ErCr: YSGG Laser.

Methods: Class I open dentinal caries was selected and divided into four groups ( = 15) depending on caries excavation methods.

Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study.

Background: Treatment modalities for cancer including surgery, radiotherapy and chemotherapy, have some complications even in the oral cavity. The literature describes oral lesions that may arise as a result of chemotherapy. However, information regarding oral symptoms in advanced cancer patients is poor.

Isolation and characterization of stem cells from human exfoliated deciduous teeth.

SHEDs have been shown to have a higher rate of proliferation and raise in cell population doublings when compared to stem cells from permanent teeth. Hence, using them in tissue engineering may be advantageous over stem cells from adult human teeth. Stem cells were removed from pulpal tissues of thirty primary teeth undergoing extraction under six to fourteen year of age.

A Comparative Evaluation of Contact Angle and Depth of Penetration of Sodium Hypochlorite With Various Surfactants: An In Vitro Study.

Objective: Sodium hypochlorite (NaOCl) is regarded as the most frequently used root canal irrigant. Its high surface tension prevents its penetration into complex canal anatomies. The present study assesses the contact angle and penetration depth of 2.

An observational analysis to evaluate the influence of occlusion on body posture and plantar pressure - An in vivo study.

Aim: The aim of this study is to evaluate the influence of occlusion on body posture and plantar arch pressure.

Settings And Design: An Observational analysis to Analyze the Influence of Occlusion on Plantar Pressure and Body Posture.

Materials And Methods: A total of 30 asymptomatic subjects were selected for the study including 18 females and 12 males from age group 22 years to 28 years with a mean age of 24.

Evaluation of the Effect of Occlusal Calibration in Periodontitis Patients with Occlusal Trauma Using T-Scan.

Background: High occlusal forces in patients with untreated periodontitis may reflect occlusal trauma-associated periodontal conditions. Occlusal analysis using T-scan might provide the distribution of occlusal loading forces in periodontitis patients. The study aimed to evaluate the effect of occlusal trauma in periodontitis patients and occlusal calibration using a T-scan.

A Comparative Analysis of Arch Widths in Class I and Class II Malocclusion: Extraction vs. Non-extraction Treatment.

Introduction: This study aimed to assess and compare dental arch widths in the anterior and posterior regions among patients undergoing extraction and non-extraction treatments for Class I and Class II malocclusions.

Materials And Methodology: A total of 40 patients were selected, with 10 in each of the categorized groups based on malocclusion type and treatment status. Dental arch widths were meticulously measured using a digital Vernier caliper at the canine and molar regions to ensure precise data collection.

Investigate how Frequently Dental Professionals Conduct Oral Cancer Screenings During Routine Dental Check-Ups and the Methods they Use.

Background: Oral cancer is a significant global health concern with substantial morbidity and mortality rates. Early detection during routine dental check-ups is crucial for improved patient outcomes. Dental professionals play a pivotal role in conducting oral cancer screenings, but the frequency and methods they employ remain understudied.

Estimation and Association of Total Protein Concentration with Early Childhood Caries in 3-6-year-old Children: A Randomized Clinical Trial.

Background And Objective: Caries is a common problem witnessed in children, early childhood caries (ECC) is the most predominant chronic disease which not only leads to distress and pain but also poor quality of life, thus affecting the overall well-being of children. Salivary protein plays a vital part in monitoring health status or disease. It was stated that the salivary proteins could regulate the equilibrium of oral health, preserve a stable ecosystem, and constrain the growth of cariogenic bacteria.

efficacy of 2% povidone iodine, chlorhexidine gluconate, and herbal extract mouthwash on SARS-CoV-2 viral load in saliva: A randomized clinical trial.

Background: One of the major techniques to reduce the transmission rate of COVID-19 would be to decrease the viral titers of SARS-CoV-2 in the saliva of infected patients and it is particularly useful in a dental setting. The present study evaluated the change in salivary viral load of COVID-19 patients using povidone iodine (PI), chlorhexidine (CHX), and an herbal extract (RightSure) oral antiviral herbal mouthwash (HM) at clinically recommended duration and concentrations.

Materials And Methods: Thirty individuals with SARS-CoV-2 were randomly allocated to three groups: (1) Group 1, PI mouthwash; (2) Group 2, CHX mouthwash; and (3) Group 3, HM mouthwash.

Role of hypoxia and epithelial-mesenchymal transition in the formation and maintenance of oral cancer stem cells in oral squamous cell carcinomas and metastatic lymph node: An immunohistochemical analysis.

Background: Inspite of having advanced treatment modalities the overall survival rate in oral squamous cell carcinoma (OSCC) remains poor. This is considered to be mainly due to local recurrence and distant metastasis. Various studies have concentrated on the role of oral cancer stem cells (OCSCs) in the progression and metastasis of OSCC.

Role of MMP1 and MMP10 in local invasion and distant metastasis in different levels of oral squamous cell carcinoma - A immunohistochemical comparative study.

Background: Matrix metalloproteinases (MMPs) are basically a part of a large family of proteolytic enzymes. They play an important role in degrading extracellular matrix and basement membrane, which is a basic mechanism in local invasion and tumour metastasis. The aim of this study was to evaluate immunohistochemically the expression of MMP1 and MMP10 in tumour invasion locally and at distant levels, including lymph nodes at different levels in oral squamous cell carcinoma (OSCC).

Knowledge, Attitude, and Practice of Patients toward Dental Implants in Need of Prosthodontic Rehabilitation.

Background: Our goal in conducting this study was to see how well-informed patients are about dental implants as a method of prosthodontic rehabilitation.

Materials And Methods: "In this cross-sectional study, 500 new dental students were asked questions using a pre-made, self-administered questionnaire. A pilot study was carried out to verify the reliability of the survey instrument.

Determination and correlation of matrix metalloproteases profile and total antioxidant capacity in severe early childhood caries children - A randomized clinical trial.

Background And Objective: Matrix metalloproteinases (MMPs) are a multigene family that belongs to the metalloproteinase class of endopeptides, responsible for the remodeling and degeneration of extracellular matrix molecules. MMPs are collectively called Matrixins are known to participate in tooth development and dentin-caries progression. Total antioxidant capacity (TAC) is the measure of the amount of free radicals scavenged by a test solution, being used to evaluate the antioxidant capacity of biological samples.

Clinical effects of as a probiotic on oral health: A systematic review.

Background: The burden of oral diseases is increasing, which constitute a major public health problem. The use of probiotics as an adjuvant, along with routine dental care practice by an individual, can produce additional benefits in the maintenance of one's oral health. The study aimed to investigate the effect of Bifidobacterium as a probiotic on oral health.

Identification and Correlation of and in Caries-active and Caries-free Children: A PCR Study.

Aim And Objectives: Dental caries is currently considered an ecological imbalance within the oral biofilm leading to the dissolution of the tooth's hard tissues. It has been traditionally thought that two species belonging to the group, (SM) and (SS), are the etiologically responsible for the onset of dental decay.

Materials And Methods: The present study was conducted on 40 children with caries-active (CA) and caries-free (CF).

Immediate flapless implant placement in a smoker patient: A challenge for optimum aesthetics and secondary stability: A case report.

The objective of this case report was to restore the young patient with missing teeth and extruded tooth using an immediate implant and synthetic bone graft material for the esthetic and comfort purpose. A 21-year young man reported extrusion of a tooth as well as missing teeth. Clinical examination revealed missing teeth in relation to (irt) 11 and 21, extrusion of tooth in relation to (irt) 12, patient had generalized fluorosis, and localized marginal gingivitis with melanin pigmentation.

Evaluation of customized cobalt-chromium abutments fabricated with different manufacturing process versus titanium stock abutments on the marginal misfit -An study.

Aim: Accurate fit of the abutment to the implant is required for the uniform load distribution throughout the assembly. The study aims to compare the marginal misfit of titanium stock abutments with the cobalt-chromium (CoCr) customized abutments fabricated with the different manufacturing processes in internal hex implant-abutment connection using an appropriate scanning technique.

Setting And Design: In vitro comparative study.

Evaluation of three different remineralizing agents on artificially demineralized enamel lesions: Using scanning electron microscopy-energy dispersive X-ray and magic-angle spinning nuclear magnetic resonance - An study.

Aim: Demineralization can be arrested or reversed when remineralization agents are applied to incipient carious or noncavitated carious lesions. A large number of therapeutic agents, including nonfluoridated products, have been developed to promote enamel remineralization. This study aims to evaluate the efficacy of different remineralizing agents on artificially demineralized enamel lesions.

mRNA Expression of Ezrin in Gingival Crevicular Fluid and Whole Blood of Gingivitis and Chronic Periodontitis Patients - A Polymerase Chain Reaction Study.

Background: A comparative analysis of protein expression of gingival crevicular fluid (GCF) obtained from healthy individuals and individuals with periodontal diseases would help to identify proteins involved in periodontal disease progression. Among the identified proteins, Moesin which is a disease-associated protein belongs to the ezrin-radixin-moesin protein family and was proved to play an important role in the recognition of oral bacteria contributing to the consequent development of inflammatory immune responses involved in periodontal disease development.

Aim: The aim of the study is to quantify and compare mRNA expression levels of ezrin in GCF and whole blood of gingivitis and chronic periodontitis patients.