A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session17magd3rvict6firl9c2n183dd8i09u2): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

Raghavendra Institute of Pharmaceutical... Publications | LitMetric

129 results match your criteria: "Raghavendra Institute of Pharmaceutical Education and Research[Affiliation]"

Decoding tumor microenvironment: EMT modulation in breast cancer metastasis and therapeutic resistance, and implications of novel immune checkpoint blockers.

Biomed Pharmacother

December 2024

Department of Breast, Thyroid and Vascular Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China. Electronic address:

Tumor microenvironment (TME) and epithelial-mesenchymal transition (EMT) play crucial roles in the initiation and progression of tumors. TME is composed of various cell types, such as immune cells, fibroblasts, and endothelial cells, as well as non-cellular components like extracellular matrix (ECM) proteins and soluble factors. These elements interact with tumor cells through a complex network of signaling pathways involving cytokines, growth factors, metabolites, and non-coding RNA-carrying exosomes.

View Article and Find Full Text PDF
Article Synopsis
  • Many countries have increased focus on physical education and sports, yet there's been a notable rise in injuries, particularly Achilles tendon ruptures, which make up 47% of such cases.
  • The review aims to identify risk factors for Achilles tendon ruptures and propose personalized prevention strategies based on extensive database research.
  • It highlights non-modifiable factors like genetics and age as well as modifiable factors such as nutrition and exercise habits, emphasizing the importance of early treatment and the latest advancements in injury management.
View Article and Find Full Text PDF

Incidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I-XI, WHO mortality database, and Global Burden of Disease (GBD)-2019.

View Article and Find Full Text PDF

This study focuses on developing novel antimicrobials to combat drug-resistant pathogens, addressing compounds failing clinical trials due to inadequate physicochemical properties. Sixteen imidazolidine-4-one derivatives were synthesized by extensive evaluation using molecular docking, absorption, distribution, metabolism, excretion (ADME) predictions, and antimicrobial testing. Molecular docking studies conducted with Schrödinger's Glide revealed that compounds S4 and G8 exhibited superior docking scores of -7.

View Article and Find Full Text PDF

Background: Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. Aging, diabetes, and obesity are significant contributors to BM niche damage, which can alter hematopoiesis and lead to the development of clonal hematopoiesis of intermediate potential (CHIP). Genetic/epigenetic alterations during aging could influence BM niche reorganization for hematopoiesis or clonal hematopoiesis.

View Article and Find Full Text PDF

Comparison of treatment adherence among TB patients with and without COVID-19 in South India.

Indian J Tuberc

October 2024

Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Deemed to Be University, Kattankulathur, Chennai, 603 203, Tamil Nadu, India. Electronic address:

Aim: The present study aimed to compare the adherence to anti-TB treatment among post-COVID-19 pulmonary TB cases and TB patients without a history of COVID-19 in South India.

Methods: A prospective, cross sectional study was conducted in all drug-sensitive pulmonary tuberculosis patients in National TB Elimination Program. The research investigates the impact of the COVID-19 pandemic on TB management, considering both subjective and objective measures of adherence.

View Article and Find Full Text PDF

This study aimed to enhance the efficacy of quercetin (QT) by formulating it into a liposomal drug delivery system utilizing the concept of central composite design. The drug:lipid ratio, cholesterol concentration, and sonication time were selected as independent variables in the study. The vesicle and percentage entrapment efficiency were selected as the dependent variables.

View Article and Find Full Text PDF

Several chemotherapeutics against breast cancer are constrained by their adverse effects and chemoresistance. The development of novel chemotherapeutics to target metastatic breast cancer can bring effective clinical outcomes. Many breast cancer patients present with tumors that are positive for estrogen receptors (ERs), highlighting the importance of targeting the ER pathway in this particular subtype.

View Article and Find Full Text PDF

Objective: This study aimed to compare the effects of β-sitosterol nanoparticles (BETNs) and β-sitosterol (BET) on cognitive impairment, oxidative stress, and inflammation in a myocardial infarction (MI) rat model using in silico and in vivo methods.

Methods: β-Sitosterol (BET) and myeloperoxidase (MPO) ligand-receptor binding affinities were evaluated using Autodock Vina for docking and Gromacs for dynamics simulations. BET nanoparticles, prepared via solvent evaporation, had their size confirmed by a nanoparticle analyzer.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzes global disparities in the incidence and mortality rates of gynecological cancers (GCs) using data from GLOBOCAN 2022, highlighting a significant impact on women’s health and healthcare systems worldwide.
  • In 2022, there were approximately 1.47 million new cases and 680,000 deaths from GCs globally, with the highest incidence and mortality rates in Eastern Africa, linked to factors like HIV and HPV.
  • Projections for 2050 indicate that if current trends continue, the burden of GCs will worsen, especially in regions with lower Human Development Index (HDI) ratings, underscoring the need for targeted health interventions.
View Article and Find Full Text PDF

Occupational pulmonary diseases (OPDs) pose a significant global health challenge, contributing to high mortality rates. This review delves into the pathophysiology of hypoxia and the safety of intermittent hypoxic conditioning (IHC) in OPD patients. By examining sources such as PubMed, Relemed, NLM, Scopus, and Google Scholar, the review evaluates the efficacy of IHC in clinical outcomes for OPD patients.

View Article and Find Full Text PDF

Background: Tracheal, Bronchus, and Lung (TBL) cancer continues to represent the majority of cancer-related incidence and mortality in United States (U.S.).

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigated the potential of khellin (KL) to counteract the effects of Parkinson's disease (PD) induced by rotenone in zebrafish, using various analyses including drug assessments, molecular docking, and dynamics studies which indicated strong binding affinity of KL to monoamine oxidase B (MAO-B).
  • - KL demonstrated significant antioxidant properties in vitro, suggesting it can help maintain redox balance, and further in vivo analysis revealed that KL treatment improved locomotor activity and social interactions in zebrafish models of PD while also reducing various oxidative stress markers.
  • - Histopathological examinations showed that KL treatment effectively alleviated brain abnormalities associated with PD, highlighting its potential therapeutic benefits for PD symptoms.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates how aloe-emodin (AE) nanoparticles can potentially protect the brain during a stroke by examining their interactions with the target protein myeloperoxidase (MPO) through advanced simulations, showing AE binds more effectively to MPO than a comparative compound (CCl).
  • - It is proposed that converting AE into nanoparticles can enhance its bioavailability, as results indicate that aloe-emodin nanoparticles (AENP) significantly improve various health parameters in stroke-affected rats compared to standard AE treatment.
  • - The research findings suggest that AENP treatment not only reduces the size of brain damage but also stabilizes heart and brain functions, leading to better overall outcomes for stroke-affected rats while highlighting severe damage and abnormalities observed
View Article and Find Full Text PDF

Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer membrane rupture, affecting mitochondrial function and cellular fate. Recent reports have described the intrinsic cellular iron metabolism and its intricate connection to ferroptosis, a significant kind of cell death characterized by iron dependence and oxidative stress regulation. Furthermore, updated molecular insights have elucidated the significance of mitochondria in ferroptosis and its implications in various cancers.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored the potential link between radiotherapy (RT) given for esophageal cancer (EC) and the risk of developing secondary head and neck cancer (SHNC).
  • Using data from the SEER database, researchers found that EC patients who received RT had a higher incidence of SHNC compared to those who did not receive radiation, with significantly lower overall survival rates for RT patients who developed SHNC.
  • The findings suggest that radiation oncologists should consider strategies to reduce the long-term risk of SHNC in EC patients treated with RT.
View Article and Find Full Text PDF

Cerebroprotective Potential of Andrographolide Nanoparticles: In silico and In vivo Investigations.

Drug Res (Stuttg)

September 2024

Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science, Technology & Research (Deemed to be University), Guntur, India.

Ischemic stroke remains the leading cause of death and disability, while the main mechanisms of dominant neurological damage in stroke contain oxidative stress and inflammation. Docking studies revealed a binding energy of - 6.1 kcal/mol for AG, while the co-crystallized ligand (CCl) exhibited a binding energy of - 7.

View Article and Find Full Text PDF

Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia.

Stem Cell Rev Rep

July 2024

Department of Pulmonary Medicine, JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.

Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process intricately regulated by neural signaling pathways. This delicate orchestration is susceptible to disruption by factors such as aging, diabetes, and obesity, which can impair the BM niche and consequently affect haematopoiesis. Genetic mutations in Tet2, Dnmt3a, Asxl1, and Jak2 are known to give rise to clonal haematopoiesis of intermediate potential (CHIP), a condition linked to age-related haematological malignancies.

View Article and Find Full Text PDF

Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits.

Ageing Res Rev

September 2024

Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain.

Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and life-threatening conditions in which significant damage of functional neurons occurs to produce psycho-motor malfunctions. NDs are an important cause of death in the elderly population worldwide. These disorders are commonly associated with the progression of age, oxidative stress, and environmental pollutants, which are the major etiological factors.

View Article and Find Full Text PDF

The presence of -nitroso compounds, particularly -nitrosamines, in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic effects. This systematic review investigates their toxicity in active pharmaceutical ingredients (APIs), drug products, and pharmaceutical excipients, along with novel analytical strategies for detection, root cause analysis, reformulation strategies, and regulatory guidelines for nitrosamines. This review emphasizes the molecular toxicity of -nitroso compounds, focusing on genotoxic, mutagenic, carcinogenic, and other physiological effects.

View Article and Find Full Text PDF

Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases.

Mol Neurobiol

December 2024

Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the origin of a diverse array of medicinal compounds. One of the compounds found in kudzu root is puerarin, a isoflavone glycoside commonly used as an alternative medicine to treat various diseases.

View Article and Find Full Text PDF

Background: This study presents preliminary results of robot-assisted nipple-sparing immediate breast reconstruction (R-NSMIBR) with gel implant combined with latissimus dorsi muscle flap without island flap and validation of the safety and utility of this novel surgical modality.

Methods: Records pertinent to R-NSMIBR with gel implants combined with latissimus dorsi muscle flap surgery for breast reconstruction between September 2022 and May 2023 were examined. A total of 13 patients who underwent R-NSMIBR were analyzed, nine of which were performed without skin island.

View Article and Find Full Text PDF

Dietary anti-inflammatory and anti-bacterial medicinal plants and its compounds in bovine mastitis associated impact on human life.

Microb Pathog

July 2024

Department of Biotechnology, Sharda School of Engineering & Technology (SSET), Sharda University, Greater Noida, India; School of Bioengineering & Biosciences, Lovely Professional University, Phagwara, 144411, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India. Electronic address:

Bovine mastitis (BM) is the most common bacterial mediated inflammatory disease in the dairy cattle that causes huge economic loss to the dairy industry due to decreased milk quality and quantity. Milk is the essential food in the human diet, and rich in crucial nutrients that helps in lowering the risk of diseases like hypertension, cardiovascular diseases and type 2 diabetes. The main causative agents of the disease include various gram negative, and positive bacteria, along with other risk factors such as udder shape, age, genetic, and environmental factors also contributes much for the disease.

View Article and Find Full Text PDF

New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis.

Eur J Med Chem

June 2024

RERDS-CPR, Raghavendra Institute of Pharmaceutical Education and Research Campus, Ananthapuramu, 515721, Andhra Pradesh, India; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur 844102, Bihar, India. Electronic address:

Through a comprehensive molecular docking study, a unique series of naphthoquinones clubbed azetidinone scaffolds was arrived with promising binding affinity to Mycobacterial Cytbc1 complex, a drug target chosen to kill multi-drug resistant Mycobacterium tuberculosis (MDR-Mtb). Five compounds from series-2, 2a, 2c, 2g, 2h, and 2j, showcased significant in vitro anti-tubercular activities against Mtb HRv and MDR clinical isolates. Further, synergistic studies of these compounds in combination with INH and RIF revealed a potent bactericidal effect of compound 2a at concentration of 0.

View Article and Find Full Text PDF