Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma.

We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.

Paraproteinemic maculopathy.

Purpose: Paraproteinemia relates to monoclonal gammopathy-producing pathologic antibodies with serous macular detachment being an uncommon ocular manifestation. We ascertained the clinical course of maculopathy in paraproteinemia and investigated the effect of various therapeutic methods on the resolution of subretinal deposits.

Design: Multicenter, retrospective, observational case series.

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders.

Twenty-three children with nonmalignant disorders received HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) after ex vivo elimination of αβ(+) T cells and CD19(+) B cells. The median number of CD34(+), αβ(+)CD3(+), and B cells infused was 16.8 × 10(6), 40 × 10(3), and 40 × 10(3) cells/kg, respectively.

Ocular manifestations of idiopathic aplastic anemia: retrospective study and literature review.

Aplastic anemia (AA) is a rare disease with few reports on its ophthalmic manifestations. The ocular findings are described in a retrospective consecutive series of 719 AA Korean patients followed at the Hematology Clinic of The Catholic University of Korea. Out of a total of 719 patients, 269 patients had eye examinations, 156 patients had retinal evaluation, and 37 (23.

Cataract surgery during active methicillin-resistant Staphylococcus aureus infection.

We present two patients with active, foul-smelling, methicillin-resistant Staphylococcus aureus (MRSA) wounds of the forehead and sternum following craniotomy or open heart surgery. Both had debilitating cataracts and were told by the infectious diseases team that cataract surgery is very risky. Both underwent sequential bilateral phacoemulsification with no sign of infection.

Combined intracorneal and subconjunctival bevacizumab injections for recurrent visual loss and intraocular hemorrhage from vascularized fibrous downgrowth.

Background: Epithelial and fibrous downgrowths result from persistently leaky wounds with conjunctival or corneal epithelium and fibroblasts growing over corneal endothelium, iris and angle structures, leading to corneal edema and difficult-to-control glaucoma. Therapies have included en bloc resection, cryotherapy, endolaser or external photocoagulation and either 5-fluorouracil or mitomycin C injections. A new complication and a novel therapy are presented.

A rare aggravation of severe mucositis post chemotherapy in a child with acute lymphoblastic leukemia.

Oral mucositis is a debilitating manifestation in children undergoing chemotherapy and radiotherapy. Children with mucositis should be properly managed in order to prevent further exacerbation and adverse complications. We hereby present the first report of a severe chemotherapy-induced mucositis, plausibly aggravated by improper dental hygiene leading to shedding of the ventral part of the tongue in a child with pre-B acute lymphoblastic leukemia (ALL).

Heterotopic intra-abdominal ossification in a complex ventral hernia defect.

Heterotopic ossification, an entity common in orthopaedic practice frequently involving the hip, knee or other joints, is rarely encountered in abdominal wounds and mesentery. This unusual condition, referred to as mesenteric ossification, is typically associated with intra-abdominal catastrophes. Surgical repair following such catastrophes has always been a challenge as the abdominal wall architecture is frequently distorted by the multiple laparotomies previously performed.

Clinical experience with insulin detemir in patients with type 2 diabetes from the near East countries.

Introduction: This study aimed at determining the clinical safety and efficacy of insulin detemir (IDet) in combination with oral anti-diabetic drugs (OADs) in type 2 diabetes (T2D) patients from four Near East Countries (Israel, Jordan, Pakistan and Lebanon).

Methods: This prospective observational study included T2D patients previously on OADs and newly diagnosed patients initiating IDet with or without OADs, at the discretion of physicians. Safety objectives included evaluation of hypoglycemia and adverse drug reactions (ADRs) from baseline to Week 24.

Anterior segment imaging and treatment of a case with syndrome of ectopia lentis, spontaneous filtering blebs, and craniofacial dysmorphism.

Purpose: To report the ultrasound biomicroscopy (UBM) and surgical findings in a subject with a syndrome of ectopia lentis, spontaneous filtering blebs, and craniofacial dysmorphism (Traboulsi syndrome).

Methods: Case report, using a 40-MHz UBM wide-field anterior segment scan and anterior segment optical coherence tomography (OCT).

Results: A 16-year-old orphan girl presented with visual loss to the level of 6/60 (20/200) bilaterally.

Fulminant Panuveitis following Iris Suture Fixation of Posterior Chamber Intraocular Lens.

We present a case of fulminant panuveitis following iris suture fixation of a posterior chamber intraocular lens. We hypothesize that the zonular dehiscence allowed the inflammatory cells in the anterior compartment to gain access to the posterior segment mimicking endophthalmitis or toxic anterior segment syndrome. Also certain bulky lens designs, like the current Rayner hydrophilic acrylic lens, are difficult to manipulate and hold in the optic capture position, and hence the iris fixation of these lenses can be traumatic and lengthy.

Identification of the first mutation in a BRE motif of the β-globin gene and its inheritance with two other α-globin gene mutations in a Lebanese family.

A 7-year old boy presented with a history of recurrent respiratory infections and hypochromic microcytic anemia. Iron profiles were normal thereby prompting genetic analysis of α- and β-globin mutations. The first mutation in a BRE motif of the β-globin gene in the proband, sibling and the mother was identified.

Insight into 144 patients with ocular vascular events during VEGF antagonist injections.

Aim: To record ocular vascular events following injections of vascular endothelium growth factor (VEGF) antagonists.

Methods: Collaborative multicenter case series (48 cases), literature reviews (32 cases), and reports to the FDA (64 cases) of patients that had vascular occlusions during anti-VEGF therapy were collected and analyzed.

Results: A total of 144 cases of ocular vascular events were identified, with these diagnosed a median of 15 days after anti-VEGF injection.

A case report of bilateral cervical chondrocutaneous remnants with review of the literature.

Cervical chondrocutaneous remnants are very rare entities. They are thought to originate either from the second branchial arch or from auricular tissues. To date, less than 40 cases have been reported in the medical literature, and only 7 cases were bilateral.

Infarcted accessory spleen due to segmental portal hypertension.

Accessory spleens are frequent entities, but their infarction due to arterial stasis caused by segmental portal hypertension is extremely rare. We present this case of a 38-year-old female patient with a three-week history of abdominal pain and an abdominal CT scan revealing a 7 cm mass near the spleen and tail of pancreas with segmental portal hypertension. The patient had no hematologic disease.

[Atrioventricular septal defect characteristics in infants with and without Down's syndrome: a Lebanese study].

Objectives: Analyze the demographic and clinical characteristics of complete atrioventricular septal defect (AVSD), its association with Down's syndrome, with other cardiac and extra-cardiac anomalies, and finally the impact of consanguineous marriages on the incidence of AVSD.

Patients & Methods: The sample consisted of 2195 consecutive patients with congenital heart defect, entered in the National Register of Paediatric and Congenital Heart Disease, Lebanese Society of Cardiology, Beirut, between Jan 1999 and Dec 2007. 120 patients with AVSD were analyzed.

Retinal vascular events after intravitreal bevacizumab.

Purpose: To record retinal vascular events following intravitreal bevacizumab injection.

Methods: Collaborative multi-centre retrospective case series.

Results: Eight patients were documented to have central retinal artery occlusion (four patients), branch retinal artery occlusion, capillary occlusion, central retinal vein occlusion and branch retinal vein occlusion (one patient each) within 0-55 days (median 2 weeks) of intravitreal bevacizumab.

Long-term visual outcomes of intravitreal bevacizumab in inflammatory ocular neovascularization.

Purpose: To assess the long-term role of bevacizumab (Avastin; Genentech Inc, South San Francisco, California, USA) in inflammatory ocular neovascularization.

Design: Retrospective multicenter consecutive case series of inflammatory ocular neovascularization.

Methods: settings: Multicenter institutional and private practices.

Periocular corticosteroid in malignant hypertensive and preeclampsic choroidopathy.

Introduction: Disk edema and serous macular detachment in either malignant hypertension or preeclampsia require several weeks to resolve, leaving these young active affected subjects with unilateral or bilateral visual handicap.

Methods: The authors treated two patients with visual loss by sub-Tenon corticosteroid.

Results: Visual improvement occurred within 1 week of the periocular corticosteroid from finger counting at 6 m to 20/70 in a woman with preeclampsia and from bilateral 20/50 to 20/25 in the right eye and 20/20 in the left eye in a man with malignant hypertension.

Intravitreal bevacizumab in inflammatory ocular neovascularization.

Purpose: To assess the role of bevacizumab in inflammatory ocular neovascularization.

Design: Retrospective, multicenter, consecutive case series of inflammatory ocular neovascularization.

Methods: Patients with inflammatory ocular neovascularization of varying causes for whom standard therapy failed were treated with intravitreal injection of bevacizumab.