Accuracy-dependent dose-constraints and dose-based safety margins for organs-at-risk in radiotherapy.

Background And Purpose: Geometrical uncertainties in radiotherapy are generally accounted for by margins for tumors, but their effect on organs-at-risk (OARs) is often ignored. We developed a model that incorporates dose- and geometry-based uncertainties in OAR planning using dose constraints.

Materials And Methods: Radiotherapy uncertainties cause real dose-volume histograms (DVHs) to spread around the planned DVH.