6,650 results match your criteria: "Radical Hysterectomy"
Case report: Multiphenotypic cervical cancer resembling human papillomavirus-related multiphenotypic sinonasal carcinoma.
Front Med (Lausanne)
December 2024
Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a biphasic epithelial tumor associated with HPV infection. This rare tumor primarily affects the nasal cavity and paranasal sinuses, with only two cases reported outside these locations to date-one in the breast and one in the vulva. This report presents a case of a tumor resembling an HMSC arising in the cervix.
View Article and Find Full Text PDFOncologic Outcomes of Laparoscopic Radical Hysterectomy Incorporating Modified Tumor-Free Techniques.
Obstet Gynecol
December 2024
National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Objective: It remains unclear whether modifying laparoscopic radical hysterectomy to adopt tumor-free principles can improve oncologic outcomes in patients with early-stage cervical cancer.
Methods: We performed a single-center retrospective cohort study of 276 patients with early-stage cervical cancer who were treated between January 2017 and January 2023, including 151 patients who underwent laparoscopic radical hysterectomy that incorporated modified tumor-free techniques (MTF group) and 125 patients who underwent conventional laparoscopic radical hysterectomy with a uterine manipulator and unprotected intracorporeal colpotomy (non-MTF group). Oncologic outcomes and perioperative results were analyzed using inverse probability treatment weighting (IPTW).
Uterine Smooth Muscle Tumor of Undetermined Malignant Potential (STUMP): A Diagnostic Challenge.
Cureus
November 2024
Medical Oncology, Tata Main Hospital, Jamshedpur, IND.
Article Synopsis
- Smooth muscle tumors of the uterus vary from benign leiomyomas to malignant leiomyosarcomas, with STUMP representing a challenging gray area of tumors with uncertain malignant potential.
- A case study is presented of a 52-year-old woman with severe menorrhagia, diagnosed with STUMP after a hysteroscopy and biopsy, which raised concerns about the possibility of leiomyosarcoma.
- The patient underwent a radical hysterectomy, where the final diagnosis remained STUMP, and has since been on regular follow-up without any recurrence, highlighting the rarity of STUMP presenting as a uterine polyp.
Undifferentiated uterine sarcoma : experience of a single center.
World J Surg Oncol
December 2024
Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 # Panjiayuannanli, Chaoyang District, Beijing, 100021, China.
Article Synopsis
- - The study analyzed 29 patients with undifferentiated uterine sarcomas (UUS) to understand their clinical features and prognosis, finding most patients diagnosed were around 52 years old and primarily in stage I at diagnosis.
- - Treatments involved extensive surgeries, with a high rate of total hysterectomy and lymphadenectomy; however, over half of the patients died within two years, revealing a median progression-free survival of 15.5 months and overall survival of 27.4 months.
- - The findings highlight UUS as aggressive tumors with poor survival outcomes, indicating that most patients experience rapid disease progression and metastatic spread despite surgical treatment.
Robotic salvage radical hysterectomy for locally recurrent cervical cancer: A comparison with open surgery in a single-surgeon series.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
Post-radical hysterectomy ovarian torsion-A gynecological emergency: a case series.
J Med Case Rep
December 2024
Consultant Gynaecology Oncologist, Royal Sussex Hospital, Brighton, UK.
Article Synopsis
- * The report highlighted two cases of ovarian torsion following laparoscopic radical hysterectomy for cervical cancer, where both patients underwent a procedure meant to prevent this complication but still experienced torsion.
- * With ovarian torsion occurring in 1-8% of post-hysterectomy cases and rising cervical cancer rates among younger women, further research and improved surgical techniques are essential for better prevention and diagnosis.
Modified abdominal radical trachelectomy used to spare fertility during surgery for early-stage cervical cancer: a case report.
J Med Case Rep
November 2024
Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam.
Article Synopsis
Factors influencing postoperative urinary retention after radical hysterectomy for cervical cancer: development and validation of a predictive model in a prospective cohort study in Southwest China.
BMJ Open
November 2024
West China School of Nursing, Sichuan University/Department of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Article Synopsis
- The study aims to identify factors influencing postoperative urinary retention (POUR) in cervical cancer patients and develop a prediction model for it.
- It includes a prospective cohort analysis of 1,101 patients undergoing surgery, along with an external validation cohort of 205 patients.
- Key factors found to significantly influence POUR include diabetes, wound healing classification, preoperative treatments, and postoperative infections, leading to a highly accurate prediction model with an AUC of 0.897.
Unusual Extension of Superficial Spreading Squamous Cell Carcinoma of Cervix to Uterus, Paraovarian, Paratubal Tissue, and Vaginal Surface: A Unique Case Report.
J Midlife Health
October 2024
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar, Telangana, India.
Article Synopsis
Diagnostic Efficacy of Hysteroscopy and Its Use as a Therapeutic Aid in Perimenopausal and Postmenopausal Women - See and Treat.
J Midlife Health
October 2024
Department of OBGYN, Gandhi Medical College, Hyderabad, Telangana, India.
Article Synopsis
Incidence and risk factor of blood transfusion after abdominal radical hysterectomy for cervical cancer: a 10-year retrospective study of the US nationwide inpatient sample.
BMC Cancer
November 2024
Department of Gynecology, Dongguan Tungwah Hospital, Dongguan, China.
Article Synopsis
Cervical Mesonephric Adenocarcinoma Treated with Neoadjuvant Chemotherapy: A Case Report and a Literature Review.
Diseases
November 2024
Department of Obstetrics and Gynecology, Toho University Medical Center Sakura, 564-1 Shimoshizu, Sakura City 285-8741, Chiba Prefecture, Japan.
Introduction: Cervical mesonephric ductal adenocarcinoma (MA) is an HPV-independent adenocarcinoma that occurs in middle-aged women. MA originates from remnants of the Wolffian duct that usually regress in females once the induction of sex differentiation is activated. MA is a rare disease that accounts for less than 1% of all cervical adenocarcinomas.
View Article and Find Full Text PDFAnalysis of Lymphovascular Infiltration and Tumor-Associated Macrophages in Cervical Cancer Immunoescape.
Onco Targets Ther
November 2024
Department of Obstetrics and Gynecology, Zhabei Centrial Hospital, Jing'an District, Shanghai, 200070, People's Republic of China.
Article Synopsis
Cost-effectiveness of robotic surgery compared to conventional laparoscopy for the management of early-stage cervical cancer: a model-based economic evaluation in China.
BMJ Open
November 2024
School of Medical Informatics, Chongqing Medical University, Chongqing, China
Article Synopsis
- - The study compares the cost-effectiveness of robotic radical hysterectomy (RRH) and laparoscopic radical hysterectomy (LRH) for treating early-stage cervical cancer, using a model-based analysis with data from existing literature and local databases.
- - Results indicate that while RRH provides more quality-adjusted life years (QALYs)—4.84 more than LRH—it also incurs significantly higher costs, with an incremental cost of 1,031,108 RMB and an ICER of 213,054 RMB per QALY.
- - The findings suggest that RRH is a cost-effective option over the patients' lifetime, despite its higher upfront cost, highlighting the need for long-term clinical trials to evaluate financial and
The complexity and challenges of fertility preservation in women with cervix cancer-A prospective cohort study reporting on reproductive outcome and overall survival.
Acta Obstet Gynecol Scand
November 2024
Department of Reproductive Medicine, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.
Article Synopsis
- The study evaluated the feasibility of fertility preservation (FP) in women with cervix cancer, focusing on long-term reproductive outcomes and overall survival.
- Conducted at Karolinska University Hospital from 1999 to 2021, it included 91 women, primarily diagnosed at an early cancer stage, with various treatment options offered.
- After an average of 8.1 years of follow-up, only a small percentage of women achieved live births, highlighting the difficulties and complexities of fertility preservation in this cancer context.
Vulvar Skin Metastasis From Cervical Adenocarcinoma.
Am J Dermatopathol
December 2024
Institute of Dermatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China; and.
Article Synopsis
- Cervical cancer is a prevalent type of cancer affecting women's reproductive systems, especially in developing nations, but skin metastasis from it is rare.
- The study discusses a case of a 44-year-old woman with stage IIA gastric-type endocervical adenocarcinoma.
- After treatment involving a radical hysterectomy and chemoradiation, the patient developed skin metastasis in the vulvar area two years later.
Establishment of a Novel Risk Stratification System Integrating Clinical and Pathological Parameters for Prognostication and Clinical Decision-Making in Early-Stage Cervical Cancer.
Cancer Med
November 2024
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Article Synopsis
- A study was conducted on 2,071 early-stage cervical cancer patients to create a risk stratification model for better prognosis by analyzing clinical and pathological factors.
- The model, developed through recursive partitioning analysis (RPA), successfully categorized patients into four distinct risk groups, showing significant differences in their 5-year overall survival rates.
- The RPA model outperformed existing staging systems and revealed that treatment efficacy varies based on risk groups, particularly benefiting patients in higher-risk categories who received adjuvant chemoradiotherapy.
Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study.
J Cancer Res Clin Oncol
November 2024
School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Article Synopsis
- This study examined if neoadjuvant chemotherapy (NACT) raises the chance of postoperative delirium (POD) in patients with gynecological tumors after radical hysterectomy.
- It involved 120 patients, split into two groups: one receiving NACT and the other not, with assessments of cognitive and olfactory function before and after surgery.
- Results showed a significantly higher POD rate in the NACT group (28.33%) compared to the non-exposed group (8.33%), and identified cognitive dysfunction and olfactory dysfunction as associated risk factors for POD.
Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.
Eur J Surg Oncol
January 2025
Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy; PhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, Sassari, Italy.
Objective: We assessed reproductive, obstetrical, and oncological outcomes in patients who underwent fertility-sparing treatment by including studies that adhere to the FIGO 2018 staging system.
Methods: Data on recurrence, mortality, pregnancy rate, live birth rate, and preterm delivery rate were collected.
Results: In patients with stages IA1, IA2, and IB1, the recurrence rate was 4.
Interim analysis of robot-assisted radical hysterectomy in Japan: a multicenter, prospective interventional single-arm clinical trial.
BMC Cancer
November 2024
The Robot Center, Tokyo International Ohori Hospital, 4-8-40, Shimorenjaku, Mitaka City, Tokyo, 181-0013, Japan.
Article Synopsis
MRI-based assessment of residual disease after neoadjuvant chemotherapy in pregnant women with cervical cancer.
Eur J Radiol
December 2024
Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Article Synopsis
- - This study investigates how effective MRI is at identifying remaining cervical cancer after patients receive platinum-based neoadjuvant chemotherapy, particularly in pregnant women.
- - The research involved 12 pregnant patients treated between 2010 and 2021, assessing tumor size and status through MRI before and after treatment, where most patients showed residual disease post-therapy.
- - Results indicate that MRI is highly sensitive (100%) in detecting residual disease, suggesting it is a reliable method to evaluate treatment response in pregnant cervical cancer patients.
Development and validation of the competing risk nomogram and risk classification system for predicting cancer-specific mortality in patients with cervical adenosquamous carcinoma treated via radical hysterectomy.
Biomol Biomed
November 2024
Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Article Synopsis
- A competing risk nomogram was developed to predict cervical adenosquamous carcinoma (ASC)-specific death in patients who had undergone radical hysterectomy, using data from the SEER database.
- Key factors influencing ASC-specific mortality included advanced age, Black race, higher tumor grade, larger tumor size, and treatment types like radiotherapy without chemotherapy.
- The nomogram showed better predictive performance compared to traditional TNM staging and may aid clinicians in creating personalized treatment plans and follow-up strategies.
Nationwide cohort study on the risk of high-grade cervical dysplasia and carcinoma after conservative treatment or hysterectomy for adenocarcinoma in situ.
Int J Cancer
November 2024
Department of Gynecologic Oncology, Center of Gynecologic Oncology Amsterdam, Antoni van Leeuwenhoek/Netherlands Cancer Institute, Amsterdam, The Netherlands.
Article Synopsis
- * It compares outcomes of large loop excision (LLETZ), cold-knife conization (CKC), and hysterectomy in a cohort of 4,243 patients, finding that LLETZ had a higher recurrence rate of high-grade dysplasia compared to CKC.
- * When a complete radical excision is achieved, both LLETZ and CKC show similar low rates of recurrence, while hysterectomy results in no cases of cervical dysplasia or cancer, suggesting conservative treatments can be
Robot-Assisted Nerve-Sparing Eradication of Deep Endometriosis Using the da Vinci SP.
J Minim Invasive Gynecol
October 2024
Department of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan (all authors).
Article Synopsis
- - The text discusses the advantages of nerve-sparing surgery for deep endometriosis, emphasizing how it can minimize pelvic organ dysfunction post-surgery through improved anatomical knowledge and surgical techniques.
- - It highlights the use of the da Vinci SP robotic system, which has advanced tools that enhance precision in complex surgeries compared to traditional single-port laparoscopic methods, though its full potential is still being explored.
- - A case study is presented involving a 47-year-old woman with chronic pelvic pain, illustrating that the technique used in the surgery mimics conventional robotic procedures, benefiting from the SP system's superior visualization and instrument maneuverability.
A retrospective study on the effect of surgical approaches and uterine manipulators on the prognosis of cervical cancer.
Arch Gynecol Obstet
December 2024
School of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Article Synopsis
- The study investigates various surgical methods (laparoscopic, robotic, etc.) for treating cervical cancer and assesses the use of uterine manipulators during radical hysterectomy.
- Data from 848 patients treated between 2009 and 2019 were analyzed, focusing on demographic, clinical, and postoperative outcomes.
- Results show no significant differences in five-year survival rates across surgical methods or between those who used uterine manipulators and those who did not, indicating similar safety and efficacy.