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Radiation Oncology Centre[Affiliation] Publications | LitMetric

161 results match your criteria: "Radiation Oncology Centre[Affiliation]"

: Grade-2 gliomas (G2-glioma) are uncommon. In 2016, RTOG9802 established the addition of chemotherapy after radiation (CRT) as a new standard of care for patients with high-risk G2-glioma, defined as subtotal resection or age ≥40 yrs. Here, we report current practices using real-world data.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of adding metastasis-directed therapy (MDT) to camrelizumab in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC).
  • A total of 39 patients participated, with no significant difference in the objective response rate (ORR) of unirradiated lesions between the Cam alone and Cam+MDT groups, despite a higher disease control rate in the latter.
  • While overall survival was better for patients with more lesions in the Cam+MDT group, adverse events were similar between both treatments, indicating no substantial safety concerns.
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Multi-modal therapies for gynecological cancers management may determine a wide range of side effects which depend on therapy-related factors and patient characteristics and comorbidities. Curative or adjuvant pelvic radiotherapy is linked with acute and late toxicity due to irradiation of organs at risk, as small and large bowel, rectum, bladder, pelvic bone, vagina and bone marrow. Successful toxicity management varies with its severity, Radiation Centre practice and experience and skills of radiation oncologists.

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Radiation Therapy in Non-Melanoma Skin Cancers: An Italian Survey on Behalf of the Italian Association of Radiotherapy and Clinical Oncology.

Clin Oncol (R Coll Radiol)

December 2024

Dipartimento di Diagnostica Per Immagini, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Radioterapia Oncologica ed Ematologia, Italy.

Aims: The National Palliative Care and Interventional Radiotherapy Study Groups of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) carried out a survey whose aim was to obtain a "snapshot" of the real-world practice of nonmelanoma skin cancer (NMSC) treatments in Italy.

Materials And Methods: The survey was conducted on SurveyMonkey's online interface and was sent via e-mail to our society Radiation Oncologists.

Results: Fifty-eight Italian radiation oncologists (ROs), representing 54 centers, answered the survey.

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Purpose: Preoperative radiosurgery (SRS) of brain metastases (BM) aims to achieve cavity local control with a reduction in leptomeningeal relapse (LMD) and without additional radionecrosis compared to postoperative SRS. We present the final results of a prospective feasibility trial of linac-based stereotactic radiosurgery (SRS) prior to neurosurgical resection of a brain metastasis (PREOP-1).

Methods: Eligibility criteria included a BM up to 4 cm in diameter for elective resection.

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Purpose: Real-world data (RWD) collected on patients treated as part of routine clinical care form the basis of cancer clinical registries. Capturing accurate death data can be challenging, with inaccurate survival data potentially compromising the integrity of registry-based research. Here, we explore the utility of data linkage (DL) to state-based registries to enhance the capture of survival outcomes.

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Objectives: Despite the unfavorable outcomes associated with continued smoking, a substantial proportion of patients with cancer continue to smoke after diagnosis. However, limited use of smoking cessation (SC) interventions has been reported. This study explored the perceptions of patients with cancer who continue to smoke/recently quit regarding SC.

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Article Synopsis
  • - The review investigates the effectiveness of brachytherapy (BT) in treating early-stage oral cavity cancer (OCC), focusing on various outcomes like local control, overall survival, and safety.
  • - Using the SPIDER framework, researchers analyzed 517 articles but included only 7 studies with 456 patients, determining that BT leads to promising five-year local control, disease-free survival, and overall survival rates ranging from 50-100%.
  • - The conclusion indicates that BT is particularly effective for specific early-stage cancers in the oral cavity and presents favorable functional and safety profiles, especially for certain types of tumors.
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Redefining the role of pulsed-dose-rate brachytherapy in cervical cancer treatment using a preplanned approach.

Brachytherapy

March 2024

Department of Radiation Oncology, Gustave Roussy Comprehensive Cancer Center, Villejuif, France; Université Paris-Saclay, Institut Gustave Roussy, Inserm, Radiothérapie Moléculaire et Innovation Thérapeutique, Villejuif, France.

Article Synopsis
  • This study looks at which cervical cancer patients might do better with a special kind of treatment called pulsed-dose-rate (PDR) brachytherapy compared to high-dose-rate (HDR).
  • They studied 50 patients to compare the two treatments and used special models to see how effective each treatment would be.
  • The results showed that only a few patients really benefited from PDR, with specific measurements helping doctors figure out who would get the most help from it.
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We investigated a novel dedicated Prostate Imaging for Local Recurrence Reporting and Data System (PI-RRADS) in biochemical recurrence after radiotherapy (RT) and rad- ical prostatectomy (RP) evaluating biparametric magnetic resonance imaging (bpMRI) exams, at 3T MRI of 55 patients. Associating bpMRI and biochemical recurrence data, we calculated bpMRI diagnostic accuracy. Four probability categories, from 1 (very low) to 4 (very high), were distinguished.

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Management Paradigm of Central Nervous System Metastases in NSCLC: An Australian Perspective.

JTO Clin Res Rep

September 2023

Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, The University of Melbourne, Melbourne, Victoria, Australia.

Article Synopsis
  • Life-prolonging therapies for metastatic non-small cell lung cancer (NSCLC) have made managing brain metastases (BMs) more complex, leading to discussions among Australian oncologists about effective management strategies.
  • Patient management should consider whether BMs are symptomatic or asymptomatic and take into account various factors like the number and location of metastases, tumor types, and overall treatment goals.
  • An individualized treatment approach is crucial due to the lack of comprehensive clinical trial data on the best way to sequence multiple modern therapies in the rapidly evolving treatment landscape.
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Background: Studies have demonstrated the efficacy of Palbociclib (CDK 4/6 inhibitor), Gedatolisib (PI3K/mTOR dual inhibitor) and PD0325901 (MEK1/2 inhibitor) in colorectal cancer (CRC), however single agent therapeutics are often limited by the development of resistance.

Methods: We compared the anti-proliferative effects of the combination of Gedatolisib and Palbociclib and Gedatolisib and PD0325901 in five CRC cell lines with varying mutational background and tested their combinations on total and phosphoprotein levels of signaling pathway proteins.

Results: The combination of Palbociclib and Gedatolisib was superior to the combination of Palbociclib and PD0325901.

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JCO In a randomized phase II clinical trial, the Trans Tasman Radiation Oncology Group compared single- versus multifraction stereotactic ablative body radiotherapy (SABR) in 90 patients with 133 oligometastases to the lung. The study found no differences in safety, efficacy, systemic immunogenicity, or survival between arms, with single-fraction SABR picked as the winner on the basis of cost-effectiveness. In this article, we report the final updated survival outcome analysis.

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Aim: Stereotactic ablative radiotherapy (SABR) showed increasing survival in oligometastatic patients. Few studies actually depicted oligometastatic disease (OMD) evolution and which patient will remain disease-free and which will rapidly develop a polymetastatic disease (PMD) after SABR. Therefore, apart from the number of active metastases, there are no clues on which proven factor should be considered for prescribing local treatment in OMD.

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The application of biparametric magnetic resonance imaging (bpMRI) [T2-weighted (T2W) and diffusion weighted imaging (DWI)/apparent diffusion coefficient (ADC)] using dedicated structured methods, such as Simplified Prostate Imaging Reporting and Data System (S-PI-RADS) for the detection, categorization, and management of prostate cancer (PCa) is reported. Also, Prostate Imaging Reporting for Local Recurrence and Data System (PI-RRADS) for the detection and assessment of the probability of local recurrence after radiotherapy (RT) or radical prostatectomy (RP) in patients with biochemical recurrence (BCR) is proposed. Both S-PI-RADS and PI-RRADS assign to DWI/ADC a main role for the above purpose.

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Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa.

J Cancer Policy

March 2023

ICEC, International Cancer Expert Corps, Washington, DC, USA; CERN, ATS-DO, Geneva, Switzerland; Department of Physics, University of Oxford, UK. Electronic address:

Background: Access to high quality radiotherapy (RT) continues to be a major issue across Africa with Africa having just 34% of its optimal capacity.

Methods: We co-developed a survey with clinical, academic and policy stakeholders designed to provide a structured assessment of the barriers and enablers to RT capacity building in Africa. The survey covered nine key themes including funding, procurement, education and training.

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Purpose: To evaluate the reliability of algebraic sum with respect to rigid fusion of treatment plans related to adjuvant external beam pelvic radiotherapy (APR) and vaginal cuff high-dose-rate brachytherapy (BT) in uterine cancer patients.

Material And Methods: For algebraic sum, APR and BT doses were mathematically added. Rigid fusion was realized overlapping computed tomography (CT) images of APR and BT treatment plans.

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Background: Cancer cachexia (CC) is highly prevalent and associated with significant morbidity and mortality, yet underrecognized. In 2011, an international cachexia consensus (ICC) proposed a definition, assessment framework, and stages for classification: cancer precachexia, cachexia, and refractory cachexia. The authors anticipated that a "more practical classification approach for clinical practice" would be required, which we interpreted as a bedside assessment based on clinical data.

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Reduced-dose WBRT as consolidation treatment for patients with primary CNS lymphoma: an LOC network study.

Blood Adv

August 2022

Department of Neuro-oncology, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne Université, Institut Hospitalier Universitaire (IHU), Institut du Cerveau et de la Moelle (ICM), Groupe Hospitalier Pitié Salpetrière, Paris, France.

The optimal consolidation strategy for primary central nervous system lymphoma (PCNSL) remains controversial. Preventing radio-induced neurotoxicity of consolidation treatment through reduced-dose whole-brain radiotherapy (rdWBRT) at a dose of 23.4 Gy is an interesting alternative to conventional WBRT in patients aged <60 years.

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Postoperative radiotherapy for meningiomas - a decision-making analysis.

BMC Cancer

May 2022

Department of Radiation Oncology, Kantonsspital St. Gallen, Rorschacherstr. 95, 9007, St. Gallen, Switzerland.

Background: The management of meningiomas is challenging, and the role of postoperative radiotherapy is not standardized.

Methods: Radiation oncology experts in Swiss centres were asked to participate in this decision-making analysis on the use of postoperative radiotherapy (RT) for meningiomas. Experts from ten Swiss centres agreed to participate and provided their treatment algorithms.

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The liver is the first metastatic site in 15-25% of colorectal cancer patients and one of the first metastatic sites for lung and breast cancer patients. A computed tomography (CT ) scan with contrast medium is a standard procedure for assessing liver lesions but magnetic resonance imaging (MRI) characterizes small lesions better thanks to its high soft-tissue contrast. Positron emission tomography with computed tomography (PET-CT ) plays a complementary role in the diagnosis of liver metastases.

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Brain metastases, the most common metastases in adults, will develop in up to 40% of cancer patients, accounting for more than one-half of all intracranial tumors. They are most associated with breast and lung cancer, melanoma and, less frequently, colorectal and kidney carcinoma. Magnetic resonance imaging (MRI) is the gold standard for diagnosis.

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30-60% of cancer patients develop lung metastases, mostly from primary tumors in the colon-rectum, lung, head and neck area, breast and kidney. Nowadays, stereotactic radiotherapy (SRT ) is considered the ideal modality for treating pulmonary metastases. When lung metastases are suspected, complete disease staging includes a total body computed tomography (CT ) and/or positron emission tomography-computed tomography (PET -CT ) scan.

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Even though systemic therapy is standard treatment for lymph node metastases, metastasis-directed stereotactic radiotherapy (SRT ) seems to be a valid option in oligometastatic patients with a low disease burden. Positron emission tomography-computed tomography (PET-CT ) is the gold standard for assessing metastases to the lymph nodes; co-registration of PET-CT images and planning CT images are the basis for gross tumor volume (GTV ) delineation. Appropriate techniques are needed to overcome target motion.

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