2 results match your criteria: "Radboud Univ. Medical Center[Affiliation]"
Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification.
Circ Genom Precis Med
October 2022
Dept of Pediatric Cardiology, Erasmus MC, Univ Medical Center Rotterdam, Rotterdam (M.H.M., M.D.).
Article Synopsis
- The study investigated the current practices and outcomes of genetic evaluations in Dutch children with dilated cardiomyopathy, focusing on genotype-phenotype correlations for prognosis.
- A total of 144 children were analyzed, with 74% undergoing genetic testing; findings showed that 36% had likely pathogenic or pathogenic variants, which were linked to poorer outcomes.
- The results suggest that genetic testing is crucial for predicting prognosis in these children, and it should be included in their clinical evaluations regardless of the initial diagnosis.
Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.
Am J Physiol Renal Physiol
March 2014
286 Dept. of Physiology, Radboud Institute for Molecular Life Sciences, Radboud Univ. Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands.
Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI. The paradoxical antidiuretic action of HCTZ in Li-NDI is generally attributed to increased sodium and water uptake in proximal tubules as a compensation for increased volume loss due to HCTZ inhibition of the Na-Cl cotransporter (NCC), but alternative actions for HCTZ have been suggested.
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