9 results match your criteria: "RWTH Medical School[Affiliation]"
Paroxysmal Nocturnal Hemoglobinuria, Pathophysiology, Diagnostics, and Treatment.
Transfus Med Hemother
October 2024
Department of Hematology, Oncology, Elblandklinikum, Riesa, University Hospital, Dresden, Germany.
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) causes intravascular hemolysis due to a lack of complement regulation, leading to symptoms like anemia, pain, and fatigue, but can be treated with complement inhibitors to reduce disease-related complications and mortality.
- Eculizumab and ravulizumab, terminal complement inhibitors, improve survival rates, but many patients still experience issues from extravascular hemolysis, necessitating new treatment options.
- Proximal complement inhibitors (like pegcetacoplan, danicopan, and iptacopan) can help normalize hemoglobin levels and enhance quality of life for patients with significant extravascular hemolysis, though a clear treatment algorithm for choosing among
Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab.
Haematologica
December 2024
Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen.
Article Synopsis
- Macrophages play a crucial role in the effectiveness of the anti-CD19 antibody tafasitamab, which is used to treat certain types of lymphoma.
- The study focuses on the CD47-SIRPα interaction, which can inhibit the macrophages' ability to effectively eliminate tumor cells, and suggests that blocking CD47 may boost tafasitamab's effectiveness.
- Experimental results showed that combining tafasitamab with an anti-CD47 antibody improved phagocytosis of lymphoma cells and resulted in better outcomes in animal models, indicating potential for clinical application.
The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages.
Cancer Immunol Res
March 2021
Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
The bone marrow niche has a pivotal role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the multiple myeloma bone marrow microenvironment. Myeloma-associated macrophages (MAM) in the bone marrow niche are M2 like.
View Article and Find Full Text PDFLenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway.
Leukemia
November 2018
Department of Internal Medicine 5-Hematology/Oncology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Macrophages are key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD38 antibody MOR202, currently introduced in multiple myeloma (MM) therapy. Therefore, it is important to understand how antibody-mediated effector functions of myeloma-associated macrophages (MAMs) are regulated. Here, we focused on the effects of vitamin D, a known regulator of macrophage effector functions.
View Article and Find Full Text PDFVitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma.
Sci Transl Med
April 2015
Department of Internal Medicine 5-Hematology/Oncology, University Hospital Erlangen, 91054 Erlangen, Germany.
Infiltration by macrophages represents a characteristic morphological hallmark in high-grade lymphatic malignancies such as Burkitt's lymphoma (BL). Although macrophages can, in principle, target neoplastic cells and mediate antibody-dependent cellular cytotoxicity (ADCC), tumor-associated macrophages (TAMs) regularly fail to exert direct cytotoxic functions. The underlying mechanisms responsible for this observation remain unclear.
View Article and Find Full Text PDFSuccessful HLA haploidentical hematopoietic SCT in chronic granulomatous disease.
Bone Marrow Transplant
October 2014
Department of Pediatrics, University Medical Center Ulm, Ulm, Germany.
Genetic characterization of acquired aplastic anemia by targeted sequencing.
Haematologica
September 2014
Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Germany.
Pluripotent stem cells escape from senescence-associated DNA methylation changes.
Genome Res
February 2013
Helmholtz Institute for Biomedical Engineering, RWTH Medical School, 52074 Aachen, Germany.
Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their proliferation and differentiation potential after a limited number of cell divisions, and this is accompanied by specific senescence-associated DNA methylation (SA-DNAm) changes. Here, we investigate SA-DNAm changes in mesenchymal stromal cells (MSC) upon long-term culture, irradiation-induced senescence, immortalization, and reprogramming into induced pluripotent stem cells (iPSC) using high-density HumanMethylation450 BeadChips. SA-DNAm changes are highly reproducible and they are enriched in intergenic and nonpromoter regions of developmental genes.
View Article and Find Full Text PDFSpontaneous orientation of transplanted olfactory glia influences axonal regeneration.
Neuroreport
September 1998
Department of Neurology, Aachen University (RWTH) Medical School, Germany.
Transplanted olfactory ensheathing cells (OECs) have previously been demonstrated to support axonal growth and myelination in the adult rat CNS. Here, the capacity of donor OECs to control the direction of axonal regeneration has been investigated following transplantation, as elongated columns, into the thalamus of adult rats. The OECs formed a 'glial bridge' which extended from the thalamus to the hippocampus.
View Article and Find Full Text PDF