High-risk catheter ablation of refractory atrial fibrillation using Impella CP in a patient with cardiogenic shock.

Background: Impella CP support during Posterior Vein Isolation/Posterior Wall Isolation (PVI/PWI) in the setting of persistent cardiogenic shock from refractory atrial fibrillation with rapid ventricular response (AF/RVR), has not been reported in the literature to the best of our knowledge.

Case: A 61-year-old male truck driver was admitted with acute HFrEF with AF/RVR 130 - 150. His EF was 20% with global hypokinesis.

Hemodynamic comparison of intravenous push diltiazem versus metoprolol for atrial fibrillation rate control.

Objective: Intravenous push (IVP) diltiazem and metoprolol are commonly used for management of atrial fibrillation (AF) with rapid ventricular rate (RVR) in the emergency department (ED). This study's objective was to determine if there was a significant difference in blood pressure reduction between agents.

Methods: This was a single-center, retrospective study of adult patients initially treated with IVP diltiazem or metoprolol in the ED from 2008 to 2018.

Detection of skin cancer with adaptive fuzzy classifier using improved whale optimization.

Skin cancer is considered as a well-known type of cancer globally, and its occurrence has been found to be raised in current days. Researchers state that the disease requires early prediction so that the identification of precise signs will make it simple for the dermatologists and clinicians. This disorder has been established to be unpredictable.

Enoxaparin Attenuates Acute Lung Injury and Inflammasome Activation after Traumatic Brain Injury.

Traumatic brain injury (TBI) patients frequently develop cardiopulmonary system complications such as acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). However, the mechanism by which TBI causes ALI/ARDS is not fully understood. Here, we used a severe TBI model to examine the effects of a low-molecular-weight heparin, enoxaparin, on inflammasome activation and lung injury damage.

Quantitative Ho-microspheres SPECT derived from a dual-isotope acquisition with Tc-colloid is clinically feasible.

Purpose: Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (Ho)-microspheres, and technetium-99 m (Tc)-colloid was developed: Ho-microspheres used as scout and therapeutic particles, and Tc-colloid to identify the healthy liver. DI SPECT allows for an automatic and accurate estimation of absorbed doses, introducing true personalized dosimetry.

The computational quantum mechanical study of sulfamide drug adsorption onto XY fullerene-like nanocages: detailed DFT and QTAIM investigations.

In the current work, the adsorption of sulfamide drug onto the exterior surface of four fullerene-like nanocages, including AlN, AlP, BN, and BP was studied by employing density functional theory (DFT) and the quantum theory of atom in the molecule (QTAIM) calculations. Our calculations revealed that the sulfamide drug connects to the Al, B, P, and N atoms of AlN, AlP, BN, and BP nanocages through the oxygen and hydrogen atoms with releasing energies of -47.27, -34.

The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer's Disease.

Mild cognitive impairment (MCI) is characterized by memory loss in the absence of dementia and is considered the translational stage between normal aging and early Alzheimer's disease (AD). Patients with MCI have a greater risk of advancing to AD. Thus, identifying early markers of MCI has the potential to increase the therapeutic window to treat and manage the disease.

Factors associated with the biphasic kinetics of serum HBV RNA in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.

Background: Serum hepatitis B virus (HBV) RNA is a novel biomarker for evaluating treatment response. Detailed information regarding serum HBV RNA kinetics during treatment with nucleos(t)ide analogues (NAs) is limited.

Aims: To ascertain serum HBV RNA kinetics during long-term NA treatment and identify associated factors.

[Investigation into the timely return visit rates after first interview in adolescent clients to the psychiatric outpatient clinic of a general hospital].

To investigate the timely return visit rates after first visits of adolescent clients to the psychiatric outpatient clinic in a general hospital and analyze the relevant factors. All adolescent clients firstly visited psychiatric outpatient clinic of the Third Affiliated Hospital of Sun Yat-sen University from May to October 2018 were surveyed. The timely return visit was defined as the return visit within one month after the first visit and the timely return visit rate (RVR) was calculated.

A Novel and Practical Method of Performing Atrioventricular Nodal Ablation via a Superior Approach in Patients with Refractory Atrial Fibrillation Undergoing Cardiac Resynchronization Device Implantation.

Atrioventricular node (AVN) ablation is a strategy to manage patients with drug-refractory atrial fibrillation (AF) and heart failure in whom cardiac resynchronization therapy (CRT) device implantation has been prescribed. This study describes a practical method to perform these two procedures using the same surgical site. Twenty-seven patients were indicated for AVN ablation and concurrent CRT device implantation while presenting with AF and rapid ventricular response (RVR) refractory to medical therapy.

A DFT study on the metal ion selectivity of deferiprone complexes.

In this work, systematic density functional theory (DFT) calculations were performed to study the interactions of various metal ions (Al, Fe, Co, Ni, Cu, and Zn) and the clinically useful chelating agent called deferiprone (DFP) at the M05-2X/6-31G(d) level of theory. The thermodynamic parameters of metal-deferiprone complexes were determined in water. Based on the obtained data, the theoretical binding energy trend is as follows: Al > Fe > Cu > Ni > Co > Zn, confirming that [Al(DFP)] has the most interaction energy.

Multi-objective optimization of permeable reactive barrier design for Cr(VI) removal from groundwater.

The present study aims to develop a practical approach for the optimal permeable reactive barrier (PRB) design towards Cr(VI) removal from groundwater. Batch and column experiments were performed to investigate the characteristics of the four proposed reactive materials; nanoscale zero-valent iron (Fe), bimetallic nanoscale zero-valent iron (Fe/Cu), activated carbon (AC) and sand/zeolite mixture (S/Z). Kinetic analysis and dynamic modeling of the experimental data were implemented to determine the controlling conditions of the reactive performance of the PRB's materials.

Heart rate outcomes with concomitant parenteral calcium channel blockers and beta blockers in rapid atrial fibrillation or flutter.

Background: Patients who present with atrial fibrillation (AF) or flutter with rapid ventricular response (RVR) and hemodynamic stability may be managed with either an intravenous (IV) nondihydropyridine calcium channel blocker (CCB) or a beta-blocker (BB). Patients without improved heart rates may need to switch to, or add, a second AV nodal blocker.

Objective: To evaluate the incidence of rate control achievement and bradycardia in patients in AF or atrial flutter with RVR who receive both an intravenous CCB and a BB.

A safety and efficacy analysis of direct-antiviral therapy in patients with chronic hepatitis C after renal transplantation.

Background: To explore the safety and efficacy of direct antiviral therapy in patients with hepatitis C virus (HCV) infection after renal transplantation.

Methods: We retrospectively reviewed the medical information of 15 cases of HCV patients treated with direct antiviral therapy after renal transplantation in our center. The effectiveness of direct antiviral therapy was evaluated by analyzing the HCV-RNA levels of patients at 1, 4, 12, 24, and 48 weeks before and after antiviral therapy.

Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation.

Background: Vladimiriae Radix (VR) is the dry root of Vladimiria souliei (Franch.) Ling or Vladimiria souliei (Franch.) Ling var.

Pure Robotic-assisted Level IV Inferior Vena Cava Thrombectomy for Angiomyolipoma Without Cardiopulmonary Bypass: A First Report.

Objective: To report the initial case of robotic-assisted level IV inferior vena cava (IVC) tumor thrombectomy, with the supra- and infradiaphragmatic caval segments managed purely by a robotic-assisted technique.

Methods: A 67-year-old female presented with a 5.3 × 2.

An atypical complicated left-sided bronchopleural fistula presenting more than seven months after lobectomy.

Background: Bronchopleural fistulas (BPF) are abnormal sinus tracts connecting the bronchi and pleural cavity and form after surgical resection of a lung lobe. It is a complication with potentially disastrous sequelae including, failure of the bronchial stump to heal, ischemia of the affected area, and/or infection of the stump. Bronchopleural fistulas caused by surgical intervention most commonly present on the right side and within 7-12 days post-operatively, i.

Renal effects of venoms of Mexican coral snakes Micrurus browni and Micrurus laticollaris.

The Micrurus snake venoms mainly cause systemic complications, essentially neurotoxicity. Previous studies, however, have described that they are involved in the occurrence of acute kidney injury (AKI) in animal models. AKI pathogenesis in snakebites is multifactorial and involves immunological reactions, hemodynamic disturbances, and direct nephrotoxicity.

The Cognitive-Functional Composite is sensitive to clinical progression in early dementia: Longitudinal findings from the Catch-Cog study cohort.

Introduction: In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive-Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional clinical endpoints.

Methods: This longitudinal construct validation study included 148 participants with subjective cognitive decline, mild cognitive impairment, or mild dementia.

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography.

The vascular supply to the retina has been shown to dynamically adapt through vasoconstriction and vasodilation to accommodate the metabolic demands of the retina. This process, referred to as retinal vascular reactivity (RVR), is mediated by neurovascular coupling, which is impaired very early in retinal vascular diseases such as diabetic retinopathy. Therefore, a clinically feasible method of assessing vascular function may be of significant interest in both research and clinical settings.

High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke.

Background and Purpose- Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. Methods- We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status-modified after 1 to 3 years of follow-up.

A novel CNN based Alzheimer's disease classification using hybrid enhanced ICA segmented gray matter of MRI.

Predicting Alzheimer's Disease (AD) from Mild Cognitive Impairment (MCI) and Cognitive Normal (CN) has become wide. Recent advancement in neuroimaging in adoption with machine learning techniques are especially useful for pattern recognition of medical imaging to assist the physician in early diagnosis of AD. It is observed that the early abnormal brain atrophy and healthy brain atrophy are same.

Prediction of cognitive performance in old age from spatial probability maps of white matter lesions.

The purposes of this study were to explore the association between cognitive performance and white matter lesions (WMLs), and to investigate whether it is possible to predict cognitive impairment using spatial maps of WMLs. These WML maps were produced for 263 elders from the OASIS-3 dataset, and a relevance vector regression (RVR) model was applied to predict neuropsychological performance based on the maps. The association between the spatial distribution of WMLs and cognitive function was examined using diffusion tensor imaging data.