Measuring the age-friendliness of cities in the Russian Federation: The translation, validation and application of the age-friendly cities and communities Questionnaire in the city of Kazan.

Numerous cities in the Russian Federation have joined the World Health Organization's (WHO) Global Network for Age-Friendly Cities and Communities since 2011. In order to do quantitative evaluations of the age-friendliness of cities, the Age-Friendly Cities and Communities Questionnaire (AFCCQ) was developed in the Netherlands. The purpose of this study was to translate and test the validity and reliability of the AFCCQ for use in the Russian Federation, and to study the views on the age-friendliness of the city of Kazan in the Republic of Tatarstan from an intergenerational perspective.

Photocrosslinking of hyaluronic acid-based hydrogels through biotissue barriers.

Photocrosslinkable hydrogels based on hyaluronic acid are promising biomaterials high in demand in tissue engineering. Typically, hydrogels are photocured under the action of UV or blue light strongly absorbed by biotissues, which limits prototyping under living organism conditions. To overcome this limitation, we propose the derivatives of well-known photosensitizers, namely chlorin , chlorin and phthalocyanine, as those for radical polymerization in the transparency window of biotissues.

Occupational exposure and sarcoidosis: a case-control study in three countries.

Background: Preceding studies of environmental and occupational risk factors of sarcoidosis yielded inconsistent findings.

Aims: We aimed to ascertain the occupational risk factors for sarcoidosis in a case-control study.

Methods: A total of 237 sarcoidosis patients with a histologically confirmed diagnosis were matched with 474 controls for sex and age (median 49, interquartile range 37; 60 years) recruited from the university hospitals and outpatient centres in Belarus, Kazakhstan and the Russian Federation.

Integrative molecular and physiological insights into the phytotoxic impact of liquid crystal monomer exposure and the protective strategy in plants.

Liquid crystal monomers (LCMs), the integral components in the manufacture of digital displays, have engendered environmental concerns due to extensive utilization and intensive emission. Despite their prevalence and ecotoxicity, the LCM impacts on plant growth and agricultural yield remain inadequately understood. In this study, we investigated the specific response mechanisms of tobacco, a pivotal agricultural crop and model plant, to four representative LCMs (2OdF3B, 5CB, 4PiMeOP, 2BzoCP) through integrative molecular and physiological approaches.

Anticancer Plant Secondary Metabolites Evicting Linker Histone H1.2 from Chromatin Activate Type I Interferon Signaling.

Previously we discovered that among 15 DNA-binding plant secondary metabolites (PSMs) possessing anticancer activity, 11 compounds cause depletion of the chromatin-bound linker histones H1.2 and/or H1.4.

Local Application of Minimally Manipulated Autologous Stromal Vascular Fraction (SVF) Reduces Inflammation and Improves Bilio-Biliary Anastomosis Integrity.

Bilio-biliary anastomosis (BBA) is a critical surgical procedure that is performed with the objective of restoring bile duct continuity. This procedure is often required in cases where there has been an injury to the extrahepatic bile ducts or during liver transplantation. Despite advances in surgical techniques, the healing of BBA remains a significant challenge, with complications such as stricture formation and leakage affecting patient outcomes.

Optical Methods for Determining the Phagocytic Activity Profile of CD206-Positive Macrophages Extracted from Bronchoalveolar Lavage by Specific Mannosylated Polymeric Ligands.

Macrophage (Mph) polarization and functional activity play an important role in the development of inflammatory lung conditions. The previously widely used bimodal classification of Mph into M1 and M2 does not adequately reflect the full range of changes in polarization and functional diversity observed in Mph in response to various stimuli and disease states. Here, we have developed a model for the direct assessment of Mph from bronchial alveolar lavage fluid (BALF) functional alterations, in terms of phagocytosis activity, depending on external stimuli, such as exposure to a range of bacteria (, and ).

Increased Mineral-Associated Organic Carbon and Persistent Molecules in Allochthonous Blue Carbon Ecosystems.

Coastal wetlands contain very large carbon (C) stocks-termed as blue C-and their management has emerged as a promising nature-based solution for climate adaptation and mitigation. The interactions among sources, pools, and molecular compositions of soil organic C (SOC) within blue C ecosystems (BCEs) remain elusive. Here, we explore these interactions along an 18,000 km long coastal line of salt marshes, mangroves, and seagrasses in China.

Drug-Induced Pulmonary Fibrosis: National Database Analysis.

Background/objectives: Pulmonary fibrosis (PF) results in a progressive decline of lung function due to scarring. Drugs are among the most common causes of PF. The objective of our study was to reveal the structure of drugs involved in PF development.

Antibiotic Resistance as a Functional Characteristic of Urban Dust Particles' Microbial Communities.

Urban dust samples were collected in Moscow (Russia) in June 2021. The samples were collected in three functional zones of Moscow (traffic, residential, and recreational) and included air microparticles, leaf dust, and paved dust. Data on the taxonomic composition of bacterial communities were obtained for dust samples, and their functional characteristics were predicted using PICRUSt2 2.

Impact of Anthropogenic Factors on the Diversity of Microbial Communities of PM10 Air and PM100 of L. Phylloplane in an Urban Ecosystem.

Identifying the relationship between the microbiomes of urban dust particles from different biotopes is important because the state of microorganisms can be used to assess the quality of the environment. The aim of this work was to determine the distribution and interaction patterns of microorganisms of dust particles in the air and on leaf surfaces. Metabarcoding of bacterial and fungal communities, PAH, and metal content analyses and electron microscopy were used in this work.

Enhancing Compliance With Preoperative Fasting Guidelines: A Closed-Loop Quality Improvement Initiative to Optimize Patient Safety and Outcomes.

Introduction Preoperative fasting is essential in surgical care to reduce the risk of pulmonary aspiration during anesthesia. International guidelines, such as those from the American Society of Anesthesiologists (ASA) and the European Society of Anaesthesiology (ESA), recommend fasting durations of six hours for solids and two hours for clear liquids. However, adherence to these guidelines often varies in clinical practice, leading to prolonged fasting times that can negatively impact patient outcomes, including dehydration, hypoglycemia, discomfort, and delayed recovery.

Contrasting effects of arsenic on mycorrhizal-mediated silicon and phosphorus uptake by rice.

Silicon (Si) and arbuscular mycorrhizal fungi (AMF) increase plant resistance to various environmental stresses, including heavy metal (and metalloid) toxicity. Although Si and AMF each independently enhance plant tolerance, the nature of their interactions and their combined impacts on nutrient uptake, especially in the context of toxic elements such as arsenic (As), remains to be elucidated. This study investigated AMF-mediated regulation of plant nutrient uptake under As stress using rice, a model Si-accumulating plant.

The functions of immune system-derived miRNAs in cardiovascular diseases.

Cardiovascular diseases (CVD) are the foremost cause of mortality worldwide, with recent advances in immunology underscoring the critical roles of immune cells in their onset and progression. MicroRNAs (miRNAs), particularly those derived from the immune system, have emerged as vital regulators of cellular functions within the cardiovascular landscape. This review focuses on "immuno-miRs," a class of miRNAs that are highly expressed in immune cells, including T cells, B cells, NK cells, neutrophils, and monocytes/macrophages, and their significant role in controlling immune signaling pathways.

Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists.

Histamine (CHN, molecular weight 111.15 g/mol) is a well-studied endogenous biogenic amine composed of an imidazole ring attached to an ethylamine side chain. It has a limited half-life of a few minutes within tissues and in circulation.

Composite Contrast Enhancement of Hydrogel-Based Implants for Photon-Counting Computed Tomography Studies.

Hydrogels have a wide range of medical applications, including use within implantable systems. However, when used in implants, their visibility under conventional medical imaging techniques is limited, creating safety risks for patients. In the current work, we assessed the possibility of enhancing hydrogels using Ln-based contrasting agents to facilitate their visualization in photon-counting computed tomography (PCCT).

Configurational Field Analysis: a new approach to global field dynamics.

This paper advances the theory of Configurational Field Analysis (CFA) as a reconfiguration of Pierre Bourdieu's field theory, aiming to address the limitations of Global Field Theory in analyzing the complexities of global and transnational phenomena. While the concept of the Global Field extended Bourdieu's ideas to transnational and global arenas, it has been critiqued for its structural determinism, Eurocentrism, and its inability to fully capture the fluid, indeterminate, and contingent nature of global social dynamics. In response, this paper introduces social configurations as dynamic, relational constructs that emerge from specific historical and contextual conditions, rather than as fixed and universal structures.

A MODERN VIEW ON THE TREATMENT OF CLASS IV RECESSION ACCORDING TO MILLER.

Introduction: Interproximal attachment has received much attention in modern periodontology because it is a key diagnostic and prognostic factor. Currently, we can find many articles with results of bare root coverage, but few data and studies that describe root closure and obtaining interproximal attachment at the same time.

Objectives: The purpose of this study is to introduce a double-layer tunnel surgical technique for gingival papilla reconstruction and regeneration of the supraalveolar interproximal attachment.

PROSPECTS AND LONG-TERM RESULTS AFTER ENDODONTIC SURGERY.

Aim: to analyze the current literature data on the topic of prospects and distant results after endodontic surgery.

Material And Methods: A systematic review was conducted following the PRISMA 2020 guidelines. This review was written with the help of literature searches in the electronic databases Google Scholar and PubMed.

Targeting inerleukin-6 for renoprotection.

Sterile inflammation has been increasingly recognized as a hallmark of non-infectious kidney diseases. Induction of pro-inflammatory cytokines in injured kidney tissue promotes infiltration of immune cells serving to clear cell debris and facilitate tissue repair. However, excessive or prolonged inflammatory response has been associated with immune-mediated tissue damage, nephron loss, and development of renal fibrosis.

Electrochemical Synthesis of 3-(Sulfonyl)quinol-4-ones from -Alkynyl--(formyl)anilides and Sulfinates.

Electrolysis of -alkynyl--(formyl)anilides and sodium sulfinates on graphite electrodes delivers biologically sound 3-(sulfonyl)quinol-4-ones with moderate to good yields. The reaction is carried out in an undivided cell in the presence of silver(I) oxide with potassium iodide or sodium tetrafluoroborate as the supporting electrolyte. The reaction tolerates variously substituted anilides as well as aryl and alkyl sulfinates.

Total synthesis of the taraxacine A natural product Ag(I)-catalysed imidate-alkyne cyclization.

A domino approach towards β-carboline natural product taraxacine A and its analogues was developed. The main step relies on a silver(I) and base co-catalysed imidate-alkyne cyclization. The reaction tolerates primary and secondary alcohols, and various substitutions in the indole are possible.

Rh(III)-Catalyzed Double C-H Activation toward Peptide-Benzazepine Conjugates.

We herein report the efficient synthesis of peptide-benzazepine conjugates from Lys-based peptides and acroleins via Rh(III)-catalyzed double C-H activation. This reaction features mild reaction conditions, broad scope, high atom and step economies, and excellent chemo- and site selectivity. The synthetic utility of this strategy is further demonstrated by scale-up experiments and product derivatizations, including diverse late-stage ligations based on the aldehyde moiety.

Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders - a review.

Neurodegeneration refers to the gradual loss of neurons and extensive changes in glial cells like tau inclusions in astrocytes and oligodendrocytes, α-synuclein inclusions in oligodendrocytes and SOD1 aggregates in astrocytes along with deterioration in the motor, cognition, learning, and behavior. Common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), spinocerebellar ataxia (SCA), and supranuclear palsy. There is a lack of effective treatment for neurodegenerative diseases, and scientists are putting their efforts into developing therapies against them.

Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy.

Copper (Cu) is essential for brain development and function, yet its overload induces neuronal damage and contributes to neurodegeneration and other neurological disorders. Multiple studies demonstrated that Cu neurotoxicity is associated with mitochondrial dysfunction, routinely assessed by reduction of mitochondrial membrane potential. Nonetheless, the role of alterations of mitochondrial dynamics in brain mitochondrial dysfunction induced by Cu exposure is still debatable.