1,363 results match your criteria: "RAK Medical & Health Sciences University RAKMHSU[Affiliation]"

Background: Coronavirus disease 2019 (COVID-19) was first reported in December 2019 in Wuhan, People's Republic of China, and caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), As the virus took hold in the world, health experts paced efforts to solve the unknown nature of this threat.

Methodology: We studied the clinical characteristics, laboratory biomarkers of healthcare workers in the single center, analytical cross-sectional study conducted in tertiary care hospital of the UAE. Sample size of 600 HCWs were screened for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction (rRT-PCR) assay using Seegene Allplex and Andis FAST SARS-CoV-2 RT-qPCR detection kits for a period of 6 months.

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Background: In June 2021, the Injury Research Engagement Project (I-REP) was established. In 2022, we preformed focus group analysis with patients/caregiver and researchers that resulted in themes in preferences, motivations, and best practices to increase participation in trauma research. The importance of trust and well-established relationships was common across all groups.

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  • * Involving 200 newly diagnosed HIV-1 patients, the research revealed significant correlations, such as lower hemoglobin levels linked to higher CD4+ counts and lower PVL, while abnormalities in various blood parameters were more pronounced in those co-infected with HIV-TB.
  • * The findings suggest that specific hematological and biochemical indicators, including hemoglobin and inflammatory markers, could serve as early warning signs for TB in HIV-infected individuals, enhancing patient management
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  • Implantable drug delivery systems improve medication efficiency by allowing lower dosages, reducing side effects, and enhancing patient adherence.
  • The review focuses on various polysaccharides like starch and chitosan, showcasing their role in creating implants for targeted therapies and discussing their biomedical applications across different areas like oral, nasal, and ocular uses.
  • The study also underscores regulatory aspects and recent innovations in polysaccharide-based implants, demonstrating their potential in drug delivery systems.
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The research targeting the prevention of complications through natural constituents, instigated by the cancer has recently drawn much more attention over the globe. The research in this direction also revealed that the use of natural constituents would considered a promising strategy for diminishing the aforementioned disease and its consequences. Because of the easy availability and safe nature, the recent years, natural resources as strong anticancer agents.

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Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging commercial platforms, highlighting key methodologies and trends shaping the field. This review spans from foundational single-cell technologies such as microfluidics and plate-based methods to newer approaches like combinatorial indexing; on the spatial side, we consider next-generation sequencing and imaging-based spatial transcriptomics.

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Background: In 2022, more than 650,000 new cases of cervical cancer and more than 340,000 deaths were registered worldwide. Poland has some of the highest incidence and mortality rates from cervical cancer in Europe, despite the Cervical Cancer Prevention Program implemented for many years. Nowadays, with more information available, women should not die from cervical cancer (CC).

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Over 768 million cases of COVID-19 infection have been reported worldwide, with pregnant women being the most vulnerable members of society during such an infectious disease outbreak. In the United Arab Emirates, there are limited studies explaining the effects of COVID-19 on pregnant women and their fetuses. In this study, the maternal and fetal outcomes in pregnant women with COVID-19 in a tertiary maternal hospital, United Arab Emirates, were examined.

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Symptom Burden and Quality of Life in Long-Term Survivors with Head and Neck Cancer.

Ear Nose Throat J

December 2024

Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg, Department of Otolaryngology, Head & Neck Surgery, University Hospital Erlangen, Erlangen, Germany.

In this study, long-term survivors of head and neck cancer (HNC) were evaluated regarding their symptom burden and quality of life (QoL). This prospective study was performed during the regular follow-up consultations at one of Germany's largest tertiary referral centers for HNC. The assessment included demographic, clinical, and oncological data, as well as the MIDOS(2) and the University of Washington Quality of Life Questionnaire (UW QoL) questionnaires.

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Background: The spread of the COVID-19 epidemic, as well as its high contagiousness, increased students' anxiety and stress. Anxiety may affect individuals' functioning and undermine their self-efficacy. Therefore, the present study aimed to determine the relationship between COVID-19 anxiety and self-efficacy among adolescent students.

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  • The outbreak of Monkeypox (Mpox), especially the clade 1b variant, has become a significant global health issue, particularly in Africa, which is experiencing ongoing epidemics that require urgent attention and study.
  • This research analyzes data from the most affected African countries, using time series techniques to predict Mpox trends and assess the growth in new cases from August 2023 to August 2024.
  • Results indicate a worrying upward trend in Mpox cases, with projections suggesting nearly 6,923 cumulative cases in about 65 weeks, highlighting the need for ongoing monitoring and tailored public health responses to manage the outbreak effectively.
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In the present study, the solubility of sulfasalazine in carbon dioxide was investigated at temperatures ranging from 313 K to 343 K and pressures ranging from 12 to 30 MPa. The experimentally determined molar solubilities of sulfasalazine in ScCO were found to be in the range of 4.08 × 10 to 8.

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Unveiling the antimicrobial potentials of : an integrated experimental and computer aided investigation.

J Biomol Struct Dyn

December 2024

Joarder DNA and Chromosome Research Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.

Although in the last three decades pharmaceutical industries invented good number of new drugs, resistance to antimicrobials is still prevailing due to the remarkable genetic plasticity of the microbes and drugs. In this present study, we have shown, exhibited maximum zone of inhibition (20.5 ± 0.

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  • Breast cancer has become the most common cancer worldwide, with metastatic cancer being the leading cause of death related to this disease, prompting the development of early detection methods using non-invasive biomarkers.
  • Exosomes, which are tiny vesicles released by cancer cells, play a crucial role in transmitting signals and contain noncoding RNAs (ncRNAs) like miRNAs, lncRNAs, and circRNAs that influence various aspects of breast cancer progression, including growth, metastasis, and immune responses.
  • The study examines the regulatory mechanisms of exosomes in breast cancer and aims to enhance understanding of the functions of exosomal ncRNAs to identify potential biomarkers and improve treatment strategies.
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Each year, a substantial number of global deaths are attributed to secondhand smoke (SHS) exposure, with children representing a significant proportion of these fatalities. This systematic review evaluates the effects of passive smoking, or SHS, on children's health outcomes, focusing on respiratory conditions, behavioral issues, cognitive impairment, growth retardation, and immune system effects. A comprehensive literature search was conducted from July 5 to July 18, 2024, across multiple databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines.

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Introduction: Over the past few years, the technology powering mobile devices such as smartphones has made significant progress. Furthermore, the healthcare industry is always progressing and actively embracing the latest technological advancements to achieve the highest level of efficiency. With the rising prevalence of smartphones and internet connection, customers are benefiting from reduced prices, convenient home delivery, and effortless accessibility through online pharmacies.

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Parkinson disease is a neurogenerative disease common in adults and results in different kinds of memory dysfuntions. This study evaluated the monoamine oxidase B (MAO-B) inhibitory potential of kaurane diterpenoids previously isolated from Xylopia aethiopica through comprehensive computational approaches. Molecular docking study and molecular dynamics simulation were used to access the binding mode and interaction of xylopic acid and MAO-B enzyme.

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Background: Remedial teaching is a tailored educational approach dedicated to enhancing the academic performance of students facing challenges within the curriculum. By identifying and addressing specific learning difficulties, it provides essential support and guidance to bring students closer to expected standards while preventing future setbacks. We hypothesize that underperforming medical students who receive daily, tailored remediation will demonstrate significant improvement in their formative and summative assessment scores in biochemistry.

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The advent of new strains of resistant microbes and the concomitant growth in multidrug resistance have made antimicrobial resistance an urgent public health concern. New antimicrobials are desperately needed to boost the success rates of treating infectious diseases and save lives. There are many intriguing biomolecules with antibacterial action, which are mostly unexplored in microorganisms.

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  • Periodontal disease arises from bacterial plaque buildup and immune reactions, possibly leading to conditions like gingivitis and severe periodontitis if not treated.
  • The study compared salivary alpha-amylase (sAA) levels between individuals with varying stages of periodontitis and healthy controls, finding significant elevation in sAA among those with periodontitis.
  • Results indicate a moderate correlation between sAA levels and clinical measures of periodontal disease, suggesting that elevated sAA could serve as a potential biomarker for assessing disease severity.
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Periodontal regeneration is a multifaceted therapeutic approach to restore the tooth-supporting structures lost due to periodontal diseases. This manuscript explores the intricate interactions between regenerative therapies and the oral microbiome, emphasizing the critical role of microbial balance in achieving long-term success. While guided tissue regeneration (GTR), bone grafting, and soft tissue grafting offer promising outcomes in terms of tissue regeneration, these procedures can inadvertently alter the oral microbial ecosystem, potentially leading to dysbiosis or pathogenic recolonization.

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Magnesium is a crucial mineral that supports various enzymatic processes in the body. It plays a vital role in maintaining vascular, metabolic, and electrical homeostasis, making it an important factor for cardiovascular health. Magnesium is also involved in oxidative and inflammatory responses.

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Purpose: Immune checkpoint inhibitors (ICIs) and target therapy have provided the clinical efficacy for improving the clinical progression-free survival (PFS) and overall survival (OS) for patients with renal cell carcinoma (RCC). There has been little report of an surrogate salvage treatment for those failure of both ICIs and target. An innovation therapeutic model named SHAPE-T (synchronized hyperthermia with autologous progenitor expanded T cells) was applied to previously heavily treated metastatic RCC (mRCC).

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Objective:  Pulsenmore ES is a self-scanning ultrasound (US) system for remote fetal assessment. It comprises a handheld transducer that serves as a smartphone cradle coupled with an application and clinician's web-viewer dashboard. Recently, a novel capability was added to the system allowing offline fetal heart rate (FHR) and maximal vertical pocket (MVP) measurements.

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