Dextran-Graft-Polyacrylamide/Zinc Oxide Nanoparticles Inhibit of Cancer Cells in vitro and in vivo.

Introduction: Tumor drug resistance and systemic toxicity are major challenges of modern anticancer therapy. Nanotechnology makes it possible to create new materials with the required properties for anticancer therapy.

Methods: In this research, Dextran-graft-Polyacrylamide/ZnO nanoparticles were used.

Anti-cancer activity of zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids.

A comparative study of anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle (ZnTPP/D--PAA/Au(Ag)NP) nanohybrids on LNCaP prostate cancer cells was carried out under 420 nm light irradiation with low power. A significant cytotoxic effect was revealed for both ZnTPP/D--PAA/AgNP and ZnTPP/D--PAA/AuNP nanohybrids, where ZnTPP/D--PAA/AgNP nanohybrids exhibited considerably higher anticancer activity (82%) compared to ZnTPP/D--PAA/AuNP nanohybrids (45%). The higher activity of silver-containing nanohybrids is rationalized based on two factors.

Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro.

Introduction: Cancer chemotherapy faces two major challenges - high toxicity of active substances and tumor resistance to drugs. Low toxic nanocarriers in combination with anticancer agents can significantly increase the effectiveness of therapy. Modern advances in nanotechnology make it easy to create materials with the necessary physical and chemical properties.

Energy Transfer in CeTbF Nanoparticles-CTAB Shell-Chlorin e System.

Formation and electronic excitation energy transfer process in the nanosystem consisting of CeTbF nanoparticles, cetrimonium bromide (CTAB) surfactant, and chlorin e photosensitizer were studied. It was shown that chlorin e molecules bind to CeTbF NP in the presence of CTAB forming thus CeTbF NP-CTAB-chlorin e nanosystem. We consider that binding occurs via chlorin e embedding in the shell of CTAB molecules, formed around NP.

The development of a malignant tumor is due to a desperate asexual self-cloning process in which cancer stem cells develop the ability to mimic the genetic program of germline cells.

To date there is no explanation why the development of almost all types of solid tumors occurs sharing a similar scenario: (1) creation of a cancer stem cell (CSC), (2) CSC multiplication and formation of a multicellular tumor spheroid (TS), (3) vascularization of the TS and its transformation into a vascularized primary tumor, (4) metastatic spreading of CSCs, (5) formation of a metastatic TSs and its transformation into metastatic tumors, and (6) potentially endless repetition of this cycle of events. The above gaps in our knowledge are related to the biology of cancer and specifically to tumorigenesis, which covers the process from the creation of a CSC to the formation of a malignant tumor and the development of metastases. My Oncogerminative Theory of Tumorigenesis considers tumor formation as a dynamic self-organizing process that mimics a self-organizing process of early embryo development.

Photodynamic activity of hematoporphyrin conjugates with gold nanoparticles: experiments in vitro.

Aim: To synthesize a conjugate of hematoporphyrin with gold nanoparticles, and to evaluate its photodynamic activity in experiments on cultures of transformed cells.

Methods: nanosized gold particles and nanocomposites synthesis methods, cell culture methods, photobiology methods, trypan blue dye exclusion test, chemiluminescence assay.

Results: Various hematoporphyrin-gold nanocomposites were obtained, which contained similar hematoporphyrin concentration (5 microg/ml) and varied concentrations (0.

Ecological aspects in cancer education.

Some aspects of modern ecology should be included in any graduate teaching program on preventive oncology and medicine. In the study of environmental carcinogenesis, the influence of carcinogenic agents on natural ecosystems and living organisms, integral ecological monitoring, naturally occurring carcinogens, and evaluation of complex risk assessment of the environment deserve particular attention. It is also important to integrate biochemical and molecular markers into epidemiology studies in order to correctly evaluate and prevent the cancer risk to humans that results from environmental factors.