97 results match your criteria: "R.D.T.; and Epilepsy Institute in the Netherlands Foundation[Affiliation]"
Multimodal nocturnal seizure detection in a residential care setting: A long-term prospective trial.
Neurology
November 2018
From the Academic Center for Epileptology (J.A., C.U., P.C., J.v.D., R.L.); Center for Residential Epilepsy Care (F.T.), Kempenhaeghe, Heeze; Faculty of Electrical Engineering (J.A., C.U., P.C., J.V.D., R.L.), Eindhoven University of Technology; Leiden University Medical Centre (R.D.T.); SEIN-Stichting Epilepsie Instellingen Nederland, Heemstede and Zwolle (R.D.T., T.G., A.d.W., B.V., W.H.); and Brain Center Rudolf Magnus (J.v.A., F.L.), Department of Neurology, and Julius Center for Health Sciences and Primary Care (G.v.T., K.C.B.R.), University Medical Center Utrecht, the Netherlands.
Objective: To develop and prospectively evaluate a method of epileptic seizure detection combining heart rate and movement.
Methods: In this multicenter, in-home, prospective, video-controlled cohort study, nocturnal seizures were detected by heart rate (photoplethysmography) or movement (3-D accelerometry) in persons with epilepsy and intellectual disability. Participants with >1 monthly major seizure wore a bracelet (Nightwatch) on the upper arm at night for 2 to 3 months.
Nocturnal supervision and SUDEP risk at different epilepsy care settings.
Neurology
October 2018
From the Stichting Epilepsie Instellingen Nederland (SEIN) (M.v.d.L., J.W.S., R.D.T.), Heemstede; Leiden University Medical Center (LUMC) (M.v.d.L., R.D.T.), Netherlands; GH Sergievsky Center and Department of Epidemiology (D.C.H.), Columbia University, New York, NY; NIHR University College London Hospitals Biomedical Research Centre (J.W.S., R.D.T.), UCL Institute of Neurology, Queen Square, London, and Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
Objective: To estimate the incidence of sudden unexpected death in epilepsy (SUDEP) in people with intellectual disabilities in residential care settings and to ascertain the effects of nocturnal seizures and nocturnal supervision on SUDEP risk.
Methods: We conducted a nested case-control study reviewing records of all people who died at 2 residential care settings over 25 years. Four controls per case were selected from the same population, matched on age (±5 years) and residential unit.
Voluntary Euthanasia - Implications for Organ Donation.
N Engl J Med
September 2018
From the Department of Medicine and the Department of Epidemiology and Biostatistics, Western University (I.M.B.), and the London Health Sciences Centre Ethics Program (R.S.) - both in London, ON, Canada; and the Center for Bioethics, Harvard Medical School, Boston (R.D.T.).
An Update on the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction Trial: 1-Year Safety and Angiographic Results.
AJNR Am J Neuroradiol
May 2018
Department of Radiology (S.T.), University of California, Los Angeles, Los Angeles, California.
Background And Purpose: The safety and efficacy of the PulseRider for the treatment of wide-neck, bifurcation aneurysms at the basilar and carotid terminus locations were studied in a prospective trial, the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction (ANSWER) trial, reporting on initial 6-month angiographic and clinical results. This report provides insight into the longer term durability and safety with 12-month data.
Materials And Methods: Aneurysms treated with the PulseRider among enrolled sites were prospectively studied.
Differentiating motor phenomena in tilt-induced syncope and convulsive seizures.
Neurology
April 2018
From the Department of Research (S.S., P.R.B., R.D.T.), Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands; NIHR University College London Hospitals Biomedical Research Centre (S.S., R.D.T.), UCL Institute of Neurology, Queen Square, London, UK; Lyon Neuroscience Research Centre (P.R.B.), INSERM U1028, CNRS UMR5292, Bron, France; and Departments of Medical Statistics (E.W.v.Z.) and Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands.
Objective: We assessed motor phenomena in syncope and convulsive seizures to aid differential diagnosis and understand the pathophysiologic correlates.
Methods: We studied video-EEG recordings of tilt-induced syncope and convulsive seizures in participants aged 15 years and older. Syncope was defined as (1) loss of consciousness (video-assessed), (2) circulatory changes (accelerating blood pressure decrease with or without bradycardia/asystole), and (3) EEG changes ("slow" or "slow-flat-slow").
Comparative safety and efficacy of combined IVT and MT with direct MT in large vessel occlusion.
Neurology
April 2018
From the Department of Neurology (N.G., G.T., A.P., R.Z., L.E., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), "Attikon University Hospital," School of Medicine, University of Athens, Greece; International Clinical Research Center (G.T.), St. Anne's Hospital, Brno, Czech Republic; Department of Interventional Neuroradiology (D.F., D.L.), Radiology Imaging Associates, Englewood, CO; Department of Neurosurgery (A.T., R.D.T.), Medical University of South Carolina, Charleston; Department of Interventional Neuroradiology (B.B.), Erlanger Hospital, Chattanooga; Cerebrovascular Program (M.T.F., K.E.), Vanderbilt University, Nashville, TN; Department of Neurosurgery (J. Mocco, J. Mascitelli), Mount Sinai Medical Center, New York, NY; Charleston Area Medical Center (K.M.), West Virginia University; and Department of Neurosurgery (D.H., L.E., A.S.A.), University of Tennessee Health Science Center and Semmes-Murphey Clinic, Memphis.
Objective: In this multicenter study, we sought to evaluate comparative safety and efficacy of combined IV thrombolysis (IVT) and mechanical thrombectomy (MT) vs direct MT in emergent large vessel occlusion (ELVO) patients.
Methods: Consecutive ELVO patients treated with MT at 6 high-volume endovascular centers were evaluated. Standard safety and efficacy outcomes (successful reperfusion [modified Thrombolysis in Cerebral Infarction IIb/III], functional independence [FI] [modified Rankin Scale (mRS) score of 0-2 at 3 months], favorable functional outcome [mRS of 0-1 at 3 months], functional improvement [mRS shift by 1-point decrease in mRS score]) were compared between patients who underwent combined IVT and MT vs MT alone.
Association Between Heart Rate and Subclinical Cerebrovascular Disease in the Elderly.
Stroke
February 2018
From the Department of Medicine (K.N., S.H., S.C.L., A.T., M.R.D.T.), Department of Biostatistics (Z.J.), and Departments of Neurology and Epidemiology (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (T.R., C.B.W., R.L.S.), Department of Public Health Sciences (T.R., C.B.W., R.L.S.), and Department of Human Genetics (R.L.S.), Miller School of Medicine, University of Miami, FL; Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); and Department of Neurology, University of California at Davis (C.D.).
Background And Purpose: Although increased heart rate (HR) is a predictor of cardiovascular events and mortality, its possible association with subclinical cerebrovascular disease, which is prevalent in the elderly, has not been evaluated. This study aimed to investigate the association of daytime, nighttime, 24-hour HR, and HR variability with subclinical cerebrovascular disease in an elderly cohort without history of stroke.
Methods: The study cohort consisted of 680 participants (mean age, 73±7 years; 42% men) in sinus rhythm who underwent 24-hour ambulatory blood pressure and HR monitoring, 2-dimensional echocardiography, and brain magnetic resonance imaging as part of the CABL study (Cardiac Abnormalities and Brain Lesion).
Effects of acute intermittent hypoxia on hand use after spinal cord trauma: A preliminary study.
Neurology
October 2017
From the Department of Physical Medicine and Rehabilitation (R.D.T.), Harvard Medical School, Cambridge; Department of Physical Medicine and Rehabilitation (R.D.T.), Spaulding Rehabilitation Hospital, Charlestown, MA; Division of Physical Therapy (H.B.H., S.L.W., V.A.S.), Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA; Center for Respiratory Research and Rehabilitation (G.S.M.), Department of Physical Therapy, and McKnight Brain Institute (G.S.M.), University of Florida, Gainesville; and Center for Visual and Neurocognitive Rehabilitation (S.L.W.), Atlanta VA Medical Center, Decatur, GA.
Objective: To test the hypothesis that daily acute intermittent hypoxia (AIH) combined with hand opening practice improves hand dexterity, function, and maximum hand opening in persons with chronic, motor-incomplete, cervical spinal cord injury.
Methods: Six participants completed the double-blind, crossover study. Participants received daily (5 consecutive days) AIH (15 episodes per day: 1.
Direct Detection Electron Energy-Loss Spectroscopy: A Method to Push the Limits of Resolution and Sensitivity.
Sci Rep
August 2017
Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania, 19104, USA.
In many cases, electron counting with direct detection sensors offers improved resolution, lower noise, and higher pixel density compared to conventional, indirect detection sensors for electron microscopy applications. Direct detection technology has previously been utilized, with great success, for imaging and diffraction, but potential advantages for spectroscopy remain unexplored. Here we compare the performance of a direct detection sensor operated in counting mode and an indirect detection sensor (scintillator/fiber-optic/CCD) for electron energy-loss spectroscopy.
View Article and Find Full Text PDFRecurrence risk of ictal asystole in epilepsy.
Neurology
August 2017
Department of Epileptology (K.G.H., C.E.E., R.S.), University Hospital Bonn, Germany; Stichting Epilepsie Instellingen Nederland-SEIN (R.D.T.), Heemstede; Department of Neurology (R.D.T.), Leiden University Medical Centre-LUMC, the Netherlands; and Section of Epileptology, Department of Neurology (R.S.), RWTH University Hospital Aachen, Germany.
Objective: To determine the recurrence risk of ictal asystole (IA) and its determining factors in people with epilepsy.
Methods: We performed a systematic review of published cases with IA in 3 databases and additionally searched our local database for patients with multiple seizures simultaneously recorded with ECG and EEG and at least one IA. IA recurrence risk was estimated by including all seizures without knowledge of the chronological order.
Hydrogel versus Bare Platinum Coils in Patients with Large or Recurrent Aneurysms Prone to Recurrence after Endovascular Treatment: A Randomized Controlled Trial.
AJNR Am J Neuroradiol
March 2017
From the Departments of Radiology (J.R., A.W., F.G., D.R.).
Background And Purpose: Some patients are at high risk of aneurysm recurrence after endovascular treatment: patients with large aneurysms (Patients Prone to Recurrence After Endovascular Treatment PRET-1) or with aneurysms that have previously recurred after coiling (PRET-2). We aimed to establish whether the use of hydrogel coils improved efficacy outcomes compared with bare platinum coils.
Materials And Methods: PRET was an investigator-led, pragmatic, multicenter, parallel, randomized (1:1) trial.
Evolving approaches to heart regeneration by therapeutic stimulation of resident cardiomyocyte cell cycle.
Anatol J Cardiol
November 2016
Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University; İstanbul-Turkey.
Heart has long been considered a terminally differentiated organ. Recent studies, however, have suggested that there is a modest degree of cardiomyocyte (CM) turnover in adult mammalian heart, albeit not sufficient for replacement of lost CMs following cardiac injuries. Cardiac regeneration studies in various model organisms including zebrafish, newt, and more recently in neonatal mouse, have demonstrated that CM dedifferentiation and concomitant proliferation play important roles in replacement of lost CMs and restoration of cardiac contractility.
View Article and Find Full Text PDFLong-term follow-up of psychogenic pseudosyncope.
Neurology
November 2016
From the Departments of Neurology and Clinical Neurophysiology (D.P.S., J.G.v.D.) and Psychiatry (I.M.v.V.), Leiden University Medical Center; Department of Neurology (M.J.O.), Medical Center Haaglanden, The Hague; and Stichting Epilepsie Instellingen Nederland (R.D.T.), Heemstede, the Netherlands.
Objective: To determine the outcome of patients with psychogenic pseudosyncope (PPS) after communication of the diagnosis.
Methods: This was a retrospective cohort study of patients with PPS referred in 2007 to 2015 to a tertiary referral center for syncope. We reviewed patient records and studied attack frequency, factors affecting attack frequency, health care use, and quality of life using a questionnaire.
Atherosclerotic Plaques in the Aortic Arch and Subclinical Cerebrovascular Disease.
Stroke
November 2016
From the Departments of Medicine (A.T., S.H., K.N., S.S., M.R.D.T.), Biostatistics (Z.J.), and Neurology and Epidemiology (M.S.V.E.), Columbia University, New York; Departments of Neurology (T.R., C.B.W., R.L.S.), Epidemiology and Public Health (T.R., C.B.W., R.L.S.), and Human Genetics (R.L.S.), Miller School of Medicine, University of Miami, FL; Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); and Department of Neurology, University of California at Davis (C.D.).
Background And Purpose: Aortic arch plaque (AAP) is a risk factor for ischemic stroke, but its association with subclinical cerebrovascular disease is not established. We investigated the association between AAP and subclinical cerebrovascular disease in an elderly stroke-free community-based cohort.
Methods: The CABL study (Cardiovascular Abnormalities and Brain Lesions) was designed to investigate cardiovascular predictors of silent cerebrovascular disease in the elderly.
Anti-LGI1 encephalitis: Clinical syndrome and long-term follow-up.
Neurology
October 2016
From the Departments of Neurology (A.v.S., M.A.A.M.d.B., P.A.E.S.S., M.J.T., M.H.v.C.-H.), Neuropsychology (E.C.C., L.C.J.), and Immunology (M.W.J.S.), Erasmus Medical Center, Rotterdam; Department of Neurology (A.v.S., P.W.W.), Haga Teaching Hospital, the Hague; Stichting Epilepsie Instellingen Nederland (SEIN) (R.D.T.), Heemstede; Department of Radiology and Nuclear Medicine (E.S.), VU University Medical Center, Amsterdam; and Department of Biology (M.H.v.C.-H.), Division of Cell Biology, Utrecht University, the Netherlands.
Article Synopsis
- This nationwide study investigates anti-LGI1 encephalitis, outlining its clinical features, incidence, and long-term outcomes following diagnosis and treatment.
- The research found that this condition often presents with subtle seizures and memory disturbances, with a high rate of response to immunotherapy, though many patients experience cognitive deficits and relapses post-recovery.
- With a two-year case fatality rate of 19%, early diagnosis and treatment are crucial, as most patients have favorable outcomes despite common relapses.
Preoperative Falls and Their Association with Functional Dependence and Quality of Life.
Anesthesiology
August 2016
From the Department of Anesthesiology (V.L.K., R.D.T., A.P.S., A.B.A., T.S.W., S.L.M., F.S., D.L.H., A.S., M.S.A.) and Program in Occupational Therapy (S.L.S.), Washington University School of Medicine, St. Louis, Missouri; and Department of Mathematics, Washington University, St. Louis, Missouri (N.L.).
Background: No study has rigorously explored the characteristics of surgical patients with recent preoperative falls. Our objective was to describe the essential features of preoperative falls and determine whether they are associated with preoperative functional dependence and poor quality of life.
Methods: This was an observational study involving 15,060 surveys from adult patients undergoing elective surgery.
Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial.
Stroke
August 2016
From the Division of Cardiology, Department of Medicine (M.R.D.T., S.H.), Department of Biostatistics, Mailman School of Public Health (M.Q., J.L.P.T., B.L., R.B.), and Department of Neurology (J.P.M.), Columbia University Medical Center, New York; Department of Cardiovascular Medicine, University of South Florida, Tampa (A.J.L.); Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO (D.L.M.); Departments of Neurology, Epidemiology and Public Health, University of Miami, FL (R.L.S.); Kent Institute of Medicine and Health Science, Canterbury, United Kingdom (P.M.P.); Division of Cardiology, Department of Medicine, Lehigh Valley Hospital, Allentown, PA (R.S.F.); Section of Cardiology, San Francisco Veterans Affairs Medical Center, University of California San Francisco (J.R.T.); Division of Cardiology, Department of Medicine, SUNY Upstate Medical University, Buffalo, NY (S.G.); University of Birmingham Centre for Cardiovascular Sciences, City Hospital, United Kingdom (G.Y.H.L.); Centro Neurológico de Tratamiento y Rehabilitación, Buenos Aires, Argentina (C.J.E.); Department of Cardiology, Deventer Hospital, The Netherlands (D.J.L.); Department of Heart Diseases, Wroclaw Medical University, Military Hospital, Poland (P.P.); and Department of Innovative Clinical Trials, University Medicine Göttingen (UMG), Germany (S.D.A.).
Background And Purpose: In heart failure (HF), left ventricular ejection fraction (LVEF) is inversely associated with mortality and cardiovascular outcomes. Its relationship with stroke is controversial, as is the effect of antithrombotic treatment. We studied the relationship of LVEF with stroke and cardiovascular events in patients with HF and the effect of different antithrombotic treatments.
View Article and Find Full Text PDFTrigeminal neuralgia: New classification and diagnostic grading for practice and research.
Neurology
July 2016
From the Special Interest Group on Neuropathic Pain (NeuPSIG) of the International Association for the Study of Pain (G.C., N.B.F., T.S.J., J.S., R.-D.T., T.N.), Washington, DC; Scientific Panel Pain of the European Academy of Neurology (G.C., T.S.J., T.N.), Vienna, Austria; Department of Neurology and Psychiatry (G.C.), Sapienza University, Rome, Italy; Danish Pain Research Centre, Department of Clinical Medicine (N.B.F., T.S.J.), and Section of Orofacial Pain and Jaw Function, Department of Dentistry (P.S.), Aarhus University, Denmark; Departments of Anesthesiology and Pharmacology (J.S.), Columbia University Medical Center, New York, NY; Department of Neurosurgery (M.S.), Hôpital Neurologique "Pierre Wertheimer," University of Lyon 1, Lyon, France; Center for Biomedicine and Medical Technology Mannheim (CBTM) (R.-D.T.), Heidelberg University, Mannheim, Germany; Facial Pain Unit, University College London Hospitals NHS Foundation Trust (J.M.Z.); and Pain Relief (T.N.), Neuroscience Research Centre, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Trigeminal neuralgia (TN) is an exemplary condition of neuropathic facial pain. However, formally classifying TN as neuropathic pain based on the grading system of the International Association for the Study of Pain is complicated by the requirement of objective signs confirming an underlying lesion or disease of the somatosensory system. The latest version of the International Classification of Headache Disorders created similar difficulties by abandoning the term symptomatic TN for manifestations caused by major neurologic disease, such as tumors or multiple sclerosis.
View Article and Find Full Text PDFPearls & Oy-sters: Diagnostic challenges in nocturnal frontal lobe epilepsy.
Neurology
April 2016
From Stichting Epilepsie Instellingen Nederland (SEIN) (F.M.E.C., G.J.L., R.D.T., G.H.V.), Heemstede; and Leiden University Medical Center (G.J.L., R.D.T.), the Netherlands.
The relevance of VGKC positivity in the absence of LGI1 and Caspr2 antibodies.
Neurology
May 2016
From the Departments of Neurology (A.v.S., M.A.A.M.d.B., M.M.P.N., E.S.P.H., P.A.E.S.S., M.J.T.) and Immunology (M.W.J.S., S.B.), Erasmus Medical Center, Rotterdam; Department of Neurology (A.v.S., P.W.W.), Haga Teaching Hospital, The Hague; Department of Neurology (R.H.E.), University Medical Center Groningen/Rijksuniversiteit Groningen; and Stichting Epilepsie Instellingen Nederland (SEIN) (R.D.T.), Heemstede, the Netherlands.
Objective: To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2.
Methods: VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients.
Clinical and Procedural Predictors of Outcomes From the Endovascular Treatment of Posterior Circulation Strokes.
Stroke
March 2016
From the Department of Neurosurgery, University of South Florida, Tampa (M.M., S.S., Z.R.); Department of Neurosurgery, University at Buffalo, State University of New York (A.S., K.V.S., E.I.L., A.H.S.); Department of Neurosurgery, Semmes-Murphey Neurologic and Spine Institute, Memphis, TN (L.E., A.A., N.G.); Department of Neurosurgery, Baylor College of Medicine, Houston, TX (P.K., E.D.); Capital Institute of Neurosciences, Capital Health Systems, Trenton, NJ (E.V., M.J.B., K.M.L., V.R.); Department of Neurosurgery and Radiology, Medical University of South Carolina, Charleston (R.D.T., A.S.T.); Department of Radiology, Erlanger Medical Center, Chattanooga, TN (B.W.B.); and Miami Cardiac and Vascular Institute and Neuroscience Center, Baptist Hospital, FL (G.D., I.L.).
Background And Purpose: Patients with posterior circulation strokes have been excluded from recent randomized endovascular stroke trials. We reviewed the recent multicenter experience with endovascular treatment of posterior circulation strokes to identify the clinical, radiographic, and procedural predictors of successful recanalization and good neurological outcomes.
Methods: We performed a multicenter retrospective analysis of consecutive patients with posterior circulation strokes, who underwent thrombectomy with stent retrievers or primary aspiration thrombectomy (including A Direct Aspiration First Pass Technique [ADAPT] approach).
Transplantation: The role of RAAS blockade in kidney transplantation.
Nat Rev Nephrol
March 2016
Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, 10526 Ravenscroft Drive, Dallas, Texas 75390, USA.
Tilt-induced vasovagal syncope and psychogenic pseudosyncope: Overlapping clinical entities.
Neurology
December 2015
From Stichting Epilepsie Instellingen Nederland (SEIN) (H.B., R.J.L., R.D.T.), Heemstede; and the Department of Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands.
Objective: To describe the combination of tilt-induced vasovagal syncope (VVS) and psychogenic pseudosyncope (PPS) and aid its clinical recognition.
Methods: We identified people with tilt-induced VVS/PPS from 2 tertiary syncope referral centers. For each case, 3 controls with tilt-induced VVS were selected at random from the same center.
Neonatal Management of a Giant Right Atrial Appendage Aneurysm.
Circulation
November 2015
From Departments of Pediatrics (R.D.T., J.B.C.), Pathology (J.M.), and Surgery (J.B.C.), The Pennsylvania State University College of Medicine, Hershey.
Electrocardiographic Left Atrial Abnormality and Risk of Stroke: Northern Manhattan Study.
Stroke
November 2015
From the Department of Neurology, Feil Family Brain and Mind Research Institute (H.K.) and Division of Cardiology (P.M.O.), Weill Cornell Medical College, New York; Department of Neurology (M.H., Y.P.M., S.Y., K.C., M.S.V.E.) and Division of Cardiology (M.R.D.T.), Columbia College of Physicians and Surgeons, New York; Department of Biostatistics, Columbia Mailman School of Public Health, New York (K.C.); Department of Neurology, Human Genetics, and Public Health Sciences, Miller School of Medicine, University of Miami, FL (R.L.S.); Departments of Epidemiology and Prevention (E.Z.S.) and Internal Medicine-Cardiology (E.Z.S.), Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC; and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York (M.S.V.E.).
Background And Purpose: Electrocardiographic left atrial abnormality has been associated with stroke independently of atrial fibrillation (AF), suggesting that atrial thromboembolism may occur in the absence of AF. If true, we would expect an association with cryptogenic or cardioembolic stroke rather than noncardioembolic stroke.
Methods: We conducted a case-cohort analysis in the Northern Manhattan Study, a prospective cohort study of stroke risk factors.