Investigating Efficacy of Atopic Dermatitis Systemic Therapeutics After Discontinuation Part I: Biologics.

Objective: The authors sought to review published literature on the efficacy of biologics as monotherapy for atopic dermatitis (AD) following discontinuation.

Methods: A comprehensive search of PubMed/MEDLINE was conducted examining drug withdrawal in AD clinical trials where participants were treated with biologics. Trials were included if they exclusively involved participants with AD that reported the maintenance or achievement of Eczema Area and Severity Index (EASI)-75 and Investigator Global Assessment (IGA) scores of 0 or 1 after withdrawal of biologic therapy.

Enticing Dimples: A Novel Observational Study Comparing the Preexisting Landmarks for Facial Dimple Creation Using 3D-Scanned Facial Images.

 Dimpleplasty, a cosmetic procedure for creating dimples, is gaining popularity. However, the ideal site for dimple creation remains subjective. This study aimed to determine the optimal dimple placement using a three-dimensional (3D) model, reviewing panelists' preferences based on facial proportions and average ratings.

The first checklist of alien vascular plants of Kyrgyzstan, with new records and critical evaluation of earlier data. Contribution 3.

Background: We continue the series of detailed treatments of alien vascular plants of Kyrgyzstan. The complete background for every species occurrence (herbarium specimens, documented observations, published literature) is uncovered and critically evaluated in a wide context of plant invasions in Central Asia with a reference to Eastern Europe and Northern Asia, based on events in the political and economic history. Complete point distribution maps are provided for each species in Central Asia, in general and Kyrgyzstan, in particular.

Fully degradable, transparent, and flexible photodetectors using ZnO nanowires and PEDOT:PSS based nanofibres.

Transparent light detection devices are attractive for emerging see-through applications such as augmented reality, smart windows and optical communications using light fidelity (Li-Fi). Herein, we present flexible and transparent photodetectors (PDs) using conductive poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS): Ag nanowires (NWs) based nanofibres and zinc oxide (ZnO) NWs on a transparent and degradable cellulose acetate (CA) substrate. The electrospun (PEDOT:PSS): Ag NW-based nanofibres exhibit a sheet resistance of 11 Ω/sq and optical transmittance of 79% (at 550 nm of wavelength).

Burn inhalation injury and intubation with dexamethasone-eluting endotracheal tubes modulate local microbiome and alter airway inflammation.

Background: Inhalation injuries, caused by exposure to extreme heat and chemical irritants, lead to complications with speaking, swallowing, and breathing. This study investigates the effects of thermal injury and endotracheal tube (ETT) placement on the airway microbiome and inflammatory response. A secondary aim is to assess the impact of localized dexamethasone delivery via a drug-eluting ETT to reduce laryngeal scarring.

Examining how fiscal policies influence innovation in TCM enterprises: the role of R&D investment and executives with pharmaceutical backgrounds.

Introduction: Innovation is crucial to realize the modernization and industrialization of traditional Chinese medicine (TCM), so its incentive methods and influence mechanisms are worth exploring. Based on externality theory and imprinting theory, this paper demonstrates the significance of external support and internal resources in the innovation of TCM enterprises.

Methods: This study adopts a sample of listed TCM enterprises in China during 2007-2023 to examine the impacts and differences between innovation subsidies and tax incentives on TCM enterprise innovation.

Global, regional and national burden of decubitus ulcers in 204 countries and territories from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021.

Background: Decubitus ulcers, also known as pressure ulcers, pose a significant public health challenge due to their substantial impact on morbidity, mortality, and healthcare expenditures.

Methods: The number and age-standardized rates (ASRs) of prevalence, death, disability adjusted life-year (DALY), years of life lost (YLL), and years lived with disability (YLD) at the global, regional, and national levels were acquired from the GBD 2021 database. Trends were evaluated based on the estimated average percentage change (EAPC) of ASRs.

Examining the dualistic model of passion in addiction recovery.

Introduction: Addiction recovery can be conceptualized as multidimensional changes to health and wellness including changes in substance use, physical and mental health, and social relationships. These outcomes are often measured through recovery capital which recognizes the various resources, both internal and external, that one may use to enhance their recovery. Internal and external resources can also be accumulated by engaging in an activity an individual is passionate about, explained by the dualistic model of passion (DMP) as enhancing mental and spiritual well-being, health, and personal growth, thereby fostering positive emotions, community involvement, deeper relationships, and heightened performance across various life domains.

Developing an advanced course of vaccinology in middle-income countries: The case of China.

•We provide the Chinese Vaccinology Course was the only national advanced vaccinology training course in China, in response to the global call to improve vaccine capacity and meet local needs.•To address the challenges for both the development of the country as well as world sustainability and to address the major needs of the country and for the lives and health of the people.•Science and technology has provided strong support in controlling infection, developing vaccines and promoting drug research and development (R& D), CNVAC provide model problems and solutions for the research community.

Severity of Achilles Tendinopathy on Preoperative MRI and Short-term Functional Outcomes After Minimally Invasive Zadek Osteotomy.

Background: Limited literature is available to guide surgeons on which patients with insertional Achilles tendinopathy (IAT) may be the best candidates for minimally invasive dorsal closing wedge calcaneal Zadek osteotomy (MIS ZO). We hypothesized that the severity of IAT on preoperative magnetic resonance image (MRI) may correlate with post-operative functional outcomes and help guide patient selection for treatment with MIS ZO.

Methods: Patients who underwent MIS ZO for IAT ± Haglund deformity were identified and retrospectively analyzed.

Enhancing drought tolerance in and through interspecific interactions with a mixed inoculum of and non-host beneficial rhizobacteria.

Introduction: Harnessing plant growth-promoting rhizobia presents a sustainable and cost-effective method to enhance crop performance, particularly under drought stress. This study evaluates the variability of plant growth-promoting (PGP) traits among three strains of LMR575, LMR571, and LMR655, and two native PGP strains LMR698 and LMR696. The primary objective was to assess the host range specificity of these strains and their effectiveness in improving drought tolerance in three legume species: , , and .

Nondestructive estimation of leaf chlorophyll content in banana based on unmanned aerial vehicle hyperspectral images using image feature combination methods.

Introduction: Nondestructive quantification of leaf chlorophyll content (LCC) of banana and its spatial distribution across growth stages from remotely sensed data provide an effective avenue to diagnose nutritional deficiency and guide management practices. Unmanned aerial vehicle (UAV) hyperspectral imagery can document abundant texture features (TFs) and spectral information in a field experiment due to the high spatial and spectral resolutions. However, the benefits of using the fine spatial resolution accessible from UAV data for estimating LCC for banana have not been adequately quantified.

Increasing jute ( L.) fiber yield through hybridization and combining ability studies to break the yield plateau.

The growing global demand and shift from synthetic to natural fibers highlight the need to overcome the yield plateau in jute production. Despite being a sustainable alternative to plastic, jute faces declining cultivation, making yield improvement crucial to meet increasing demand. In this direction, the study was designed to explore hybridization and combining ability to improve the genetic yield potential of jute.

Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report.

Background: Cardiac light-chain amyloidosis represents a critical component of this multi-systemic disease, significantly impacting prognosis. The extent of cardiac free light-chain deposition is the primary determinant of survival.

Case Presentation: We report the case of a 67-year-old male with a 10-year history of diabetes mellitus and arterial hypertension who presented with a two-day history of chest discomfort and difficulty lying down or sleeping, along with a two-month history of progressively worsening exertional dyspnea.

Efficient energy transfer from organic triplet states to Mn dopants for dynamic tunable multicolor afterglow in 1D hybrid cadmium chloride.

Metal ion-doped organic-inorganic hybrid metal halides have emerged as promising room-temperature phosphorescence (RTP) materials owing to their tunable afterglow properties and significant potential in information security applications. However, optimizing RTP performance and achieving dynamic control over afterglow colors remain challenging in 1D hybrid systems, primarily because of the inefficient energy transfer from RTP-active organic components to external emissive sites. Herein, we report a novel 1D hybrid metal halide benchmark material, [(NBP)CdClHO] (NBP-Cd, NBP = -benzylpiperidone), and a series of Mn-doped derivatives, NBP-Cd:Mn (where represents doping levels from 1% to 50%).

Arthroscopic Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Versus Traditional Tendon to Bone Fixation: Outcomes and Retear Rates at 4-Year Follow-up.

Background: Full-thickness, transtendinous supraspinatus rotator cuff tears involve a significant portion of the remanent tendon attached to the footprint.

Purpose: To compare outcomes and failure rates for arthroscopic side-to-side (STS) suture repair for transtendinous tears versus traditional double-row repair for common tendon-to-bone type tears.

Study Design: Cohort study; Level of evidence, 3.

Examining the Accuracy and Reproducibility of Responses to Nutrition Questions Related to Inflammatory Bowel Disease by Generative Pre-trained Transformer-4.

Background: Generative pre-trained transformer-4 (GPT-4) is a large language model (LLM) trained on a vast corpus of data, including the medical literature. Nutrition plays an important role in managing inflammatory bowel disease (IBD), with an unmet need for nutrition-related patient education resources. This study examines the accuracy, comprehensiveness, and reproducibility of responses by GPT-4 to patient nutrition questions related to IBD.

Serum A20 level is associated with bone mineral density in male patients with type 2 diabetes mellitus.

Background: A20, also known as TNF-α-induced protein 3 (TNFAIP3), is a crucial negative regulator of inflammation and immune responses. Emerging evidence suggests that A20 is involved in the regulation of glucose metabolism and plays a significant role in bone metabolic diseases by inhibiting nuclear factor (NF)-κB activation. However, the potential relationship between serum A20 level and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM) has not been explored.

Corrigendum: Gestational diabetes mellitus and polycystic ovary syndrome, a position statement from EGOI-PCOS.

[This corrects the article DOI: 10.3389/fendo.2025.

A unified hypothesis-free feature extraction framework for diverse epigenomic data.

Motivation: Epigenetic assays using next-generation sequencing have furthered our understanding of the functional genomic regions and the mechanisms of gene regulation. However, a single assay produces billions of data points, with limited information about the biological process due to numerous sources of technical and biological noise. To draw biological conclusions, numerous specialized algorithms have been proposed to summarize the data into higher-order patterns, such as peak calling and the discovery of differentially methylated regions.

Non-destructive analysis of composition using hyperspectral imaging and machine learning.

Background: is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging. This study addresses the need for fast, noninvasive testing methods by combining hyperspectral imaging with machine learning to predict polysaccharide and ergosterol levels in cap and powder.

Methods: Hyperspectral images in the visible near-infrared (385-1009 nm) and short-wave infrared (899-1695 nm) ranges were collected, with ergosterol measured by high-performance liquid chromatography and polysaccharides assessed via the phenol-sulfuric acid method.

Genomic identification of a pair of multidrug-resistant but non-pathogenic serovar Goldcoast isolates in southeast China.

Introduction: is an important foodborne pathogen that can induce severe diseases such as gastrointestinal disease and typhoid fever. Accumulating evidence revealed that 's resistance to antibiotics also seriously affects human health. Pathogenic serovar Goldcoast ( Goldcoast) was first detected in 2010 in China and was predicted to have an increasing tendency.

Stigma and self-perceived burden in postoperative liver cancer patients: the mediating role of financial toxicity.

Purpose: To investigate the mediating effect of financial toxicity on stigma and self-perceived burden in patients with liver cancer after surgery.

Methods: Using a convenience sampling method, 236 postoperative liver cancer patients treated at a tertiary hospital in Nanjing from April 2024 to July 2024 were selected for the study. Questionnaires were administered, including a general information survey, the Social Impact Scale (SIS), the Self-Perceived Burden Scale for Cancer Patients (SPBS-CP), and the Comprehensive Score for Financial Toxicity-Functional Assessment of Chronic Illness Therapy Version 2 (COST-FACIT-V2).

Biowaste to biochar: a techno-economic and life cycle assessment of biochar production from food-waste digestate and its agricultural field application.

Unlabelled: Biochar has high potential for long-term atmospheric carbon storage in terrestrial environments, contributing to meeting the UK and global greenhouse gas emission reduction targets. This study investigates the greenhouse gas emissions and techno-economics associated with biochar produced from food waste anaerobic digestate using hydrothermal carbonisation followed by high-temperature post carbonisation. Owing to high moisture contents, digestates are challenging to valorise.

Morphosyntactic production and processing skills in relation to age effects and lexical-phonological levels among children with cochlear implants and typically hearing peers: a focus on vowel nasality.

Introduction: Significant variability in the language performance of children with cochlear implant (CI) is widely recognized in the literature, particularly concerning morphosyntactic (MS) skills. The perceptual limitations of the CI, which can lead to phonological difficulties, may be responsible for this increased vulnerability in grammatical abilities. In this context, the present study focuses on the morphophonemic processing of items distinguished by nasal and oral vowels in the French language - the feature of vowel nasality being known as challenging for the CI population.