Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum.

Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment.

An alternative approach to biokinetic modelling for phenol pollutant degradation and microbial growth using Genetic Programming.

Biokinetic models can optimise pollutant degradation and enhance microbial growth processes, aiding to protect ecosystem protection. Traditional biokinetic approaches (such as Monod, Haldane, etc.) can be challenging, as they require detailed knowledge of the organism's metabolism and the ability to solve numerous kinetic differential equations based on the principles of micro, molecular biology and biochemistry (first engineering principles) which can lead to discrepancies between predicted and actual degradation rates.

Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.

Background: For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now permit randomized, controlled trials of shortened-duration, all-oral treatments for rifampin-resistant tuberculosis.

Methods: We conducted a phase 3, multinational, open-label, randomized, controlled noninferiority trial to compare standard therapy for treatment of fluoroquinolone-susceptible, rifampin-resistant tuberculosis with five 9-month oral regimens that included various combinations of bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C), and pyrazinamide (Z).

Temperature-driven development and reproduction in Cacopsylla citrisuga (Hemiptera: Psyllidae): insights from an age-stage, two-sex life table analysis.

The citrus pest Cacopsylla citrisuga (Yang & Li), a vector for Citrus Huanglongbing (HLB), exhibits distinct sensitivity to temperature variations. This study utilized an age-stage, 2-sex life table to evaluate the development and reproduction of C. citrisuga across 5 temperatures (17, 20, 25, 28, and 31 °C).

Electrochemically Driven Selective Olefin Epoxidation by Cobalt-TAML Catalyst.

Epoxides are versatile chemical intermediates that are used in the manufacture of diversified industrial products. For decades, thermochemical conversion has long been employed as the primary synthetic route. However, it has several drawbacks, such as harsh and explosive operating conditions, as well as a significant greenhouse gas emissions problem.

Prediction of rain garden runoff control effects based on multiple machine learning techniques.

Due to the rapid development of urbanisation, cities frequently experience waterlogging during rainfall. Rain gardens are widely used in new urban construction because they effectively control surface runoff from rainwater, thereby reducing waterlogging. The runoff control effectiveness of rain gardens is influenced by multiple factors.

Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.

Background And Objectives: Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.

Vintages for New Fashion: Red-Shifted Photoswitching via the Triplet-Photoreaction Channel with Charge-Transfer Complex Sensitizers.

Triplet-sensitization has been proven invaluable for creating photoswitches operated over a full visible-light spectrum. While designing efficient triplet-sensitizers is crucial for establishing visible-light photochromism, it remains an appealing yet challenging task. In this work, we propose a versatile strategy to fabricate triplet-sensitizers with intermolecular charge-transfer complexes (CTCs).

Dual Pathways of Photorelease Carbon Monoxide via Photosensitization for Tumor Treatment.

Carbon monoxide (CO) gas therapy, as an emerging therapeutic strategy, is promising in tumor treatment. However, the development of a red or near-infrared light-driven efficient CO release strategy is still challenging due to the limited physicochemical characteristics of the photoactivated carbon monoxide-releasing molecules (photoCORMs). Here, we discovered a novel photorelease CO mechanism that involved dual pathways of CO release via photosensitization.

Effects of volunteering on the psychological wellbeing of undergraduate college students.

The mental health of college students is declining at an alarming rate. Understanding behaviors linked to positive mental health outcomes and psychological wellbeing (PWB) are needed. The objective of this study was to determine the relationship between volunteering and PWB.

"Water" Populations: Environment-Health, from the Social Determination and Health Policy perspective, in the Baixo Amazonas Region-PA.

The relationship between the environment and health has become a relevant topic on the public policy agenda since the 1990s. This study seeks to describe this relationship from the perspective of the National Policy for Comprehensive Health of Populations of the Countryside, Forest, and Waters in the community of São Pedro, in the Lower Amazon region of Pará. This is a descriptive study focused on conducting diagnoses that consider the environment-health relationship in the Community.

Timely initiation of antenatal care in adolescent victims of sexual violence: implications for legal abortion in Brazil.

We investigated the timely initiation of antenatal care among Brazilian adolescents to support the national discussion on the gestational age limit for legal abortion. Using data from the Live Births Information System (SINASC) 2020-2022, we correlated the timely antenatal care (first quarter of pregnancy) with the adolescent's age, region, ethnicity/skin color, and schooling level; 11,607 annual births result from vulnerable rape. The timely initiation of antenatal care was 70.

Costs and characteristics of admissions due to ambulatory care-sensitive conditions in children under one year of age in São Paulo, Brazil.

This research aimed to estimate the direct costs and analyze the epidemiological aspects of ambulatory care-sensitive conditions (ACSC) in children under one year of age, São Paulo municipality, 2011-2022. Total and average costs were calculated according to ACSC diagnosis groups by components (early neonatal, late neonatal, and post-neonatal). The trend in ACSC rates was analyzed using Prais-Winsten generalized linear regression.

Social health determinants associated with mammography performance according to the 2013 and 2019 National Health Survey.

Mammography is one of the main methods available for breast cancer screening in Brazil. However, differences in timely access and performance of the exam can be highlighted based on social determinants of health, considered relevant due to their influence on the health situation of a population. Thus, the present study aimed to identify the social determinants of health associated with access to and performance of mammography in Brazilian women.

[Offer and participation in body practices and physical activities in primary health care in Brazil: analysis from 2014 to 2022].

The scope of this article is to analyze the temporal trend and macro-regional distribution of the options on offer in terms of collective activities of bodily practices and physical activities (BPPA) and the number of participants in primary health care, developed by all health professionals and by Physical Education Professionals in Brazil. It involved an ecological time-series study, using data from the Health Information System for Primary Health Care (Sisab) between 2014 and 2022, which was assessed using regression analysis and Joinpoint software. At the national level, the results revealed an increase in the number of collective BPPA activities and participants in primary health care developed by all health professionals and by Physical Education Professionals between 2014 and 2019, followed by a reduction in both in 2020.

Model of care in freestanding birth centers in Brazil: a scoping review.

Freestanding birth centers (FBCs) in Brazil are regulated to provide care for women with a straightforward pregnancy. The systematization of the literature on FBCs can broaden our knowledge of these facilities. We conducted a scoping review to answer the following research question: "What are the characteristics of the model of care in freestanding birth centers in Brazil?".

[Quality evaluation of Brazilian Mortality Information System (SIM): a scoping review].

The aim was to map evidence on the quality of records in the Mortality Information System (SIM) through a national scoping review of articles published up to April 2023 across five databases (PubMed, Embase, Scopus, LILACS, and SciELO). Studies focused on specific causes of death were excluded. Dimensions evaluated included accessibility, methodological clarity, coverage, completeness, reliability, consistency, non-duplication, timeliness, validity, and studies on ill-defined causes/garbage codes.

Use of WhatsApp® aplicattion in health manegement, work, and care in fighting the COVID-19 pandemic.

This study aims to analyze the use of the WhatsApp® application in health management, work process, and care in coping with the COVID-19 pandemic. A qualitative research was carried out by multiple case studies with semi-structured interviews with SUS managers and workers from May to November 2022. The material was transcribed and processed on ATLAS.

[How did men report their long COVID experience? Health-Disease socio-anthropological meaning].

The study aims to explain the discourse of the collective subject of adult and elderly men about the experience of long COVID. Qualitative research, derived from a national multicenter clinical-virtual observatory involving 92 adult men, between 2022 and 2023 in Brazil. IRaMuTeQ software was used (data processing), the Collective Subject Discourse technique (analysis) and socio-anthropological references of the disease experience (interpretation).

Lactating women and the perception of useful value for breastfeeding in a prison environment.

The aim is to unveil the useful value of breastfeeding for lactating women in a prison environment, based on Max Scheler's axiological perspective. This work was a qualitative, developed in a prison unit in Rio de Janeiro, where seven lactating women were interviewed. The phenomenological interview was used for data collection, while Laurence Bardin's content analysis was used for data analysis and treatment.

Gender and remote work: associations between mental health and hours of remote work and housework.

To investigate the association between hours of remote work (RWHs) and housework (HWHs), independently, as well as the combined total of work hours (WHs), with gender and mental health of remote workers during the COVID-19 pandemic. Cross-sectional study with data from the ELSA-Brasil (N = 2,318). On average, women reported more time spent on HWHs and WHs than men, while no difference was found in RWHs.

[Performance of the "a body shape index" as a discriminator of obesity and sarcopenic obesity - ELSA-Brasil].

The scope of this study was to determine the diagnostic performance of ABSI for obesity and sarcopenic obesity, compared to the results of bioimpedance analysis (BIA) and BMI, by sex and age group. It involved a cross-sectional study with 12,793 participants in the second round of ELSA-Brasil (Longitudinal Study of Adult Health in Brazil), which obtained measurements of body fat percentage using BIA and anthropometry, verifying the performance of the diagnostic tests in order to compare the indices. The results showed that for obesity in men in all three age groups, the sensitivity was below 49%.