Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer.

Prostate cancer presents a major health issue, with its progression influenced by intricate molecular factors. Notably, the interplay between miRNAs and changes in transcriptomic patterns is not fully understood. Our study seeks to bridge this knowledge gap, employing computational techniques to explore how miRNAs and transcriptomic alterations jointly regulate the development of prostate cancer.

Accuracy of remote, video-based supraventricular tachycardia detection in patients undergoing elective electrical cardioversion: a prospective cohort.

Unobtrusive pulse rate monitoring by continuous video recording, based on remote photoplethysmography (rPPG), might enable early detection of perioperative arrhythmias in general ward patients. However, the accuracy of an rPPG-based machine learning model to monitor the pulse rate during sinus rhythm and arrhythmias is unknown. We conducted a prospective, observational diagnostic study in a cohort with a high prevalence of arrhythmias (patients undergoing elective electrical cardioversion).

CompositIA: an open-source automated quantification tool for body composition scores from thoraco-abdominal CT scans.

Background: Body composition scores allow for quantifying the volume and physical properties of specific tissues. However, their manual calculation is time-consuming and prone to human error. This study aims to develop and validate CompositIA, an automated, open-source pipeline for quantifying body composition scores from thoraco-abdominal computed tomography (CT) scans.

Association of digital eye strain with central corneal thickness: a cross-sectional observational pilot study.

Purpose: This study aimed to evaluate whether the digital eye strain (DES) was associated with the low central corneal thickness (CCT).

Methods: This observational cross-sectional pilot study was conducted from April 2023 to October 2023 at a tertiary eye care centre in North India, where CCT values were compared between subjects with DES and those without DES. Two hundred and eighty subjects (n = 280) aged 15-40 years with clear corneas and lenses were initially included in this study.

Evaluation of the role of circular RNA (circ-FAF1) as a diagnostic biomarker for breast cancer in a cohort of Egyptian breast cancer patients.

Background: The identification of circulating potential biomarkers may help earlier diagnosis of breast cancer, which is critical for effective treatment and better disease outcomes. We aimed to study the role of circ-FAF1 as a diagnostic biomarker in female breast cancer using peripheral blood samples of these patients, and to investigate the relation between circ-FAF1 and different clinicopathological features of the included patients.

Methods And Results: This case-control study enrolled 60 female breast cancer patients and 60 age-matched healthy control subjects.

Thermal ocular burns and evaluation of associated limbal stem cell deficiency in the light of global consensus.

Purpose: The aim of the present study is to examine the demographic data and clinical features of ocular surface injuries due to thermal burns and to evaluate LSCD in the light of global consensus.

Methods: Thirty-three eyes of 20 cases with ocular surface injury due to thermal burn who attended to the clinic between 2012 and 2023 were included in the study. LSCD severity was staged according to the global consensus which was published in 2019.

Cross-priming in cancer immunology and immunotherapy.

Cytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-presenting cells termed conventional type 1 dendritic cells (cDC1s) to cross-present antigens. Cross-presentation comprises redirection of exogenous antigens taken from other cells to the major histocompatibility complex class I antigen-presenting machinery. In addition, once activated and having sensed viral moieties or T helper cell cooperation via CD40-CD40L interactions, cDC1s provide key co-stimulatory ligands and cytokines to mount and sustain CD8 T cell immune responses.

Intradermal Advanced Glycation End-products Relate to Reduced Sciatic Nerve Structural Integrity in Type 2 Diabetes.

Background: Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed to evaluate the correlation between skin auto-fluorescence (sAF), an indicator of dermal advanced glycation end-product (AGE) accumulations, cardiovascular risk, and changes in peripheral nerve integrity.

Similar patient-reported satisfaction and professional appraisal of implant-supported fixed dental prosthesis fabricated by different workflows.

Design: A triple-armed, double-blind randomized controlled trial with cross-over design investigated patient-reported satisfaction and objective dental evaluation of a 3-unit, monolithic zirconium dioxide (ZrO2), implant-supported fixed dental prosthesis (iFDP) fabricated with 2 completely digital workflows and 1 mixed analog-digital workflow.

Case Selection: Participants enrolled required rehabilitation of 2 dental implants in posterior region of either of the arches with a 3-unit, ZrO2 iFDP. A total of 20 participants received the 3 types of ZrO2, iFDP fabricated by 3 different methods.

CARD domains mediate anti-phage defence in bacterial gasdermin systems.

Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome activity and pyroptosis. Following pathogen recognition by nucleotide binding-domain, leucine-rich, repeat-containing (NLR) proteins, CARDs recruit and activate caspases, which, in turn, activate gasdermin pore-forming proteins to induce pyroptotic cell death. Here we show that CARD domains are present in defence systems that protect bacteria against phage.

C-terminal amides mark proteins for degradation via SCF-FBXO31.

During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites. Such modifications have been proposed to trigger the selective removal of chemically marked proteins; however, identifying modifications that are sufficient to induce protein degradation has remained challenging.

Degradable thermosets via orthogonal polymerizations of a single monomer.

Crosslinked thermosets are highly durable materials, but overcoming their petrochemical origins and inability to be recycled poses a grand challenge. Many strategies to access crosslinked polymers that are bioderived or degradable-by-design have been proposed, but they require several resource-intensive synthesis and purification steps and are not yet feasible alternatives to conventional consumer materials. Here we present a modular, one-pot synthesis of degradable thermosets from the commercially available, biosourced monomer 2,3-dihydrofuran (DHF).

Sacrum1-pubic angle: a novel and alternative morphologic radiological parameter for assessing spinopelvic sagittal alignment in human adults.

Objective: Spinopelvic sagittal balance ensures efficient posture and minimizes energy expenditure by aligning the spine, pelvis, and lower extremities. Deviations can cause clinical issues like back pain and functional limitations. Key radiographic parameters, including pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), and lumbar lordosis (LL), are essential for evaluating spinal pathologies and planning surgeries.

A manifesto for a globally diverse, equitable, and inclusive open science.

The field of psychology has rapidly transformed its open science practices in recent years. Yet there has been limited progress in integrating principles of diversity, equity and inclusion. In this Perspective, we raise the spectre of Questionable Generalisability Practices and the issue of MASKing (Making Assumptions based on Skewed Knowledge), calling for more responsible practices in generalising study findings and co-authorship to promote global equity in knowledge production.

The enlarged perivascular spaces in the hippocampus is associated with memory function in patients with type 2 diabetes mellitus.

Early detection of cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM) is important for preventive measures due to the lack of effective treatments. The purpose of this study is to investigate the relationship between enlarged perivascular space in the hippocampus (H-EPVS) and cognitive performance in patients with T2DM, and to determine whether it can serve as an imaging marker for cognitive dysfunction. 66 T2DM patients with cognitive impairment (T2DM-CI) and 71 T2DM patients with normal cognitive function (T2DM-NC) underwent cranial MRI scans and comprehensive neuropsychological assessments.

[Treatment of ankle osteoarthritis : Analysis of a German nationwide survey].

Background: In most cases osteoarthritis of the ankle is of posttraumatic origin. Younger people are more frequently affected, which makes treatment a particular challenge. In addition to conservative treatment numerous surgical procedures are available for the treatment of advanced arthrosis.

Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, and critically ill patients with T2DM in intensive care unit (ICU) have an increased risk of mortality. In this study, we investigated the relationship between nine inflammatory indicators and prognosis in critically ill patients with T2DM to provide a clinical reference for assessing the prognosis of patients admitted to the ICU. Critically ill patients with T2DM were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and divided into training and testing sets (7:3 ratio).

Ecofriendly remediation of cadmium, lead, and zinc using dead cells of Microcystis aeruginosa.

The utilization of cyanobacteria toxin-producing blooms for metal ions adsorption has garnered significant attention over the last decade. This study investigates the efficacy of dead cells from Microcystis aeruginosa blooms, collected from agricultural drainage water reservoir, in removing of cadmium, lead, and zinc ions from aqueous solutions, and simultaneously addressing the mitigation of toxin-producing M. aeruginosa bloom.

Deep learning model based prediction of vehicle CO emissions with eXplainable AI integration for sustainable environment.

The transportation industry contributes significantly to climate change through carbon dioxide ( ) emissions, intensifying global warming and leading to more frequent and severe weather phenomena such as flooding, drought, heat waves, glacier melting, and rising sea levels. This study proposes a comprehensive approach for predicting emissions from vehicles using deep learning techniques enhanced by eXplainable Artificial Intelligence (XAI) methods. Utilizing a dataset from the Canadian government's official open data portal, we explored the impact of various vehicle attributes on emissions.

A reagent to access methyl sulfones.

A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF-, CF- and even bicyclo[1.

Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults, a NHANES weighted analysis.

Overactive bladder (OAB) is a prevalent condition among older adults and may be linked to cognitive health. This study explored a relationship between OAB and cognitive health among adults aged 60 ≥ years in the United States, using NHANES 2011-2014. A cross-sectional analysis was conducted using a nationally representative sample of 2,324 (45.

Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors.

Lung cancer is the leading cause of cancer-related fatalities globally, accounting for the highest mortality rate among both men and women. Mutations in the epidermal growth factor receptor (EGFR) gene are frequently found in non-small cell lung cancer (NSCLC). Since curcumin and CB[2]UN support various medicinal applications in drug delivery and design, we investigated the effect of curcumin and CB[2]UN-based drugs in controlling EGFR-mutant NSCLC through a dodecagonal computational approach.

Polycotton waste textile recycling by sequential hydrolysis and glycolysis.

As a result of the current high throughput of the fast fashion collections and the concomitant decrease in product lifetime, we are facing enormous amounts of textile waste. Since textiles are often a blend of multiple fibers (predominantly cotton and polyester) and contain various different components, proper waste management and recycling are challenging. Here, we describe a high-yield process for the sequential chemical recycling of cotton and polyester from mixed waste textiles.