The impact of different cooking temperatures on the quality and moisture distribution of beef.

The objective of this study was to investigate the water-holding capacity (WHC) and quality changes of beef during heating at specific temperatures (including 40 °C, 60 °C, 80 °C, and 100 °C), as well as the degradation of proteins and the distribution of water within the muscle at different heating temperatures. The experiment utilized the sirloin section from eight crossbred cattle of and breeds, with four sampling sessions, two cattle per session. Each cattle were divided into 30 beef sirloin samples, each weighing 150 ± 10 g, and each session was completed within 3 days with the following tests.

Extracting Housing and Food Insecurity Information From Clinical Notes Using cTAKES.

Objective: To assess the utility and challenges of using natural language processing (NLP) in electronic health records (EHRs) to ascertain health-related social needs (HRSNs) among older adults.

Study Setting And Design: We extracted HRSN information using the NLP system Clinical Text Analysis and Knowledge Extraction System (cTAKES), combined with Concept Unique Identifiers and Systematized Nomenclature for Medicine codes. We validated cTAKES performance, via manual chart review, on two HRSNs: food insecurity, which was included in the healthcare system's HRSN screening tool, and housing insecurity, which was not.

Exploring the progress and trends of immunotherapy for type 1 diabetes: A comprehensive bibliometric analysis spanning nearly two decades.

Introduction: Immunotherapy is a crucial treatment for type 1 diabetes (T1D), yet analyses focusing on research priorities and trends in this field are limited. Therefore, this study employs bibliometric methods to systematically explore the current research status of immunotherapy for T1D.

Methods: Based on the Web of Science Core Collection Database, 1573 articles and review articles related to immunotherapy for T1D published from 2004 to 2023 were screened for bibliometric analysis.

A Solvatochromic and Photosensitized Lipid Droplet Probe Detects Local Polarity Heterogeneity and Labels Interacting Proteins in Human Liver Disease Tissue.

The intricate morphology, physicochemical properties, and interacting proteins of lipid droplets (LDs) are associated with cell metabolism and related diseases. To uncover these layers of information, a solvatochromic and photosensitized LDs-targeted probe based on the furan-based D-D-π-A scaffold is developed to offer the following integrated functions. First, the turn-on fluorescence of the probe upon selectively binding to LDs allows for direct visualization of their location and morphology.

On-line Inductively Coupled Plasma Mass Spectrometry Reveals Material Degradation Dynamics of Au and Cu Catalysts during Electrochemical CO Reduction.

A significant challenge in commercializing electrochemical CO reduction (COR) is achieving catalyst durability. In this study, online inductively coupled mass spectrometry (ICP-MS) was used to investigate catalyst degradation via nanoparticle detachment and/or dissolution into metal ions under COR operating conditions in 0.1 M KHCO.

Model-Informed Recommendation of Mavacamten Posology for Chinese Adults With Obstructive Hypertrophic Cardiomyopathy.

Mavacamten is a cardiac myosin inhibitor for adults with obstructive hypertrophic cardiomyopathy (HCM). Dose optimization is performed 4 weeks after starting mavacamten, guided by periodic echo measurements of Valsalva left ventricular outflow tract gradient (VLVOTg) and left ventricular ejection fraction (LVEF). Previously, a population pharmacokinetic (PPK) model was developed and exposure-response (E-R) of VLVOTg (efficacy) and LVEF (safety) was used to identify the mavacamten titration regimen with the optimal benefit/risk ratio, now included in the US prescribing information.

Endothelial Dysfunction in Acute Myocardial Infarction: A Complex Association With Sleep Health, Traditional Cardiovascular Risk Factors and Prognostic Markers.

Background: Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI).

Hypothesis: AMI patients experience endothelial dysfunction (EndDys), associated with traditional CV risk factors and sleep patterns. EndFx may also predict short and mid-term outcomes.

Synergistically Enhanced Co-Adsorption of Reactant and Hydroxyl on Platinum-Modified Copper Oxide for High-Performance HMF Oxidation.

Electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) provides an environmentally friendly route for producing the sustainable polymer monomer 2,5-furandicarboxylic acid (FDCA). Thus, precisely adjusting the synergistic adsorption among key reactive species, such as HMF and OH, on the carefully designed catalyst surface is essential for achieving satisfactory catalytic performance for HMF oxidation to FDCA as it is closely related to the adsorption strength and configuration of the reaction substrates. This kind of regulation will ultimately facilitate the improvement of HMF oxidation performance.

Nanoparticles modified with glucose analogs to enhance the permeability of the blood-brain barrier and their accumulation in the epileptic brain.

Drug delivery for epilepsy treatment faces enormous challenges, where the sole focus on enhancing the ability of drugs to penetrate the blood-brain barrier (BBB) through ligand modification is insufficient because of the absence of seizure-specific drug accumulation. In this study, an amphipathic drug carrier with a glucose transporter (GLUT)-targeting capability was synthesised by conjugating 2-deoxy-2-amino-D-glucose (2-DG) to the model carrier DSPE-PEG. A 2-DG-modified nano drug delivery system (NDDS) possessing robust stability and favourable biocompatibility was then fabricated using the nanoprecipitation method.

GABA Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1.

GABA receptor (GABAR) activation is known to alleviate pain by reducing neuronal excitability, primarily through inhibition of high voltage-activated (HVA) calcium (Ca2.2) channels and potentiating G protein-coupled inwardly rectifying potassium (GIRK) channels. Although the analgesic properties of small molecules and peptides have been primarily tested on isolated murine dorsal root ganglion (DRG) neurons, emerging strategies to develop, study, and characterise human pluripotent stem cell (hPSC)-derived sensory neurons present a promising alternative.

Dynamic fluidic manipulation in microfluidic chips with dead-end channels through spinning: the Spinochip technology for hematocrit measurement, white blood cell counting and plasma separation.

Centrifugation is crucial for size and density-based sample separation, but low-volume or delicate samples suffer from loss and impurity issues during repeated spins. We introduce the "Spinochip", a novel microfluidic system utilizing centrifugal forces for efficient filling of dead-end microfluidic channels. The Spinochip enables versatile fluid manipulation with a single reservoir for both inlet and outlet functions.

Construction of a laccase/CeO/attapulgite nanocomposite for photoenzymatic catalytic CO reduction coupled with biomass oxidation.

Herein, a photoenzymatic synergistic catalytic material, laccase/CeO/attapulgite, was prepared for simultaneous CO conversion and biomass conversion. Based on the synergistic effect of the photoenzyme in the prepared composites, a remarkable CO (27.15 μmol g h) and CH (64.

Self-Supported α-MoB/β-MoB Ceramic Electrodes for Efficient High-Current-Density Hydrogen Evolution in Acidic, Neutral, and Alkaline pH-Values.

This paper describes the production and high-current-density hydrogen evolution reaction (HER) performance in the whole pH range (from acidic to basic pH values) of self-supported α-MoB/β-MoB ceramic electrodes, aiming for use in industrial electrocatalytic water splitting. Tape-casting and phase-inversion process, followed by sintering, were employed to synthesize self-supported β-MoB ceramic electrodes, which exhibited well arranged large finger-like pores, providing numerous active sites and channels for electrolyte entry and hydrogen release. The reaction between β-MoB and the sintering aid of MoO produces α-MoB/β-MoB heterojunctions, which significantly improve the electrocatalytic performance.

Dual-Ligand Assisted Anisotropic Assembly for the Construction of NIR-II Light-Propelled Mesoporous Nanomotors.

The advent of autonomous nanomotors presents exciting opportunities for nanodrug delivery. However, significant potential remains for enhancing the asymmetry of nanomotors and advancing the development of second near-infrared (NIR-II) light-propelled nanomotors capable of operating within deep tissues. Herein, we developed a dual-ligand assisted anisotropic assembly strategy that enables precise regulation of the interfacial energy between selenium (Se) nanoparticle and periodic mesoporous organosilica (PMO).

Anchoring Ru single-atoms on MXene achieves dual-enzyme activities for mild photothermal augmented nanocatalytic therapy.

Single-atom catalysts with abnormally high catalytic activity have garnered extensive attention and interest for their application in tumor therapy. Despite the advancements made with current nanotherapeutic agents, developing efficient systems for cancer treatment remains challenging due to low activity, uncontrollable behavior, and nonselective interactions. Herein, we have constructed Ru single-atom-anchored MXene nanozymes (Ru-TiCT-PEG) with a mild photothermal effect and multi-enzyme catalytic activity for synergistic tumor therapy.

Unveiling the inhibition mechanism of host-defense peptide cathelicidin LL-37 on the amyloid aggregation of the human islet amyloid polypeptide.

The aberrant aggregation of the human islet amyloid polypeptide (hIAPP) is a hallmark of type II diabetes. LL37, the only cathelicidin host-defense peptide in humans, plays essential roles in antimicrobial and immunomodulatory activities. Mounting evidence indicates that LL37 can inhibit the amyloid aggregation of hIAPP, suggesting possible interplays between infections and amyloid diseases while the mechanism remains unclear.

Evaluating Computerised Assessment of Motor Imitation (CAMI) for identifying autism-specific difficulties not observed for attention-deficit hyperactivity disorder or neurotypical development.

Background: Reliable and specific biomarkers that can distinguish autism spectrum disorders (ASDs) from commonly co-occurring attention-deficit/hyperactivity disorder (ADHD) are lacking, causing misses and delays in diagnosis, and reducing access to interventions and quality of life.

Aims: To examine whether an innovative, brief (1-min), videogame method called Computerised Assessment of Motor Imitation (CAMI), can identify ASD-specific imitation differences compared with neurotypical children and children with ADHD.

Method: This cross-sectional study used CAMI alongside standardised parent-report (Social Responsiveness Scale, Second Edition) and observational measures of autism (Autism Diagnostic Observation Schedule-Second Edition; ADOS-2), ADHD (Conners) and motor ability (Physical and Neurological Examination for Soft Signs).

Polysiloxane-Modified PMMA-Shell Phase Change Microcapsules for Thermal Management Fabrics.

Critical issues such as leakage, degradation, and thermal response hysteresis have become the focus in the application of phase change materials (PCMs) in area such as thermal management of fabrics. The encapsulation of PCMs prepared as microcapsules using polysiloxanes, etc. as a component unit of crosslinking agents represents a highly promising avenue of research.

RETRACTION: Kaempferol Increases Apoptosis in Human Acute Promyelocytic Leukemia Cells and Inhibits Multidrug Resistance Genes.

M. Moradzadeh, A. Tabarraei, H.

Molecular Dynamics Insights into Water Transport Mechanisms in Polyamide Membranes: Influence of Cross-Linking Degree.

Polyamide (PA) membranes are widely utilized in desalination and water treatment applications, yet the mechanisms underlying water transport within these amorphous polymer materials remain insufficiently understood. To gain more insight into these problems on a microscopic scale, we employ molecular dynamics (MD) simulations to analyze the relationship between the structural properties and the water permeation behavior of PA membranes. Two distinct atomistic models of PA membranes are developed by controlling their degrees of cross-linking (DC).

Gelatin-Based Adhesive Hydrogels with Self-Healing, Injectable and Temperature-Triggered Detachable Properties.

Adhesive hydrogels are emerging as attractive functional materials for various fields, such as tissue engineering, wound healing, E-skins, etc. However, the removal of adhesive hydrogels from covered area may be painful and cause a secondary damage. In the current study, gelatin-based hydrogels are prepared by cross-linking with tannic acid and 4-formylphenyl boronic acid, through simultaneous dynamic covalent boronic ester and imine bond formations.

How Droplets Dry on Stretched Soft Substrates.

Droplet evaporation on solid substrates is a ubiquitous phenomenon and is relevant in many natural and industrial processes. Whereas it has been reported that the evaporation process is sped up on soft substrates compared with that on hard substrates, no attempt has been made in exploring how substrate stretching affects droplet evaporation and evaporative deposition patterns. Here, we systematically investigate the contact line dynamics of droplets evaporating on substrates with different stiffnesses and stretching ratios and the structures of the evaporative deposition patterns of nanoparticles.

Systemic Inflammatory Diseases in Children with Sickle Cell Disease: A French Multicenter Observational Study on Diagnostic and Therapeutic Issues.

Background: Systemic inflammatory diseases (SIDs) have been reported in patients with sickle cell disease (SCD), but clinical data in children are scarce.

Objectives: To identify clinical and laboratory features at diagnosis of SID in children with SCD and to describe their evolution.

Methods: Data from children with SCD and SIDs were retrospectively collected in a French multicenter study from 1991 to 2018.

Earthquake effects on youth: understanding psychological challenges and support needs.

The aim of this study is to examine the effects of the earthquake on the psychological symptoms of high school students, and to understand the readiness of school counseling services based on the available data. In this context, the research was designed within the scope of two different studies: Study 1: The views of school counselors, and students on the difficulties experienced due to the earthquake. Study 2: The effects of the earthquake on students' psychological symptoms.

Cell signaling communication within papillary craniopharyngioma revealed by an integrated analysis of single-cell RNA sequencing and bulk RNA sequencing.

Objective: This study aims to elucidate the primary signaling communication among papillary craniopharyngioma (PCP) tumor cells.

Methods: Five samples of PCP were utilized for single-cell RNA sequencing. The most relevant ligand and receptor interactions among different cells were calculated using the CellChat package in R software.