Medical Students' Knowledge and Perceptions of Herbal Medicine in Saudi Arabia: Should Medical Schools Take Immediate Action?

Background: Herbal medicine is integral to Saudi Arabia's Vision 2030, which seeks to improve the healthcare system and promote alternative practices while ensuring safety through education and research. This study aims to evaluate medical students' knowledge and perceptions regarding herbal medicine in Saudi Arabia.

Methods: A cross-sectional study was conducted among medical students in three medical colleges in Saudi Arabia over a six-month period from 1 February to 31 July 2024.

Posttraumatic hyperalgesia and associated peripheral sensitization after temporomandibular joint injury in mice.

Temporomandibular disorder (TMD) is the most prevalent painful condition in the craniofacial area. Recent studies have suggested that external or intrinsic trauma to the temporomandibular joint (TMJ) is associated with the onset of painful TMD in patients. Here, we investigated the effects of TMJ trauma through forced-mouth opening (FMO) in mice to determine pain behaviors and peripheral sensitization of trigeminal nociceptors in both sexes.

Generalized Anxiety Disorder Among Physicians: A Cross-Sectional Study.

Background: Generalized anxiety disorder (GAD) is defined as excessive worry that occurs on most days for at least six months, causes significant distress or impairment, and is associated with increased use of health services.

Methodology: A cross‑sectional study was carried out among physicians working in Saudi Arabia through an online questionnaire. The questionnaire consisted of a sociodemographic part and the validated Arabic version of the Generalized Anxiety Disorder‑7 (GAD‑7) questionnaire.

Public Awareness Levels Regarding Cervical Spine Injury and the Suitable First Aid Response Among Adults in Makkah, Saudi Arabia.

Purpose: Cervical spine injuries (CSIs) are a growing concern, leading to severe and permanent disabilities. Educating the public about these injuries and appropriate emergency responses is crucial to prevent irreversible damage, minimize disability, and save lives, especially with the rising number of trauma victims worldwide. Herein, we assessed the awareness of CSIs, trauma identification, and first-aid procedures among adults in Makkah, Saudi Arabia.

Sun Exposure Awareness and Sunscreen Use Among College Students in Saudi Arabia: A Cross-Sectional Analysis.

Background: Excessive sun exposure is a significant risk factor for various skin conditions, including sunburn, premature aging, and skin cancer. This study aimed to assess the awareness, attitudes, and practices regarding sun exposure and sunscreen use among college students in Saudi Arabia.

Methodology: A cross-sectional study was conducted with 388 college students from various disciplines.

Optical, Opto-Mechanical, and Antimicrobial Characterization of TiO and ZnO-Enhanced Polypropylene Fibers Using Interferometric Techniques and Fourier Transform Analysis.

This study investigates the optical, mechanical, and antimicrobial properties of polypropylene (PP) fibers enhanced with titanium dioxide (TiO) and zinc oxide (ZnO) nanoparticles. Using a Mach-Zehnder interferometric system, we examined the refractive indices, birefringence, and opto-mechanical behavior of blank PP, PP/TiO, and PP/ZnO nanocomposite fibers under various conditions, including different polarization orientations and during cold drawing processes. The 2D Fourier transform algorithm is employed to analyze interferometric data, enabling precise measurements of refractive index profiles and birefringence.

RHCE genotyping using next generation sequencing: Allele specific reference sequences.

Background: The Rh blood group system (ISBT004) is encoded by two homologous genes, RHD and RHCE. Polymorphism in these two genes gives rise to 56 antigens, which are highly immunogenic and clinically significant. This study extended previous work on the establishment of RHD allele specific reference sequences using next generation sequencing (NGS) with the Ion Personal Genome Machine (Ion PGM) to sequence the complete RHCE gene.

Investigating the impact of oral health status on the prevalence of falls among caregivers and non-caregivers in the United States: A retrospective study.

Objective: Examining the association between oral health and the prevalence of falls among US caregivers.

Background: There is a scarcity of research on the association between oral health status and the prevalence of falls among older adults and caregivers.

Materials And Methods: Data from the Behavioral Risk Factor Surveillance System (BRFSS) surveys from 2016 to 2020 were analyzed.

Hesperidin ameliorates thioacetamide-induced liver fibrosis via antioxidative and anti-inflammatory mechanisms targeting TGF-β/α-SMA pathways in rats.

Our study intended to explore Hesp antioxidant and anti-inflammatory effects against TAA hepatic fibrosis in rats. Hesperidin (Hesp), is a pharmacologically active flavonoid, found abundantly in citrus species. Our present research attempts to inspect the potential hepatoprotective role of Hesp against thioacetamide (TAA)-induced hepatic fibrosis.

Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia.

Background: Apium graveolens Linn., also known as celery, is a member of the Apiaceae family and has shown promising pharmacological properties, including diabetes. Indeed, the current investigation aimed to investigate the potential inhibitory effects of A.

Unveiling the Influence of AI on Advancements in Respiratory Care: Narrative Review.

Background: Artificial intelligence is experiencing rapid growth, with continual innovation and advancements in the health care field.

Objective: This study aims to evaluate the application of artificial intelligence technologies across various domains of respiratory care.

Methods: We conducted a narrative review to examine the latest advancements in the use of artificial intelligence in the field of respiratory care.

Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.

Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.

Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development.

Facile synthesis of novel nanocomposite composed of CoO, MgO, and MgBO for malachite green dye decontamination from aqueous media.

Malachite green is a hazardous chemical that poses serious threats to aquatic ecosystems due to its toxicity and persistence in the environment. Additionally, it is harmful to human health, recognized as a carcinogenic and mutagenic agent that can cause long-term adverse effects. Hence, in this study, malachite green dye was efficiently removed from aqueous media using CoO/MgO/MgBO novel nanocomposites, known as CBM600 and CBM800.

The inhibitory activities of two compounds from Fresen on the acetylcholinesterase from wheat pest Rondani: analysis.

Wheat is the third most widely consumed cereal in the world, after maize and rice. However, it is regularly attacked by the wheat aphid (), causing considerable damage to wheat crops. The acetylcholinesterase enzyme, which plays a key role in the transmission of the synaptic cholinergic signal, has emerged as a promising target for the development of pest control strategies.

Navigating Sensor-Skin Coupling Challenges in Magnetic-Based Blood Pressure Monitoring: Innovations and Clinical Implications for Hypertension and Aortovascular Disease Management.

Non-invasive blood pressure monitoring has emerged as a critical frontier in cardiovascular healthcare, with magnetic sensors playing an increasingly pivotal role in wearable health technologies. This comprehensive review critically examines the complex challenges of sensor-skin coupling and its profound impact on the accuracy of blood pressure measurements in patients with hypertension and aortovascular disease. Despite the growing demand for precise, real-time health monitoring, significant limitations persist in current magnetic sensor technologies.

An evaluation framework and comparative analysis of the widely used learning management systems.

Learning Management System (LMS) is a major tool used in most universities and institutions for online/distance education purposes. A variety of LM systems are being used in different universities and institutions, and these LM systems are also updating their versions and patches to stay in the competition. Hence, the selection of an appropriate LMS is an important task as it is going to influence the academic proceedings of an academic institution.

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Alzheimer's disease (AD) is characterized by the aggregation of amyloid β (Aβ) peptides and the formation of plaques in the brain, primarily derived from the proteolytic degradation of amyloid precursor protein (APP). Cathepsin B (CatB) is a cysteine protease that plays a pivotal role in this process, making it a potential target for the development of anti-Alzheimer's therapies. Apart from AD, CatB is implicated in various physiological and pathological processes, including cancer.

A Cross-Sectional Study Assessing Saudi Population's Awareness Toward the Relationship Between Oral Health and Overall Well-Being.

Background And Aim: Oral health constitutes a critical component of overall health. Additionally, there is evidence of a bidirectional interaction between oral health and the progression of chronic diseases. Many chronic illnesses present oral manifestations and thus can impact oral health but conversely, oral health, particularly the presence of oral bacteria, can influence the progression of chronic diseases.

Factors associated with tobacco use among Saudi Arabian youth: Application of the Theory of Planned Behavior.

Introduction: The epidemic of tobacco use poses one of the most severe public health challenges globally, responsible for over 8 million deaths annually according to the World Health Organization (WHO). This study investigates the factors associated with tobacco use among Saudi Arabian youth using the Theory of Planned Behavior (TPB) framework.

Methods: A cross-sectional study used the 2022 Global Youth Tobacco Survey (GYTS) to assess tobacco use among 5610 Saudi students aged 13-15 years.

Combined and isolated effects of workstation ergonomics and physiotherapy in improving cervicogenic headache and work ability in office workers: a single-blinded, randomized controlled study.

Objective: The objective of the study is to compare and investigate the combined and individual effects of workstation ergonomics, physiotherapy and patient education in improving CgH headaches and work ability in office workers.

Methods: 96 eligible CgH participants were divided into the ergonomics modifications group (EMG;  = 24), physiotherapy group (PTG;  = 24), and ergonomics modifications combined with physiotherapy group (EPG;  = 24) and education control group (CNG;  = 24), the participants received the respective treatment for 4 weeks. Primary (CgH frequency) and secondary (CgH pain intensity, CgH disability, flexion rotation test (right and left), neck disability index and work ability) scores were measured.

Unlocking the pharmacological potential of Brennnesselwurzel (Urtica dioica L.): an in-depth study on multifaceted biological activities.

Brennnesselwurzel (Urtica dioica L.) is recognized for its diverse pharmacological properties. With a range of chemical constituents, such as vitamins, minerals, phenolic compounds, fibers, and amino acids, Brennnesselwurzel (BWE) has a long history of traditional medicinal use in Europe and Asia.

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters.

Background: Multidrug resistance (MDR), mainly caused by ATP-binding cassette transporters (ABCTs) efflux, makes it difficult for many anticancer drugs to treat breast cancer (BC). Phytochemicals can reverse cancer's MDR by modifying ABC transporter expression and function, as well as working synergistically with anticancer drugs to target other molecules. The reversal effect of the isoquinoline alkaloid coptisine (COP) was assessed on four breast cell lines; Two sensitive MCF-7 cell lines with positive estrogen, androgen, progesterone, and glucocorticoid receptors, as well as MDB-MB-231 cells with negative estrogen, progesterone, and HER2 receptors, and two doxorubicin-resistant cell lines, MCF-7/ADR and MDB-MB-231/ADR.

Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion.

Introduction: Chiral nanocarriers enhance therapeutic efficacy by improving in vivo stability and cellular uptake. Chemical functionalization reduces cytotoxicity, resulting in favorable biocompatibility. Nanoparticles self-assemble into supraparticles, enhancing drug delivery through improved retention and drug loading.