931 results match your criteria: "Queensland Centre for Mental Health research[Affiliation]"

Interventions to prevent alcohol use: systematic review of economic evaluations.

BJPsych Open

June 2023

PhD, Health Economics Group, School of Public Health and Preventive Medicine, Monash University, Australia.

Article Synopsis
  • Alcohol use is a major global risk factor for death and disability, prompting a systematic review of cost-effectiveness for prevention interventions throughout life.
  • 69 studies were evaluated, revealing that many alcohol prevention strategies, especially universal ones like taxation and advertising bans, are cost-saving and effective, particularly for younger populations.
  • Further economic analysis is essential to guide policies in lower-income countries and among different age groups, as evidence indicates limited cost-effectiveness for interventions targeting older adults.
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Objective: To describe the process of collaborative, contextualised development and implementation of a model of care for adults with symptoms suggestive of attention deficit and hyperactivity disorder in an Aboriginal community-controlled health service.

Conclusion: The current article describes an attempt to reduce unmet mental health needs through a systemic approach within a well-established Indigenous community-controlled organisation.

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an intensive but effective treatment for malignant and non-malignant diseases. However, long-term survival often comes at a cost, with survivors experiencing chronic morbidity and are at risk of relapse and secondary malignancy. This study aimed to describe decisional regret in a large cohort of Australian long-term allo-HSCT survivors.

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Developmental vitamin D (DVD)-deficiency is an epidemiologically established risk factor for autism. Emerging studies also highlight the involvement of gut microbiome/gut physiology in autism. The current study aims to examine the effect of DVD-deficiency on a broad range of autism-relevant behavioural phenotypes and gut health.

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Sense of purpose interventions for depression and anxiety in youth: A scoping review and cross-cultural youth consultation.

J Affect Disord

October 2023

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Queensland Centre for Mental Health Research (QCMHR), The Park Centre for Mental Health, Wacol, QLD, Australia; Child Health Research Centre, The University of Queensland South Brisbane, Qld Australia; Child and Youth Mental Health Service, Children's Hospital Queensland, South Brisbane, Qld, Australia.

Background/objectives: To investigate the effectiveness, feasibility, and acceptability of sense of purpose (SOP) interventions in preventing or reducing anxiety or depression in youth aged 14-24 years.

Methods: A systematic search was conducted of the academic (PubMed/MEDLINE, PsycINFO, EMBASE) and grey literature. We also consulted two SOP experts and an Australian and Indian youth advisory group with lived experience of anxiety and/or depression.

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Services data are an important source of information for policymakers and planners. In Australia, significant work has been undertaken to develop and implement collections of mental health services data. Given this level of investment, it is important that collected data are fit for purpose.

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Aims: We provide an overview of nationwide environmental data available for Denmark and its linkage potentials to individual-level records with the aim of promoting research on the potential impact of the local surrounding environment on human health.

Background: Researchers in Denmark have unique opportunities for conducting large population-based studies treating the entire Danish population as one big, open and dynamic cohort based on nationally complete population and health registries. So far, most research in this area has utilised individual- and family-level information to study the clustering of disease in families, comorbidities, risk of, and prognosis after, disease onset, and social gradients in disease risk.

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Global warming is bringing with it continued long-term changes in the climate system. Extreme weather-related events, which are already becoming a daily reality around the world, are predicted to be more intense and frequent in the future. The widespread occurrence of these events and climate change more broadly are being experienced collectively and at scale and do not affect populations evenly.

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Background: Schizophrenia spectrum disorders (SSD) comprise a group of related mental disorders, which share clinical features and common genetic disposition, but it is unknown if there is a diagnostic transition between these disorders over time. We aimed to study the incidence at the first SSD diagnosis between 2000 and 2018, defined as schizophrenia, schizotypal or schizoaffective disorder, and the early diagnostic transition between these disorders.

Methods: Using Danish nationwide healthcare registers, we identified all individuals aged 15-64 years during the period from 2000 to 2018 in Denmark and calculated the yearly incidence rates for the specific SSDs.

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National mental health surveys play a critical role in determining the prevalence of mental disorders in a population and informing service planning. However, current surveys have important limitations, including the exclusion of key vulnerable groups and increasing rates of non-response. This review aims to synthesise information on excluded and undersampled groups in national mental health surveys.

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Mental health systems modelling for evidence-informed service reform in Australia.

Aust N Z J Psychiatry

November 2023

Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Article Synopsis
  • Australia's Fifth National Mental Health Plan mandates that governments report on both the progress of mental health service changes and future service planning.
  • Predicting future treatment demand is difficult, but systems modelling can help decision-makers anticipate changes and choose effective responses.
  • The paper discusses the new capabilities in mental health modelling in Australia and how these approaches can assist health service planners in making informed decisions for the population.
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Introduction: Surveys and registers have provided important insights into the mental health of the community. However, both sources have strengths and limitations. While participation in surveys has been shown to be lower among those with mental disorders, misclassification and limited information on confounders are typical issues for registers.

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Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice.

Neuropharmacology

August 2023

Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia; Queensland Centre for Mental Health Research, Wacol, QLD, 4076, Australia; QIMR Berghofer Medical Research Institute, Herston, QLD, 4029, Australia. Electronic address:

The cognitive symptoms of schizophrenia are wide ranging and include impaired goal-directed action. This could be driven by an increase in dopamine transmission in the dorsomedial striatum, a pathophysiological hallmark of schizophrenia. Although commonly associated with psychotic symptoms, dopamine signalling in this region also modulates associative learning that aids in the execution of actions.

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Vitamin D has been identified as a key factor in dopaminergic neurogenesis and differentiation. Consequently, developmental vitamin D (DVD) deficiency has been linked to disorders of abnormal dopamine signalling with a neurodevelopmental basis such as schizophrenia. Here we provide further evidence of vitamin D's role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein re-distribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including SH-SY5Y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures.

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Background: Register-based studies of major depressive disorder (MDD) do not capture all prevalent cases, as untreated cases and diagnoses made by general practitioners are not recorded in the registers. We examined the prevalence and agreement of survey- and register-based measures of depression, and explored sociodemographic and health-related factors that may have influenced this agreement.

Methods: All 32,407 participants in the 2017 Central Denmark Region How are you? survey were linked to hospital and prescription records.

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Background: Effective and scalable prevention approaches are urgently needed to address the rapidly increasing rates of e-cigarette use among adolescents. School-based eHealth interventions can be an efficient, effective, and economical approach, yet there are none targeting e-cigarettes within Australia. This paper describes the protocol of the OurFutures Vaping Trial which aims to evaluate the efficacy and cost-effectiveness of the first school-based eHealth intervention targeting e-cigarettes in Australia.

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Background: Posttraumatic stress disorder (PTSD) is associated with significant morbidity, but efficacious pharmacotherapy and psychotherapy are available. Data from the World Mental Health Surveys were used to investigate extent and predictors of treatment coverage for PTSD in high-income countries (HICs) as well as in low- and middle-income countries (LMICs).

Methods: Seventeen surveys were conducted across 15 countries (9 HICs, 6 LMICs) by the World Health Organization (WHO) World Mental Health Surveys.

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Background: The most common treatment for major depressive disorder (MDD) is antidepressant medication (ADM). Results are reported on frequency of ADM use, reasons for use, and perceived effectiveness of use in general population surveys across 20 countries.

Methods: Face-to-face interviews with community samples totaling = 49 919 respondents in the World Health Organization (WHO) World Mental Health (WMH) Surveys asked about ADM use anytime in the prior 12 months in conjunction with validated fully structured diagnostic interviews.

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Objective: In the general population, repeated cognitive testing produces learning effects with potential for improved test performance. It is currently unclear whether the same effect of repeated cognitive testing on cognition pertains to people living with schizophrenia, a condition often associated with significant cognitive impairments. This study aims to evaluate learning ability in people with schizophrenia and-considering the evidence that antipsychotic medication can additionally impair cognitive performance-explore the potential impact of anticholinergic burden on verbal and visual learning.

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Article Synopsis
  • The study investigates the link between child maltreatment and mental disorders in the Australian population, using data from a representative survey of residents aged 16 and older.
  • Findings reveal that 38% of participants met criteria for a mental disorder, with significantly higher rates among those who experienced maltreatment—21.6% in non-maltreated versus 54.8% in those with multi-type maltreatment.
  • Maltreated individuals have about three times higher odds for mental disorders, particularly post-traumatic stress disorder, generalised anxiety disorder, and major depressive disorder, with no significant differences based on gender or socioeconomic factors.
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Objectives: To examine associations between child maltreatment and health service use, both overall, by type and by the number of types of maltreatment reported.

Design, Setting: Cross-sectional, retrospective survey using the Juvenile Victimization Questionnaire-R2: Adapted Version (Australian Child Maltreatment Study); computer-assisted mobile telephone interviews using random digit dialling, Australia, 9 April - 11 October 2021.

Participants: Australians aged 16 years or more.

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