17,280 results match your criteria: "Queen Elizabeth Hospital.[Affiliation]"
bioRxiv
September 2024
Laboratory of Data Discovery for Health Limited, Hong Kong SAR, China.
Apicomplexa are single-celled eukaryotes that can infect humans and include the mosquito-borne parasite , the cause of malaria. Increasing rates of drug resistance in human-only species are reducing the efficacy of control efforts and antimalarial treatments. There are also rising cases of , the only zoonotic species that causes severe disease and death in humans.
View Article and Find Full Text PDFCardiol Rev
September 2024
Department of Interventional Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Transcatheter aortic valve replacement (TAVR) is frequently associated with stroke due to debris embolization. Although the risk of stroke with newer-generation devices is lower, stroke still represents a significant cause of mortality and morbidity post-TAVR. The Sentinel cerebral embolic protection device (CEPD) is a dual-embolic filter device designed to capture debris dislodged during TAVR.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
September 2024
Discipline of Surgical Specialties, Adelaide Medical School, University of Adelaide, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia.
Background: Lactation is associated with long-term reduced risk of breast cancer. However, there is a transient increased risk of breast cancer in the 5 to 10 years postpartum and this is associated with a high incidence of metastasis and mortality. Breastmilk is a physiological fluid secreted by the mammary glands intimately connected with breast cells and the microenvironment that may affect postpartum breast cancer development and progression.
View Article and Find Full Text PDFCommun Biol
September 2024
Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Disease recurrence following chemotherapy is a major clinical challenge in ovarian cancer (OC), but little is known regarding how the tumour epigenome regulates transcriptional programs underpinning chemoresistance. We determine the single cell chromatin accessibility landscape of omental OC metastasis from treatment-naïve and neoadjuvant chemotherapy-treated patients and define the chromatin accessibility profiles of epithelial, fibroblast, myeloid and lymphoid cells. Epithelial tumour cells display open chromatin regions enriched with motifs for the oncogenic transcription factors MEIS and PBX.
View Article and Find Full Text PDFCancers (Basel)
September 2024
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.
Intensity-modulated radiation therapy (IMRT) improves disease control and reduces treatment-related toxicity in patients with localized nasopharyngeal carcinoma (NPC). However, due to the proximity of the auditory apparatus to the treatment volume and the frequent incorporation of cisplatin-based chemotherapy, treatment-related sensorineural hearing loss (SNHL) remains a common debilitating complication among NPC survivors. The reported crude incidence of SNHL following IMRT for NPC varies widely at 1-46% due to differences in auditory assessment methods and thresholds, follow-up durations, chemotherapy usage, and patient compositions.
View Article and Find Full Text PDFCancer Cell Int
September 2024
School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Breast cancer, the most prevalent and aggressive tumor affecting women, requires identification of disease determinants to facilitate the development of effective therapeutic strategies. Transient receptor potential vanilloid 2 (TRPV2), an ion channel highly permeable for calcium (Ca), is implicated in physiological and pathological processes. Nevertheless, the role of TRPV2 in breast cancer remains poorly elucidated.
View Article and Find Full Text PDFRespir Med
November 2024
Department of Respiratory Medicine, Queen Elizabeth Hospital, Karung Berkunci No. 2029, 88586, Kota Kinabalu, Sabah, Malaysia. Electronic address:
Radiother Oncol
December 2024
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Australia; School of Medicine, University of Western Australia, Perth, Australia; Institute for Respiratory Health, Perth, Australia.
Background & Purpose: Local treatment of oligometastases has been found to improve survival and prognosis. Stereotactic body radiotherapy (SBRT) has emerged as a treatment option for oligometastases but its use in ultra-central (UC) areas can cause significant toxicity and mortality. Fiducial markers (FM) can be used to improve SBRT accuracy, and can be inserted in the central thorax using linear endobronchial ultrasound (EBUS) bronchoscopy.
View Article and Find Full Text PDFInt J Surg Case Rep
November 2024
General Surgery Department, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.
Introduction & Importance: Situs Inversus Abdominalis (SIA) & Paraduodenal Hernias (PDH) are extremely rare causes acute surgical emergencies among adults. We present a case of an adult patient with intestinal obstruction secondary to PDH through the fossa of Landzert with concurrent SIA.
Presentation Of Case: A thirteen-year-old Southeast Asian female with situs inversus abdominalis due to Kartagener syndrome presented with bowel obstruction.
Intern Med J
October 2024
Department of Clinical Pharmacology and Therapeutics, Austin Health, Melbourne, Victoria, Australia.
High-cost medicines (HCMs) can be clinically impactful for individual patients but are also subject to variable funding mechanisms. Public hospitals and health services are often asked to fund HCMs, but inconsistent processes frequently create large variations in care. CATAG (Council of Australian Therapeutic Advisory Groups) is the Australian peak national advisory body for the quality use of medicines in hospitals and health services, with all states and territories collaborating to support Drug and Therapeutics Committees (DTCs).
View Article and Find Full Text PDFClin Microbiol Infect
December 2024
OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:
Asia Pac J Ophthalmol (Phila)
October 2024
Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Hong Kong Eye Hospital, Hong Kong, China. Electronic address:
Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an emerging, immune-mediated fibroinflammatory orbital disease, characterized by tumefactive lesions with noticeable IgG4+ plasma cell infiltration and distinctive pathohistological features. This disease is often associated with elevated serum IgG4 concentrations. IgG4-ROD may affect any ophthalmic tissues, particularly the lacrimal gland, extraocular muscles, and trigeminal nerves.
View Article and Find Full Text PDFJ Infect
November 2024
Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, England, UK.
Science
September 2024
Department of Vision and Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.
During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition and utterance length, languages use pronouns, like the word "she," to refer to nouns and phrases that were previously introduced. It has been suggested that language comprehension requires that pronouns activate the same neuronal representations as the nouns themselves.
View Article and Find Full Text PDFJ Clin Orthop Trauma
September 2024
Department of Orthopaedics, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, NE7 7DN, UK.
Introduction: Total ankle replacements (TARs) is emerging as a successful alternate treatment option to arthrodesis for surgical treatment of end stage ankle arthritis. This has led to manufacturers producing a selection of implants. There is wide variations in post-operative rehab protocols being adopted for treatment following TAR surgery.
View Article and Find Full Text PDFJ Med Virol
October 2024
Liver Unit, Birmingham Children's Hospital, Birmingham, England.
Hepatitis B e antigen (HBeAg) loss is a key event in the natural history of chronic hepatitis B virus infection. The rate and determinants of HBeAg loss depend upon cohort characteristics at baseline. Few studies have examined the age-dependent rate, and none have examined the effect of patient sex and ethnicity on the age-dependant rate.
View Article and Find Full Text PDFBull World Health Organ
October 2024
School of Medicine, Universidad San Sebastian, Lota 2465, Providencia, Santiago7510157, Chile.
The normative role of the World Health Organization (WHO) involves creating evidence-based, principled guidelines to guide its Member States in making well-informed public health decisions. While these guidelines often need to be adapted to ensure contextual relevance, foster better implementation and adherence, adapting existing guidelines is more efficient than creating new ones. Here we describe the adaptation of the WHO coronavirus disease 2019 (COVID-19) living guideline on pharmacological interventions for the Caribbean using the grading of recommendations, assessment, development and evaluation (GRADE)-ADOLOPMENT method.
View Article and Find Full Text PDFEur J Neurol
September 2024
Headache Group, NIHR King's Clinical Research Facility and SLaM Biomedical Research Centre, The Wolfson Sensory, Pain and Regeneration Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
J Med Imaging Radiat Oncol
October 2024
Department of Diagnostic and Interventional Radiology, Princess Margaret Hospital, Kowloon, Hong Kong SAR, China.
Post-radiation nasopharyngeal necrosis (PRNN) is a rare but life-threatening condition that often poses a diagnostic challenge in imaging studies owing to its overlapping features with recurrent nasopharyngeal tumours. We herein describe the characteristic imaging appearance of PRNN on post-contrast T1-weighted magnetic resonance imaging, diffusion-weighted imaging (DWI) and fluorodeoxyglucose (FDG)-PET/CT which may provide insights into its pathological findings.
View Article and Find Full Text PDFResusc Plus
December 2024
Royal College of Surgeons in Ireland - Bahrain, Building No. 2441, Road 2835, Busaiteen 228, Bahrain.
Expert Opin Pharmacother
October 2024
Liverpool Heart and Chest Hospital, Liverpool, UK.
Introduction: Updated guidelines for heart failure with reduced ejection fraction (HFrEF) and acute decompensation have improved outcomes, but ongoing efforts are focused on uncovering new evidence and developing novel therapies. This review examines the limitations of current treatments and the potential impact of emerging therapies.
Areas Covered: A literature search focused on studies investigating drugs for HFrEF.
Medicine (Baltimore)
September 2024
Teaching Faculty, University of Khartoum, Khartoum, Sudan.
Physiol Rev
April 2025
Division of Gastroenterology, Center for Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy.
Intern Med J
November 2024
Health and Information, Canberra, Australian Capital Territory, Australia.
Given their frontline role in Australia and Aotearoa New Zealand (ANZ) healthcare, trainee medical officers (TMOs) will play a crucial role in the development and use of artificial intelligence (AI) for clinical care, ongoing medical education and research. As 'digital natives', particularly those with technical expertise in AI, TMOs should also be leaders in informing the safe uptake and governance of AI within ANZ healthcare as they have a practical understanding of its associated risks and benefits. However, this is only possible if a culture of broad collaboration is instilled while the use of AI in ANZ is still in its initial phase.
View Article and Find Full Text PDFWorld J Surg
November 2024
Department of Surgery, Centre for Gastro-esophageal Reflux Disease, Limmattal Hospital, Schlieren, Switzerland.
Background: The surgical technique in large hiatal hernia (HH) repair is controversially discussed and the outcome measures and follow-up schemes are highly heterogeneous. The aim of this study is to assess the true recurrence rate using computed tomography (CT) in patients with standardized large HH repair.
Methods: Prospective single-center study investigating the outcome after dorsal, mesh-enforced large HH repair with anterior fundoplication.