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856 results match your criteria: "Queen Charlottes and Chelsea Hospital[Affiliation]"
Obstet Med
June 2023
Fetal Maternal Medicine Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Non-alcoholic fatty liver disease (NAFLD) is now the commonest liver pathology in the UK; however, relatively little is known about its course in pregnancy or the effect it has on maternal or fetal outcomes. Described here is a 24-year-old woman in her first pregnancy who presented with non-specific symptoms and raised alanine aminotransferase with ultrasonography of her liver showing changes of steatosis and suspicious for cirrhosis, leading to a diagnosis of NAFLD. The case illustrates the need for the clinician to have awareness of this increasingly prevalent condition and for multidisciplinary management.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
August 2023
Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University of Parma, Parma, Italy.
Climacteric
August 2023
Department of Gynaecology, Queen Charlotte's and Chelsea Hospital, Imperial College London, London, UK.
The demand for non-hormonal therapies for vulvovaginal atrophy (VVA) is increasing due to an increasing number of patients surviving long term post cancer diagnosis, as well as increased public knowledge of the symptoms of menopause and availability of non-hormonal therapies. Treatment options are wide-ranging and encompass different formulations and methods of application. This review summarizes the key characteristics of the main forms of these therapies, as well as considering the current evidence for each of them and where future clinical studies should be directed.
View Article and Find Full Text PDFAm J Obstet Gynecol
May 2023
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom; Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address:
Background: This review aims to summarize associations of the perinatal environment with arterial biophysical properties in childhood, to elucidate possible perinatal origins of adult cardiovascular disease (CVD).
Methods: A systematic search of PubMed database was performed (December 2020). Studies exploring associations of perinatal factors with arterial biophysical properties in children 12 years old or less were included.
Ultrasound Obstet Gynecol
June 2023
Department of the Mother and Neonate, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Am J Obstet Gynecol
August 2023
Obstetrics and Gynecology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Ultrasound Obstet Gynecol
June 2023
Institute of Developmental and Reproductive Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Ultrasound Obstet Gynecol
August 2023
Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University of Parma, Parma, Italy.
Objective: The prediction of adverse perinatal outcomes in low-risk pregnancies is poor, mainly owing to the lack of reliable biomarkers. Uterine artery (UtA) Doppler is closely associated with placental function and may facilitate the peripartum detection of subclinical placental insufficiency. The objective of this study was to evaluate the association of mean UtA pulsatility index (PI) measured in early labor with obstetric intervention for suspected intrapartum fetal compromise and adverse perinatal outcome in uncomplicated singleton term pregnancies.
View Article and Find Full Text PDFBJPsych Open
January 2023
Department of Surgery and Cancer, Imperial College London, UK; and Department of Obstetrics and Gynaecology, Queen Charlottes and Chelsea Hospital, Imperial College NHS Trust, UK.
Background: COVID-19 has created many challenges for women in the perinatal phase. This stems from prolonged periods of lockdowns, restricted support networks and media panic, alongside altered healthcare provision.
Aims: We aimed to review the evidence regarding the psychological impact on new and expecting mothers following changes to antenatal and postnatal service provision within the UK throughout the pandemic.
JAMA Oncol
February 2023
Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Importance: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.
Objective: To investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step strategy.
Ultrasound Obstet Gynecol
May 2023
Department of Women's Health, University College Hospital London, London, UK.
Objective: To investigate whether psychological wellbeing of women with an intrauterine pregnancy of uncertain viability can be modified during the waiting period to final diagnosis, by offering predictive information regarding the likely outcome of the pregnancy (chance of ongoing viability).
Methods: This was a single-center two-arm randomized controlled trial conducted over 18 months at a teaching hospital in London, UK. Consecutive eligible women attending the early pregnancy assessment unit with an interim ultrasound finding of intrauterine pregnancy of uncertain viability were recruited.
J Perinatol
June 2023
Neonatal unit, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.
Objective: Near-infrared spectroscopy (NIRS) allows assessment of regional tissue oxygen delivery and extraction. There are doubts regarding reliability of gut NIRS measurements. This study assesses reliability of NIRS for monitoring gut oxygenation.
View Article and Find Full Text PDFBr J Hosp Med (Lond)
November 2022
Department of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, Imperial Healthcare NHS Trust, London, UK.
Medicine research and development has been instrumental in improving outcomes for countless individuals, but women, especially pregnant women, have been left behind. Disadvantaged during pregnancy as a result of apprehension over drug use for new or existing conditions, women face worse outcomes for under- or untreated disease. Solving this problem will require input from regulators, the pharmaceutical industry and clinicians.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
February 2023
Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Objective: To evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short-term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR).
Methods: This cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32 + 0 to 36 + 6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and/or fetal abdominal circumference < 10 percentile, or umbilicocerebral ratio (UCR) ≥ 95 percentile or a drop of more than 40 percentile points in abdominal circumference measurement from the 20-week scan.
Ultrasound Obstet Gynecol
February 2023
Department of Medicine and Surgery, Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy.
Life (Basel)
October 2022
St. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Rhombencephalitis refers to inflammation of the brainstem and cerebellum, and can be caused by infections, autoimmune disorders or paraneoplastic syndromes. The most common infective cause is the bacterium Listeria monocytogenes. Listeria monocytogenes is the predominant species to cause human listeriosis, and is commonly due to the ingestion of contaminated foods.
View Article and Find Full Text PDFOpen Forum Infect Dis
October 2022
Division of Infectious Diseases, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Background: Tuberculosis is a leading cause of death among women of reproductive age. However, tuberculous meningitis, the most severe form of extrapulmonary tuberculosis, is rarely discussed in pregnancy despite this being a unique period of immune modulation that may predispose women to active disease.
Methods: We identified and described cases of tuberculous meningitis among pregnant or postpartum women screened during meningitis clinical trials in Uganda from 2018 to 2022.
Ultrasound Obstet Gynecol
February 2023
Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.
Objective: Previous work has suggested that the ultrasound-based benign simple descriptors (BDs) can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. This study aimed to validate a modified version of the BDs and to validate a two-step strategy to estimate the risk of malignancy, in which the modified BDs are followed by the Assessment of Different NEoplasias in the adneXa (ADNEX) model if modified BDs do not apply.
Methods: This was a retrospective analysis using data from the 2-year interim analysis of the International Ovarian Tumor Analysis (IOTA) Phase-5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery).
Ultrasound Obstet Gynecol
January 2023
EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.
BJA Educ
October 2022
Hammersmith Hospital, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare Trust, London, UK.
J Clin Med
August 2022
Department of Surgery & Cancer, Imperial College London, London W12 0NN, UK.
Increasing numbers of females are participating in elite sports, with a record number having competed at the Tokyo Olympic Games. Importantly, the ages of peak performance and fertility are very likely to coincide; as such, it is inevitable that pregnancy will occur during training and competition. Whilst there is considerable evidence to promote regular exercise in pregnancy, with benefits including a reduction in hypertensive disorders, gestational diabetes, and reduced rates of post-natal depression, few studies have been conducted which include elite athletes.
View Article and Find Full Text PDFPLoS One
September 2022
Department of Statistics, University of Oxford, Oxford, United Kingdom.
The early transmission dynamics of SARS-CoV-2 in the UK are unknown but their investigation is critical to aid future pandemic planning. We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020.
View Article and Find Full Text PDFArch Gynecol Obstet
November 2022
Centre for Reproductive and Genetic Health, Great Portland Street, London, W1W 5QS, UK.