Improving the prebiotic activity and oxidative stability of carboxymethyl curdlan - quercetin conjugates stabilized Pickering emulsions for the colonic targeting delivery of curcumin.

The carboxymethyl curdlan-quercetin conjugate (CMCD-QUE) was synthesized to stabilize curcumin (CUR) -loaded Pickering emulsions. The physicochemical properties, antioxidant activity, and prebiotic activity of CMCD-QUE were investigated. The effects of different concentrations of CMCD-QUE on CUR-loaded emulsions were also explored.

Using peer narrative support to promote return to work for cancer survivors: a protocol study of action research.

Background: Chinese cancer survivors are not doing well in returning to work. Peer support, as an external coping resource to help cancer survivors return to work, brings together members of the lay community with similar stressors or problems for mutual support. Peer volunteers have not received systematic training, so inappropriate language in the support process can often cause secondary damage to both the peer and the cancer survivor.

Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis.

The identification of oncogenic gene fusions in diffuse gliomas may serve as potential therapeutic targets and prognostic indicators, representing a novel strategy for treating gliomas consistent with the principles of personalized medicine. This study identified detectable oncogene fusions in glioma patients through an integrated analysis of genomic and transcriptomic data, which encompassed whole exon sequencing and next-generation RNA sequencing. In addition, this study also conducted a comparison of the genetic characteristics, tumor microenvironment, mutation burden and survival between glioma patients with or without gene fusions.

Biologic Therapy Is Associated With Improved Oncologic Outcomes in Crohn's Disease-Associated Colorectal Cancer.

Background: Patients with Crohn's disease face an elevated risk of colorectal cancer, in part due to underlying chronic inflammation. Biologic therapy is the mainstay of medical treatment; however, the impact of treatment on colorectal cancer-related outcomes remains unclear.

Objective: To investigate the association between prior exposure to biologic treatment and colorectal cancer-related outcomes in patients with underlying Crohn's disease.

Incidence and Risk Factors for Nonreversal of Stoma in Patients With Crohn's Disease: A Single-Center Study.

Background: Even in the biological era, permanent stoma is not uncommon in patients with Crohn's Disease.

Objective: This study aimed to investigate the incidence and risk factors of permanent stoma in Crohn's disease patients and provide clinical evidence for reducing this disabling outcome.

Design: Consecutive patients with Crohn's disease who underwent ostomies in the past decade were reviewed.

Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone.

Background: Cellular histones are DNA-binding nuclear proteins involved in chromatin remodelling and regulation of gene expression. However, extracellular histones act as damage-associated molecular patterns (DAMPs) and contribute to multiorgan damage in conditions with sepsis and diseases with acute critical illnesses. Alongside, histones are associated with thrombocytopenia due to dysfunctional platelets that regulate hemostasis and thrombosis.

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Introducción: La Terapia de Estimulación Cognitiva (TEC) se originó en el Reino Unido. Se trata de un programa de estimulación que ha demostrado en un estudio multicéntrico, leatorizado y de diseño controlado beneficios en la cognición y la calidad de vida de los pacientes con demencia. La TEC fue adaptada e implementada en más de 30 países.

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Objetivo: evaluar la calidad, hábitos y algunos trastornos del sueño días previos a la declaración del fin de la pandemia por COVID-19. Método: estudio observacional de corte transversal. Encuesta en línea distribuida a través de una plataforma web desde el 1 de marzo al 15 de abril 2023.

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Introducción y objetivo: La Frontal Systems Behavior Scale (FrSBe) es una escala autoadministrable que evalúa cambios comportamentales (apatía, desinhibición y disfunción ejecutiva) luego de una lesión cerebral. El objetivo del trabajo fue obtener indicadores de rendimiento del puntaje total y las sub-escalas de la FrSBe para adultos de habla hispana de la Provincia de Buenos Aires, Argentina, analizar el efecto de variables demográficas y obtener datos normativos del instrumento. Materiales y métodos: se incluyeron 169 participantes y 83 familiares de esos participantes de Buenos Aires que completaron una encuesta para datos demográficos y la versión en español de la FrSBe.

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Objetivo: El acceso efectivo a servicios esenciales es crucial para algunas personas con autismo. En Argentina, el certificado único de discapacidad (CUD) asegura derechos y beneficios esenciales para las personas con autismo. Analizar la demanda de CUD relacionadas con el autismo puede ofrecer valiosos conocimientos sobre las necesidades de esta población.

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El trastorno por déficit de atención e hiperactividad (TDAH) ha sido tradicionalmente concebido como una condición privativa de la infancia. Sin embargo, una creciente evidencia sugiere que el TDAH persiste en la vida adulta, manifestándose de diversas maneras. A pesar de su prevalencia y de las significativas consecuencias en la vida cotidiana, el TDAH en adultos ha sido considerablemente subestimado y subdiagnosticado, lo que resulta en una carga sustancial tanto para los individuos afectados como para su entorno familiar y social.

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El suicidio representa un desafío crítico de salud pública. La presente revisión narrativa se propuso actualizar la evidencia disponible sobre detección y prevención del riesgo, con la finalidad de promover líneas de acción para el abordaje temprano e integral de este complejo y multicausal problema; evaluar la posibilidad de fortalecer políticas, programas y acciones para potenciar los recursos existentes y/o promover la creación de otros nuevos. La prevención destaca la necesidad de estrategias personalizadas y colaboración interdisciplinaria.

Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinical trial.

Background: Increasing evidence suggests that insomnia plays an important role in the development of depression, supporting insomnia intervention as a promising approach to prevent depression in youth. This randomized controlled trial evaluated the effectiveness of app-based cognitive behavioral therapy for insomnia (CBT-I) in preventing future onset of major depressive disorder (MDD) in youth.

Methods And Findings: This was a randomized, assessor-blind, parallel group-controlled trial in Chinese youth (aged 15-25 years) with insomnia disorder and subclinical depressive symptoms.

Determinantes sociales del testeo de VIH en Chile: Resultados a partir de la Encuesta Nacional de Salud, Sexualidad y Género 2022-2023.

Dado el aumento constante en la tasa de incidencia del VIH en Chile, se han impulsado estrategias de prevención conjunta, con la promoción del testeo de VIH como uno de sus pilares fundamentales. El presente estudio se propuso identificar los determinantes sociales del testeo de VIH en la población chilena a partir de datos secundarios provenientes de la Encuesta Nacional de Salud, Sexualidad y Género 2022-2023. Se contó con un diseño transversal y una muestra representativa de 20392 adultos chilenos residentes en sectores urbanos.

Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.

Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting myocardial mitochondrial function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered by the release of cytochrome c. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2) is considered a potential therapeutic target for treating myocardial I/R injury by enhancing the cellular antioxidant capacity through the induction of endogenous antioxidant enzymes.

Contamination of retail market meat with extended-spectrum beta-lactamase genes in Vietnam.

The contamination of retail meat with antibiotic-resistant bacteria poses a substantial public health risk because of the potential spread of these bacteria within communities. The contamination of retail meat with extended-spectrum beta-lactamase (ESBL)-producing bacteria was investigated in four cities in Vietnam using real-time PCR, employing ESBL marker genes. This method provides a more comprehensive assessment of ESBL-producing bacterial contamination in meat samples than culture-based methods because it directly detects resistance genes from the extracted sample DNA.

Effect of triple-frequency sono-germination and soaking treatments on techno-functional characteristics of barley.

This research aimed to evaluate the effect of triple-frequency ultrasound treatment (TFUT), germination (GE), and traditional soaking (TS) methods on the nutritional and techno-functional properties of two different barley varieties, including ZQ2000 and XMLY22. Both ZQ2000 and XMLY22 varieties exhibited the highest total phenolic content (TPC) with 840.73 ± 23.

Association of different emotional support status with cardio-cerebrovascular diseases.

Background: Evidence suggests that emotional status affect physical health. We aimed to investigate the association of different emotional support sources with morbidity or mortality of cardio-cerebrovascular diseases (CVDs).

Methods: We conducted a retrospective-cohort analysis using data in National Health and Nutrition Examination Survey from 1999 to 2004.

Control of metalloenzyme activity using photopharmacophores.

Metalloenzymes are responsible for numerous physiological and pathological processes in living organisms; however, there are very few FDA-approved metalloenzyme-targeting therapeutics (only ~ 67 FDA-approved metalloenzyme inhibitors as of 2020, less than ~ 5 % of all FDA-approved therapeutics). Most metalloenzyme inhibitors have been developed to target the catalytic metal centers in metalloenzymes the incorporation of metal-binding groups. Light-controlled inhibition of metalloenzymes has been used as a means to specifically activate and inactivate inhibitor engagement at a desired location and time light irradiation, allowing for precise spatiotemporal control over metalloenzyme activity.

Application of advanced quantum dots in perovskite solar cells: synthesis, characterization, mechanism, and performance enhancement.

Quantum dots have garnered significant interest in perovskite solar cells (PSCs) due to their stable chemical properties, high carrier mobility, and unique features such as multiple exciton generation and excellent optoelectronic characteristics resulting from quantum confinement effects. This review explores quantum dot properties and their applications in photoelectronic devices, including their synthesis and deposition processes. This sets the stage for discussing their diverse roles in the carrier transport, absorber, and interfacial layers of PSCs.