Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains.

The outbreak and persistence of coronavirus disease 2019 (COVID-19) threaten human health. B cells play a vital role in fighting the infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite many studies on the immune responses in COVID-19 patients, it is still unclear how B cell receptor (BCR) constituents, including immunoglobulin heavy (IGHs) and light chains (IGLs), respond to SARS-CoV-2 in patients with varying symptoms.

[Analysis of malaria situation in Quanzhou City, 1963-2012].

Objective: To understand the situation of malaria in Quanzhou City for 50 years, so as to provide the evidence for eliminating malaria.

Methods: The data of epidemic situation of malaria and intermediary surveillance were collected and analyzed statistically from 1963 to 2012.

Results: The incidence of malaria has been periodically increased, but seasonal distribution was not obvious.

[Imported malaria and control strategies in Quanzhou City].

Objective: To understand the epidemic situation of imported malaria in Quanzhou City, and put forward control strategies, so as to provide the evidence for the elimination of malaria on time in 2014.

Methods: The data of epidemic situation, the annual sheets, and case investigation tables of malaria were collected and analyzed statistically in Quanzhou City from 2007 to 2011.

Results: The total imported malaria cases were 15 in Quanzhou City from 2007 to 2011, all the cases were male, and 46.