Energy intake restriction significantly improves POCD after internal fixation of tibial fractures in mice.

Objective: To investigate the effect of energy intake restriction on postoperative cognitive dysfunction (POCD) after internal fixation of tibial fractures in mice.

Methods: Thirty mice were divided into model groups of internal fixation of tibial fractures with 0%, 20%, 30% and 40% energy intake restriction and sham operation group (n = 6). Novel object recognition task and elevated plus maze test were used to assess the ability of recognition memory and anxiety-related behavior before and one week after surgery.

Tocilizumab attenuates acute lung injury in rats with sepsis by regulating S100A12/NLRP3.

Objective: To investigate the mechanism of Tocilizumab (TCZ) in attenuating acute lung injury in rats with sepsis by regulating the S100A12/NLRP3 axis.

Methods: A rat model of sepsis was constructed using cecal ligation and puncture (CLP). Rats were treated with TCZ, and their lung tissue was collected.

[Comparative study on the effect of microscopic revascularization and apexification in the treatment of pulp necrosis of permanent teeth].

Purpose: To compare the curative effect of microscopic revascularization and apexification in the treatment of pulp necrosis of permanent teeth.

Methods: Seventy-five cases of pulp necrosis in young permanent teeth were divided into two groups according to different treatment methods. Group A (n=30) underwent revascularization under microscope, while group B (n=45) underwent apexification.

[Study on the mechanism of endothelial progenitor cells in periodontal revascularization during orthodontic tooth movement].

Purpose: To investigate the mechanism of endothelial progenitor cells(EPCs) bone remodeling during orthodontic tooth movement.

Methods: Experimental tooth movement model was established. EPCs were isolated, cultured, and labeled with 10 μmol/L Brdu and injected into rats through tail vein to observe the distribution in periodontal tissue.

Vitamin D retards intervertebral disc degeneration through inactivation of the NF-κB pathway in mice.

To determine the efficacy and specific mechanism of vitamin D on intervertebral disc degeneration. The model of intervertebral disc degeneration was established in 3-month-old mice. Furthermore, the levels of intervertebral disc degeneration in the vitamin D group and the control group were detected one month later by X-ray, Western boltting, quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) et al.