Hierarchical deep learning model to simulate phytoplankton at phylum/class and genus levels and zooplankton at the genus level.

Harmful algal blooms (HABs) have become a global issue, affecting public health and water industries in numerous countries. Because funds for monitoring HABs are limited, model development may be an alternative approach for understanding and managing HABs. Continuous monitoring based on grab sampling is time-consuming, costly, and labor-intensive.

Adverse events following third dose of mRNA COVID-19 vaccination among nursing home residents who received the primary series.

Background: We sought to compare rates of adverse events among nursing home residents who received an mRNA COVID-19 vaccine booster dose with those who had not yet received their booster.

Methods: We assessed a prospective cohort of 11,200 nursing home residents who received a primary COVID-19 mRNA vaccine series at least 6 months prior to September 22, 2021 and received a third "booster dose" between September 22, 2021 and February 2, 2022. Residents lived in 239 nursing homes operated by Genesis HealthCare, spanning 21 U.

Dissipation rates, residue distribution, degradation products, and degradation pathway of sulfoxaflor in broccoli.

Broccoli was selected as the research object in this paper to reveal the dissipation, distribution, and degradation pathway of sulfoxaflor under greenhouse and open-field cultivation conditions for the ecological risk assessment of sulfoxaflor. Results showed that the dissipation of sulfoxaflor in broccoli leaves, flowers, stems, roots, and the whole broccoli was in accordance with the first-order kinetic equation. The sulfoxaflor concentration in broccoli roots reached the maximum value after 1 day of application and then gradually decreased.

Spatial and temporal effects of fish feed on antibiotic resistance in coastal aquaculture farms.

For the first time, both spatial and temporal effects of fish feed on changes in abundance of antibiotic resistance genes (ARGs) were investigated in South Korea via quantifying ARGs and analyzing physicochemical parameters in the influent (IN) and effluent before (BF) and 30 min after (AF) the fish feeding time of sixteen flow-through fish farms. The absolute abundance of ARGs in AF samples was 5 times higher than in BF and 12 times higher than in IN samples. Values of physicochemical parameters such as ammonia, total nitrogen, suspended solids and turbidity in the effluent significantly increased by 21.

Identification of factors affecting removal of antibiotic resistance genes in full-scale anaerobic digesters treating organic solid wastes.

Efficiencies of removing antibiotic resistance genes (ARGs) and intI1 were explored using eight full-scale anaerobic digesters. The digesters demonstrated different characteristics on the basis of substrate types (food waste, manure or sludge); configuration (single or two-stage); temperature (psychrophilic, mesophilic or thermophilic); hydraulic retention time (HRT) (9.7-44 days); and operation mode (continuous stirred tank reactor or plug flow reactor).

Access to community-based reproductive health services and incidence of low birthweight delivery among refugee and displaced mothers: a retrospective study in the Thailand-Myanmar border region.

Objectives: Over 2.4 million people have been displaced within the Thailand-Myanmar border region since 1988. The efficacy of community-driven health models within displaced populations is largely unstudied.

Activation of persulfate by humic substances: Stoichiometry and changes in the optical properties of the humic substances.

Persulfate activation through electron transfer from humic substances (HS) was investigated. Persulfate consumption in the presence of standard HS and HS model compounds linearly correlated with the phenol contents of the HS. Redox-active carbonyl groups such as aromatic ketones and quinone also contributed to persulfate consumption by donating electrons while being reduced.

LYRUS: a machine learning model for predicting the pathogenicity of missense variants.

Summary: Single amino acid variations (SAVs) are a primary contributor to variations in the human genome. Identifying pathogenic SAVs can provide insights to the genetic architecture of complex diseases. Most approaches for predicting the functional effects or pathogenicity of SAVs rely on either sequence or structural information.

The chronic disease Self-Management Programme: A phenomenological study for empowering vulnerable patients with chronic diseases included in the EFFICHRONIC project.

Introduction: The Chronic Disease Self-Management Programme (CDSMP) has resulted in improved health outcomes for patients. However, research has focused mainly on those with chronic conditions and has not extensively explored prevention programmes targeting individuals with specific vulnerability profiles.

Aim: This study aimed to understand the effects of the CDSMP on the lived experience of vulnerable patients included in the EFFICHRONIC project in France, based on their needs and expectations before and after participation.

The effect of levetiracetam treatment on survival in patients with glioblastoma: a systematic review and meta-analysis.

Background: Levetiracetam (LEV) is an anti-epileptic drug (AED) that sensitizes glioblastoma (GBM) to temozolomide (TMZ) chemotherapy by inhibiting O-methylguanine-DNA methyltransferase (MGMT) expression. Adding LEV to the standard of care (SOC) for GBM may improve TMZ efficacy. This study aimed to pool the existing evidence in the literature to quantify LEV's effect on GBM survival and characterize its safety profile to determine whether incorporating LEV into the SOC is warranted.

Reaction kinetics and degradation efficiency of halogenated methylparabens during ozonation and UV/HO treatment of drinking water and wastewater effluent.

This study investigated the reaction kinetics and degradation efficiency of methylparaben and its halogenated products (Cl-, Br-, Cl,Cl-, Br,Cl-, and Br,Br-methylparabens) during ozonation and UV/HO treatment. Second-order rate constants for reactions of the parabens with ozone and OH were [Formula: see text] = 10 - 10 M s and [Formula: see text] = (2.3 - 4.

Transcriptome analysis reveals the molecular mechanism of boron deficiency tolerance in leaves of boron-efficient Beta vulgaris seedlings.

Sugar beet (Beta vulgaris L.) has a high demand for B, and B deficiency inhibits normal growth and productivity. However, there is a lack of information on how B deficiency affects the growth of beet at the transcriptome level, and the factors that govern B utilisation efficiency.

Adverse Events Following One Dose of mRNA COVID-19 Vaccination Among US Nursing Home Residents With and Without a Previous SARS-CoV-2 Infection.

Objectives: To compare rates of adverse events following Coronavirus Disease 2019 (COVID-19) vaccination among nursing home residents with and without previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design: Prospective cohort.

Setting And Participants: A total of 20,918 nursing home residents who received the first dose of messenger RNA COVID-19 vaccine from December 18, 2020, through February 14, 2021, in 284 facilities within Genesis Healthcare, a large nursing home provider spanning 24 US states.

Effect of seasonal succession of algal communities on fouling of MF membrane.

An emerging threat to membrane application is the seasonal proliferation of algae in water sources such as rivers, reservoirs and lakes. This study investigated the link between feed parameters and the membrane performance of a pilot-scale microfiltration (MF) plant for 7 months. The seasonal succession of algae in relation to temperature dynamics was monitored.

A natural single-nucleotide polymorphism variant in sulfite reductase influences sulfur assimilation in maize.

Plants absorb sulfur from the environment and assimilate it into suitable forms for the biosynthesis of a broad range of molecules. Although the biochemical pathway of sulfur assimilation is known, how genetic differences contribute to natural variation in sulfur assimilation remains poorly understood. Here, using a genome-wide association study, we uncovered a single-nucleotide polymorphism (SNP) variant in the sulfite reductase (SiR) gene that was significantly associated with SiR protein abundance in a maize natural association population.

Adverse events following mRNA SARS-CoV-2 vaccination among U.S. nursing home residents.

Background: The devastating impact of the SARS-CoV-2 pandemic prompted the development and emergency use authorization of two mRNA vaccines in early 2020. Vaccine trials excluded nursing home (NH) residents, limiting adverse event data that directly apply to this population.

Methods: To prospectively monitor for potential adverse events associated with vaccination, we used Electronic Health Record (EHR) data from Genesis HealthCare, the largest NH provider in the United States.

Increasing Advance Care Planning Conversations Among Korean Americans Through a Faith Community Nurse Intervention.

Minority populations have lower rates of advance care planning (ACP) than the general population. Faith community nurses (FCNs) can facilitate ACP training to improve end-of-life care outcomes for patients and caregivers. A nurse-led ACP training delivered to a primarily Korean American faith community increased the number of families who discussed end-of-life care values and wishes.

2017 National Standards for Diabetes Self-Management Education and Support.

Purpose: The purpose of this study is to review the literature for Diabetes Self-Management Education and Support (DSMES) to ensure the National Standards for DSMES (Standards) align with current evidence-based practices and utilization trends.

Methods: The 10 Standards were divided among 20 interdisciplinary workgroup members. Members searched the current research for diabetes education and support, behavioral health, clinical, health care environment, technical, reimbursement, and business practice for the strongest evidence that guided the Standards revision.

Lensoside Aβ as an Adjuvant to the Anti-Glioma Potential of Sorafenib.

Aim: The anti-glioma effect of lensoside Aβ alone and in combination with sorafenib (pro-survival Raf kinase inhibitor) was evaluated for the first time in terms of programmed cell death induction in anaplastic astrocytoma and glioblastoma multiforme cell lines as an experimental model. Apoptosis, autophagy, and necrosis were identified microscopically (fluorescence and scanning microscopes) and confirmed by flow cytometry (mitochondrial membrane potential MMP and cell death). The expression of apoptotic (caspase 3) and autophagic markers (beclin 1) as well as Raf kinase were estimated by immunoblotting.

A Phylogenetic Approach to Analyze the Conservativeness of BRCA1 and BRCA2 Mutations.

Identifying pathogenic mutations in BRCA1 and BRCA2 is a critical step for breast cancer prediction. Genome-wide association studies (GWAS) are the most commonly used method for inferring pathogenic mutations. However, identifying pathogenic mutations using GWAS can be difficult.

Coding Free-Text Chief Complaints from a Health Information Exchange: A Preliminary Study.

Chief complaints are important textual data that can serve to enrich diagnosis and symptom data in electronic health record (EHR) systems. In this study, a method is presented to preprocess chief complaints and assign corresponding ICD-10-CM codes using the MetaMap natural language processing (NLP) system and Unified Medical Language System (UMLS) Metathesaurus. An exploratory analysis was conducted using a set of 7,942 unique chief complaints from the statewide health information exchange containing EHR data from hospitals across Rhode Island.

Extracting Angina Symptoms from Clinical Notes Using Pre-Trained Transformer Architectures.

Anginal symptoms can connote increased cardiac risk and a need for change in cardiovascular management. In this study, a pre-trained transformer architecture was used to automatically detect and characterize anginal symptoms from within the history of present illness sections of 459 primary care physician notes. Consecutive patients referred for cardiac testing were included.