THBS1 is a new autosomal recessive non-syndromic hearing impairment gene.

Background: Prelingual hearing impairment (HI) is genetically highly heterogenous. Early diagnosis and intervention are essential for psychosocial development. In this study we investigated a consanguineous family from Pakistan with autosomal recessive (AR) non-syndromic sensorineural HI (NSHI).

Pharmacological investigation of selected 1,2,4 triazole derivative against ethanol induced gastric ulcer.

The present study aims to assess the therapeutic potential of (2S,3S,4S,5S,6S-2-(acetoxymethyl)-6-(4-chlorophenyl)-3-(pyridine-4-yl)5-thioxo-4,5-dihydro-1,2,4-triazol-1-yl tetrahydro-2H-pyran 3,4,5tryltriacetate (JAK05) on gastric ulcer. The current study was designed to evaluate the anti-ulcer potential of JAK05 against ethanol-induced gastric ulcer by employing in silico, in vitro and in vivo techniques. In silico studies, JAK05 has a binding score ranging from -8.

Correction: Habib et al. Thiolated Chitosan Microneedle Patch of Levosulpiride from Fabrication, Characterization to Bioavailability Enhancement Approach. 2022, , 415.

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Chaos analysis of nonlinear variable order fractional hyperchaotic Chen system utilizing radial basis function neural network.

This research explores the various chaotic features of the hyperchaotic Chen dynamical system within a variable order fractional (VOF) calculus framework, employing an innovative approach with a nonlinear and adaptive radial basis function neural network. The study begins by computing the numerical solution of VOF differential equations for the hyperchaotic Chen system through a numerical scheme using the Caputo-Fabrizio derivative across a spectrum of different system control parameters. Subsequently, a comprehensive parametric model is formulated using RBFNN, considering the system's various initial values.

Evaluation of Antimicrobial Peptides in Saliva as Potential Therapeutic Agents Against Oral Pathogens in Pakistan.

Background: Maintaining optimal oral health is essential for overall well-being; however, conditions such as dental caries and gingivitis remain prevalent in Pakistan and are further worsened by increasing antibiotic resistance.

Objective: To evaluate the antimicrobial properties of salivary peptides as potential therapeutic agents against common oral pathogens in Pakistan.

Methodology: A one-year cross-sectional study was conducted in Lahore, Pakistan, at Sharif Medical and Dental College and Akhter Saeed Medical and Dental College, involving 384 participants aged 18-65 years.

In silico designing and characterization of outer membrane protein (OmpC) gene from Salmonella enterica and its expression in Nicotiana tabacum for developing a plant-based vaccine against salmonellosis.

Salmonella, a gram-negative bacteria, is the leading cause of foodborne illness globally. Two serovars of Salmonella, S. enteritidis and S.

Modeling and forecasting carbon dioxide emission in Pakistan using a hybrid combination of regression and time series models.

Carbon dioxide (CO) emissions continue to rise globally despite efforts to combat climate change. Energy industry emissions are a pressing global issue, causing devastating impacts. Hence, it is vital to accurately and efficiently forecast CO emissions.

Electrifying energy storage by investigating the electrochemical behavior of CoCrO/graphene-oxide nanocomposite as supercapacitor high performance electrode material.

This study reports novel three-step electrochemical fabrication of CoCrO/graphene-oxide nanocomposite on glassy carbon electrode including sequential synthesis of graphene-oxide using modified Hummer's method, CoCrO nanoparticles using sol-gel method and the cost-effective co-precipitation technique for nanocomposite formation. The resulting nanocomposite was subjected to comprehensive analytical and morphological analysis. X-ray diffractometry (XRD) confirms nanocomposite formation with reduced average crystallite size value of 26.

Revolutionizing diabetes care with innovative decision-making using cubic intuitionistic fuzzy Schweizer and Sklar power aggregation operators.

The cubic intuitionistic fuzzy set is an expansion of the cubic fuzzy set that displays massive information to demonstrate interval-valued intuitionistic fuzzy sets and intuitionistic fuzzy sets. This increment informs limitations essential in existing frameworks, primarily focusing on the significance of embracing our access for more accurate decisions in compound and unresolved structures. The Schweizer and Sklar (SS) operations are engaged in promoting strong aggregation operators for cubic intuitionistic fuzzy sets through this research.

On the development of survey methods for novel mean imputation and its application to abalone data.

Non-response in surveys is a common problem faced by surveyors, this results in missing data. Missing values are often omitted when doing any statistical analysis, but this reduces the sample size and consequently decreases the precision of estimates. In such situations, imputation is a commonly used method to deal with missing data, this involves estimating the missing values based on the observed data.

Complete genome sequence of an ST7366 strain harboring an extended-spectrum β-lactamase gene isolated from sewage water in Pakistan.

We announce the complete genome of strain PEC1003 belonging to ST7366, isolated from sewage water in Pakistan. This strain harbored a plasmid carrying various antibiotic resistance genes, including extended-spectrum β-lactamase (ESBL), , emphasizing the management and surveillance of ESBL-producing in the environment of developing countries.

Relationship of difficult endoscopic retrograde cholangiopancreatography cannulation and visual characteristics of papilla.

Background And Aim: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used to diagnose and treat bile duct and pancreatic disorders. Successful cannulation of the papilla is crucial for the effectiveness of ERCP; however, sometimes, it can be challenging to achieve. This study explores the relationship between net difficult ERCP cannulation with bile visibility, papilla orifice visibility, and papilla position and compares it with successful cannulation.

Naringenin loaded solid lipid nanoparticles alleviate oxidative stress and enhance oral bioavailability of naringenin.

Naringenin (Nrg) is the most abundant natural dietary flavonoid with promising anti-inflammatory potential. However, its therapeutic application is limited due to poor absorption, low bioavailability, and inability to cross physiological barriers. Herein, we designed biocompatible solid lipid nanoparticles (SLNs) to overcome these challenges and to enhance the oral bioavailability and therapeutic potential of Nrg.

Nephroprotective Potential of 1,3,4-Oxadiazole Derivative Against Methotrexate-Induced Nephrotoxicity in Rats by Upregulating Nrf2 and Downregulating NF-κB and TNF-α Signaling Pathways.

Nephrotoxicity is a prominent complication of methotrexate (MTX) therapy that limits clinicians in its extensive use. MTX triggers oxidative burden and inflammation, so the nephroprotective potential of the synthetic derivative of 1,3,4-oxadiazole (5b) was explored in this research. Male Wistar rats were divided into four groups i.

Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities.

Monoterpene indole alkaloids (MIAs) are valuable metabolites produced in numerous medicinal plants from the Apocynaceae family such as Alstonia scholaris, which synthesizes strictamine, a MIA displaying neuropharmacological properties of a potential importance. To get insights into the MIA metabolism in A. scholaris, we studied here both the spatial and transcriptional regulations of MIA genes by performing a robust transcriptomics analysis of the main plant organs, leaf epidermis but also by sequencing RNA from leaves transiently overexpressing the master transcriptional regulator MYC2.

Recognition of Conus species using a combined approach of supervised learning and deep learning-based feature extraction.

Cone snails are venomous marine gastropods comprising more than 950 species widely distributed across different habitats. Their conical shells are remarkably similar to those of other invertebrates in terms of color, pattern, and size. For these reasons, assigning taxonomic signatures to cone snail shells is a challenging task.

A framework for generating recommendations based on trust in an informal e-learning environment.

Rapid advancement in information technology promotes the growth of new online learning communities in an e-learning environment that overloads information and data sharing. When a new learner asks a question, how a system recommends the answer is the problem of the learner's cold start. In this article, our contributions are: (i) We proposed a Trust-aware Deep Neural Recommendation (TDNR) framework that addresses learner cold-start issues in informal e-learning by modeling complex nonlinear relationships.

Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice.

Background: Stress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression, oxidative stress, increased levels of neuroinflammatory cytokines, and increased expression of apoptotic genes contribute to the underlying cause of the seizure.

Recent trends in production and potential applications of microbial amylases: A comprehensive review.

α-amylases are vital biocatalysts that constitute a billion-dollar industry with a substantial and enduring global demand. Amylases hydrolyze the α-1,4-glycosidic linkages in starch polymers to generate maltose and malto-oligosaccharides subunits. Amylases are key enzymes that have promising applications in various industrial processes ranging from pharmaceutical, pulp and paper, textile food industries to bioremediation and biofuel sectors.

Synthesis and evaluation of drug-loaded silver nanoparticles as hemostatic agents to halt uncontrolled bleeding.

Objective: The aim of this research study was to formulate a cost-effective, stable, less toxic and more efficacious intravenous nanoformulation that could rapidly augment the process of hemostasis.

Significance: Silver nanoparticles (AgNPs) evoked platelet activation, whereas alum (AM) neutralized the plasma proteins, causing blood coagulation. Tranexamic acid (TA) inhibited fibrinolysis and stabilized the formed blood clot.

Significance of finite difference approach for application of Cattaneo-Christov theory conveying radiative ternary-hybrid nanofluids flow.

This paper investigates the characteristics of ternary-hybrid nanoliquid for time-dependent Darcy-Forchheimer flow. Formulation is based for mixture of water subject to ternary nanoparticles with different shapes like (platelet, spherical and cylindrical). Heat transfer consists of convective condition, radiation and heat generation.

Barley a nutritional powerhouse for gut health and chronic disease defense.

Background: Digestive issues are recognized as significant contributors to various chronic diseases, including obesity, diabetes, and cardiovascular disease. Barley, a traditional grain, offers considerable promise in addressing these health challenges due to unique nutritional and bioactive compounds.

Objective: This review examines the therapeutic potential of various parts of barley, underutilized resource, for chronic disease prevention and management.