Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure-activity relationship (SAR): a new treatment opportunity for Alzheimer's disease.

It is believed that inflammation influences several physiological processes, including the function of the central nervous system. Moreover, the impairment of lipid mechanisms/pathways is associated with neurodegenerative disorders and onset of Alzheimer's disease (AD). AD is a chronic neurodegenerative disease representing the major cause of dementia worldwide.

Electrochemical analysis of anticancer and antibiotic drugs in water and biological specimens.

The increasing prevalence of pharmaceuticals in water and complex matrices necessitates accurate measurement and monitoring of their environmental contamination levels. This is crucial not only for environmental conservation but also for comprehending the intricate mechanisms involved and developing more effective treatment approaches. In this context, electrochemical techniques show significant potential for the detection of pharmaceuticals across various matrices.

Novel interfaces for internet of wearable electrochemical sensors.

The integration of wearable devices, the Internet of Things (IoT), and advanced sensing platforms implies a significant paradigm shift in technological innovations and human interactions. The IoT technology allows continuous monitoring in real time. Thus, Internet of Wearables has made remarkable strides, especially in the field of medical monitoring.

Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies.

To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives (6a-j) were designed and synthesized straightforward and multistep synthesis. The structure of these derivatives (6a-j) was confirmed by FTIR, H, and C NMR spectroscopic techniques. The biological screening of these compounds was carried out to assess their bacterial, α-amylase, and proteinase K inhibition potential.

Thermo-catalytic decomposition of cotton seed press cake over nickel doped zeolite Y, hydrogen: enhanced yield of bio-oil with highly selective fuel-range hydrocarbons.

This research reports the yield of bio-oil from cotton seed press cake (CSPC) an optimized thermo-catalytic pyrolysis using nickel impregnated zeolite Y, hydrogen catalyst. The catalyst, raw biomass and catalyst impregnated biomass were characterized using different analytical techniques. The ideal temperature, duration, and catalyst concentration for pyrolysis experiments were determined to be 300 °C, 20 minutes, and 5% of Ni-doped zeolite Y, hydrogen, respectively, in order to achieve the best bio-oil yield (35%).

Visible light driven (VLD) reduced TiO nanocatalysts designed by inorganic and organic reducing agent-mediated solvothermal methods for electrocatalytic and photocatalytic applications.

This work presents a comparative study on the structural, optical and electrochemical characteristics of visible light driven (VLD) reduced titanium dioxide (TiO ) nanocatalysts synthesized inorganic and organic synthetic routes. X-ray diffraction (XRD) patterns, Raman spectra and X-ray absorption fine structure (XAFS) analyses reflected anatase phase titania. Whereas, the quantitative EXAFS fit and XANES analysis revealed structural distortion due to the presence of oxygen and titanium vacancies with low valent Ti states in anatase lattices of certain nanocatalysts, which subsequently leads to better electrochemical and photocatalytic activities.

Electrochemical and optical protocols for the detection and removal of an antibiotic drug rifaximin from wastewater.

Improper disposal of pharmaceutical drugs is increasing the pollution level of water reservoirs which in turn adversely impacts the ecosystem. The current study presents an electrochemical scaffold that comprises a glassy carbon electrode modified with amino-functionalized multiwalled carbon nanotubes (NH-MWCNTs) for the detection of a pharmaceutical drug rifaximin in wastewater. Electrochemical impedance spectroscopic characterization revealed efficient charge transport through the modified electrode surface.

MXene boosted MOF-derived cobalt sulfide/carbon nanocomposites as efficient bifunctional electrocatalysts for OER and HER.

The development of effective bifunctional electrocatalysts that can realize water splitting to produce oxygen and hydrogen through oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is still a great challenge to be addressed. Herein, we report a simple and versatile approach to fabricate bifunctional OER and HER electrocatalysts derived from ZIF67/MXene hybrids sulfurization of the precursors in hydrogen sulfide gas atmosphere at high temperatures. The as-prepared CoS@C/MXene nanocomposites were characterized using a series of technologies including X-ray diffraction, gas sorption, scanning electronic microscopy, transmission electronic microscopy, energy dispersive spectroscopy, and X-ray photoelectron spectroscopy.

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review.

Acyl thioureas represent a privileged moiety with vast potential applicability across diverse fields, making them the subject of extensive research efforts. The inherent flexibility of thiourea facilitates the synthesis of a wide range of core structures with diverse functionalities and properties. The distinctive presence of hard and soft donor sites renders acyl thioureas inclined to act as versatile ligands, thereby engendering a diverse array of metal complexes incorporating acyl thiourea as a pivotal ligand.

Novel isatin-triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies.

Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin-triazole hybrids 3a and 3b were accessed copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC), together with their mono and bis-thiosemicarbazone derivatives 4a-h and 5a-h. In addition to the characterization by physical, spectral and analytical data, a DFT study was carried out to obtain the optimized geometries of all thiosemicarbazones.

High performance electrochemical CO reduction over Pd decorated cobalt containing nitrogen doped carbon.

Efficient electrocatalytic CO reduction reaction (eCORR) to various products, such as carbon monoxide (CO), is crucial for mitigating greenhouse gas emissions and enabling renewable energy storage. In this article, we introduce Pd nanoparticles which are deposited over in-house synthesized nitrogen doped tubular carbon (NC) whose ends are blocked with cobalt oxide (CoOx). This composite material is denoted as Pd@CoOx/NC.

Comprehensive assessment of carbon-, biomaterial- and inorganic-based adsorbents for the removal of the most hazardous heavy metal ions from wastewater.

Owing to the high cost of recycling waste, underdeveloped countries discharge industrial, agricultural, and anthropogenic effluents without pretreatment. As a result, pollutant-loaded waste enters water bodies. Among the diverse toxic contaminants, heavy metal ions are the most detrimental because of their chronic toxicity, non-degradability, prevalence, and bioaccumulation.

An integrated experimental and theoretical approach to probe Cr(vi) uptake using decorated halloysite nanotubes for efficient water treatment.

Halloysite nanotubes (HNTs) were surface functionalized using four distinct chemical moieties (amidoxime, hydrazone, ethylenediamine (EDA), and diethylenetriamine (DETA)), producing modified HNTs (H1-H4) capable of binding with Cr(vi) ions. Advanced techniques like FTIR, XRD, SEM, and EDX provided evidence of the successful functionalization of these HNTs. Notably, the functionalization occurred on the surface of HNTs, rather than within the interlayer or lumen.

Electrochemical detection and removal of brilliant blue dye photocatalytic degradation and adsorption using phyto-synthesized nanoparticles.

Herein, we report a sensitive electrochemical platform prepared by modifying the electrode surface with copper-doped zinc oxide nanoparticles; these nanoparticles were prepared a green synthetic approach using the extract of leaves and multiwalled carbon nanotubes (MWCNTs). For the best response of the electrode modifier, a number of experimental conditions were optimized to obtain the most intense signal of the target analyte Coomassie brilliant blue using a rapid analysis technique square wave voltammetry. The designed sensor displayed remarkable sensitivity for Coomassie brilliant blue with a detection limit of 0.

Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies.

In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a-j) was designed and synthesized through a multistep sequence and the synthesized compounds were screened for their antifungal, antibacterial and antioxidant activities as well as urease, amylase and α-glucosidase inhibitory activities. The synthesized series (5a-o) was characterized using a combination of spectroscopic techniques, including FT-IR, H NMR and C NMR. All compounds (5a-j) were found to have significant potency against urease, α-glucosidase, α-amylase, and DPPH.

Palladium-anchored donor-flexible pyridylidene amide (PYA) electrocatalysts for CO reduction.

The conversion of CO into CO as a substitute for processing fossil fuels to produce hydrocarbons is a sustainable, carbon neutral energy technology. However, the electrochemical reduction of CO into a synthesis gas (CO and H) at a commercial scale requires an efficient electrocatalyst. In this perspective, a series of six new palladium complexes with the general formula [Pd(L)(Y)]Y, where L is a donor-flexible PYA, ,-bis(1-ethylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, ,-bis(1-butylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, or ,-bis(1-benzylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, and Y = OAc or Cl, were utilized as active electrocatalysts for the conversion of CO into a synthesis gas.

Synthesis, biological evaluation and investigations of benzotriazole derivatives as potential inhibitors of NIMA related kinase.

In the current study, a novel compound, bis(3-(2-benzo[][1,2,3]triazol-2-yl)-2-(prop-2-yn-1-yloxy)-5-(2,4,4-trimethylpentan-2-yl)phenyl)methane (TAJ1), has been synthesized by the reaction of 6,6'-methylenebis(2-(2-benzo[][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol) (1), propargyl bromide (2) and potassium carbonate. Spectroscopic (FTIR, H-NMR, C-NMR) and single-crystal assays proved the structure of the synthesized sample. XRD analysis confirmed the structure of the synthesized compound, showing that it possesses two aromatic parts linked a -CH carbon with a bond angle of 108.

Recent biological applications of heterocyclic hybrids containing -triazine scaffold.

-Triazine possesses an auspicious status in the field of drug discovery and development owing to its presence in many naturally occurring compounds as well as commercially available drugs like enasidenib, gedatolisib, bimiralisib, atrazine, indaziflam, and triaziflam. Easy, cost-effective, and efficient access to its derivatives in addition to their splendid biological activities such as anticancer, anti-inflammatory, antiviral, anticonvulsant, anti-tubercular, antidiabetic, antimicrobial, makes it an attractive heterocyclic nucleus in the field of medicinal chemistry. Other than the direct access of its derivatives from simple commercially available starting materials like amidine, the -triazine derivatives have also been obtained starting from an inexpensive commercially available 2,4,6-trichloro-1,3,5-triazine (TCT) commonly known as cyanuric chloride.

Insight into a pure spinel CoO and boron, nitrogen, sulphur (BNS) tri-doped CoO-rGO nanocomposite for the electrocatalytic oxygen reduction reaction.

The intricate problems concerning energy require innovative solutions. Herein, we propose a smart composite nano system that can be used in a sustainable and dichotomous manner to resolve energy crises. The current study describes a new way to synthesize a pure spinel cobalt oxide (CoO) and boron (B), nitrogen (N), and sulfur (S) tri-doped CoO-reduced graphite oxide (rGO) nanocomposite (CBNS).

Molybdenum disulfide (MoS) along with graphene nanoplatelets (GNPs) utilized to enhance the capacitance of conducting polymers (PANI and PPy).

Hybrid composites of molybdenum disulfide (MoS), graphene nanoplatelets (GNPs) and polyaniline (PANI)/polypyrrole (PPy) have been synthesized as cost-effective electrode materials for supercapacitors. We have produced MoS from molybdenum dithiocarbamate by a melt method in an inert environment and then used a liquid exfoliation method to form its composite with graphene nanoplatelets (GNPs) and polymers (PANI and PPy). The MoS melt/GNP ratio in the resultant composites was 1 : 3 and the polymer was 10% by wt.

Neem plant extract-assisted synthesis of CeO nanoparticles for photocatalytic degradation of piroxicam and naproxen.

Piroxicam and naproxen are well-known non-steroidal anti-inflammatory drugs that are frequently detected in aquatic environments due to their widespread usage and improper disposal practices. This research investigates the photocatalytic degradation of these drugs by using CeO nanoparticles. The nanoparticles were synthesized by using plant extract and were characterized through various characterization techniques such as UV-visible spectroscopy, FTIR spectroscopy, SEM, EDX, and XRD.

Raman spectroscopy of a few layers of bismuth telluride nanoplatelets.

We can shape the electronic and phonon properties of BiTe crystals the variation of the number of layers. Here, we report a Raman study with the aid of first-principles calculations on few-layered BiTe systems ranging from 5 to 24 nm layer thickness using 1.92, 2.

Synthesis of novel coumarin-hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies.

Diabetes mellitus is a metabolic disorder and more than 90% of diabetic patients suffer from type-2 diabetes, which is characterized by hyperglycemia. α-Glucosidase inhibition has become an appropriate approach to tackle high blood glucose levels. The current study was focused on synthesizing coumarin-hydrazone hybrids (7a-i) by using facile chemical reactions.

Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for -NTPDases.

The aim of this research work is the synthesis of sulfamoyl-benzamides as a selective inhibitor for -NTPDases. Sulfonamides are synthesized in aqueous medium from chlorosulfonylbenzoic acid while carboxamides are synthesized using carbodiimide coupling decorated with different biologically relevant substituents such as -butyl, cyclopropyl, benzylamine, morpholine, and substituted anilines. In addition, sulfonamide-carboxamide derivatives were synthesized having the same substituents on either side.