Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for -NTPDases.

The aim of this research work is the synthesis of sulfamoyl-benzamides as a selective inhibitor for -NTPDases. Sulfonamides are synthesized in aqueous medium from chlorosulfonylbenzoic acid while carboxamides are synthesized using carbodiimide coupling decorated with different biologically relevant substituents such as -butyl, cyclopropyl, benzylamine, morpholine, and substituted anilines. In addition, sulfonamide-carboxamide derivatives were synthesized having the same substituents on either side.