85 results match your criteria: "Quaid-i-Azam University Islamabad 45320[Affiliation]"

The increasing prevalence of pharmaceuticals in water and complex matrices necessitates accurate measurement and monitoring of their environmental contamination levels. This is crucial not only for environmental conservation but also for comprehending the intricate mechanisms involved and developing more effective treatment approaches. In this context, electrochemical techniques show significant potential for the detection of pharmaceuticals across various matrices.

View Article and Find Full Text PDF

The integration of wearable devices, the Internet of Things (IoT), and advanced sensing platforms implies a significant paradigm shift in technological innovations and human interactions. The IoT technology allows continuous monitoring in real time. Thus, Internet of Wearables has made remarkable strides, especially in the field of medical monitoring.

View Article and Find Full Text PDF

In silico drug encapsulation using 2-hydroxypropyl-β-CD, tyrosine kinase and tyrosinase inhibition of dinuclear Cu(II) carboxylate complexes.

J Mol Graph Model

January 2025

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.

Article Synopsis
  • Copper carboxylate complexes have gained attention for their potential in biological applications, with this study examining 20 selected Cu(II) complexes and their interaction with the carrier 2-hydroxypropyl-β-cyclodextrin (2HPβCD) to improve drug delivery.
  • Monte Carlo calculations and DFT-D simulations showed that a neutral medium enhances the adsorption of these complexes to 2HPβCD, with certain complexes (4, 5, and 7) demonstrating strong interactions suitable for drug delivery systems.
  • The study also revealed variations in the release efficiency of the complexes and highlighted their potential effects on c-kit tyrosine kinase and Mushroom tyrosinase, where complexes containing 1,
View Article and Find Full Text PDF
Article Synopsis
  • Cefixime is an antibiotic that struggles with solubility and effectiveness, requiring larger doses that can increase healthcare costs and potential side effects.
  • Researchers developed a solution by using franklinite nanostructures to stabilize cefixime, enhancing its properties.
  • The new formulation, Cef-ZnFeO, showed improved solubility, bioavailability, and safety, as well as strong antifungal and antioxidant abilities compared to regular cefixime.
View Article and Find Full Text PDF

This research reports the yield of bio-oil from cotton seed press cake (CSPC) an optimized thermo-catalytic pyrolysis using nickel impregnated zeolite Y, hydrogen catalyst. The catalyst, raw biomass and catalyst impregnated biomass were characterized using different analytical techniques. The ideal temperature, duration, and catalyst concentration for pyrolysis experiments were determined to be 300 °C, 20 minutes, and 5% of Ni-doped zeolite Y, hydrogen, respectively, in order to achieve the best bio-oil yield (35%).

View Article and Find Full Text PDF

This work presents a comparative study on the structural, optical and electrochemical characteristics of visible light driven (VLD) reduced titanium dioxide (TiO ) nanocatalysts synthesized inorganic and organic synthetic routes. X-ray diffraction (XRD) patterns, Raman spectra and X-ray absorption fine structure (XAFS) analyses reflected anatase phase titania. Whereas, the quantitative EXAFS fit and XANES analysis revealed structural distortion due to the presence of oxygen and titanium vacancies with low valent Ti states in anatase lattices of certain nanocatalysts, which subsequently leads to better electrochemical and photocatalytic activities.

View Article and Find Full Text PDF

Improper disposal of pharmaceutical drugs is increasing the pollution level of water reservoirs which in turn adversely impacts the ecosystem. The current study presents an electrochemical scaffold that comprises a glassy carbon electrode modified with amino-functionalized multiwalled carbon nanotubes (NH-MWCNTs) for the detection of a pharmaceutical drug rifaximin in wastewater. Electrochemical impedance spectroscopic characterization revealed efficient charge transport through the modified electrode surface.

View Article and Find Full Text PDF

The development of effective bifunctional electrocatalysts that can realize water splitting to produce oxygen and hydrogen through oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is still a great challenge to be addressed. Herein, we report a simple and versatile approach to fabricate bifunctional OER and HER electrocatalysts derived from ZIF67/MXene hybrids sulfurization of the precursors in hydrogen sulfide gas atmosphere at high temperatures. The as-prepared CoS@C/MXene nanocomposites were characterized using a series of technologies including X-ray diffraction, gas sorption, scanning electronic microscopy, transmission electronic microscopy, energy dispersive spectroscopy, and X-ray photoelectron spectroscopy.

View Article and Find Full Text PDF

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review.

RSC Adv

May 2024

Departamento de Química, CEQUINOR (UNLP, CONICET-CCT La Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata Bv. 120 1465 La Plata 1900 Argentina.

Article Synopsis
View Article and Find Full Text PDF
Article Synopsis
  • Current pharmacological treatments for chronic neuropathic pain are inadequate, leading to a need for new medications.
  • This study tested two novel compounds, KB 09 and KB 10, on rats with sciatic nerve injury to assess their pain relief effectiveness.
  • Results showed that both compounds significantly reduced pain and inflammation markers, suggesting they may be promising candidates for treating neuropathic pain through multiple mechanisms.
View Article and Find Full Text PDF

Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin-triazole hybrids 3a and 3b were accessed copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC), together with their mono and bis-thiosemicarbazone derivatives 4a-h and 5a-h. In addition to the characterization by physical, spectral and analytical data, a DFT study was carried out to obtain the optimized geometries of all thiosemicarbazones.

View Article and Find Full Text PDF

Efficient electrocatalytic CO reduction reaction (eCORR) to various products, such as carbon monoxide (CO), is crucial for mitigating greenhouse gas emissions and enabling renewable energy storage. In this article, we introduce Pd nanoparticles which are deposited over in-house synthesized nitrogen doped tubular carbon (NC) whose ends are blocked with cobalt oxide (CoOx). This composite material is denoted as Pd@CoOx/NC.

View Article and Find Full Text PDF

Owing to the high cost of recycling waste, underdeveloped countries discharge industrial, agricultural, and anthropogenic effluents without pretreatment. As a result, pollutant-loaded waste enters water bodies. Among the diverse toxic contaminants, heavy metal ions are the most detrimental because of their chronic toxicity, non-degradability, prevalence, and bioaccumulation.

View Article and Find Full Text PDF

Halloysite nanotubes (HNTs) were surface functionalized using four distinct chemical moieties (amidoxime, hydrazone, ethylenediamine (EDA), and diethylenetriamine (DETA)), producing modified HNTs (H1-H4) capable of binding with Cr(vi) ions. Advanced techniques like FTIR, XRD, SEM, and EDX provided evidence of the successful functionalization of these HNTs. Notably, the functionalization occurred on the surface of HNTs, rather than within the interlayer or lumen.

View Article and Find Full Text PDF

Herein, we report a sensitive electrochemical platform prepared by modifying the electrode surface with copper-doped zinc oxide nanoparticles; these nanoparticles were prepared a green synthetic approach using the extract of leaves and multiwalled carbon nanotubes (MWCNTs). For the best response of the electrode modifier, a number of experimental conditions were optimized to obtain the most intense signal of the target analyte Coomassie brilliant blue using a rapid analysis technique square wave voltammetry. The designed sensor displayed remarkable sensitivity for Coomassie brilliant blue with a detection limit of 0.

View Article and Find Full Text PDF

In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a-j) was designed and synthesized through a multistep sequence and the synthesized compounds were screened for their antifungal, antibacterial and antioxidant activities as well as urease, amylase and α-glucosidase inhibitory activities. The synthesized series (5a-o) was characterized using a combination of spectroscopic techniques, including FT-IR, H NMR and C NMR. All compounds (5a-j) were found to have significant potency against urease, α-glucosidase, α-amylase, and DPPH.

View Article and Find Full Text PDF

The conversion of CO into CO as a substitute for processing fossil fuels to produce hydrocarbons is a sustainable, carbon neutral energy technology. However, the electrochemical reduction of CO into a synthesis gas (CO and H) at a commercial scale requires an efficient electrocatalyst. In this perspective, a series of six new palladium complexes with the general formula [Pd(L)(Y)]Y, where L is a donor-flexible PYA, ,-bis(1-ethylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, ,-bis(1-butylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, or ,-bis(1-benzylpyridin-4(1)-ylidene)pyridine-2,6-dicarboxamide, and Y = OAc or Cl, were utilized as active electrocatalysts for the conversion of CO into a synthesis gas.

View Article and Find Full Text PDF

In the current study, a novel compound, bis(3-(2-benzo[][1,2,3]triazol-2-yl)-2-(prop-2-yn-1-yloxy)-5-(2,4,4-trimethylpentan-2-yl)phenyl)methane (TAJ1), has been synthesized by the reaction of 6,6'-methylenebis(2-(2-benzo[][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol) (1), propargyl bromide (2) and potassium carbonate. Spectroscopic (FTIR, H-NMR, C-NMR) and single-crystal assays proved the structure of the synthesized sample. XRD analysis confirmed the structure of the synthesized compound, showing that it possesses two aromatic parts linked a -CH carbon with a bond angle of 108.

View Article and Find Full Text PDF

This study aimed to fabricate Miconazole Nitrate transethosomes (MCZN TESs) embedded in chitosan-based gel for the topical treatment of Cutaneous Candidiasis. A thin film hydration method was employed to formulate MCZN TESs. The prepared MCZN TESs were optimized and analyzed for their physicochemical properties including particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (%EE), Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), deformability, and Transmission electron microscopy (TEM).

View Article and Find Full Text PDF

-Triazine possesses an auspicious status in the field of drug discovery and development owing to its presence in many naturally occurring compounds as well as commercially available drugs like enasidenib, gedatolisib, bimiralisib, atrazine, indaziflam, and triaziflam. Easy, cost-effective, and efficient access to its derivatives in addition to their splendid biological activities such as anticancer, anti-inflammatory, antiviral, anticonvulsant, anti-tubercular, antidiabetic, antimicrobial, makes it an attractive heterocyclic nucleus in the field of medicinal chemistry. Other than the direct access of its derivatives from simple commercially available starting materials like amidine, the -triazine derivatives have also been obtained starting from an inexpensive commercially available 2,4,6-trichloro-1,3,5-triazine (TCT) commonly known as cyanuric chloride.

View Article and Find Full Text PDF

The intricate problems concerning energy require innovative solutions. Herein, we propose a smart composite nano system that can be used in a sustainable and dichotomous manner to resolve energy crises. The current study describes a new way to synthesize a pure spinel cobalt oxide (CoO) and boron (B), nitrogen (N), and sulfur (S) tri-doped CoO-reduced graphite oxide (rGO) nanocomposite (CBNS).

View Article and Find Full Text PDF

Hybrid composites of molybdenum disulfide (MoS), graphene nanoplatelets (GNPs) and polyaniline (PANI)/polypyrrole (PPy) have been synthesized as cost-effective electrode materials for supercapacitors. We have produced MoS from molybdenum dithiocarbamate by a melt method in an inert environment and then used a liquid exfoliation method to form its composite with graphene nanoplatelets (GNPs) and polymers (PANI and PPy). The MoS melt/GNP ratio in the resultant composites was 1 : 3 and the polymer was 10% by wt.

View Article and Find Full Text PDF

Piroxicam and naproxen are well-known non-steroidal anti-inflammatory drugs that are frequently detected in aquatic environments due to their widespread usage and improper disposal practices. This research investigates the photocatalytic degradation of these drugs by using CeO nanoparticles. The nanoparticles were synthesized by using plant extract and were characterized through various characterization techniques such as UV-visible spectroscopy, FTIR spectroscopy, SEM, EDX, and XRD.

View Article and Find Full Text PDF