Antidepressant effects of SY-2476: A caffeine derivative's role in A1/A2 gene expression modulation in corticosterone-induced depressed rats.

Depression is a pervasive mood disorder that continues to challenge researchers and clinicians worldwide. Caffeine and its derivatives have been studied for their neuroprotective and antidepressant effect. Current study aimed to explore the potential antidepressant effect of a caffeine derivative, Sy-2476 [4-(1, 3, 7-trimethyl-2, 6-dioxo-2, 3, 6, 7-tetrahydro-1H-purin-8-yl) benzo nitrile], in corticosterone-induced rat model of depression.

A Path Analysis of Relationship between War Trauma, Post - Traumatic Stress and Post Traumatic Growth.

Background & Objective: Police officials who participated in war on terror were exposed to high frequency of traumatic exposures. Previous research suggests that exposure of war trauma can results in negative changes like stress and positive changes like growth. Our objective was to study the role of post-traumatic stress in relationship between war trauma and post traumatic growth among police officials.

Estimation and attribution of nonlinear trend of water use efficiency using a normalized partial derivative approach.

Investigating trends in water use efficiency (WUE) and its causality is critical for understanding ecosystem behaviors. Although WUE has shown nonlinear changes in the last several decades across most global ecosystems, the majority of available studies have focused on its linear trend. This study attempted to accurately attribute the linear and nonlinear variations in WUE using normalized driving factors in the Partial Derivative (PD) equation to develop a Normalized Partial Derivative model (NPD-model).

Impact of COVID-19 on nephropathy in diabetes mellitus type-II patients: a systematic literature review and meta-analysis.

Background: Recent reports have revealed that nephropathy leading to kidney injury (KI) is a prevalent complication of COVID-19 and is linked to high mortality and morbidity in diabetes mellitus type II (DM-T-II) patients. This systematic literature review and meta-analysis aimed to critically analyze existing studies and evidence on the impact of COVID-19 on nephropathy and kidney injury in diabetes mellitus type II (DM-T-II) patients.

Method: A systematic search was conducted in the Web of Science (WoS), PubMed and Cochrane databases for relevant studies published between March 2020 and July 2023.

The Investigation of Structural, Optical and Thermal Properties of Nickel Doped CeO Integrated PVC Nanocomposite.

PVC nanocomposite (NC) films with cubic CeO and Ni-doped CeO (NDC) have been prepared using a conventional solution-casting technique. The prepared films were characterized with FT-IR spectrometer, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The optical and thermal properties of the films were evaluated using a UV-visible spectrophotometer and TGA/DSC.

An assessment of economy- and transport-oriented health performance.

Background: Good health can prolong one's lifespan and is a fundamental human right. Thus, human health is being influenced by prejudiced from sociological, environmental, economic, and geographic aspects. The economy and transportation system pose a serious challenge to the assessment of the health performance of economies.

A Longitudinal Investigation on the Reciprocal Relationship of Problematic Smartphone Use with Bedtime Procrastination, Sleep Quality, and Mental Health Among University Students.

Background: Problematic smartphone use (PSU) is linked to various mental health issues, but the relationship between PSU, bedtime procrastination, and mental health symptoms is unclear. Sleep factors related to PSU and its mental health effects have been understudied. This study explores the longitudinal associations between PSU, bedtime procrastination, sleep quality, and mental health in university students.

Synthesis, Characterization, and Evaluation of the Antimicrobial and Anticancer Activities of Zinc Oxide and Aluminum-Doped Zinc Oxide Nanocomposites.

In this research, we developed undoped and aluminum-doped zinc oxide for antimicrobial and anticancer activities. This study focuses on the synthesis, characterization, and biological activities of zinc oxide nanoparticles (ZnO NPs) and aluminum-doped zinc oxide nanocomposites (ZnAlO NCs) at varying concentrations (x = 0, 0.25, 0.

Synthesis and characterization of Lanthanum Oxide nanoparticles using Citrus aurantium and their effects on Citrus limon Germination and Callogenesis.

The plant extract-mediated method is eco-friendly, simple, safe, and low-cost, using biomolecules as a reducing agent to separate nanoparticles. Lanthanum (La) is a rare earth metal that positively affects plant growth and agriculture. Citrus limon is a leading citrus fruit with many varieties.

Modification of polyurethane foams with zinc sulfide nanoparticles and their novel composites with multani mitti and charcoal for oil spill cleanup.

With the rapid growth of the automobile industry, the excessive number of industrial pollutants, particularly oil spills, has become a huge threat to the natural environment. Therefore, an environmentally benign and sustainable solution is required for an effective oil spill cleanup. To enhance the sorption capacity of pristine polyurethane (PU) foam used in oil spill cleanup, ZnS nanoparticles were deposited on PU foam a coprecipitation approach.

Diet, Gut Microbes, and Cancer.

Gut microbes are important and may play important role in spreading cancers specially the gastrointestinal malignancies preferably colorectal cancers. Gut microbes and diet can influence the tissues in gastrointestinal tract increasing the risk of cancer spread. Insufficient nutrient intake and imbalance diet can disturb the microbiome of gastrointestinal tract causing metabolism of xenobiotics which is beneficial as well as detrimental.

Lie symmetry analysis and solitary wave solution of biofilm model Allen-Cahn.

The investigation presented in this study delves into the analysis of Lie symmetries for the bistable Allen-Cahn (BAC) equation with a quartic potential, specifically applied to the biofilm model. By employing the Lie symmetry method, we have acquired the Lie infinitesimal generators for the considered model. Using a transformation method, the nonlinear partial differential equations (NPDEs) are converted into various nonlinear ordinary differential equations (NLODEs), providing the numerous closed-form solitary wave solutions.

Comparison of contrast sensitivity among strabismic and anisometropic amblyopes and its association with disease-related parameters.

Purpose: To evaluate and contrast the contrast sensitivity defects present in strabismic and anisometropic amblyopes. And to find out the association of contrast deterioration with the visual acuity of the amblyopic eye, the magnitude of strabismus, and the amount of anisometropia in both groups.

Methods: This cross-sectional study was carried out in the orthoptics unit of a tertiary eye care facility between October 2021 and December 2021.

In vivo effects of a selected thiourea derivative 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) against nociception, inflammation and gastric ulcerogenicity: Biochemical, histopathological and in silico approaches.

The current study was designed to investigate the potential of a synthetic therapeutic agent for better management of pain and inflammation, exhibiting minimal to non-existent ulcerogenic effects. The effect of 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) thiourea was assessed through model systems of nociception and anti-inflammatory activities in mice. In addition, the ulcerogenic potential was evaluated in rats using the NSAID-induced pyloric ligation model, followed by histopathological and biochemical analysis.

Multiple-Drug Resistant Shiga Toxin-Producing in Raw Milk of Dairy Bovine.

Introduction: Raw milk may contain pathogenic microorganisms harmful to humans, e.g., multidrug-resistant non-O157:H7, which can cause severe colitis, hemolytic uremia, and meningitis in children.

Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects.

To develop a biocompatible conjugated ciprofloxacin-PEG-FeO nanodelivery system with increased efficacy of available therapeutics in a controlled manner. FeO nanoparticles were synthesized by chemical and biological methods and modified as ciprofloxacin-PEG-FeO nanoformulations. After initial antibacterial and cytotoxicity studies, the effective and biocompatible nanoformulations was further fabricated as nanotherapeutics for studies in mouse models.

In-silico analysis of potential anticancer drug for NEK7 and PPP1CA proteins overexpressed in pancreatic ductal adenocarcinoma.

NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current study was to identify a possible NEK7 and PPP1CA therapeutic inhibitor. For this investigation, 5000 compounds were retrieved from the IMPPAT library of phytochemicals, which were docked with our respective target proteins.

A novel probabilistic q-rung orthopair linguistic neutrosophic information-based method for rating nanoparticles in various sectors.

The idea of probabilistic q-rung orthopair linguistic neutrosophic (P-QROLN) is one of the very few reliable tools in computational intelligence. This paper explores a significant breakthrough in nanotechnology, highlighting the introduction of nanoparticles with unique properties and applications that have transformed various industries. However, the complex nature of nanomaterials makes it challenging to select the most suitable nanoparticles for specific industrial needs.

Practices Used to Improve Patient Safety Culture Among Healthcare Professionals in a Tertiary Care Hospital.

Introduction: A patient safety culture primarily refers to the values, beliefs, attitudes, and behaviors within a healthcare setup in a community that assists in prioritizing patient safety and encouraging the reporting of errors and near-misses in that facility. There is a direct impact of patient safety culture on how well patient safety and quality improvement programs work. The aim of this cross-sectional descriptive study was to investigate the practices to improve patient safety culture and adverse event reporting practices among healthcare professionals in a tertiary care hospital located in Mirpur Azad Jammu and Kashmir.

Genome-wide identification of NAC transcription factors and regulation of monoterpenoid indole alkaloid biosynthesis in .

NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in , a perennial ornamental plant, is lacking. Homology modelling was employed to identify and characterize NACs in .

Monkeypox Entry and Emergence Preparation in Pakistan.

Monkeypox (Mpox) is a virus that first emerged in Africa in 1970 [...