Enhanced cardioprotective activity of ferulic acid-loaded solid lipid nanoparticle in an animal model of myocardial injury.

Myocardial infarction results in an increased inflammatory and oxidative stress response in the heart, and reducing inflammation and oxidative stress after MI may offer protective effects to the heart. In the present study, we examined the cardioprotective effects of ferulic acid (FA) and ferulic acid nanostructured solid lipid nanoparticles (FA-SLNs) in an isoproterenol (ISO) induced MI model. Male Sprague Dawley rats were divided into five experimental groups to compare the effects of FA and FA-SLNs.

A cohort study investigating the role of Bisphenol A in the molecular pathogenesis of breast cancer.

Background: Breast cancer is an abnormal division of breast cells. Bisphenol A (BPA), an environmental toxicant, is identified as an emerging risk factor for breast cancer development. However, to the best of our knowledge, no previous study has investigated the BPA levels in breast cancer patients in Pakistan.

The contemporary immunoassays for HIV diagnosis: a concise overview.

Recent advances in human immunodeficiency virus (HIV) diagnostics have improved the management of disease progression significantly, which have also boosted the efficacy of antiviral therapies. The detection of HIV at the earliest is very important. A highly recognized and effective virological biomarker for acute HIV infections is p24 antigen.

Larvicidal activity of green synthesized iron oxide nanoparticles using Grevillea robusta Cunn. leaf extract against vector mosquitoes and their characterization.

Extensive fumigation of synthetic pesticides to control the mosquito vector during each post-monsoon season in Pakistan significantly enhanced the environmental contamination and extinction of beneficial insects from the urban ecosystems. In this context, the present study examined the larvicidal efficacy of green synthesized iron nanoparticles (IONPs), using an aqueous leaf extract of Grevillea robusta against the early 2nd and 4th instar larvae of Aedes aegypti and Anopheles stephensi in Pakistan. The prepared IONPs were characterized by UV-Vis spectrum, FTIR, X-ray diffraction, scanning electron microscopy, and energy-dispersive diffraction.

Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for -NTPDases.

The aim of this research work is the synthesis of sulfamoyl-benzamides as a selective inhibitor for -NTPDases. Sulfonamides are synthesized in aqueous medium from chlorosulfonylbenzoic acid while carboxamides are synthesized using carbodiimide coupling decorated with different biologically relevant substituents such as -butyl, cyclopropyl, benzylamine, morpholine, and substituted anilines. In addition, sulfonamide-carboxamide derivatives were synthesized having the same substituents on either side.

Enhancing the FRET by tuning the bandgap of acceptor ternary ZnCdS quantum dots.

In this article, we report the band gap tuning of ternary ZnCdS quantum dots (QDs) by varying the concentration of the capping ligand, mercaptoacetic acid (MAA). The functionalization of QDs leads to the control of their size and band gap due to the quantum confinement effect, causing blue shift in the absorption and photoluminescence (PL) spectra with a gradual change in the concentration of the capping ligand from 0.5 to 2.

Exchange rate volatility and India-US commodity trade: evidence of the third country effect.

The relationship between trade flows and exchange rate uncertainty is still being debated in academic circles while examining the effects of exchange rate uncertainty on India's bilateral trade flows, prior research disregard the "third-county" effect. This study investigates the effect of third-country risk on the amount of India-US commodity trade using time series data for 79 Indian commodity export and 81 Indian commodity import businesses. The results show that the volume of trade in a select few industries is considerably impacted by third-country risk in terms of dollar/yen and rupee/yen.

Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations.

The COVID-19 pandemic has necessitated the development of reliable diagnostic methods for accurately detecting the novel coronavirus and its variants. Deep learning (DL) techniques have shown promising potential as screening tools for COVID-19 detection. In this study, we explore the realistic development of DL-driven COVID-19 detection methods and focus on the fully automatic framework using available resources, which can effectively investigate various coronavirus variants through modalities.

Analysis of sperm chromatin packaging and reproductive biomarker to evaluate the consequence of advanced male age.

In this study, the semen parameters, sperm chromatin integrity, antioxidant enzyme levels, and reproductive hormone levels of subfertile male subjects from Pakistan were assessed in relation to their age. Data on the demographic characteristics of the 750 study participants, including their general health, body mass index (BMI), and reproductive status, were collected from subfertile men from Pakistan. Semen and blood were collected to determine standard semen parameters, sperm chromatin dispersion (Halosperm-SCD), sperm chromatin integrity using toluidine blue (TB) staining, sperm chromatin maturity using chromomycin A3 (CMA3+) staining, and reproductive hormone (FSH, LH, prolactin and testosterone levels).

Synthesis, DNA binding and biological evaluation of benzimidazole Schiff base ligands and their metal(ii) complexes.

Two novel benzimidazole ligands ()-2-((4-(1-benzo[]imidazole-2-yl)phenylimino)methyl)-6-bromo-4-chlorophenol (L) and ()-1-((4-(1-benzo[]imidazole-2-yl)phenylimino)methyl)naphthalene-2-ol (L) with their corresponding Cu(ii), Ni(ii), Pd(ii) and Zn(ii) complexes were designed and synthesized. The compounds were characterized by elemental, IR, and NMR (H & C) spectral analyses. Molecular masses were determined by ESI-mass spectrometry, and the structure of ligand L was confirmed by single crystal X-ray diffraction analysis.

Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications.

Cancer is still the leading cause of death worldwide, burdening the global medical system. Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a bioactive compound identified in plants such as Boraginaceae and Nepetoideae subfamilies of the Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, and Hyptis pectinate. This updated review is to highlight the chemopreventive and chemotherapeutic effects of RA and its derivatives, thus providing valuable clues for the potential development of some complementary drugs in the treatment of cancers.

New Parasitic Records of Aves: Phasianidae () in Malakand Division Northern, Pakistan.

More than 24,000 species of helminth parasitize wild birds worldwide, and this number is expanding as interest in wildlife parasitology increases. The objective of the current study was to update the baseline of helminthological surveys conducted on chukar partridges () in northern Pakistan. After reviewing the available literature, a parasite-host association checklist was developed.

Analyzing the Differential Impact of Semen Preparation Methods on the Outcomes of Assisted Reproductive Techniques.

Sperm separation plays a critical role in assisted reproductive technology. Based on migration, density gradient centrifugation and filtration, a properly selected sperm could help in increasing assisted reproductive outcomes in teratozoospermia (TZs). The current study aimed to assess the prognostic value of four sperm selection techniques: density gradient centrifugation (DGC), swim-up (SU), DGC-SU and DGC followed by magnetic-activated cell sorting (DGC-MACS).

Graphene Oxide-Grafted Hybrid Diblock Copolymer Brush (GO--PEG--P(MA-POSS)) as Nanofillers for Enhanced Lithium Ion Conductivity of PEO-Based Nanocomposite Solid Polymer Electrolytes.

Nanocomposite solid polymer electrolytes (NSPEs) with PEO as the matrix and (i) GO or (ii) GO--PEG or (iii) GO--PEG--P(MA-POSS) as nanofillers have been fabricated to elucidate the impact of the filler morphology on the lithium ion conductivity. GO--PEG was obtained by grafting PEG onto GO esterification. GO--PEG--P(MA-POSS) was prepared surface-initiated atom transfer radical polymerization.

Synthesis of cerium oxide embedded perovskite type bismuth ferrite nanocomposites for sonophotocatalysis of aqueous micropollutant ibuprofen.

Ibuprofen is potentially toxic and carcinogenic for freshwater ecosystems and poses a serious threat to human health by affecting kidney function. The present study focused on the sunlight-controlled degradation of ibuprofen from water using a novel magnetically separable cerium oxide-embedded bismuth ferrite heterostructure. Catalysts were synthesized by solvothermal and co-precipitation methods and characterized by X-ray diffractometry, transmission electron microscopy, X-ray photoelectron spectroscopy, UV-vis optical absorption spectroscopy, and nitrogen adsorption.

Relationship Between Work-Family Conflict and Depressive Symptoms Among Male Firefighters in China: Job Types and Family Structure as Moderators.

Objectives: This study aims to examine the relationship between work-family conflict and depressive symptoms while considering job types and family structure as moderators.

Methods: In July and August 2021, 1328 male Chinese firefighters completed an online cross-sectional survey.

Results: The results indicated that work-family conflicts among Chinese firefighters presented a significant association with worse depressive symptoms.

Gender difference in the relationship between personality traits and changes in depressive symptoms before and after the COVID-19 outbreak: A follow-up study among Chinese adults.

Objectives: Increasing depressive symptoms have become an urgent public health concern worldwide. This study aims to explore the correlation between personality traits and changes in depressive symptoms before and after the COVID-19 outbreak and to examine the gender difference in this association further.

Methods: Data were obtained from the China Family Panel Studies (CFPS, wave in 2018 and 2020).

Effects of Dietary Diversity on Growth Outcomes of Children Aged 6 to 23 Months in India: Evidence from National Family and Health Survey.

Low dietary diversity significantly interplays with children’s growth failure. However, evidence of its crucial role in children’s health remains inconclusive in developing countries such as India. This study attempts to find the association between dietary diversity and growth outcomes among children aged between 6 and 23 months in India using the fourth round of the National Family Health Survey (NFHS), 2015−2016.

Alumina supported copper oxide nanoparticles (CuO/AlO) as high-performance electrocatalysts for hydrazine oxidation reaction.

Direct hydrazine liquid fuel cell (DHFC) is perceived as effectual energy generating mean owing to high conversion efficiency and energy density. However, the development of well-designed, cost effective and high performance electrocatalysts is the paramount to establish DHFCs as efficient energy generating technology. Herein, gamma alumina supported copper oxide nanocatalysts (CuO/AlO) are synthesized via impregnation method and investigated for their electrocatalytic potential towards hydrazine oxidation reaction.

Determination of possible contraceptive potential of methanolic leaf extract of L. in adult male rats: a biochemical and histological study.

L (ML) is locally used as an herbal contraceptive. We aim to assess the toxicity profile and validate the antifertility effects of its leaves in male rats. Adult male Sprague Dawley rats ( = 10 animals/group) were divided into four groups.