Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses.

The current research work reports the synthesis of three 4-((3-arylthiazolo[3,4-]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-)isoxazole-based fused ring heterocyclic system. The synthesized and characterized derivatives, namely, 4-(3-(2-hydroxy-3-methoxyphenyl)thiazolo[3,4-]soxazole-5-ylamino)benzenesulfonamide (YM-1), 4-(3-(4-chlorophenyl)isoxazolo[3,4-]thiazol-5-ylamino)benzenesulfonamide (YM-2), and 4-(3-(3-hydroxyphenyl)isoxazolo[3,4-]thiazol-5-ylamino)benzenesulfonamide (YM-3) were further explored for their binding interactions with DNA and enzymes (urease and carbonic anhydrase). Cytotoxicity of these derivatives for both healthy (HEK-293) and cancerous (MG-U87) cells was determined by MTT analysis.

Instability analysis for MHD boundary layer flow of nanofluid over a rotating disk with anisotropic and isotropic roughness.

The study focuses on the instability of local linear convective flow in an incompressible boundary layer caused by a rough rotating disk in a steady MHD flow of viscous nanofluid. Miklavčič and Wang's (Miklavčič and Wang, 2004) [9] MW roughness model are utilized in the presence of MHD of Cu-water nanofluid with enforcement of axial flows. This study will investigate the instability characteristics with the MHD boundary layer flow of nanofluid over a rotating disk and incorporate the effects of axial flow with anisotropic and isotropic surface roughness.

Computational fluid dynamics analysis on endoscopy of main left coronary artery: An application of applied mathematics.

The endoscopy of a coronary arterial segment having a symmetric emergence of plaque at its innermost region is numerically modeled via computational fluid dynamics toolbox Open-FOAM. The considered left coronary artery for this model has a radius of 2 mm and span of 10 mm. The formation of plaque inside the artery that is a stenosis has length 2 mm and height 0.

Analytical investigation of Carreau fluid flow through a non-circular conduit with wavy wall.

Peristaltic flow through an elliptic channel has vital significance in different scientific and engineering applications. The peristaltic flow of Carreau fluid through a duct with an elliptical cross-section is investigated in this work . The proposed problem is defined mathematically in Cartesian coordinates by incorporating no-slip boundary conditions.

From doping to composites: zirconia (ZrO) modified hematite photoanodes for water splitting.

Herein, a ZrO added α-FeO photoanode that can split water at low applied potential is reported. First, the pristine hematite α-FeO photoanode was synthesized using an aerosol-assisted chemical vapour deposition (AACVD) method followed by modification with various amounts of ZrO (2 to 40%) in the form of thin films on conducting glass substrate. The XRD, Raman spectroscopy and scanning electron microscopy (SEM) analyses confirmed the presence of the monoclinic phase of ZrO in the composites with multifaceted particles of compact morphology.

Modeling and simulation for Cattaneo-Christov heat analysis of entropy optimized hybrid nanomaterial flow.

Here, the hydromagnetic entropy optimized flow of a hybrid (Pb + FeO/CHO) nanoliquid by a curved stretchable surface is addressed. The Darcy-Forchheimer model is utilized for porous space. Lead (Pb) and ferric oxide (FeO) are considered the nanoparticles and ethylene glycol (CHO) as the base liquid.

Entropy generation in bioconvection hydromagnetic flow with gyrotactic motile microorganisms.

Here, the magnetohydrodynamic bioconvective flow of a non-Newtonian nanomaterial over a stretched sheet is scrutinized. The characteristics of convective conditions are analyzed. Irreversibility analysis in the presence of gyrotactic micro-organisms is discussed.

Non-enzymatic amperometric glucose sensing on CuO/mesoporous TiO modified glassy carbon electrode.

The present study illustrates the fabrication of a glucose sensing electrode based upon binary composite of copper oxide and mesoporous titanium dioxide on glassy carbon (CuO/TiO/GCE). The X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis evidently showed the phase pure monoclinic CuO nanoparticles and anatase TiO. N adsorption-desorption analysis verified the mesoporosity in TiO with specific surface area greater than 105 m g.

Synthesis of amantadine clubbed -aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies.

A series of ten novel compounds were synthesized by incorporating a 1,3 thiazole core into amantadine and their structures were validated using different analytical and spectral methods such as FTIR, EI-MS, H NMR, and C NMR. The antibacterial and enzyme inhibitory properties of these newly synthesized compounds were evaluated. Remarkably, the compounds exhibited significant antibacterial activity against and .

Leveraging machine learning to consolidate the diversity in experimental results of perovskite solar cells.

Perovskite solar cells offer great potential for smart energy applications due to their flexibility and solution processability. However, the use of solution-based techniques has resulted in significant variations in device fabrication, leading to inconsistent results on the same composition. Machine learning (ML) and data science offer a potential solution to these challenges by enabling the automated design of perovskite solar cells.

Three-dimensional MHD flow of hybrid material between rotating disks with heat generation.

In this study, we investigate the flow of electrically conducting hybrid nanofluid , due to rotating disks, along with thermal slip, heat generation, and viscous dissipation. The nonlinear differential system is modelled and transformed into dimensionless partial differential equations using suitable dimensionless variables. To obtain solutions for the considered model, a finite difference toolkit is implemented, and numerical solutions are achieved.

Research on dye sensitized solar cells: recent advancement toward the various constituents of dye sensitized solar cells for efficiency enhancement and future prospects.

It is universally accepted that the financial advancement of a state is essentially dependent upon the energy sector as it is essential in the growth, development, and improvement of the farming, mechanical, and defense sectors. A dependable source of energy is expected to enhance society's expectation of everyday comforts. Modern industrial advancement, which is indispensable for any nation, relies upon electricity.

Thermodynamic irreversibility effects with Marangoni convection for third grade nanofluid flow.

In this study, an analysis was performed to investigate the thermal and mass transport of radiative flow of a third-grade nanofluid with magnetohydrodynamic. The analysis concerns two-dimensional flow around an infinite disk. Heat transport is studied via heat generation/absorption, thermal radiation and Joule heating.

Modeling and multi-objective optimal control of reaction-diffusion COVID-19 system due to vaccination and patient isolation.

In this paper, a reaction-diffusion COVID-19 model is proposed to explore how vaccination-isolation strategies affect the development of the epidemic. First, the basic dynamical properties of the system are explored. Then, the system's asymptotic distributions of endemic equilibrium under different conditions are studied.

Numerical simulation for peristalsis of Quemada fluid: A dynamic mesh approach.

Introduction: Flow dynamics due to the peristaltic pumping has been the topic of great interest for the researchers. But numerical and analytical analyses for the peristaltic motion are limited where flow domain is deformed real-time. Research on peristalsis has a limitation where theoretical aspects of walls motion are considered, neglecting the real time deformation of the walls.

Entropy analysis for a novel peristaltic flow in a curved heated endoscope: an application of applied sciences.

Entropy interpretation with a descriptive heat generation analysis is carried out for the heated flow between two homocentric and sinusoidally fluctuating curved tubes. A novel peristaltic endoscope is considered for the first time inside a curved tube with evaluation of heat transfer and entropy. This flexible and novel endoscope with peristaltic locomotion is more efficient for endoscopy of complex mechanical structures and it is more comfortable for patients undergoing the endoscopy of a human organs.

Dynamics and strategies evaluations of a novel reaction-diffusion COVID-19 model with direct and aerosol transmission.

The COVID-19 epidemic has infected millions of people and cast a shadow over the global economic recovery. To explore the epidemic's transmission law and provide theoretical guidance for epidemic prevention and control. In this paper, we investigate a novel SEIR-A reaction-diffusion COVID-19 system with direct and aerosol transmission.

Melamine-derived N-rich C-entrapped Au nanoparticles for sensitive and selective monitoring of dopamine in blood samples.

Several neurological disorders, including Parkinson's disease, schizophrenia, human immunodeficiency virus infection, and restless leg syndrome, majorly result from disruption in the dopamine (DA) level. Thus, useful information about the treatment and prevention of various genetic majorly mental health problems can be obtained through precise and real-time monitoring of DA. Herein, we report the fabrication of novel N-rich carbon-coated Au nanoparticles (NC@Au-NPs) by deriving from melamine-crosslinked citrate-stabilized Au NPs.

Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its and investigations for RNR, DNA binding, urease inhibition and radical scavenging activities.

-((4-Acetylphenyl)carbamothioyl)-2,4-dichlorobenzamide (4) was synthesized by the treatment of 2,4-dichlorobenzoyl chloride with potassium thiocyanate in a 1 : 1 molar ratio in dry acetone to afford the 2,4-dichlorobenzoyl isothiocyanate which on reaction with acetyl aniline furnished (4) in good yield and high purity. The compound was confirmed by FTIR, H-NMR, and C-NMR and single crystal X-ray diffraction studies. The planar rings were situated at a dihedral angle of 33.

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review.

The interest in acyl thioureas has continually been escalating owing to their extensive applications in diverse fields, such as synthetic precursors of new heterocycles, pharmacological and materials science, and technology. These scaffolds exhibit a wide variety of biological activities such as antitumor, enzyme inhibitory, anti-bacterial, anti-fungal, and anti-malarial activities and find utilization as chemosensors, adhesives, flame retardants, thermal stabilizers, antioxidants, polymers and organocatalysts. In addition, the synthesis, and applications of coordination complexes of these ligands have also been overviewed.

TBAI-assisted direct C-H activation of indoles with β--styrene sulfonyl hydrazides: a stereoselective access to 3-styryl thioindoles.

The current work describes the challenging introduction of a vinyl sulfide group by simple C-H activation on a variety of substrates. The direct C-H activation of indoles with β-()-styrene sulfonyl hydrazides under the sulfenylation conditions, assisted by the iodic catalyst -butyl ammonium iodide (TBAI), afforded a series of ()-styrylthioindoles. Accordingly, β-()-styrene sulfonyl hydrazides undergo radical cross-coupling reactions with a variety of substituted indoles to afford structurally diverse indole vinyl thioethers in moderate to high yields with -stereoselectivity.

Mixed convective flow of CNTs nanofluid subject to varying viscosity and reactions.

The addressed work explains SWCNTs (Single walled carbon nanotubnes) and MWCNTs (Multi walled carbon nanotubnes) nanofluid flow under the influences of temperature dependent viscosity and mixed convection. Comparative study of SWCNTs and MWCNTs suspended in base liquid is presented. Further heat and mass transfer are addressed for nanofluid effected by radiation, heat generation/absorption and diffusion species.

Entropy optimized dissipative flow of hybrid nanofluid in the presence of non-linear thermal radiation and Joule heating.

Present article reads three dimensional flow analysis of incompressible viscous hybrid nanofluid in a rotating frame. Ethylene glycol is used as a base liquid while nanoparticles are of copper and silver. Fluid is bounded between two parallel surfaces in which the lower surface stretches linearly.

A new modified Kies Fréchet distribution: Applications of mortality rate of Covid-19.

The purpose of this paper is to identify an effective statistical distribution for examining COVID-19 mortality rates in Canada and Netherlands in order to model the distribution of COVID-19. The modified Kies Frechet (MKIF) model is an advanced three parameter lifetime distribution that was developed by incorporating the Frechet and modified Kies families. In particular with respect to current distributions, the latest one has very versatile probability functions: increasing, decreasing, and inverted U shapes are observed for the hazard rate functions, indicating that the capability of adaptability of the model.