65,401 results match your criteria: "Qld; Crestmead Medical Centre[Affiliation]"

The theory of preloading: A cognitive-behavioural motivational model.

Harm Reduct J

December 2024

School of Applied Psychology, Griffith University, 176 Messines Ridge Road, Mt Gravatt, QLD, 4122, Australia.

Preloading of alcohol and/or drugs before an event has been examined in the research literature for the past two decades. Despite the considerable interest and scrutiny on the behaviour, there are limited, if any, attempts to conceptualise a theoretical understanding of why people preload before an event. Here we propose a Theory of Preloading (TOP)-a general cognitive-behavioural motivational model for alcohol and drug preloading.

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Background: Novel antimalarials are needed to address emerging resistance to artemisinin and partner drugs. We did two trials to evaluate safety, tolerability, pharmacokinetics, and activity against blood stage Plasmodium falciparum for the drug candidate MMV533.

Methods: A phase 1a first-in-human (FIH) trial was conducted at Nucleus Network (Melbourne, VIC, Australia).

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Getting the host antiviral machinery back on track: Targeting viral suppressors of RNA interference.

Mol Ther

December 2024

Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia. Electronic address:

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An objective and sensitive electrophysiological marker of word semantic categorization impairment in Alzheimer's disease.

Clin Neurophysiol

December 2024

Université de Lorraine, CNRS, IMoPA, 29 Avenue du Maréchal de Lattre de Tassigny, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Service de Neurologie, 29 Avenue du Maréchal de Lattre de Tassigny, F-54000 Nancy, France. Electronic address:

Objective: Combining electroencephalographic (EEG) recording and fast periodic visual stimulation (FPVS) to provide an implicit, objective and sensitive electrophysiological measure of semantic word categorization impairment in Alzheimer's Disease (AD).

Methods: Twenty-five AD patients and 25 matched elderly healthy controls were tested with a validated FPVS-EEG paradigm in which different written words of the same semantic category (cities) appear at a fixed frequency of 4 words per second (4 Hz) for 70 seconds. Words from a different semantic category (animal) appear every 4 stimuli (i.

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Harvesting of stormwater and injecting it into aquifers for storage and recovery during high water demand periods is a promising technology for augmenting conventional water reserves. However, little has been known on how stormwater impacts the biofouling of water distribution infrastructure. This study evaluated the effect on harvested and limestone aquifer treated stormwater on biofilm formation in a pilot distribution pipe network compared to an identical drinking water pipe rig.

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Article Synopsis
  • The study investigates how reallocating time among physical activity, sedentary behavior, and sleep affects obesity indicators like BMI and waist circumference across various age groups.
  • Researchers analyzed data from 9,818 participants using isotemporal substitution models to understand the implications of these behavior changes.
  • Results indicated that even small shifts of 10-30 minutes can significantly impact obesity, with reallocating moderate-to-vigorous physical activity (MVPA) to lighter activities or sedentary behavior having particularly detrimental effects.
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Voltage-Induced Bromide Redox Enables Capacity Restoration of Fast-Charging Batteries.

Adv Mater

December 2024

College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang Province, 310027, China.

Fast-charging lithium-ion batteries (LIBs) are essential for electric vehicles (EVs) to compete with conventional gasoline ones in terms of charging viability, yet the aggressive capacity drop in fast-charging scenarios gives rise to concerns regarding durability and sustainability. Herein, it is clarified that for fast-charging batteries, the excessive lithium (Li) plating on graphite anode inevitably brings capacity fading, and the concurrent accumulation of LiO-dominant passivation species that form dead Li is the main reason for their poor rechargeability. To refresh the passivated graphite, a voltage-induced activation mechanism is developed to leverage bromide (Br/Br ) redox couple for LiO and isolated Li activation in situ.

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Background: Kidney transplant recipients with severe acute respiratory syndrome-coronavirus-2 infection have an increased risk of severe disease and mortality. Nirmaltrevir/ritonavir (Paxlovid) is an effective oral disease-modifying therapy that has been shown to reduce risk of progression to severe disease in high-risk, nonhospitalized adults. However, owing to the potential for serious drug-drug interactions owing to ritonavir-induced inhibition of the CYP3A enzyme, this drug is not suitable option for transplant recipients with mild-moderate severe acute respiratory syndrome-coronavirus-2 infection.

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The MYC proto-oncogene is upregulated in >60% of triple-negative breast cancers (TNBCs), it can directly promote tumor cell proliferation, and its overexpression negatively regulates anti-tumor immune responses. For all these reasons, MYC has long been considered as a compelling therapeutic target. However, pharmacological inhibition of MYC function has proven difficult due to a lack of a drug-binding pocket.

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Interval variational approach for production control and waste reduction using artificial hummingbird algorithm.

Sci Rep

December 2024

Centre for Artificial Intelligence Research and Optimisation, Torrens University Australia, Fortitude Valley, Brisbane, QLD, 4006, Australia.

Nowadays, consumers show more interest towards eco-friendly products. To meet this demand, however, manufacturing processes often generate a lot of hazardous waste, which creates challenges for companies. To tackle these issues, this work develops an optimization model to help companies with managing production, reduce waste, and maintain green product standards.

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Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreover, it remains elusive how ChP is linked to brain regions associated with peripheral inflammation in SSD.

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Meteorin-like protein alleviates intervertebral disc degeneration by suppressing lipid accumulation in nucleus pulposus cells via PPARα-CPT1A activation.

Biochim Biophys Acta Mol Basis Dis

December 2024

Department of Spine Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Disturbances in lipid metabolism are closely related to intervertebral disc degeneration (IDD). However, the lipid metabolism characteristics of nucleus pulposus (NP) cells during IDD are unclear. Exercise protects against IDD and acts as a potent mediator of organ metabolism, in which muscle-secreted myokines actively participate.

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Beyond nutrition: Exploring immune proteins, bioactive peptides, and allergens in cow and Arabian camel milk.

Food Chem

December 2024

Edith Cowan University, School of Science, Joondalup, WA 6027, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australia; Commonwealth Scientific and Industrial Research Organisation, 306 Carmody Rd, St Lucia Agriculture and Food, Brisbane, QLD 4067, Australia. Electronic address:

Bovine milk has dominated the dairy segment, yet alternative milk sources are gaining attention due to perceived superior health benefits, with immune proteins and bioactive peptides (BPs) contributing to these benefits. Fractionation affects protein recovery and composition. Here, the cream fraction resulted in the highest yield of proteins, identifying 1143 camel and 851 cow proteins.

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were originally developed for the treatment of type 2 diabetes but have recently been approved for chronic weight management and reducing cardiovascular risk in individuals with overweight and obesity. Despite this approval, significant heterogeneity in the cardioprotective benefits and less desirable increases in resting heart rate (RHR) with GLP-1 RAs have been reported. To better understand cardiovascular responses to GLP-1 RAs, and the potential role of health behaviors in influencing these responses, we leveraged wearable technology and causal inference analysis.

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Extreme longevity may be the rule not the exception in Balaenid whales.

Sci Adv

December 2024

Centre for Planetary Health and Food Security, Griffith University, Nathan, QLD, Australia.

We fit ongoing 40+-year mark-recapture databases from the thriving southern right whale (SRW), , and highly endangered North Atlantic right whale (NARW), , to candidate survival models to estimate their life spans. Median life span for SRW was 73.4 years, with 10% of individuals surviving past 131.

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Introduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.

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The COVID-19 pandemic, caused by SARS-CoV-2, highlighted the importance of understanding transmission modes and implementing effective mitigation strategies. Recognizing airborne transmission as a primary route has reshaped public health measures, emphasizing the need to optimize indoor environments to reduce risks. Numerous tools have emerged to assess airborne infection risks in enclosed spaces, providing valuable resources for public health authorities, researchers, and the general public.

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Cerebrospinal fluid (CSF) biomarkers are currently the only clinically validated biofluid diagnostic test for Alzheimer's Disease (AD) available in Australia. Testing of CSF biomarkers via lumbar puncture (LP), including quantification of amyloid-β peptide, total tau protein, and phosphorylated tau, can give insight into underlying pathophysiological changes and provide greater certainty in confirming or excluding the presence of Alzheimer's disease changes compared to standard clinical and radiological assessments. Despite CSF analysis being a safe and cost-effective diagnostic method, the use of CSF biomarkers in the evaluation of potential AD remains limited in Australian clinical practice due to a variety of factors, including regional access challenges, concerns over the perceived invasiveness of LP and a lack of confidence among clinicians in interpreting the results.

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Feline caudal vena cava to aorta ratio reference interval.

J Feline Med Surg

December 2024

School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia.

Objectives: The primary objective of this investigation was to ultrasonographically evaluate the caudal vena cava to aorta (CVC:Ao) ratio in healthy, conscious cats and to generate reference intervals. A secondary objective was to identify the site of examination with the least intra- and inter-observer variability. This investigation was undertaken to assess whether the CVC:Ao ratio holds promise as a technique to assess intravascular volume responsiveness in cats.

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Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's Disease.

Mol Neurobiol

December 2024

Laboratory for Stem Cell & Restorative Neurology, Department of Biotechnology, Era's Lucknow Medical College and Hospital, Era University, Sarfarazganj, Lucknow, 226003, India.

Alzheimer's disease (AD) is currently the seventh leading cause of death worldwide. In this study, we explored the critical role of autophagy in AD pathology using a streptozotocin (STZ)-induced AD model in Wistar rats. The experimental groups included sham, STZ-induced AD, and STZ + MCC950-treated animals.

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The living centre: an innovative open-access model of breast cancer survivorship care.

Support Care Cancer

December 2024

Human Performance Research Centre, INSIGHT Research Institute, Faculty of Health, University of Technology Sydney (UTS), Sydney, NSW, Australia.

People affected by breast cancer experience a multitude of toxicities and unmet needs across physical, cognitive, psychosocial, and economic domains that adversely impact their quality of life. High-quality and diverse supportive care is required to improve outcomes and rehabilitation for people affected by breast cancer. However, the availability and access to high-quality supportive care services is limited due to factors including cost and demand.

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Habits are mental representations of associations between actions and contextual contingencies. Habit formation can be efficacious in promoting health behavior maintenance, including for highly complex behaviors such as physical activity. Changes in circumstances (e.

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