Immune traits in combination with inflammatory proteins revealing the pathogenesis of autoimmune liver diseases: A Mendelian randomization study.

Background: Prior observational research has shown relationships between immune cells, inflammatory proteins, and autoimmune liver diseases (AILD), but their causal associations remain controversial. Therefore, we aimed to clarify the causal association between them.

Methods: We carried out a comprehensive Mendelian randomization (MR) analysis to clarify causal associations between 731 immune traits, 91 circulating inflammatory proteins, and AILD, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH).

Biomechanical comparison of different surgical suture techniques for four-stranded all-inside cruciate ligament grafts.

Background: All-inside cruciate ligament reconstruction is an emerging technique for treating anterior cruciate ligament and posterior cruciate ligament injuries. The all-inside technique uses a 4-stranded graft made of a single tendon that wraps around itself. Four strands of the graft must be immobilized to form a closed loop, and the free ends of the graft must be attached using a suture technique.

MRI Radiomics-Based Machine Learning to Predict Lymphovascular Invasion of HER2-Positive Breast Cancer.

This study aims to develop and prospectively validate radiomic models based on MRI to predict lymphovascular invasion (LVI) status in patients with HER2-positive breast cancer. A total of 225 patients with HER2-positive breast cancer who preoperatively underwent breast MRI were selected, forming the training set (n = 99 LVI-positive, n = 126 LVI-negative). A prospective validation cohort included 130 patients with breast cancer from the Affiliated Zhongshan Hospital of Dalian University (n = 57 LVI-positive, n = 73 LVI-negative).

%BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus.

Purpose: To investigate the relationship between obesity indices and sarcopenia in postmenopausal patients with type 2 diabetes mellitus (T2DM) at different body mass index (BMI) levels.

Patients And Methods: This retrospective cross-sectional study included 298 hospitalized postmenopausal women diagnosed with T2DM. We collected demographic, biochemical, and anthropometric data on each subject.

Two-Step Iterative Medical Microwave Tomography.

In the field of medical imaging, microwave tomography (MWT) is based on the scattering and absorption characteristics of different tissues to microwaves and can reconstruct the electromagnetic property distribution of biological tissues non-invasively and without ionizing radiation. However, due to the inherently nonlinear and ill-posed characteristics of MWT calculations, actual imaging is prone to overfitting or artifacts. To address this, this paper proposes a two-step iterative imaging approach for rapid medical microwave tomography.

Repeated high-dose esketamine in early postnatal rats leads to behavioural deficits with long-term modifications in white matter microstructural integrity.

Esketamine is commonly used for sedation or general anaesthesia in infants and young children. However, repeated esketamine administration during periods of rapid brain growth and development may result in various pathophysiological and cognitive changes. Therefore, this study aimed to investigate the influence of recurrent esketamine exposure on long-term behavioural and white matter consequences.

pH responsive and zwitterionic micelle for enhanced cellular uptake and antitumor performance.

The side effects of small molecule chemotherapeutic drugs (SMCD) have brought great pain to the cancer patients. Many nanodrug carriers can relieve the shortcomings of SMCD, but they have complex synthesis processes and lack biodegradability. To overcome both problems, we synthesized a pH responsive biodegradable zwitterionic molecules (EK-D) by linking zwitterionic polypeptide (EK7) and dodecyl acrylate through a simple click reaction.

Comparison of a novel side-to-side tenorrhaphy with Pulvertaft weave: an in vitro biomechanical study.

Purpose: The aim of this study was to characterize the biomechanical properties of a novel side-to-side tenorrhaphy (SST), this tenorrhaphy is designed to achieve reliable strength utilizing fewer knots and greater operationalization. This is compared with a well-established tendon reconstruction technique called the Pulvertaft weave technique (PWT).

Methods: Twenty fresh porcine hindfoot flexor tendons were collected, and 10 novel SST and 10 PWT were performed in each group.

Screening and application of aptamers as fluorescent biosensors for selective and sensitive detection of hepatocellular carcinoma and in vivo targeted delivery studies.

The incidence of primary hepatocellular carcinoma (HCC) has recently ranked fifth in the world, and the incidence rate is increasing year by year worldwide. Therefore, early diagnosis is the highest priority in the treatment of HCC. In this paper, four anti-HCC aptamers were obtained using magnetic bead SELEX technology.

Radiomic Machine Learning in Invasive Ductal Breast Cancer: Prediction of Ki-67 Expression Level Based on Radiomics of DCE-MRI.

Purpose: Our study aimed to investigate the potential of radiomics with DCE-MRI for predicting Ki-67 expression in invasive ductal breast cancer.

Method: We conducted a retrospective study including 223 patients diagnosed with invasive ductal breast cancer. Radiomics features were extracted from DCE-MRI using 3D-Slicer software.

Nedl1 knockout impaired the learning and memory of mice.

Background: Protein ubiquitination is a common post-translational modification involved in protein degradation and various life processes in cells. NEDL1 is a ubiquitin ligase that is highly expressed primarily in the brain. However, the functions of NEDL1 in social approach/novelty preference, anxiety, learning and memory remain poorly understood.

Development of a novel nomogram for predicting prognosis of North Chinese with autoimmune cerebellar ataxia.

Purpose: The aim of this study was to develop a prognostic nomogram which could predict the prognosis of north Chinese patients with autoimmune cerebellar ataxia (ACA) after immunotherapy.

Methods: Patients with an initial diagnosis of ACA who accepted first-line immunotherapy at our hospital from March 2018 to May 2023 were retrospectively reviewed. Modified Rankin Scale (mRS) was used to evaluate neurological outcomes.

Air pollution exposure during preconception and first trimester of pregnancy and gestational diabetes mellitus in a large pregnancy cohort, Hebei Province, China.

Objective: To explore the relationship between the exposure level of particulate matter 2.5 (PM2.5) and particulate matter 10 (PM10) in the air of pregnant women during preconception and first trimester of pregnancy and the risk of gestational diabetes mellitus (GDM).

An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic Target.

Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological activities, and their disorders or imbalances can lead to various diseases. As a subgroup of deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many biological processes. USP53, one of the family members, is widely expressed in human tissues and participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling.