Neuroprotective effect of intermittent hypobaric hypoxia preconditioning on cerebral ischemia/reperfusion in rats.

Background: Ischemic tolerance is an endogenous protective mechanism in organs or tissues undergoing one or more short-term sublethal ischemias. Intermittent hypobaric hypoxia preconditioning (IHHP) can induce tolerance and thus protect brain tissues from cerebral ischemic injury (CIR). The current study evaluated the neuroprotective effect of IHHP.

Nintedanib ameliorates tracheal stenosis by activating HDAC2 and suppressing IL-8 and VEGF in rabbit.

Acquired tracheal stenosis is a common disease occurring after endotracheal intubation or tracheotomy. Currently, surgery is the main option to treat the stenosis. This study investigated therapeutic effect and possible mechanism of nintedanib on tracheal stenosis.

Effects of α-zirconium phosphate and zirconium organophosphonate on the thermal, mechanical and flame retardant properties of intumescent flame retardant high density polyethylene composites.

The combination of synergistic agents with intumescent flame retardants (IFRs) is an excellent strategy for the development of high-performance flame retardant composites. Zirconium-based compounds are multifunctional materials with applications in various fields. In this study, zirconium-based compounds were synthesized and then combined with an IFR composed of ammonium polyphosphate (APP) and tris (2-hydroxyethyl) isocyanurate (THEIC) to prepare flame retardant high density polyethylene (HDPE) composites.

Identifying specific miRNAs and associated mRNAs in CD44 and CD90 cancer stem cell subtypes in gastric cancer cell line SNU-5.

Cancer stem cells (CSCs) are capable of generating multiple types of cells and play a vital role in promoting gastric cancer (GC) progression. Our previous research indicated that gastric CSCs with surface markers of CD44+ were more invasive compared to CD44- CD90+ CSCs (CD90+ CSCs), whereas CD90+ CSCs exhibited higher levels of proliferation than CD44+ CSCs. However, the mechanism and characteristics of marker-positive gastric CSCs are poorly understood.

[Regional suitability analysis of endangered medicinal plant Dactylorhiza hatagirea].

The wild plant Dactylorhiza hatagirea commonly used in Tibetan medicine. In recent years, it is on the verge of extinction due to improper excavation and habitat deterioration. Based on the literature review, and the meteorological and ecological data of Qinghai Province and data derived from the field survey, this study took the altitude, humidity index, annual average wind speed, monthly average sunshine, precipitation and temperature in growing season, soil type and vegetation type as the zoning indexes, and applied ArcGIS software for spatial superposition analysis.

Can polyploidy confer invasive plants with a wider climatic tolerance? A test using .

Polyploidy can cause variation in plant functional traits and thereby generate individuals that can adapt to fluctuating environments and exploit new environments. However, few empirical studies have tested for an association between ploidy level and climatic tolerance of invasive cytotypes relative to conspecific native-range cytotypes. Here, we used an invasive plant to test whether invasive populations had a higher proportion of polyploids, greater height and stem-base diameter, and occupied a wider range of climatic conditions than conspecific native-range populations.

Preparation of SnO nanotubes a template-free electrospinning process.

A facile and environmentally friendly template-free method is developed for the fabrication of SnO nanotubes electrospinning and precisely controlled heat treatment method. It is revealed that the as-spun solid SnO precursor fibers gradually transformed into hollow-structured nanotubes when the temperature was controlled precisely from 200 °C to 600 °C. It was confirmed, that this remarkable structural evolution corporate the respective thermal decomposition of polyvinyl butyral (PVB) at the surface and inside of the fibers.

Pathogenesis and anti-proliferation mechanisms of Crocin in human gastric carcinoma cells.

Gastric cancer is the fourth most common cause of cancer death globally and the second most common in Asia. Many studies suggest that Crocin has the potential for gastric cancer antineoplastic combined chemotherapy protocols. Here we investigated genomic changes related to the inhibitory effect of Crocin, and elucidated the molecular mechanism of this inhibition in gastric carcinoma cells.

Trait means predict performance under water limitation better than plasticity for seedlings of Poaceae species on the eastern Tibetan Plateau.

Water availability may be altered by changes in precipitation under global climate change in alpine areas. Trait means and plasticity are important for plants in response to a changing environment. In an examination of alpine plant responses to changed water availability, and for determination of how trait means and plasticity predict the performance (e.

Aggregation-induced enhanced emission-type cruciform luminophore constructed by carbazole exhibiting mechanical force-induced luminescent enhancement and chromism.

One D-A type cruciform luminophore MDCS-BC based on carbazole has been prepared. We observed that this compound exhibits unique intramolecular charge-transfer (ICT) and typical aggregation-induced enhanced emission (AIEE) properties with the solid-state luminescence efficiency of 0.184.

microRNA-1908-5p inhibits proliferation and promotes apoptosis by targeting PP5 in NSCLC.

MicroRNA-1908 is involved in the occurrence and development of various tumors. However, the mechanism of microRNA-1908-5p in the pathogenesis of non-small cell lung cancer (NSCLC) is not thoroughly studied. Protein phosphatase 5 catalytic subunit (PP5), a member of the protein phosphatase catalytic subunit family, may be a target of the microRNA-1908-5p.

[Network pharmacology research on high frequency use of Tibetan medicine in treatment of HAPC based on data mining].

Based on the results of previous data mining,the mechanism of high frequency use of Tibetan medicine in the treatment of high altitude polycythemia(HAPC) was analyzed in this study by network pharmacology. The author obtained the high frequency use data on Tibetan medicine Terminalia chebula,Aucklandia lappa,Crocus sativus and Myristica fragrans for the treatment of HAPC by data mining in the previous period. The first five main active ingredients of each high frequency Tibetan medicine were screened out by reviewing comprehensive literature and TCMSP database.

[Study on sustainable development of Tibetan medicine resources on Qinghai-Tibet Plateau].

Through using the theoretical research results of traditional Chinese medicine resource management and sustainable utilization as references,this article systematically analyzes the relationship between economic subsystems for utilization of wild renewable resources in Tibetan medicine,resources,environment and social systems. It sorts out and designs the relationship diagram of the sustainable utilization system for Tibetan medicine resources,input and output relationship diagrams of economics subsystems for Tibetan medicine resources,development model diagram for Tibetan medical industrial chain,market development flow chart of wild herb resources of Tibetan medicine,causal circuit diagram of sustainable use mechanism for Tibetan medicine resources,cause tree of the stock and function for Tibetan medicine resources,cause tree of total income for Tibetan medicine resource utilization and tree diagram of compensation fund usage of Tibetan medicine resources. It provides an innovative research method for Tibetan medicine resources,and theoretical basis and relevant countermeasure for constructing sustainable approaches to development of wild renewable resources in Tibetan medicine.

[Study on regularity of drug use in Tibetan medicine treating hypertension based on multi-center clinical medical records and "prescription-property-efficacy-disease"].

This study aimed to explore the rule of Tibetan medicine in clinical treatment of hypertension( k Hrag-rLung-stod-vtshangs) and analyze the characteristics of its prescriptions. One hundred and thirty-seven cases of hypertension treated Tibetan medicine were collected. Data mining,Gephi,Cytoscape and other methods and software were used to analyze the characteristics of Tibetan medicine.

species in south-western China.

Three strains of the genus were isolated from different plant hosts in south-western China. Phylogenetic analyses of the combined ITS, -tubulin, 1 and calmoudulin dataset indicated that these strains represented three independent lineages in . clustered with and , grouped with , and and strain GUCC9146, isolated from , was grouped in the species complex with a close relationship to .

Low-cost and environmentally friendly synthesis of an Al and Mn co-doped LiTiO composite with carbon quantum dots as an anode for lithium-ion batteries.

To increase the specific capacity and conductivity of lithium titanate (LTO), low-cost and environmentally friendly carbon quantum dots (CQDs) were used to composite with Al and Mn co-doped LiTiO (LTO-Al/Mn) to improve its electrical properties. The Al and Mn were successfully substituted for Ti located at (16d) sites in the LTO and the CQDs formed a composite with LTO-Al/Mn. The specific capacity of the first cycle at 0.

Maxent modeling for predicting the spatial distribution of three raptors in the Sanjiangyuan National Park, China.

Upland buzzard (), Saker falcon (), and Himalayan vulture () are three common large raptors in the Sanjiangyuan National Park (SNP), China's first national park. Among them, Upland buzzard and Saker falcon play a significant role in controlling plateau rodent populations and reducing the transmission of pathogens carried by rodents. The Himalayan vulture can provide services for the redistribution and recycling of nutrients in the ecosystem, and play an irreplaceable role in the celestial burial culture of Tibetans in China.

Effects of the fenugreek extracts on high-fat diet-fed and streptozotocin-induced type 2 diabetic mice.

Background: To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin (STZ)-induced type 2 diabetic (T2DM) mice fed a high-fat diet (HFD).

Methods: We established C57BL/6J mice model of T2DM using HFD-fed and STZ-induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose (FBG), weight, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and pathological indexes were investigated.

Preparation, crystal structure and luminescence properties of a novel single-phase red emitting phosphor CaSr(PO):Sm,Li.

Single-phase CaSr(PO):Sm,Li phosphors were prepared a high-temperature solid-state method under air. The powder X-ray diffraction patterns, scanning electron microscopy images, photoluminescence spectra, and concentration-dependent emission spectra were measured to characterize the as-prepared phosphors and luminescence decay curves. The results showed that the CaSr(PO):Sm,Li phosphors exhibited red luminescence, and the emission spectra of the phosphors consisted of four sharp peaks at around 565, 601 (the strongest one), 647 and 707 nm.

Structure and luminescence properties of LaBa(SiO)F:Dy phosphor with apatite structure.

In this study, we investigated the structure, luminescence properties and morphology of LaBa(SiO)F:Dy in detail using X-ray diffraction (XRD), photoluminescence spectroscopy, scanning electron microscopy (SEM) and decay kinetics measurements. The results indicate that LaBa(SiO)F:Dy was well crystallized, and its structure is of apatite-type and belongs to the hexagonal system. The prepared samples exhibit two intense characteristic bands in the blue (484 nm) and yellow (579 nm) spectral ranges corresponding to the Dy transitions F → H and F → H, respectively.

Clinical case report on treatment of meningoencephalitis: Intrathecal injection.

This article mainly reports the process of clinical diagnosis and treatment of a misdiagnosed meningoencephalitis. The patient's condition is aggravated because of the ineffective prophase therapy. In the later stage, we were mainly through combined antibiotics and given proper routes of administration, so that patient can recover quickly.

Preparation and fire behavior of rigid polyurethane foams synthesized from modified urea-melamine-formaldehyde resins.

In this study, a series of ethylene glycol modified urea-melamine-formaldehyde resins (EUMFs) were synthesized from urea, melamine, paraformaldehyde and ethylene glycol, and then incorporated into rigid polyurethane foams (RPUFs) as a reactive-type liquid flame retardant. The structure of EUMFs was characterized by Fourier transform infrared spectrometry; the morphology of the foams was characterized by scanning electron microscopy; and the thermal degradation and fire behavior of RPUFs were characterized by limiting oxygen index (LOI), cone calorimetry test and thermogravimetry analysis. The results show that the incorporation of EUMFs results in an increase in thermal stability, smoke suppression and LOI of RPUFs.

Crystal structure and luminescence properties of a novel single-phase orange-red emitting phosphor CaLa (PO):Sm.

CaLa (PO):Sm phosphors (0.01 < < 0.25) were synthesized high temperature solid-state reaction.

green oxidation synthesis of Ti and N self-doped SrTiO N nanoparticles with enhanced photocatalytic activity under visible light.

A simple green oxidation synthesis route was developed to prepare Ti and N self-doped SrTiO N nanoparticles using TiN and HO as precursors. X-ray diffraction (XRD), scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM) were used to characterize the crystallinity, structure and morphology. X-ray photoelectron spectroscopy (XPS) tests confirmed the presence of Ti and N in the prepared SrTiO N nanoparticles.