Changing Trends in Job Satisfaction and Burnout for Care Aides in Long-Term Care Homes: The Role of Work Environment.

Objectives: This study examined the association between care unit work environments in long-term care (LTC) homes and trends in care aides' job satisfaction and burnout (exhaustion, cynicism, reduced professional efficacy) from 2014 to early 2020.

Design: This was a retrospective longitudinal study using data from care aide surveys collected by the Translating Research in Elder Care research program over 3 periods: September 2014-May 2015 (T), May 2017-December 2017 (T), and September 2019-March 2020 (T).

Settings And Participants: The study included 631 care aides from a stratified random sample of 84 LTC homes in 3 Canadian provinces, who participated in data collection at all 3 time points.

The Relationship between Coping Strategies and Internalizing and Externalizing Problems of Bullied Students: The Moderating Role of Classroom Discipline Management.

Bullying has become a worldwide concern, and is particularly serious in vocational high schools in China. The bullied students typically resort to coping strategies to mitigate its adverse consequences. However, there is a lack of research on which bullying coping strategies might mitigate the negative effects of bullying on students and which types of classroom discipline management might play a moderating role.

Organic-inorganic complex S-scheme photocatalyst resorcinol-formaldehyde resins/BiOCO with enhanced photocatalytic HO production.

Herein, resorcinol formaldehyde resins/BiOCO S-scheme heterojunctions are constructed polymerization. The composites displayed an improved separation efficiency of photo-induced carriers and the HO production rate achieved 1178.08 μmol h g, marking 47.

Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study.

Polatuzumab vedotin plus R-CHP (Pola-R-CHP) is approved as a new standard first-line therapy for diffuse large B-cell lymphoma (DLBCL) based on the POLARIX trial. However, real-world data on its efficacy and safety in unselected patients is lacking. We conducted a retrospective cohort study to evaluate Pola-R-CHP versus R-CHOP outcomes in routine clinical practice in China.

Identification of oxidative stress-related biomarkers in uterine leiomyoma: a transcriptome-combined Mendelian randomization analysis.

Background: Oxidative stress has been implicated in the pathogenesis of uterine leiomyoma (ULM) with an increasing incidence. This study aimed to identify potential oxidative stress-related biomarkers in ULM using transcriptome data integrated with Mendelian randomization (MR) analysis.

Methods: Data from GSE64763 and GSE31699 in the Gene Expression Omnibus (GEO) were included in the analysis.

Balancing growth and preservation: Unravelling Africa's carbon-economic nexus through the environmental kuznets curve.

Africa is vulnerable to the challenges of global climate change, which poses a significant obstacle to achieving economic development while protecting the environment. Despite numerous Environmental Kuznets Curve (EKC) studies, evidence remains inconclusive, especially in African countries. This study delves into the carbon-economic nexus within the EKC framework across 46 African countries from 1990 to 2020.

HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway.

Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells (hucMSCs) have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis.

The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis. Epigenetic dysregulation plays a crucial role in PDAC progression, but its comprehensive landscape and clinical implications remain unclear.

Methods: We integrated single-cell RNA sequencing, bulk RNA sequencing, and clinical data from multiple public databases.

New-Occurrence of Postoperative Modic Changes and Its Influence on the Surgical Prognosis After Percutaneous Endoscopic Lumbar Disc Discectomy.

Objectives: Lumbar disc herniation (LDH) is a common degenerative spinal disease in clinical practice. This study aims to investigate the impact of Modic changes (MCs) on postoperative recovery and disease recurrence following percutaneous endoscopic lumbar disc discectomy (PELD), providing important insights for improving the management of chronic low back pain. This study investigates the 1-year progression rate of MCs after PELD and their impact on surgical outcomes and recurrence.

Different scanning protocol to assess left atrial appendage thrombus in patients with atrial fibrillation by cardiovascular computed tomography.

To investigate whether we can rule out the left atrial appendage (LAA) thrombus in patients with atrial fibrillation (AF) using different scanning protocol by Cardiovascular Computed Tomography (CCT). We retrospectively reviewed the CCT images of 138 patients with AF to assess LAA thrombus. Patients with no thrombosis diagnosed by preoperative CCT should be confirmed using intraoperative findings as the reference standard.

Ultrasound-based radiomics to predict the volume reduction rate of benign thyroid nodules after microwave ablation.

Objective: To evaluate the predictive power of ultrasound-based radiomics models for benign thyroid nodules with a volume reduction rate (VRR) of < or ≥75% at 12 months after microwave ablation.

Methods: A retrospective study was conducted on 194 individuals with benign thyroid nodules who received ultrasound-guided microwave ablation between November 2019 and June 2023. The clinical and ultrasound features, including age, gender, volume, echogenicity, duration of ablation, and so on were analysed by t-test or chi-square test.

Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.

Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.

Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Ultrasensitive Organic Photoelectrochemical Transistor Biosensor Based on DNA as Nanocarrier for Efficient Immobilization of Signal Probe with Pimping Background.

Organic photoelectrochemical transistor (OPECT) assays are mainly focused on the improvement of photoactive materials at the gating interface, which leads to an enhanced initial signal alongside significant background noise. This phenomenon can cause considerable deviations and impose limits on target detection. In this study, we achieved sensitive and low-background detection of alkaline phospholipase (ALP) activity using single-stranded DNA (ssDNA) as a nanocarrier to effectively immobilizing CdS quantum dots (QDs) sensitizing UiO-66.

Short-chain fatty acids and cancer.

Short-chain fatty acids (SCFAs), derived from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer. They function as energy sources through β-oxidation and regulate macromolecular synthesis, G protein-coupled receptor (GPCR) and histone deacetylase (HDAC) activities, protein modifications, signaling pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune cells. The critical role of SCFAs in maintaining normal homeostasis and influencing tumor progression highlights the potential of targeting SCFA-mediated cellular processes for cancer prevention and treatment.

Anisotropic hydrogel sensors with muscle-like structures based on high-absorbent alginate fibers.

Hydrogel sensors have attracted much attention as they play a critical role in health monitoring, multifunctional electronic skin, and human-machine interfaces. However, the isotropic structure makes existing hydrogel sensors exhibit isotropic sensing performance. Therefore, it is a challenge to fabricate hydrogels with human tissue-like structures to achieve anisotropic sensing performance.

Wood's lamp for early detection of Microsporum Canis tinea capitis in children.

Background: Pediatric alopecia is increasingly common, influenced by conditions like alopecia areata and infections such as tinea capitis, primarily caused by Microsporum canis. Diagnosing tinea capitis in primary care is challenging due to limited access to advanced tools, leading to treatment delays.

Objectives: This study evaluates the effectiveness of Wood's lamp for early diagnosis of tinea capitis and its role in distinguishing it from other pediatric alopecia types.

Improved mechanical performance and forming accuracy of ZrO fixed partial denture based on the digital light processing technology.

Fixed partial dentures are the primary treatment for dentition defects. Digital light processing (DLP) 3D printing technology is an advanced technique with significant advantages and potential in the field of dental restoration, particularly in cases requiring high precision and personalization. However, challenges persist in printing fixed partial dentures that meet the strength requirements for clinical applications.

The impact of COVID-19 on women's reproductive system.

The coronavirus disease 2019 (COVID-19) pandemic has been a major global focus since 2019. However, drug development and vaccination have been unable to stop the rise in the number of COVID-19 infections. As a result, almost everyone has been infected with COVID-19.

Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study.

Background: The mechanism underlying new-onset postoperative atrial fibrillation (POAF) in adult cardiac surgery is not well understood. However, efficient pharmacological methods to prevent and treat arrhythmic complications are still lacking. In the present study, we explored the efficacy and safety of sacubitril/valsartan (sac/val) in the control of POAF in adult cardiac surgery patients.

Toward stakeholders' understanding of media reporting on doctor-patient relationship issues: trust, unfamiliarity and uncertainty in the Chinese context.

Introduction: This study explores doctors' and patients' understandings of citizen journalism on doctor-patient relationship issues. It also examines the communication effect of citizen journalism as a communication platform on doctors and patients who are taking part in the doctor-patient relationship in contemporary China.

Method: This study draws on the analysis of 24 semi-structured interviews with doctors from both publicly funded and privately operated hospital, and nine focus groups which included 36 patients with different socio-economic backgrounds.

Reconstructing the phase of vanadium oxides enables redox-catalysis manipulated reversible sulfur conversion for stable Zn-S batteries.

The naturally sluggish redox kinetics and limited utilization associated with the sulfur conversion in Zn/S electrochemistry hinder its real application. Herein, we report an phase reconstruction strategy that activates the catalytic activity of vanadium oxides for invoking redox-catalysis to manipulate reversible sulfur conversion. It was identified that the VO@C/S precursor derived from metal organic frameworks could be transformed into VO ·HO@C/S by a facile electrochemical induction process.

Improvement effect of insulin resistance in one-day outpatient service by reducing stress adaptation disorders in patients with gestational diabetes mellitus.

Aim: Conducted a one-day outpatient service for GDM patients, analyzed the relationship between stress adaptation disorder and insulin resistance in GDM patients after intervention, and tried to provide some new clues for the prevention and treatment of GDM, provide some theoretical basis for the multidisciplinary diagnosis and treatment model of GDM patients.

Methods: 240 GDM women were included in this study, 120 women were included in one-day diabetes clinic management for GDM women as GDM Intervention Group, and 120 GDM women receiving regular dietary education as GDM Control Group. One-day diabetes clinic management including disease knowledge and dietary education, sports education and blood sugar monitoring and personalized issues and follow-up visits, and intervention time lasting for 1 month.