Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation.

Background: Fangji Huangqi Decoction (FJHQD), a famous Traditional Chinese Medicine (TCM) formula, has been widely applied in improving renal function. However, the interaction of bioactives from FJHQD with the targets involved in acute renal injury (AKI) has not been elucidated yet.

Purpose: A network pharmacology-based approach combined with molecular docking and in vitro and in vivo validation was performed to determine the bioactives, key targets, and potential pharmacological mechanism of FJHQD against AKI.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein.

Background: Preeclampsia (PE) is a pregnancy-specific, multisystemic disorder that affects 2-8% pregnancies worldwide and is a leading cause of maternal and perinatal mortality. At present, there is no cure for PE apart from delivery the placenta. Therefore, it is important and urgent to possess a suitable animal model to study the pathology and treatment of PE.

Epilepsy and brain health: a large prospective cohort study.

Background: Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.

Methods: The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline.

Near-infrared fluorescence imaging platform with ultra large Stokes shift for monitoring and bioimaging of hydrogen peroxide in the process of ferroptosis.

Hydrogen peroxide (HO), as a strong oxidant, is crucial for the aerobic metabolism of organisms and is intricately linked to the onset of numerous diseases. Real-time monitor HO levels in the environment and biological microenvironment is of paramount importance for environment protection and elucidating HO-related physiological and pathological processes. In this study, a novel near-infrared fluorescence imaging platform was developed and a near-infrared fluorescent probe FBMH was constructed based on the platform with photoinduced electron transfer mechanism.

Rational Design and Application of Breath Sensors for Healthcare Monitoring.

Biomarkers contained in human exhaled breath are closely related to certain diseases. As a noninvasive, portable, and efficient health diagnosis method, the breath sensor has received considerable attention in recent years for early disease screening and prevention due to its user-friendly and easy-accessible features. Although some key challenges have been addressed, its capability to precisely monitor specific biomarkers of interest and its physiological relevance to health metrics is still to be ascertained.

High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.

Aim: Imbalanced M1/M2 macrophage phenotype activation is a key point in diabetic kidney disease (DKD). Macrophages mainly exhibit the M1 phenotype, which contributes to inflammation and fibrosis in DKD. Studies have indicated that autophagy plays an important role in M1/M2 activation.

TaqMan Array Card real-time polymerase chain reaction panel to detect pathogens in whole blood of febrile inpatients in northern Tanzania, 2016-2019.

Background: Acute febrile illness is a common reason for seeking healthcare in low- and middle-income countries. We describe the diagnostic utility of a TaqMan Array Card (TAC) real-time polymerase chain reaction (PCR) panel for pathogen detection in paediatric and adult inpatients admitted with febrile illness.

Methods: In this prospective cohort study, we screened medical admissions for a tympanic temperature ≥38.

Recurrence Patterns and Long-Term Results After Curative Surgery for Patients With Breast Cancer.

Background: The current study aimed to examine second breast cancer (SBC) risks associated with breast-conserving surgery (BCS) and unilateral mastectomy among breast cancer (BC) survivors.

Methods: The study enrolled patients with diagnoses of stages I to III BC who underwent surgery between 2000 and 2019. Fine-Gray competing risk regression models were used to estimate the cumulative incidence of SBC and to evaluate the associations between clinical factors and SBC development.

Machine Learning Prediction of Early Recurrence in Gastric Cancer: A Nationwide Real-World Study.

Background: Patients with gastric cancer (GC) who experience early recurrence (ER) within 2 years postoperatively have poor prognoses. This study aimed to analyze and predict ER after curative surgery for patients with GC using machine learning (ML) methods.

Patients And Methods: This multicenter population-based cohort study included data from ten large tertiary regional medical centers in China.

The influencing of obesity on lung ventilation function among middle-aged and elderly people.

This study examined the effect of obesity on lung ventilation function in middle-aged and older adults using data from the China Health and Retirement Longitudinal Study. Lung function was measured using peak expiratory flow, and obesity was assessed using waist circumference and body mass index (BMI). Logistic regression and the bivariate logit model were applied to analyze the data.

Combination drug therapy prevents CIAKI by suppressing ER stress-induced apoptosis.

Contrast-induced acute kidney injury (CIAKI) is an important clinical complication that occurs after the application of contrast agent in percutaneous coronary intervention. The pathogenesis of CIAKI is complex. Studies have shown that cell apoptosis induced by endoplasmic reticulum stress (ERS) plays an important role in renal tubular injury in CIAKI.

The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality.

Sexual activity exists in a complex relationship with human health. This study aims to elucidate the correlation between the sexual frequency and the incidence of cardiovascular diseases (CVD) and all-cause mortality among young and middle-aged adults of the United States. We analyzed 17,243 participants from the National Health and Nutrition Examination Survey(NHANES)(2005-2016), comparing CVD incidence and all-cause mortality risks across sexual frequencies using multivariable Logistic and Cox regression models.

Molecular Mechanisms Underlying the Loop-Closing Dynamics of β-1,4 Galactosyltransferase 1.

The β-1,4 galactosylation catalyzed by β-1,4 galactosyltransferases (β4Gal-Ts) is not only closely associated with diverse physiological and pathological processes in humans but also widely applied in the -glycan modification of protein glycoengineering. The loop-closing process of β4Gal-Ts is an essential intermediate step intervening in the binding events of donor substrate (UDP-Gal/Mn) and acceptor substrate during its catalytic cycle, with a significant impact on the galactosylation activities. However, the molecular mechanisms in regulating loop-closing dynamics are not entirely clear.

Research progress of novel anti-tumor drug formulations.

Cancers have become the second leading cause of death worldwide, following cardiovascular diseases.Traditional anti- cancer strategies, including radiotherapy chemotherapy, surgery, and targeted therapies, have been widely used but are often reassessed due to their significant side effects and relatively low cure rate. Recently, the development of novel formulations for anti-tumor drugs has gained considerable attention, marking a pivotal step forward in cancer treatment advancements.

Inhibition of lysine-specific histone demethylase 1A suppresses adenomyosis through reduction in ectopic endometrial stromal cell proliferation, migration, and invasion.

Objective: Deep endometriosis is now referred to as adenomyosis externa, whereas adenomyosis is once known as endometriosis interna. Lysine-specific histone demethylase 1A (KDM1A, commonly LSD1) is a lysine demethylase that targets histone and non-histone proteins. This study aimed to assess how KDM1A affects the migration, invasion, and proliferation of adenomyosis-derived endometrial stromal cells (ESCs).

Gastrointestinal stromal tumor mimicking perineurioma: A case report.

Although gastrointestinal stromal tumor (GIST) can present with various histological characteristics, GIST mimicking perineurioma has not been previously reported. We present the case of a 47-year-old woman diagnosed with GIST after laparoscopic resection of a stomach tumor near the lesser curvature of the gastric body close to the cardia. Morphological features resembled a perineurioma.

Exploring the causal relationship of gut microbiota in nonunion: a Mendelian randomization analysis mediated by immune cell.

Background: Emerging research indicates that gut microbiota (GM) are pivotal in the regulation of immune-mediated bone diseases. Nonunion, a bone metabolic disorder, has an unclear causal relationship with GM and immune cells. This study aims to elucidate the causal relationship between GM and nonunion using Mendelian Randomization (MR) and to explore the mediating role of immune cells.

Cov-trans: an efficient algorithm for discontinuous transcript assembly in coronaviruses.

Background: Discontinuous transcription allows coronaviruses to efficiently replicate and transmit within host cells, enhancing their adaptability and survival. Assembling viral transcripts is crucial for virology research and the development of antiviral strategies. However, traditional transcript assembly methods primarily designed for variable alternative splicing events in eukaryotes are not suitable for the viral transcript assembly problem.

Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function.

Background: Previous genome-wide association studies (GWAS) have established association between genetic variants and pulmonary function across various ethnics, whereas such associations are scarcely reported in Chinese adults. Therefore, we conducted an GWAS to explore relationships between genetic variants and pulmonary function among middle-aged Chinese dizygotic twins and further validated the top variants using data from the UK Biobank (UKB).

Methods: In the discovery phase, 139 dizygotic twin pairs were drawn from the Qingdao Twin Registry.

Insights and perspectives of chitosan-based hydrogels for the removal of heavy metals and dyes from wastewater.

Water pollution has become an increasingly serious issue, necessitating the design and development of more effective wastewater treatment methods. Chitosan-based hydrogels, owing to their unique structural and chemical properties, have demonstrated high efficiency in removing contaminants. However, the application remains restricted by the scarcity of effective adsorption sites and limited environmental stability.

Preparation and anti-inflammation activity of λ-carrageenan oligosaccharides degraded by a novel λ-carrageenase Car3193.

To date, less attention has been paid to λ-carrageenases and their enzymatic hydrolysates than to κ- and ι-carrageenases and their hydrolysates. In this study, a Gram-negative strain Polaribacter sp. NJDZ03 was isolated from the surface of an Antarctic macroalga, Desmarestia sp.