Wheat WW Domain-Containing Protein TaCFL1 Negatively Regulates Cuticular Wax Biosynthesis.

Waxy cuticle covers plant aerial organs and protects plants against environmental challenges. Although improved cuticle-associated traits are aimed at the wheat breeding programs, the mechanism governing wheat cuticular wax biosynthesis remains to be elucidated. Herein, wheat WW domain-containing protein TaCFL1 is characterized as a negative regulator of wax biosynthesis.

Bioinspired Fern-like FeO Functionalized with Pd/PdO Nanoparticles for High-Performance Acetone Sensing.

The accurate monitoring and detection of acetone vapor are essential for environmental and human safety. Consequently, fern-like FeO with hierarchical vein-like structures is synthesized via a concise hydrothermal method. Compared with pure fern-like FeO, fern-like Pd/PdO-FeO shows the best acetone-sensing characteristics, in terms of lower operating temperature (180 °C), better selectivity and excellent long-term stability.

Study on the Regulatory Mechanism of Niacin Combined with in Alleviating Alcoholic Fatty Liver Disease by Up-Regulating GPR109A.

Background: This study aimed to investigate the effects of niacin combined with F1-7 on the improvement of alcoholic fatty liver disease (AFLD) in mice and its potential regulatory mechanism.

Methods: A total of 75 8-week-old male C57BL/6N mice were acclimated for one week and randomly divided into five groups: control group, alcohol model group (AFLD), niacin intervention group (NA), F1-7 intervention group (F1-7), and niacin combined with F1-7 intervention group (NF). The experiment lasted for 8 weeks.

Bamboo Kraft Pulp Black Liquor as a Renewable Source of Value-Added Carbon Dots.

China is the country with the most abundant bamboo resources in the world. Using bamboo as a raw material for pulping and papermaking can save a lot of wood and protect forests. Bamboo pulping enterprises mostly adopt sulfate processes to produce a large amount of black liquor (BL), which contains monosaccharides, polysaccharides, oligosaccharides, pectin, lignin, etc.

Insight into the Amelioration Effect of Nitric Acid-Modified Biochar on Saline Soil Physicochemical Properties and Plant Growth.

Soil salinization is a major factor threatening global food security. Soil improvement strategies are therefore of great importance in mitigating the adverse effect of salt stress. Our study aimed to evaluate the effect of biochar (BC) and nitric acid-modified biochar (HBC) (1%, 2%, and 3%; m/m) on the properties of salinized soils and the morphological and physiological characteristics of pakchoi.

Arbuscular Mycorrhizal Fungi-Assisted Phytoremediation: A Promising Strategy for Cadmium-Contaminated Soils.

Arbuscular mycorrhizal fungi (AMF) have been shown to play a major role in regulating the accumulation, transport, and toxicity of cadmium (Cd) in plant tissues. This review aims to highlight the current understanding of the mechanisms by which AMF alleviate Cd toxicity in plants. Cd accumulation in agricultural soils has become an increasing global concern due to industrial activities and the use of phosphatic fertilizers.

Primary intraosseous squamous cell carcinoma originating from a mandibular odontogenic cyst: A case report.

Malignant transformation arising in the background of jaw cysts is a rare and often misdiagnosed condition, particularly when developing from residual root-derived cysts. We present a case of epithelial malignancy originating from a residual root-derived cyst in the mandible of a man around 50 years old. Histological evaluation of the sections revealed that the epithelial lining of the cystic lesion contained well-differentiated squamous cell carcinoma components.

Effects and mechanisms of Apelin in treating central nervous system diseases.

Apelin, an endogenous ligand of G protein-coupled receptor APJ, is widely distributed in the central nervous system (CNS). It can be divided into such subtypes as Apelin-13, Apelin-17, and Apelin-36 as they have different amino acid structures. All Apelin is widely studied as an adipokine, showing a significant protective effect through regulating apoptosis, autophagy, oxidative stress, angiogenesis, inflammation, and other pathophysiological processes.

Role of mA methyltransferase METTL3 in keratoconus pathogenesis.

Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (mA) modification-related proteins in KC samples and human stromal keratocyte (HTK) cells stimulated by mechanical stretch (MS) using Western blotting and immunohistochemistry.

Rabeprazole inhibits lung cancer progression by triggering NLRP3/CASP-1/caspase-dependent pyroptosis.

Background: Gastric acid-related diseases could be treated using proton pump inhibitors (PPIs), which have been found to have anti-tumor ability. Rabeprazole is a type of PPI whose effect and mechanism in lung cancer remained to be clarified.

Methods: Lung cancer cells and lung cancer mice were treated with different concentrations of Rabeprazole and then cell proliferation was detected by CCK-8 and colony formation assays.

Cyanobacteria-probiotics symbionts for modulation of intestinal inflammation and microbiome dysregulation in colitis.

Inflammatory bowel disease (IBD) is often associated with excessive inflammatory response and highly dysregulated gut microbiota. Traditional treatments utilize drugs to manage inflammation, potentially with probiotic therapy as an adjuvant. However, current standard practices often suffer from detrimental side effects, low bioavailability, and unsatisfactory therapeutic outcomes.

Cis-Regulation of an mA Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.

N6-methyladenosine (mA) serves as one of the crucial RNA modifications for genes involved in cancer progression. Here, 7273 expression quantitative trait loci potentially regulating 30 m6A pathway genes are identified from the GTEx database, with 69 single nucleotide polymorphisms significantly associated with survival of non-small cell lung carcinoma (NSCLC) patients (n = 1523) from the ongoing genome-wide association study after false positive probability tests. Notably, the rs151198415 locus, situated in a potential enhancer region, demonstrated a prolonged survival effect with the C>CCACG insertion, which is validated in an independent prospective cohort (n = 237), yielding a pooled hazard ratio of 0.

Susceptibility of Mitophagy-Deficient Tumors to Ferroptosis Induction by Relieving the Suppression of Lipid Peroxidation.

The identification of ferroptosis-sensitive cancers is critical for the application of ferroptosis-inducing therapies in cancer therapy. Here, patient-derived organoid screening models of colorectal cancer are established to identify tumors that are sensitive to ferroptosis-inducing therapy. This study discovers that patient-derived tumors characterized by mitophagy deficiency are hypersensitive to ferroptosis-inducing therapies.

Stimulus Responsive Nanocarrier for Enhanced Antitumor Responses Against Hepatocellular Carcinoma.

Background: Hepatocellular carcinoma (HCC) is a serious global health concern, accounting for about 90% of all liver cancer instances. Surgical treatment is a fundamental aspect of HCC management; however, the challenge of postoperative recurrence significantly impacts mortality rates.

Methods: We have developed a pH and reactive oxygen species (ROS) dual stimulus-responsive drug delivery system (PN@GPB-PEG NPs) loaded with chemotherapeutic paclitaxel (PTX) and indoleamine 2.

Prognostic prediction models for postoperative patients with stage I to III colorectal cancer based on machine learning.

Background: Colorectal cancer (CRC) is characterized by high heterogeneity, aggressiveness, and high morbidity and mortality rates. With machine learning (ML) algorithms, patient, tumor, and treatment features can be used to develop and validate models for predicting survival. In addition, important variables can be screened and different applications can be provided that could serve as vital references when making clinical decisions and potentially improving patient outcomes in clinical settings.

Effect of different internal fixation devices on intertrochanteric fractures.

Aims: To analyze the postoperative recovery effects of different internal fixations on intertrochanteric fractures, so as to select the best fixation method for clinical practice.

Methods: This is a retrospective analysis. A total of 100 patients with intertrochanteric fractures hospitalized at The Affiliated Tai'an City Central Hospital of Qingdao University from March 2022 to March 2024 were grouped according to the treatment method.

Recent advances in biotin-based therapeutic agents for cancer therapy.

Biotin receptors, as biomarkers for cancer cells, are overexpressed in various tumor types. Compared to other vitamin receptors, such as folate receptors and vitamin B12 receptors, biotin receptor-based targeting strategies exhibit superior specificity and broader potential in treating aggressive cancers, including ovarian cancer, leukemia, colon cancer, breast cancer, kidney cancer, and lung cancer. These strategies promote biotin transport receptor-mediated endocytosis, which is triggered upon ligand binding.

Longitudinal correlation of cerebrospinal fluid GFAP and the progression of cognition decline in different clinical subtypes of Parkinson's disease.

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed mainly in astrocytes of the central nervous system (CNS), a potential biomarker of cognitive decline in Parkinson's disease (PD). The central motor subtypes of PD include tremor-dominant (TD), postural instability and gait disorder (PIGD), and indeterminate subtypes, whose different course of disease requires the development of biomarkers that can predict progression based on motor subtypes. In this study, we aimed to assess the predictive value of cerebrospinal fluid (CSF) GFAP for PD motor subtypes in PD.

Evidence for the metabolic activation of higenamine to quinone methide and ortho-quinone metabolites in vitro and in vivo using liquid chromatography tandem mass spectrometry.

Higenamine (HG), a naturally occurring benzyltetrahydroisoquinoline alkaloid, has been revealed a variety of biological activities and is extensively utilized in dietary supplements. Currently, HG is under investigation in phase I clinical trials, however, the liver metabolism of HG has so far not been fully elucidated. The present study aimed to identify reactive metabolites of HG using ultrahigh-performance liquid chromatography-tandem mass spectrometry.

Polyimide/cellulose composite membrane with excellent heat-resistance and fast lithium-ion transport for lithium-ion batteries.

Polyimide membranes have long been of great interest in the battery industries due to their outstanding thermal stability and flame retardancy. However, the preparation of polyimide membranes with ideal pore structure and excellent lithium-ion transference remains a challenge. In this study, we reported for the first time, that a nano-porous fluorinated and partially carboxylated polyimide/cellulose composite membrane was successfully synthesized by selected monomers and prepared by thermal imidization, phase separation, and alkaline hydrolysis method.

Patterned durable superhydrophobic and UV protective cotton fabric prepared through inkjet printing of Zn-based MOFs and long alkyl chain siloxane.

In order to solve the problems of high energy consumption, high raw material consumption and poor air permeability of fabrics in the dip-baking method, a simple low-liquid inkjet printing method was used to prepare superhydrophobic cotton fabrics. Inkjet printing technology enables precise control over the printing position and droplet amount, allowing for the creation of superhydrophobic patterns on the fabric surface. ZIF-8 precursor solution and long alkyl chain siloxane were formulated as suitable inks and printed on the surface of the fabric, forming a rough interface with low surface energy.

From waste to wealth: Exploring the effect of particle size on biopolymer harvesting from aerobic granular sludge.

This study aimed to examine the impact of aerobic granular sludge (AGS) sizes on its properties and alginate-like exopolymers (ALE) recovery potential. The AGS was cultivated in a lab-scale bioreactor and categorized into six size classes with 200 μm intervals. There appeared a critical size (400-800 μm) for developing stable AGS structure and excellent ALE recovery.

Redox potentials of sulfonamide antibiotics mediating the electron transfer process in single-atom Cu catalyst/peroxymonosulfate system: Selective removal mechanisms for sulfonamides.

The oxidative behaviors of target pollutants in single-atom catalysts-activated peroxymonosulfate (SACs/PMS) system has mostly been studied from the loaded metal and coordination structure of SACs. However, the origin of the altered degradation behavior caused by the specific properties of pollutants has been neglected. Herein, Cu atoms coordinated with four N atoms embedded in biochar (Cu@C) was prepared to establish the relationship between the selective degradation behavior of sulfonamide antibiotics in Cu@C/PMS system and their own properties.