Astragaloside II alleviates the symptoms of experimental ulcerative colitis and .

Background: Ulcerative colitis (UC) is a chronic inflammatory intestinal disease, and its morbidity is rising worldwide. Previous study indicated that astragaloside II (AS II), a monomeric compound, was used to treat bowel disease. However, the effects of AS II on UC remains unclear.

[Intramuscular type of nodular fasciitis: a report of 3 cases and review of literature].

Purpose: To retrospectively analyze the clinical characteristics of impacted supernumerary teeth in 115 patients.

Methods: One hundred and fifteen patients with im-pacted supernumerary teeth who were admitted to the Department of Oral and Max-illofacial Surgery of Hefei Stomatological Hospital were selected randomly. The age, sex, number of teeth, location, direction, clinical manifestation, anaes-thesia method and operation time were analyzed retrospectively, T test and Chi-square test were used to determine the statistical differences with SPSS 19.

[The symmetry of nasal maxillary complex of patients with unilateral complete cleft lip and palate at the stage of mixed dentition-A cone beam CT study].

Purpose: To investigate the symmetry of nasal maxillary complex in the three-dimensional directions of patients with unilateral complete cleft lip and palate(UCLP) at the stage of mixed dentition.

Methods: Craniofacial cone-beam CT(CBCT) images of 20 UCLP patients at the stage of mixed dentition were selected. Three-dimensional reconstruction of bone tissue was carried out by Mimics software, nasal root point and 32 markers with the same name of the healthy side and the cleft side of the nasal maxillary complex were traced, three-dimensional reference planes were set up, then the distances between the points to the three-dimensional planes were measured respectively.

[Dens in dente: report of 3 cases and review of the literature].

Purpose: To explore the diagnosis and clinical treatment of dens in dente.

Methods: Preventive resin restoration, root canal treatment, apical barrier technique and apexification were used to treat three cases of dens in dente, respectively. The curative effects were assessed by general examinations and imageological examinations during postoperative follow-up visits.

[Comparative study on using multiple kinds of sternocleidomastoid flaps or free flaps to repair defects in oral cancer surgery].

Purpose: To compare the outcomes of using multiple kinds of sternocleidomastoid flap or free flaps to repair defects after oral cancer surgery.

Methods: Twenty-eight cases using sternocleidomastoid flaps and 30 cases using free flaps were included in this study. Operation was performed in 58 patients with oral cavity cancer.

[Effect of strontium-containing cross-linked sodium alginate gel on adhesion and proliferation of pre-osteoblasts].

Purpose: To study the physicochemical properties of bismuth-containing cross-linked alginate gel, to observe and detect the adhesion and proliferation of mouse MC3T3-E1 cells in gluten-containing cross-linked alginate gel and provides a theoretical basis for alginate injectable tissue engineering scaffolds.

Methods: Five sets of electrolytes with a final concentration of 4 g/L were prepared and cross-linked with sodium alginate solution, respectively. The compression modulus and swelling ratio of each group of gels were measured.

Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide and novel therapeutic approaches are urgently required. Anemoside B4 (AB4) is a compound extracted from (). Previous studies have indicated that extract saponins has anti-cancer activity.

[A case report of multiple dentigerous cyst of mandible and review of literature].

Dentigerous cyst belongs to one kind of odontogenic cysts, and is also known as follicular cyst. After the formation of the crown or root of the tooth, liquid exudates between the residual enamel epithelium and the crown surface to form odontogenic cysts. Multiple odontogenic cysts are rare in the oral and maxillofacial regions, especially in different areas of the jaw.

Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects .

10,11-Methylenedioxy-camptothecin (FL118) is a novel camptothecin analogue that possesses exceptional antitumor efficacy in human tumor xenograft models. The aim of the current study was to develop novel 20-substituted FL118 derivatives coupled with glycosyl-succinic acid esters with improved antitumor efficacy. These FL118 glycoside derivatives were designed, synthesized and their cytotoxicity evaluated in three tumor cell lines (A-549, MDA-MB-231 and RM-1).

Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche.

Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients. The pathological description and clinical significance of PNI are clearly understood, but exploration of the underlying molecular mechanism is ongoing.

[Experimental study of a new animal model with trigeminal neuralgia produced by administration of talc to peripheral infraobital nerve in rats].

Purpose: To establish a new animal model of trigeminal neuralgia（TN） produced by administration of talc to peripheral infraobital nerve in rats.

Methods: Thirty male Wistar rats were randomly divided into 2 groups. Talcum powder (30％,0.

Ultrasensitive strips for the quadruple detection of nitrofuran metabolite residues.

In this biosensor system, metabolite residues were derived by using a previous B-CBA synthesis method to label a biotin moiety for enrichment by streptavidin coated magnetic beads. Antibodies specific for derivatives were conjugated with carboxyl-modified barcode DNAs which were used as templates for strand displacement amplification (SDA). The assay can detect trace levels of 7.

[Effect of 2 bleaching therapies on decoloring of stained dental fluorosis].

Purpose: To evaluate the clinical performance of at-home bleaching and its application in combination with cold-light bleaching for esthetic management of fluorosed teeth，providing guidance for clinicians to choose the right treatment regimen and communicate with patients successfully.

Methods: We divided 43 cases with stained dental fluorosis into 2 groups, with 22 cases in the at-home bleaching group and 21 in the combination therapy group. Stained spots were chosen and colorimetric assay was performed using CMYK colorimetric table before treatment.

An experimental hyperlipidemia model with periodontitis in mice.

Purpose: In many animal models and clinical trials, the relationship between periodontitis and hyperlipidemia is bidirectional and interlinked. In this study, an experimental hyperlipidemia model with periodontitis in mice is introduced.

Methods: C57BL/6J mice were assigned into group A and B and Apolipoprotein E-deficient (ApoE) mice into group C.

[Cytotoxicity of carboxymethyl chitosan zinc and peptide to human periodontal ligament cells].

Purpose: The purpose of this investigation was to study the cytotoxicity of carboxymethyl chitosan zinc and peptide to human periodontal ligament cells in vitro, in order to provide a reference for understanding materials' safety.

Methods: The primary cells were obtained from human periodontal tissues and cultured. The cultured cells were identified by observing the shape under microscope and by immunocytochemical method.

MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression.

MicroRNAs (miRs), acting as tumor suppressor or oncogenes genes, play a critical role in controlling tumor invasion, metastasis and survival via regulating a variety of targets. MiR-148a has been observed low expressed in several types of human cancers, and overexpression of miR-148a inhibits tumorigenesis. However, the molecular mechanisms of miR-148a-mediated these effects are largely elusive.

[Expression and significance of human Dachshund homolog 1 in tongue squamous cell carcinoma and tongue atypical hyperplasia].

Purpose: To investigate the expression and role of human Dachshund homolog1(DACH1)in the development and prognosis of tongue squamous cell carcinoma(TSCC).

Methods: The expression of DACH1 was detected immunohistochemistrically in 51 samples of paraffin-embedded TSCC, paired adjacent tissues and 25 samples of atypical hyperplasia tissues of the tongue. Statistical analysis was performed using SPSS 16.

[Synovial chondromatosis in the temporomandibular joint: report of 2 cases].

The clinical manifestations, radiographic findings, intraoperative view, histopathologic features of synovial chondromatosis（SC） in the temporomandibular joint (TMJ) were summarized in 2 cases. Preoperative symptoms included preauricular pain（2/2）, swelling（2/2） and limitation of mouth opening (0/2). X-ray findings showed widened joint space.

Serum glycoprotein-derived N- and O-linked glycans as cancer biomarkers.

Early detection of cancer is the key to improving survival. Since most clinically used serum cancer biomarkers are either glycoproteins or glycan structures that can be recognized by specific monoclonal antibodies, developing glycan structure-based biomarkers from human serum/plasma glycoproteins through mass spectrometry (MS) analysis are active research field during the past decades. Numerous studies have shown that changes in serum/plasma glycan structures occur during cancer initiation, progression, and treatment.

Targeting of slug sensitizes anaplastic thyroid carcinoma SW1736 cells to doxorubicin via PUMA upregulation.

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers and often shows resistance to multimodal therapeutic approaches. It has been shown that the transcriptional repressor Slug inhibits the chemotherapeutic agent-induced apoptosis of cancer cells. We evaluated whether targeting of Slug could augment doxorubicin (DOX)-induced apoptosis of ATC cells.

[Pigmented villonodular synovitis of the temporomandibular joint：report of one case and review of literatures].

Pigmented villonodular synovitis (PVNS) is a benign， proliferative disorder of synovium. It often affects the knee, and rarely occurs in the temporomandibular joint (TMJ). This paper reported a 45-year-old male patient with PVNS of the TMJ, who was referred with a chief complaint of slowly growing and painless preauricular mass that was noticed about 1 year.

Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling.

Objective: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies. However, the molecular mechanisms of ATC invasion are poorly understood. The transforming growth factor-beta (TGF-β) signaling pathway plays a critical role in promoting tumor metastasis.

[The effect of carboxymethyl chitosan zinc and peptide on IL-1,TNF-α and PGE-2 in gingival crevicular fluid of miniature pigs].

Purpose: This experiment was aimed at exploring whether carboxymethyl chitosan zinc and peptide （CMC-Zn(+)-P） can reduce the occurrence and development of periodontal tissue inflammation effectively by observing the change of IL-1,TNF-α and PGE-2 level in gingival crevicular fluid （GCF） before and after brushing, so as to find a new effective material in preventing and treating periodontal diseases.

Methods: Miniature pigs were selected as experimental subjects and divided into 4 groups randomly: the control group; CMC-Zn(+)-P group (material group);brushing group; brushing + CMC-Zn(+)-P group (composite group). Gingival crevicular fluid before and one month after the experiment was collected.

CXCL12/CXCR4 axis induces proliferation and invasion in human endometrial cancer.

Objective: Since that we have previously found CXCL12/CXCR4, an important biological axis is highly transcribed in several cancer cells. We aim to investigate whether CXCL12/CXCR4 axis regulates critical processes in neoplastic transformation that affects endometrial cancer cell biology.

Methods: The expression levels of CXCR4 were analyzed in human normal endometrial tissue, simple hyperplasia, atypical hyperplasia and endometrial cancer cells by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR).