Erratum: Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.

[This corrects the article on p. 11076 in vol. 8, PMID: 26617826.

Erratum: DLC-3 suppresses cellular proliferation, migration, and invasion in triple-negative breast cancer by the Wnt/β-catenin pathway.

[This corrects the article on p. 1224 in vol. 12, PMID: 31933937.

Erratum: CXCL12 chemokine expression suppresses human breast cancer growth and metastasis in vitro and in vivo.

[This corrects the article on p. 6671 in vol. 7, PMID: 25400746.

Value of prognostic nutritional index and controlling nutritional status score for advanced non-small cell lung cancer patients receiving PD-1 inhibitors.

Objective: To explore the value of preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score in predicting response and prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving programmed cell death protein 1 (PD-1) inhibitors.

Methods: A retrospective study was conducted in patients who received PD-1 inhibitors for advanced NSCLC. Patients were assigned by immunotherapy effects into response (partial and complete response, pCR) group (n=52) and non-response (non-pCR) group (n=132).

[An in vitro experiment on the stability and irritant of hypochlorous acid in oral cavity].

Purpose: To study the stability of physicochemical properties and sterilizing effect about two commercially available hypochlorous acid (HClO) products under simulated clinical conditions, and to evaluate the compatibility of HClO on soft and hard tissues and cells in oral cavity.

Methods: Samples of HClO solution with different production processes were prepared, to detect the changes of physicochemical indexes of each sample over time under simulated clinical conditions (shielded from light at 20-25 ℃, open the cover for 5 minutes every day), including free available chlorine, oxidation-reduction potential and pH. Through suspension quantitative germicidal test, the antibiosis-concentration curve of HClO solution was made, so as to calibrate the change of antibacterial ability of disinfectant with the decrease of available chlorine content during storage.

Low RPMB indicates better disease-free survival of adjuvant radiotherapy after radical surgery in thymoma.

Background: The current use of adjuvant radiotherapy in thymoma (THYM) following radical surgery is primarily based on clinical factors and is a subject of ongoing debate.

Methods: We developed a new biomarker, promotor methylation burden of Deoxyribonucleic acid repair genes (RPMB), to identify patients who may benefit from adjuvant radiotherapy after complete resection in THYM. RPMB quantitatively measures the promoter methylation level of Deoxyribonucleic acid (DNA) repair genes.

Endostar (rh-endostatin) consolidation therapy after sequential chemoradiotherapy in stage III, unresectable lung adenocarcinoma with novel STK11, TP53 and ATM mutations: a case report.

Concurrent chemoradiotherapy (cCRT) has been predominantly used as the standard therapy for locally advanced or unresectable non-small cell lung cancer (NSCLC) patients with stage III disease. Based on the outstanding results of Phase III Pacific study, Programmed Death-Ligand 1 (PD-L1) inhibitor consolidation therapy after cCRT without progression disease (PD) has been recommended by National Comprehensive Cancer Network (NCCN) guideline as standard therapy for these patients. However, not all patients can tolerate a full course of cCRT due to the poor performance status, concurrent complications, or poor pulmonary function.

Prevalence of mobile phone addiction among medical students: a systematic review.

The incidence and factors related to mobile phone addiction among Chinese medical students were analyzed through meta-analysis. Chinese literature databases (such as China Knowledge Network and VIP Information Resource System) and English literature databases (such as PubMed and Web of Science) were searched for cross-sectional studies on the incidence and factors related to mobile phone addiction, and the required data were extracted. Meta-analysis was performed using a random effects model with RevMan 5.

Exosomal transfer of miR-548aq-3p confers cisplatin resistance MED12 downregulation in epithelial ovarian cancer.

The RNA polymerase II mediator complex subunit 12 (MED12) is an important factor for chemotherapy sensitivity. We explored the roles of exosomal transfer of carcinogenic microRNAs (miRNAs) in MED12 regulation and cisplatin resistance of ovarian cancer cells. In this study, the correlation between MED12 expression and cisplatin resistance was analyzed in ovarian cancer cells.

Electroactive nanofibrous membrane with temperature monitoring for wound healing.

Developing functional dressings for promoting cellular activities and monitoring the healing progress is receiving increasingly widespread attention. In this study, Ag/Zn electrodes were deposited on the surface of a polylactic acid (PLA) nanofibrous membrane which can mimic the extracellular matrix. When wetted by wound exudate, the Ag/Zn electrodes could generate an electric stimulation (ES), promoting the migration of fibroblasts that heal wounds.

[Comparison of three root canal disinfection methods for removal of Enterococcus faecalis under minimally invasive root canal treatment].

Purpose: To obtain an efficient and simple root canal disinfection method based on minimally invasive root canal treatment by comparing different root canal disinfection methods between minimally invasive root canal treatment and conventional root canal treatment.

Methods: Sixty-six extracted maxillary first molars were randomly divided into experimental group (computer-guided precision minimally invasive root canal treatment) and control group (conventional root canal treatment). All teeth were prepared to ProTaper universal F2, and Enterococcus faecalis infection models were established.

Preparation of mussel-inspired silver/polydopamine antibacterial biofilms on Ti-6Al-4V for dental applications.

The properties of osseointegration and antibacterial ability is vital import for dental materials. Herein, we designed the multilayer TC4-Ag-polydopamine coatings, to provide TC4 with slow-release antibacterial properties whilst maintaining cytocompatibility. In brief, thickness of Ag inner layer can be easily controlled by magnetron sputtering technology.

CCR10/CCL27 crosstalk regulates cell metastasis via PI3K-Akt signaling axis in non-small-cell lung cancer.

Previous research has shown that CCR10 acts as a vital oncogene in the progression of multiple malignancies. However, its effect on the treatment of non-small-cell lung cancer (NSCLC) has not been investigated. Current research examined the effect of CCR10 on the cellular survival and migration of NSCLC, and the modulation of cell death and found that the expression levels of CCR10 and CCL27 (ligand) were highly upregulated in human NSCLC tissue and cell lines, A549 and H157, compared with adjacent normal lung specimens.

[Effect of protection and remineralization of glass ionomer protective film and fluoride varnish on enamel: an in vitro study].

Purpose: To compare the remineralization and protection effect of glass ionomer protective film and fluoride varnish on enamel.

Methods: One hundred and twenty-two premolars were collected and made into enamel blocks, two enamel blocks were randomly selected for scanning electron microscope(SEM) observation, the others were used for two experiments. In enamel protection test (experimental A), 60 enamel blocks were divided into 3 groups (n=20) randomly and treated with glass ionomer protective film(A1) and fluoride varnish(A2), the control group(A3) was not treated.

[Effect of PRRX1 on autophagy of salivary adenoid cystic carcinoma cells].

Purpose: To investigate the effect of paired related homeobox1 (PRRX1) on autophagy of salivary adenoidcystic carcinoma (SACC) cells.

Methods: PRRX1-overexpressed lentiviral vectors and their negative control lentiviral vectors were used to transfect SACC cells. The transfection effect was detected by Western blot.

A multi-class COVID-19 segmentation network with pyramid attention and edge loss in CT images.

At the end of 2019, a novel coronavirus COVID-19 broke out. Due to its high contagiousness, more than 74 million people have been infected worldwide. Automatic segmentation of the COVID-19 lesion area in CT images is an effective auxiliary medical technology which can quantitatively diagnose and judge the severity of the disease.

[Evaluation on the fracture resistance of dental tissues after guided plate-mediated precision minimally invasive root canal treatment].

Purpose: In order to achieve accurate and minimally invasive root canal treatment and enhance the fracture resistance of tooth tissue after root canal therapy, this study explores digital guided mediated minimally invasive root canal treatment and compares it with conventional root canal treatment to provide a more favorable method for clinical practice.

Methods: Forty freshly extracted first permanent molars were randomly divided into control group and experimental group. Teeth in the control group were treated with conventional root canal treatment, while teeth in the experimental group were treated with precise minimally invasive root canal treatment.

[Related factors of atrophic glossitis in 124 consecutive cases].

Purpose: To study the relationship between atrophic glossitis and anemia, anemia types and other related factors(oral candida infection, xerostomia) in 124 consecutive cases.

Methods: One hundred and twenty-four cases with atrophic glossitis and 53 healthy controls were collected from Qingdao local population. The main indexes including general status, oral examination findings, hemoglobin (Hb), mean red blood cell volume (MCV), vitamin B12, ferritin, folic acid, anemia and anemia type, xerostomia and candida infection were statistically analyzed using SPSS 20.

Blockade of CXCR2 suppresses proinflammatory activities of neutrophils in ulcerative colitis.

Ulcerative colitis (UC) is one chronically remittent and progressive inflammatory disorder. Chemokine receptor CXCR2 is reported to be involved in the pathogenesis of several inflammatory diseases. However, how CXCR2 modulate mucosal inflammation in UC is still obscure.

[Analysis of cortical density in zygomatic alveolar ridge of different vertical facial types].

Purpose: To measure the density of the cortex in the zygomatic alveolar ridge region of adults by 3D reconstruction, and to analyze the differences of cortical bone density between different vertical facial types in the zygomatic alveolar ridge in different vertical facial types.

Methods: Spiral CT scanning data of 48 patients (24 males and 24 females) were chosen for 3D reconstruction and divided into 3 groups(low-angle group, average-angle group and high-angle group) according to the size of the mandibular plane angle (FH-MP), 18 points at which the six planes of the zygomatic alveolar ridge on the left of the upper jaw intersected at 13, 15 and 17 mm above the baseline(the horizontal line of mesial buccal tip of the first maxillary molar) were measured. SPSS 17.

Biointerface topography mediates the interplay between endothelial cells and monocytes.

Endothelial cell (EC) monolayers located in the inner lining of blood vessels serve as a semipermeable barrier between circulating blood and surrounding tissues. The structure and function of the EC monolayer affect the recruitment and adhesion of monocytes, which plays a pivotal role in the development of inflammation and atherosclerosis. Here we investigate the effect of material wrinkled topographies on the responses of human umbilical vein endothelial cells (HUVECs) and adhesion of monocytes to HUVECs.

MicroRNA-21 and microRNA-155 promote the progression of Burkitt's lymphoma by the PI3K/AKT signaling pathway.

Introduction: Burkitt's lymphoma (BL) is a rare and highly aggressive B cell non-Hodgkin lymphoma. High toxicity of chemotherapy for BL treatment causes morbidity and mortality. Many miRNAs have been used as biomarkers for early detection or therapy targets for tumors.

TRB3 regulates pulmonary interstitial fibrosis through the MAPK signaling pathway.

This study aims to investigate the effects of TRB3 on the EMT and MAPK signaling pathways in a bleomycin (BLM)-induced pulmonary fibrosis mouse model. TRB3 adenovirus vector with green fluorescent protein (GFP) and TRB3-siRNA adenovirus vector were constructed for overexpression and down-regulation of TRB3, respectively. The pulmonary fibrosis mouse model was induced by bleomycin, and then treated with adenovirus on the next day.

The efficacy of Tc-MIBI imaging in I seed implantation treatment of rabbit VX2 transplanted liver cancer.

Purpose: To evaluate the efficacy of Tc-MIBI imaging in the evaluation of I radioactive particle implantation for treatment of rabbit VX2 transplanted liver cancer.

Methods: Twelve New Zealand white rabbit VX2 liver cancer models were successfully prepared by tumor cell suspension method and randomly divided into a control group and treatment group. The treatment group received I particle implantation according to the TPS plan, and the control group received the same number of hollow particle implantation.

DLC-3 suppresses cellular proliferation, migration, and invasion in triple-negative breast cancer by the Wnt/β-catenin pathway.

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Our study investigated the functional role of DLC-3 in TNBC. The expression of DLC-3 was assessed by immunohistochemistry in TNBC to evaluate the clinicopathologic significance of DLC-3.