Exposure to titanium dioxide nanoparticles disrupts the BTB by interfering with the assembly of stress granules in germ cells.

Titanium dioxide nanoparticles (TiO NPs) are among the most prevalent nanomaterials utilized in industrial and medical fields. However, their impact on spermatogenesis and male fertility remains insufficiently characterized. This study addresses the reproductive toxicity of TiO NPs and elucidates the underlying molecular mechanisms involved.

Stearic acid metabolism in human health and disease.

Named after the Greek term for "hard fat", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis.

Complications and patient-reported outcomes after radiotherapy in breast cancer patients undergoing implant-based breast reconstruction: a retrospective study from a large Chinese breast disease center.

Background: Postmastectomy radiation therapy (PMRT) can influence the outcome of implant-based breast reconstruction (IBBR). This study aims to investigate the complications and patient-reported outcomes (PROs) following PMRT between direct-to-implant (DTI) and tissue expander-to-implant (TEI) reconstruction.

Methods: The retrospective study included breast cancer patients undergoing IBBR and PMRT.

Heterozygous Inversion on Chromosome 17 involving PAFAH1B1 Detected by Whole Genome Sequencing in a Patient Suffering from Pachygyria.

Lissencephaly (LIS) is a subtype of malformations of cortical development (MCD), characterized by smooth brain surfaces and underdeveloped gyri and sulci. This study investigates the genetic cause of pachygyria in a Chinese male infant diagnosed with the condition, who previously showed no causative variant through trio whole exome sequencing (Trio-WES) and copy number variation sequencing (CNVseq). Whole-genome sequencing (WGS) was conducted, revealing a novel heterozygous inversion spanning 1.

Helicobacter pylori and rheumatoid arthritis: Investigation of relation from traditional Chinese medicine.

Rheumatoid arthritis (RA) is an autoimmune condition that predominantly affects synovial joints, manifesting with joint swelling, pain, and stiffness. In advanced stages, unchecked inflammation can inflict damage on bone and cartilage, resulting in disabilities and deformities of the joints. Additionally, systemic and extra-articular complications may arise due to the consequences of uncontrolled inflammation.

Brain endocannabinoid control of metabolic and non-metabolic feeding behaviors.

The central endocannabinoid (eCB) system in brain shows a crucial role in the regulation of feeding behaviors, influencing both metabolic and non-metabolic mechanisms of appetite control, which has been paid much attention. Although there are already many review articles discussing eCB modulation of feeding behaviors, our paper attempts to summarize the recent advancements through synapses, circuits, and network in brain. Our focus is on the dual role of eCB signalling in regulating metabolic energy balance and hedonic reward-related feeding.

Isoquercitrin improves diabetes nephropathy by inhibiting the sodium-glucose co-transporter-2 pathway.

Diabetic nephropathy (DN) is one of the most severe kidney complications and the primary contributor to end-stage renal disease on a global scale. It exacerbates the morbidity, mortality, and financial burden for individuals with diabetes. Isoquercitrin, a natural compound found in various plants, has demonstrated potential as an antidiabetic agent.

Tracking the nitrogen transformation in saline wastewater by marine anammox bacteria-based Fe(II)-driven autotrophic denitratation and anammox.

Marine anammox bacteria-based Fe(II)-driven autotrophic denitratation and anammox (MFeADA) was investigated for nitrogen removal from saline wastewater for the first time. The study demonstrated that varying influent doses of Fe(II), which participate in the Fe cycle, significantly influenced nitrogen removal performance by altering the fate of nitrite. When 50 mg/L Fe(II) was added, the nitrogen removal was mainly performed by the anammox and Fe(II)-driven autotrophic denitratation (FeAD).

Endoscopic Papillary Large Balloon Dilatation With or Without Endoscopic Sphincterotomy in the Treatment of Common Bile Duct Stones.

Purpose Of Review: Endoscopic papillary large balloon dilation (EPLBD) has been proved to have better efficacy and safety in removing common bile duct stones. Conventional endoscopic sphincterotomy (EST) is usually performed before EPLBD. However, EPLBD without EST has recently reported short-term outcomes similar to those of EPLBD with EST.

Study on the Mechanism of Bifidobacterium animalis subsp. lactis F1-3-2 Regulating Bile Acid Metabolism Through TMA-TMAO Pathway to Improve Atherosclerosis.

Atherosclerosis is a major cause of cardiovascular disease (CVD). The trimethylamine (TMA)-trimethylamine N-oxide (TMAO) pathway is a key crossover pathway highly associated with diet, gut microbiome, and atherosclerosis. The Bifidobacterium animalis subsp.

Application of machine learning methods for predicting esophageal variceal bleeding in patients with cirrhosis.

Objective: To develop and compare machine learning models based on CT morphology features, serum biomarkers, and basic physical conditions to predict esophageal variceal bleeding.

Materials And Methods: Two hundred twenty-four cirrhotic patients with esophageal variceal bleeding and non-bleeding were included in the retrospective study. Clinical and serum biomarkers were used in our study.

Effect of traction therapy on muscle satellite cell proliferation and differentiation in a rat model of knee stiffness.

Background: In the rat knee stiffness model, the duration of traction treatment is mostly 20-40 min; however, relatively few studies have been conducted on longer traction treatment of extended knee stiffness in rats. Therefore, the aim of this study was to explore the efficacy of prolonged traction and its mechanism of action in extended knee stiffness in rats.

Methods: The model of extended knee joint stiffness was established in rats and treated with powered flexion position traction.

Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice.

Obesity is a worldwide health issue. Effective and safe methods for obesity management are highly desirable. In the current study, hyperbaric oxygen (HBO) treatment was investigated as a potential treatment against obesity-associated hyperphagia and hyperenergy intake.

HCC Model Induced by P53 and Pten Knockout in HBV-Transgenic Mice Mirrors Human HCC at the Transcriptome Level.

With a multitude of HCC mouse models available, choosing the one that most closely resembles human HCC can be challenging. This study addresses this gap by conducting a comprehensive transcriptomic similarity analysis of widely used HCC mouse models. In this study, RNA-seq was performed on a model induced by double knockout of P53 and Pten via CRISPR/Cas9 in HBV-transgenic mice.

Primary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report.

A 67-year-old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic-keratosis-like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive.

Synergy of Cu-doping and reconstruction on BiOCO for promoting CO electroreduction over a wide pH range.

A one-pot hydrothermal reaction was proposed to synthesize Cu-doped BiOCO. Doping Cu with smaller electronegativity than that of Bi and electrochemical reconstruction on BiOCO optimize the hybridization between Bi 6p of BiOCO and O 2p of *OCHO, acquiring FE of ∼100% at a current density of >100 mA cm over a wide pH range.

NUF2 is associated with cancer stem cell characteristics and a potential drug target for prostate cancer.

Background: Cancer stem cells are characterized by self-renewal, clonal tumor initiation capacity, and treatment resistance, which play essential roles in the tumor progression of prostate cancer (PCa). In this study, we aim to explore the features of cancer stemness and characterize the expression of stem cell-related genes for PCa.

Methods: We downloaded RNA-seq data and related clinical information from The Cancer Genome Atlas (TCGA) database.

Organogel Polymer Electrocatalysts for Two-Electron Oxygen Reduction.

Polymer gels, renowned for unparalleled chemical stability and self-sustaining properties, have garnered significant attention in electrocatalysis. Notably, organic polymer gels that exhibit temperature sensitivity and incorporate suitable polar nonvolatile liquids, enhance electronic conductivity, and impart distinct morphological features, but remain largely unexplored as electrocatalysts for oxygen reduction reaction (ORR). To address this issue, an innovative strategy is proposed for synergistic modulation of the rigidity of mainchain molecular skeleton and length of alkyl sidechains, enabling the development of organogel polymers with a sol-gel temperature-sensitive phase transition that promises high selectivity and enhanced activity in electrocatalytic processes.

Limonin alleviates imiquimod-induced psoriasis-like skin inflammation in mice model by downregulating inflammatory responses.

Psoriasis is a chronic inflammatory condition affecting 1-2% of the global population. Phytomedicine, which uses plant-based compounds, is emerging as a promising approach to managing such inflammatory diseases. Limonin, a phytochemical found in citrus fruits and known for its bitter taste, possesses significant pharmacological properties.

A twenty-year dataset of hourly energy generation and consumption from district campus building energy systems.

Distributed energy resources (DERs) would play a crucial role in the transition towards decentralized and decarbonized energy systems. However, due to the limited availability of long-term, high-resolution datasets, there has been little research on the descriptive analysis of distributed energy systems throughout the lifespan of distributed power generators and beyond. To address this challenge, this study has collected and described a twenty-year dataset (from 2002 to 2021) consisting of hourly energy generation and consumption profiles from a campus distributed energy system, covering the entire lifespan of on-site generators.

Intra-articular injection of vancomycin after arthrotomy closure following gentamicin-impregnated bone cementation in primary total knee arthroplasty provides a high intra-articular concentration while avoiding systemic toxicity: a prospective study.

Background: This study aimed to elucidate the safety and intra-articular elution profiles of vancomycin and gentamicin bone cement in patients undergoing primary total knee arthroplasty (TKA), with a focus on serum safety thresholds and therapeutic efficacy.

Methods: Consecutive patients who underwent unilateral primary TKA were prospectively enrolled. The implants were fixed using gentamicin-impregnated bone cement, and after arthrotomy closure, 1000 mg of vancomycin suspended in 25 mL of normal saline was directly injected into the joint.

Compressive interatomic distance stimulates photocatalytic oxygen-oxygen coupling to hydrogen peroxide.

Photocatalytic hydrogen peroxide (HO) generation is largely subject to the sluggish conversion kinetics of the superoxide radical (O) intermediate, which has relatively low reactivity and requires high energy. Here, we present a lattice-strain strategy to accelerate the conversion of O to highly active singlet oxygen(O) by optimizing the distance between two adjacent active sites, thereby stimulating HO generation via low-barrier oxygen-oxygen coupling. As the initial demonstration, the defect-induced strain in ZnInS nanosheet optimizes the distance of two adjacent Zn sites from 3.

Impact of microplastics on aquatic flora: Recent status, mechanisms of their toxicity and bioremediation strategies.

The accumulation of microplastics (MPs) in aquatic environments has occurred pervasively. The MPs affect almost all the aquatic plants including the aquatic microorganisms, ultimately disturbing the food chain. Aquatic flora attracts MPs due to the formation of several chemical bonds and interactions, including hydrogen bonds, electrostatic, hydrophobic, and van der Waals.

A multi-functional oxidative konjac glucomannan/ε-poly-l-lysine hydrogel with antibacterial, haemostatic, and chronic diabetic wound-treating properties.

A chronic diabetic wound, one of the most severe complications of diabetes, has a high incidence and causes great pain to patients, threatening their lives. In this paper, oxidative konjac glucomannan (OKGM) was reacted with ε-poly-l-lysine (EPL) through the dynamic Schiff's base reaction to make a multi-functional hydrogel. This hydrogel had excellent mechanical properties, injectability, self-healing ability, adhesivity and cytocompatibility.

Effects of 3,4-methylenedioxymethamphetamine on the gut microbiota and metabolites in the small intestine, cecum, and colon of male rats.

3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) is a widely abused recreational drug that has also gained interest for potential clinical applications in mental health. With the growing recognition of gut microbiota's role in mental health, this study examined whether repeated oral MDMA administration could affect gut microbiota in the small intestine, cecum, and colon of male rats. Repeated oral MDMA administration (10 mg/kg/day for 14 days) caused significant changes in the gut microbiota across these regions, with distinct effects observed in each.