A single nucleotide polymorphism of the interferon-γ gene and susceptibility to hepatitis B virus-related cirrhosis: a randomized controlled trial.

Objective: This study aimed to explore the correlation between a single nucleotide polymorphism (SNP) of the interferon-γ (IFN-γ) gene and susceptibility to hepatitis B virus (HBV) -related cirrhosis in the Chinese population.

Method: PCR-LDR was employed for the genotyping of two SNPs, rs1861494 and rs2069718, of the IFN-γ gene in 230 patients with HBV-related cirrhosis and 320 inactive HBsAg carriers without cirrhosis. It was then determined whether the Hardy-Weinberg (H-W) equilibrium was satisfied.

Downregulation of ubiquitin-specific peptidase 39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells.

Ubiquitin-specific peptidase 39 (USP39) has been reported to participate in the mitotic spindle checkpoint and the process of cytokinesis. and has been identified as a therapeutic target for various types of cancer. However, the effect of USP39 in colorectal cancer (CRC) has not been investigated.

Effects of HIV on metabolic and biological pathways of CD4 T lymphocytes.

The effects of human immunodeficiency virus (HIV) on the metabolic and biological pathways of cluster of differentiation (CD)4 T lymphocytes were investigated. A total of 150 patients with acquired immune deficiency syndrome (AIDS) and 50 healthy individuals who were admitted to hospital for physical examination during the period of June 2016 to January 2017, were selected as subjects in the present study. According to the virus load, 150 AIDS patients were divided into three groups: i) Viral load >10 copies/ml (group A, n=39), ii) 10 copies/ml < viral load <10 copies/ml (group B, n=76), and iii) viral load <10 copies/ml (group C, n=35).

Copious Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Complicated Appendicitis in Adults.

Objective: The objective of this study was to determine whether copious irrigation of peritoneal cavity during laparoscopic appendectomy for complicated appendicitis effectively reduces the incidence of postoperative complications and improves the postoperative recovery in adults compared with suction alone.

Methods: In this prospective randomized trial, adult patients with complicated appendicitis were randomized to "irrigation and suction"(IS) group or "suction only"(SO) group. All surgery was performed with a standardized 3-port laparoscopic approach.