Dithieno[3,2-:2',3'-]silole-based conjugated polymers for bioimaging in the short-wave infrared region.

The short-wave infrared window (SWIR, 900-1700 nm) fluorescence imaging has been demonstrated to have excellent imaging performance in signal/noise ratio and tissue penetration compared to the conventional NIR biological window (NIR-I, 700-900 nm). Conventional organic SWIR fluorescent materials still suffer from low fluorescence quantum efficiency. In this work, a donor unit with sp hybrid configuration and an acceptor unit with small hindered alkyl side chains are employed to construct donor-acceptor (D-A) type conjugated polymers P1 and P2, which were substituted with one or two fluorine atoms.

Development of paclitaxel loaded pegylated gelatin targeted nanoparticles for improved treatment efficacy in non-small cell lung cancer (NSCLC): an in vitro and in vivo evaluation study.

Purpose: To develop and evaluate paclitaxel (PTX) loaded pegylated gelatin targeted nanoparticles for improved efficacy in non-small cell lung cancer (NSCLC) treatment.

Method: PTX loaded gelatin nanoparticles (PTX-GNP) were prepared by crosslinking with glutaraldehyde aqueous solution. These nanoparticles (NPs) were further incubated with PEG 400 to form PEGylated NPs (PEG-PTX-GNP).

Benchmarking of electron beam parameters based on Monte Carlo linear accelerator simulation.

Background: The main objective in this paper is to build up a simplified benchmarking procedure to determine the incident electron beam parameters independently using a Monte Carlo linear accelerator model.

Methods: A 10×10 cm field is used to acquire the parameters influences on the dose distributions for 6 MeV megavoltage electron beams.

Results: The calculated depth doses had no significant changes when the electron mean energy and radial intensity varied from 5.

Complete genomic sequence of bacteriophage P23: a novel Vibrio phage isolated from the Yellow Sea, China.

A novel Vibrio phage, P23, belonging to the family Siphoviridae was isolated from the surface water of the Yellow Sea, China. The complete genome of this phage was determined. A one-step growth curve showed that the latent period was approximately 30 min, the burst size was 24 PFU/cell, and the rise period was 20 min.

Clinical study on labor pain relief using the combined spinal-epidural analgesia and inhaling nitrous oxide.

Objective: To study the pain relief effectiveness of the combined spinal-epidural analgesia (CSEA) and the inhalation of nitrous oxide, and the influences on the mothers and infants.

Methods: The 300 cases of pregnant women were randomly divided into 3 groups: CSEA group, nitrous oxide group and control group. The nitrous oxide group was that pregnant women inhaled nitrous oxide premixed with oxygen (50%:50%), the pregnant women of the CSEA group were injected fentanyl and bupivacaine in the subarachnoid and epidural space, analgesic was not used in the control group.